ECSP11010913A - Anticuerpos biespecíficos anti-egfr / anti-igf-1r - Google Patents
Anticuerpos biespecíficos anti-egfr / anti-igf-1rInfo
- Publication number
- ECSP11010913A ECSP11010913A EC2011010913A ECSP11010913A ECSP11010913A EC SP11010913 A ECSP11010913 A EC SP11010913A EC 2011010913 A EC2011010913 A EC 2011010913A EC SP11010913 A ECSP11010913 A EC SP11010913A EC SP11010913 A ECSP11010913 A EC SP11010913A
- Authority
- EC
- Ecuador
- Prior art keywords
- antibodies
- igf
- egfr
- biespectific
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención está relacionada con anticuerpos biespecíficos frente a EGFR y frente a IGF-1R, métodos para su producción, composiciones farmacéuticas que contienen dichos anticuerpos, y usos de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08016952 | 2008-09-26 | ||
EP09004908 | 2009-04-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP11010913A true ECSP11010913A (es) | 2011-08-31 |
Family
ID=41338633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2011010913A ECSP11010913A (es) | 2008-09-26 | 2011-03-25 | Anticuerpos biespecíficos anti-egfr / anti-igf-1r |
Country Status (18)
Country | Link |
---|---|
US (2) | US20100081796A1 (es) |
EP (1) | EP2342231A1 (es) |
JP (1) | JP2012503612A (es) |
KR (1) | KR20110047255A (es) |
CN (2) | CN102164960A (es) |
AR (1) | AR073664A1 (es) |
AU (1) | AU2009296297A1 (es) |
BR (1) | BRPI0919382A2 (es) |
CA (1) | CA2736408A1 (es) |
CO (1) | CO6362023A2 (es) |
EC (1) | ECSP11010913A (es) |
IL (1) | IL211675A0 (es) |
MA (1) | MA32713B1 (es) |
MX (1) | MX2011003133A (es) |
PE (1) | PE20110926A1 (es) |
RU (1) | RU2011116112A (es) |
TW (1) | TW201019960A (es) |
WO (1) | WO2010034441A1 (es) |
Families Citing this family (116)
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EP4218801A3 (en) | 2006-03-31 | 2023-08-23 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
AR062223A1 (es) | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
PE20090368A1 (es) | 2007-06-19 | 2009-04-28 | Boehringer Ingelheim Int | Anticuerpos anti-igf |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
PL2344540T3 (pl) | 2008-10-02 | 2018-05-30 | Aptevo Research And Development Llc | Białka wiążące wiele celów antagonistyczne względem cd86 |
BRPI0923359B8 (pt) | 2008-12-12 | 2021-05-25 | Boehringer Ingelheim Int | molécula de anticorpo anti-igf, método para a produção da mesma, molécula de dna, vetor de expressão, e composição farmacêutica e método in vitro para inibir a ligação do igf-1 e do igf-2 ao receptor de igf-1 e ao receptor de insulina ir-a |
EP2414391B1 (en) | 2009-04-02 | 2018-11-28 | Roche Glycart AG | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
PL2417156T3 (pl) | 2009-04-07 | 2015-07-31 | Roche Glycart Ag | Trójwartościowe, bispecyficzne przeciwciała |
AU2010252284A1 (en) * | 2009-05-27 | 2011-11-17 | F. Hoffmann-La Roche Ag | Tri- or tetraspecific antibodies |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
RU2573915C2 (ru) | 2009-09-16 | 2016-01-27 | Дженентек, Инк. | Содержащие суперспираль и/или привязку белковые комплексы и их применение |
LT2519543T (lt) * | 2009-12-29 | 2016-10-10 | Emergent Product Development Seattle, Llc | Heterodimerus rišantys baltymai ir jų panaudojimas |
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TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
CN102241774B (zh) * | 2010-05-27 | 2014-05-14 | 四川大学 | 重组IgE-Fc-抗EGFR单链抗体融合蛋白及其制备方法和用途 |
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-
2009
- 2009-09-21 EP EP09815644A patent/EP2342231A1/en not_active Withdrawn
- 2009-09-21 AU AU2009296297A patent/AU2009296297A1/en not_active Abandoned
- 2009-09-21 PE PE2011000643A patent/PE20110926A1/es not_active Application Discontinuation
- 2009-09-21 CA CA2736408A patent/CA2736408A1/en not_active Abandoned
- 2009-09-21 CN CN2009801377233A patent/CN102164960A/zh not_active Withdrawn
- 2009-09-21 RU RU2011116112/10A patent/RU2011116112A/ru not_active Application Discontinuation
- 2009-09-21 KR KR1020117006890A patent/KR20110047255A/ko not_active Application Discontinuation
- 2009-09-21 CN CN2012100823052A patent/CN102643345A/zh active Pending
- 2009-09-21 MX MX2011003133A patent/MX2011003133A/es not_active Application Discontinuation
- 2009-09-21 JP JP2011528222A patent/JP2012503612A/ja active Pending
- 2009-09-21 WO PCT/EP2009/006782 patent/WO2010034441A1/en active Application Filing
- 2009-09-21 BR BRPI0919382A patent/BRPI0919382A2/pt not_active IP Right Cessation
- 2009-09-23 AR ARP090103662A patent/AR073664A1/es unknown
- 2009-09-23 TW TW098132098A patent/TW201019960A/zh unknown
- 2009-09-24 US US12/565,786 patent/US20100081796A1/en not_active Abandoned
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2011
- 2011-03-10 IL IL211675A patent/IL211675A0/en unknown
- 2011-03-25 EC EC2011010913A patent/ECSP11010913A/es unknown
- 2011-03-30 CO CO11039189A patent/CO6362023A2/es not_active Application Discontinuation
- 2011-04-13 MA MA33773A patent/MA32713B1/fr unknown
- 2011-12-20 US US13/330,724 patent/US20120149879A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2011116112A (ru) | 2012-11-10 |
PE20110926A1 (es) | 2011-12-29 |
AU2009296297A1 (en) | 2010-04-01 |
JP2012503612A (ja) | 2012-02-09 |
KR20110047255A (ko) | 2011-05-06 |
CA2736408A1 (en) | 2010-04-01 |
CO6362023A2 (es) | 2012-01-20 |
US20100081796A1 (en) | 2010-04-01 |
MX2011003133A (es) | 2011-04-21 |
WO2010034441A1 (en) | 2010-04-01 |
MA32713B1 (fr) | 2011-10-02 |
TW201019960A (en) | 2010-06-01 |
IL211675A0 (en) | 2011-06-30 |
CN102643345A (zh) | 2012-08-22 |
CN102164960A (zh) | 2011-08-24 |
AR073664A1 (es) | 2010-11-24 |
BRPI0919382A2 (pt) | 2016-01-05 |
US20120149879A1 (en) | 2012-06-14 |
EP2342231A1 (en) | 2011-07-13 |
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