ECSP21022719A - Formas cristalinas de un inhibidor de fosfoinositida 3quinasa (pi3k) - Google Patents
Formas cristalinas de un inhibidor de fosfoinositida 3quinasa (pi3k)Info
- Publication number
- ECSP21022719A ECSP21022719A ECSENADI202122719A ECDI202122719A ECSP21022719A EC SP21022719 A ECSP21022719 A EC SP21022719A EC SENADI202122719 A ECSENADI202122719 A EC SENADI202122719A EC DI202122719 A ECDI202122719 A EC DI202122719A EC SP21022719 A ECSP21022719 A EC SP21022719A
- Authority
- EC
- Ecuador
- Prior art keywords
- crystalline forms
- pi3k
- phosphoinositide
- kinase inhibitor
- imidazo
- Prior art date
Links
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 title abstract 3
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 title 2
- 102000038030 PI3Ks Human genes 0.000 title 1
- 108091007960 PI3Ks Proteins 0.000 title 1
- VHMODILVAAVUJY-UHFFFAOYSA-N 8-amino-N-(2-hydroxy-2-methylpropyl)-3-[2-methyl-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide Chemical compound NC=1C=2N(C=C(N=1)C(=O)NCC(C)(C)O)C(=CN=2)C1=C(C=CC(=C1)C(C(F)(F)F)(C)O)C VHMODILVAAVUJY-UHFFFAOYSA-N 0.000 abstract 2
- AIJMGQDXUVKDIN-UHFFFAOYSA-N 2-[3-[8-amino-6-(trifluoromethyl)imidazo[1,2-a]pyrazin-3-yl]-4-methylphenyl]-3,3,3-trifluoro-2-hydroxypropanamide Chemical compound NC=1C=2N(C=C(N=1)C(F)(F)F)C(=CN=2)C=1C=C(C=CC=1C)C(C(=O)N)(C(F)(F)F)O AIJMGQDXUVKDIN-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000012828 PI3K inhibitor Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a sales y formas cristalinas de 2(3(8amino6(trifluorometil)imidazo[1,2a]pirazin3il)4metilfenil)3,3,3trifluoro2hidroxipropanamida, formas cristalinas de 8aminoN(2hidroxi2metilpropil)3(2metil5(1,1,1trifluoro2hidroxipropan2il)fenil)imidazo[1,2a]pirazin6carboxamida y formas cristalinas de 8aminoN(2hidroxi2metilpropil)3(2(metild3)5(1,1,1trifluoro2hidroxipropan2il)fenil)imidazo[1,2a]pirazin6carboxamida, que son inhibidores de PI3K de utilidad en el tratamiento de cáncer y otras enfermedades.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862727339P | 2018-09-05 | 2018-09-05 | |
US201862727321P | 2018-09-05 | 2018-09-05 | |
US201862727328P | 2018-09-05 | 2018-09-05 | |
US201862746928P | 2018-10-17 | 2018-10-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP21022719A true ECSP21022719A (es) | 2021-06-30 |
Family
ID=69642051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI202122719A ECSP21022719A (es) | 2018-09-05 | 2021-03-31 | Formas cristalinas de un inhibidor de fosfoinositida 3quinasa (pi3k) |
Country Status (27)
Country | Link |
---|---|
US (2) | US11186580B2 (es) |
EP (2) | EP3847175B1 (es) |
JP (1) | JP2021535182A (es) |
KR (1) | KR20210091121A (es) |
CN (1) | CN113677683A (es) |
AU (1) | AU2019336675A1 (es) |
BR (1) | BR112021004094A2 (es) |
CA (1) | CA3111629A1 (es) |
CL (1) | CL2021000539A1 (es) |
CO (1) | CO2021004061A2 (es) |
CR (1) | CR20210165A (es) |
DK (1) | DK3847175T3 (es) |
EC (1) | ECSP21022719A (es) |
FI (1) | FI3847175T3 (es) |
HR (1) | HRP20240252T1 (es) |
IL (2) | IL309869A (es) |
LT (1) | LT3847175T (es) |
MA (1) | MA53561A (es) |
MX (2) | MX2021002551A (es) |
PE (1) | PE20211815A1 (es) |
PH (1) | PH12021550472A1 (es) |
PT (1) | PT3847175T (es) |
RS (1) | RS65334B1 (es) |
SG (1) | SG11202102224UA (es) |
SI (1) | SI3847175T1 (es) |
TW (1) | TWI833796B (es) |
WO (1) | WO2020051169A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019079469A1 (en) | 2017-10-18 | 2019-04-25 | Incyte Corporation | CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED WITH HYDROXY TERTIARY GROUPS AS INHIBITORS OF PI3K-GAMMA |
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US10138248B2 (en) | 2016-06-24 | 2018-11-27 | Incyte Corporation | Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-b]pyridazines and substituted imidazo[1,2-a]pyrazines as PI3K-γ inhibitors |
WO2018038265A1 (ja) | 2016-08-26 | 2018-03-01 | 田辺三菱製薬株式会社 | 二環式含窒素複素環化合物 |
WO2019079469A1 (en) * | 2017-10-18 | 2019-04-25 | Incyte Corporation | CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED WITH HYDROXY TERTIARY GROUPS AS INHIBITORS OF PI3K-GAMMA |
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