ECSP045348A - "procedimientos de preparacion de combretastatinas" - Google Patents

"procedimientos de preparacion de combretastatinas"

Info

Publication number
ECSP045348A
ECSP045348A EC2004005348A ECSP045348A ECSP045348A EC SP045348 A ECSP045348 A EC SP045348A EC 2004005348 A EC2004005348 A EC 2004005348A EC SP045348 A ECSP045348 A EC SP045348A EC SP045348 A ECSP045348 A EC SP045348A
Authority
EC
Ecuador
Prior art keywords
combretastatinas
procedures
preparation
phosphonium salt
wittig
Prior art date
Application number
EC2004005348A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ECSP045348A publication Critical patent/ECSP045348A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

La invención se refiere a nuevos procedimientos de preparación de combretastatinas mediante condensación de Wittig entre nitrometoxi-benzaldehido y una sal de trimetoxibencil-fosfonio ó inversamente una sal de nitrometoxibencil-fosfonio con trimetoxi-benzaldehido o además mediante una reacción de Wittig sobre los mismos derivados, en la que la función nitro se ha reducido a un grupo amino.
EC2004005348A 2002-04-11 2004-10-08 "procedimientos de preparacion de combretastatinas" ECSP045348A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0204499A FR2838437B1 (fr) 2002-04-11 2002-04-11 Procedes de preparation de combretastatines

Publications (1)

Publication Number Publication Date
ECSP045348A true ECSP045348A (es) 2004-11-26

Family

ID=28459732

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005348A ECSP045348A (es) 2002-04-11 2004-10-08 "procedimientos de preparacion de combretastatinas"

Country Status (28)

Country Link
EP (3) EP1497255A2 (es)
JP (1) JP4299677B2 (es)
KR (1) KR101018983B1 (es)
CN (1) CN1291970C (es)
AR (2) AR039198A1 (es)
AU (1) AU2003260026B2 (es)
BR (1) BR0309087A (es)
CA (1) CA2481742C (es)
CR (1) CR7481A (es)
EA (1) EA007965B1 (es)
EC (1) ECSP045348A (es)
FR (1) FR2838437B1 (es)
HK (1) HK1075651A1 (es)
HR (1) HRP20040935A2 (es)
IL (1) IL164247A0 (es)
MA (1) MA26407A1 (es)
ME (1) MEP91508A (es)
MX (1) MXPA04009112A (es)
NO (2) NO329701B1 (es)
NZ (1) NZ535318A (es)
OA (1) OA12804A (es)
PL (3) PL213708B1 (es)
RS (3) RS20110561A3 (es)
TN (1) TNSN04201A1 (es)
TW (1) TWI262179B (es)
UA (1) UA76079C2 (es)
WO (1) WO2003084919A2 (es)
ZA (1) ZA200407417B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235688B1 (en) 2004-11-04 2007-06-26 University Of Notre Dame Du Lac Process for preparing histone deacetylase inhibitors and intermediates thereof
FR2928148B1 (fr) * 2008-02-28 2013-01-18 Sanofi Aventis Procede de preparation de combretastatine
FR2939665B1 (fr) 2008-12-12 2011-10-07 Sanofi Aventis Combinaison antitumorale associant l'ave8062a et le docetaxel
FR2945210B1 (fr) 2009-05-07 2011-07-01 Sanofi Aventis Combinaison antitumorale comprenant l'ave8062 et le sorafenib
FR2953518B1 (fr) * 2009-12-03 2012-01-20 Sanofi Aventis Procede de preparation d'un derive de combretastatine
CA2802974A1 (en) 2010-06-18 2011-12-22 Sanofi An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
EP2481404A1 (en) 2010-11-15 2012-08-01 Sanofi An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
EP2397135A1 (en) 2010-06-18 2011-12-21 Sanofi An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
EP2407161A1 (en) 2010-07-13 2012-01-18 Sanofi An antitumoral combination comprising ombrabulin and bevacizumab
FR2968557A1 (fr) 2010-12-09 2012-06-15 Sanofi Aventis Combinaison antitumorale comprenant un derive de la famille des combretastatines et le cetuximab
FR2978662A1 (fr) 2011-08-01 2013-02-08 Sanofi Sa Combinaison antitumorale comprenant l'ombrabuline et le cisplatine, associee a la radiotherapie
FR2978663A1 (fr) 2011-08-01 2013-02-08 Sanofi Sa Combinaison antitumorale comprenant l'ombrabuline et le cetuximab, associee a la radiotherapie
CN103012248B (zh) * 2013-01-11 2014-11-05 浙江大德药业集团有限公司 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用
EP2805705B1 (en) 2013-05-23 2016-11-09 IP Gesellschaft für Management mbH Packaging with one or more administration units comprising a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1 H-imidazol-4-yl)-propionic acid
EP4079327A1 (en) 2021-04-22 2022-10-26 Centaurus Polytherapeutics Payloads for drug-conjugates and their use for treating cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996237A (en) 1987-01-06 1991-02-26 Arizona Board Of Regents Combretastatin A-4
UA19045A (uk) * 1988-02-24 1997-12-25 Ф.Хофманн - Ля Рош Аг Спосіб одержаhhя похідhих стильбеhу
NZ232897A (en) * 1989-04-03 1992-12-23 Squibb & Sons Inc Interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogues, preparation and pharmaceutical compositions thereof
TW325458B (en) 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
US5731353A (en) * 1993-09-08 1998-03-24 Ajinomoto Co., Inc. Stilbene derivatives and pharmaceutical compositions containing them
CN1053658C (zh) * 1994-04-06 2000-06-21 日本新药株式会社 氨基芪唑衍生物和药
TW334418B (en) * 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
JP4551514B2 (ja) * 1999-07-23 2010-09-29 住友化学株式会社 不飽和炭化水素残基置換アニリン類の製造方法
GB9918912D0 (en) 1999-08-12 1999-10-13 Angiogene Pharm Ltd New stilbenes with vascular damaging activity

Also Published As

Publication number Publication date
PL213708B1 (pl) 2013-04-30
MEP91508A (en) 2011-12-20
FR2838437B1 (fr) 2004-06-04
IL164247A0 (en) 2005-12-18
MA26407A1 (fr) 2004-12-01
NO331372B1 (no) 2011-12-12
KR101018983B1 (ko) 2011-03-07
RS20110561A3 (en) 2013-10-31
PL371629A1 (en) 2005-06-27
AU2003260026B2 (en) 2008-01-03
RS20110562A2 (en) 2012-10-31
UA76079C2 (en) 2006-06-15
RS20110561A2 (en) 2012-10-31
TW200401762A (en) 2004-02-01
NO20101215L (no) 2004-01-07
PL213967B1 (pl) 2013-05-31
HK1075651A1 (en) 2005-12-23
AR039198A1 (es) 2005-02-09
JP2005522478A (ja) 2005-07-28
HRP20040935A2 (en) 2005-10-31
RS86504A (en) 2007-02-05
BR0309087A (pt) 2005-02-09
KR20040108717A (ko) 2004-12-24
TNSN04201A1 (fr) 2007-03-12
NO329701B1 (no) 2010-12-06
PL394820A1 (pl) 2011-09-12
OA12804A (fr) 2006-07-11
FR2838437A1 (fr) 2003-10-17
NZ535318A (en) 2007-02-23
CA2481742C (fr) 2012-06-19
CR7481A (es) 2008-11-25
EA007965B1 (ru) 2007-02-27
PL394821A1 (pl) 2011-09-12
CA2481742A1 (fr) 2003-10-16
AR082581A2 (es) 2012-12-19
EP1497255A2 (fr) 2005-01-19
RS20110562A3 (en) 2013-12-31
TWI262179B (en) 2006-09-21
ZA200407417B (en) 2006-04-26
WO2003084919A2 (fr) 2003-10-16
PL214129B1 (pl) 2013-06-28
CN1646476A (zh) 2005-07-27
EA200401350A1 (ru) 2005-02-24
NO20044814L (no) 2004-01-07
MXPA04009112A (es) 2004-12-07
RS52331B (en) 2012-12-31
CN1291970C (zh) 2006-12-27
EP2348012A1 (fr) 2011-07-27
EP2354118A1 (fr) 2011-08-10
WO2003084919A3 (fr) 2004-04-08
JP4299677B2 (ja) 2009-07-22
AU2003260026A1 (en) 2003-10-20

Similar Documents

Publication Publication Date Title
ECSP045348A (es) "procedimientos de preparacion de combretastatinas"
CY1109088T1 (el) Μεθοδος για την παρασκευη υποκατεστημενων ενωσεων 3-αρυλο-βουτυλ-αμινης
CR7995A (es) Nueva difenilazetidinona con caracteristicas fisiologicas mejoradas correspondiente metodo de produccion , medicamentos que lo contienen y uso de los mismos
HN1997000072A (es) Procedimiento para la preparacion de sildenafil
DK0670310T3 (da) Bisulfitaddukt af argininaldehyder egnet som thrombininhibitorer og som antikoagulanter
BR122018016045B8 (pt) proteína variante otimizada
UY26451A1 (es) Procedimiento para la obtención de 1,2,3,4- tetrahidroquinolinas 4-carboxiamino-2-sustituidas
CY1107681T1 (el) Χρηση παραγωγων τροπινεστερα για την παραγωγη φαρμακευτικων μεσων
BRPI0514406A (pt) compostos de 2-(amino ou amino substituìdo) fenol-3-5-6-substituìdo, composições para tingimento contendo os mesmos, e uso das mesmas
ECSP034531A (es) Derivados sustituidos de c-ciclohexilmetilamina
HN1998000167A (es) Nuevo procedimiento para preparar una cetoimina
NO20050019L (no) Polytylenglykolaldehyd-derivater
NI200700227A (es) Procesos para la purificación de compuestos benzoxazol sustituidos.
MEP36808A (en) Ambroxol-containing lozenge
ES2186989T3 (es) Cristales de maltitol de formas especificas, compuestos cristalinos que los contienen y procedimientos para su preparacion.
HUP0401916A2 (hu) Eljárás fenolos vegyületek nitrálására
HN1999000043A (es) Procedimiento para alquilar sulfonamidas impedidas estericamente.
MXPA03008248A (es) Agentes colorantes para fibras de queratina que contienen derivados de n-heteroarilmetil-m-fenilendiamina, asi como nuevos derivados de n-heteroarilmetil-m-fenilendiamina.
BR0112600A (pt) Compostos calcilìticos
BR0101437A (pt) Método para preparar um ciclopropeno
CO5021190A1 (es) Agentes terapeuticos
AR015147A1 (es) Compuestos de 1-bis-trifluorometilbenzoil-2-indolilmetil-4-bencilamino-metil-piperazina, medicamentos que los contienen, y procedimiento para supreparacion
AR021343A1 (es) Nuevos acetales derivados de los 2-alquil-5-halo-3-[2'-(tetrazol-5-il)-bifenil-4-ilmetil]-3h-imidazol-4-carbaldehidos
BRPI0410125A (pt) intermediários úteis para a sìntese de inibidores de protease de hiv, e métodos para os preparar
IT1320082B1 (it) Procedimento per la realizzazione di reggiseni, nonche' reggisenocosi' ottenuto.