MEP91508A - Method for preparing combretastatins - Google Patents
Method for preparing combretastatinsInfo
- Publication number
- MEP91508A MEP91508A MEP-915/08A MEP91508A MEP91508A ME P91508 A MEP91508 A ME P91508A ME P91508 A MEP91508 A ME P91508A ME P91508 A MEP91508 A ME P91508A
- Authority
- ME
- Montenegro
- Prior art keywords
- combretastatins
- preparing
- group
- phosphonium salt
- vititi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0204499A FR2838437B1 (fr) | 2002-04-11 | 2002-04-11 | Procedes de preparation de combretastatines |
| PCT/FR2003/001117 WO2003084919A2 (fr) | 2002-04-11 | 2003-04-09 | Procedes de preparation de combretastatines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP91508A true MEP91508A (en) | 2011-12-20 |
Family
ID=28459732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-915/08A MEP91508A (en) | 2002-04-11 | 2003-04-09 | Method for preparing combretastatins |
Country Status (28)
| Country | Link |
|---|---|
| EP (3) | EP1497255A2 (es) |
| JP (1) | JP4299677B2 (es) |
| KR (1) | KR101018983B1 (es) |
| CN (1) | CN1291970C (es) |
| AR (2) | AR039198A1 (es) |
| AU (1) | AU2003260026B2 (es) |
| BR (1) | BR0309087A (es) |
| CA (1) | CA2481742C (es) |
| CR (1) | CR7481A (es) |
| EA (1) | EA007965B1 (es) |
| EC (1) | ECSP045348A (es) |
| FR (1) | FR2838437B1 (es) |
| HK (1) | HK1075651A1 (es) |
| HR (1) | HRP20040935A2 (es) |
| IL (1) | IL164247A0 (es) |
| MA (1) | MA26407A1 (es) |
| ME (1) | MEP91508A (es) |
| MX (1) | MXPA04009112A (es) |
| NO (2) | NO329701B1 (es) |
| NZ (1) | NZ535318A (es) |
| OA (1) | OA12804A (es) |
| PL (3) | PL214129B1 (es) |
| RS (3) | RS20110562A3 (es) |
| TN (1) | TNSN04201A1 (es) |
| TW (1) | TWI262179B (es) |
| UA (1) | UA76079C2 (es) |
| WO (1) | WO2003084919A2 (es) |
| ZA (1) | ZA200407417B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235688B1 (en) | 2004-11-04 | 2007-06-26 | University Of Notre Dame Du Lac | Process for preparing histone deacetylase inhibitors and intermediates thereof |
| FR2928148B1 (fr) * | 2008-02-28 | 2013-01-18 | Sanofi Aventis | Procede de preparation de combretastatine |
| FR2939665B1 (fr) | 2008-12-12 | 2011-10-07 | Sanofi Aventis | Combinaison antitumorale associant l'ave8062a et le docetaxel |
| FR2945210B1 (fr) | 2009-05-07 | 2011-07-01 | Sanofi Aventis | Combinaison antitumorale comprenant l'ave8062 et le sorafenib |
| FR2953518B1 (fr) | 2009-12-03 | 2012-01-20 | Sanofi Aventis | Procede de preparation d'un derive de combretastatine |
| EP2582369A1 (en) | 2010-06-18 | 2013-04-24 | Sanofi | An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative |
| EP2397135A1 (en) | 2010-06-18 | 2011-12-21 | Sanofi | An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative |
| EP2481404A1 (en) | 2010-11-15 | 2012-08-01 | Sanofi | An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative |
| EP2407161A1 (en) | 2010-07-13 | 2012-01-18 | Sanofi | An antitumoral combination comprising ombrabulin and bevacizumab |
| FR2968557A1 (fr) | 2010-12-09 | 2012-06-15 | Sanofi Aventis | Combinaison antitumorale comprenant un derive de la famille des combretastatines et le cetuximab |
| FR2978662A1 (fr) | 2011-08-01 | 2013-02-08 | Sanofi Sa | Combinaison antitumorale comprenant l'ombrabuline et le cisplatine, associee a la radiotherapie |
| FR2978663A1 (fr) | 2011-08-01 | 2013-02-08 | Sanofi Sa | Combinaison antitumorale comprenant l'ombrabuline et le cetuximab, associee a la radiotherapie |
| CN103012248B (zh) * | 2013-01-11 | 2014-11-05 | 浙江大德药业集团有限公司 | 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用 |
| EP2805705B1 (en) | 2013-05-23 | 2016-11-09 | IP Gesellschaft für Management mbH | Packaging with one or more administration units comprising a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1 H-imidazol-4-yl)-propionic acid |
| EP4079327A1 (en) | 2021-04-22 | 2022-10-26 | Centaurus Polytherapeutics | Payloads for drug-conjugates and their use for treating cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4996237A (en) | 1987-01-06 | 1991-02-26 | Arizona Board Of Regents | Combretastatin A-4 |
| UA18265A (uk) * | 1988-02-24 | 1997-12-25 | Ф.Хоффманн-Ля Рош Аг | Спосіб одержаhhя похідhих стильбеhу |
| NZ232897A (en) * | 1989-04-03 | 1992-12-23 | Squibb & Sons Inc | Interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogues, preparation and pharmaceutical compositions thereof |
| TW325458B (en) | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| US5731353A (en) * | 1993-09-08 | 1998-03-24 | Ajinomoto Co., Inc. | Stilbene derivatives and pharmaceutical compositions containing them |
| CN1053658C (zh) * | 1994-04-06 | 2000-06-21 | 日本新药株式会社 | 氨基芪唑衍生物和药 |
| TW334418B (en) * | 1995-03-07 | 1998-06-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions |
| JP4551514B2 (ja) * | 1999-07-23 | 2010-09-29 | 住友化学株式会社 | 不飽和炭化水素残基置換アニリン類の製造方法 |
| GB9918912D0 (en) | 1999-08-12 | 1999-10-13 | Angiogene Pharm Ltd | New stilbenes with vascular damaging activity |
-
2002
- 2002-04-11 FR FR0204499A patent/FR2838437B1/fr not_active Expired - Fee Related
-
2003
- 2003-03-28 AR ARP030101111A patent/AR039198A1/es active IP Right Grant
- 2003-04-09 RS RS20110562A patent/RS20110562A3/en unknown
- 2003-04-09 WO PCT/FR2003/001117 patent/WO2003084919A2/fr active Application Filing
- 2003-04-09 IL IL16424703A patent/IL164247A0/xx not_active IP Right Cessation
- 2003-04-09 RS YU86504A patent/RS52331B/en unknown
- 2003-04-09 EA EA200401350A patent/EA007965B1/ru not_active IP Right Cessation
- 2003-04-09 ME MEP-915/08A patent/MEP91508A/xx unknown
- 2003-04-09 NZ NZ535318A patent/NZ535318A/en not_active IP Right Cessation
- 2003-04-09 KR KR1020047016132A patent/KR101018983B1/ko not_active IP Right Cessation
- 2003-04-09 EP EP03740582A patent/EP1497255A2/fr not_active Withdrawn
- 2003-04-09 CN CNB038075660A patent/CN1291970C/zh not_active Expired - Fee Related
- 2003-04-09 EP EP10183123A patent/EP2348012A1/fr not_active Withdrawn
- 2003-04-09 OA OA1200400275A patent/OA12804A/fr unknown
- 2003-04-09 PL PL394821A patent/PL214129B1/pl not_active IP Right Cessation
- 2003-04-09 MX MXPA04009112A patent/MXPA04009112A/es active IP Right Grant
- 2003-04-09 AU AU2003260026A patent/AU2003260026B2/en not_active Ceased
- 2003-04-09 PL PL394820A patent/PL213967B1/pl not_active IP Right Cessation
- 2003-04-09 CA CA2481742A patent/CA2481742C/fr not_active Expired - Fee Related
- 2003-04-09 BR BR0309087-6A patent/BR0309087A/pt not_active IP Right Cessation
- 2003-04-09 RS RS20110561A patent/RS20110561A3/en unknown
- 2003-04-09 EP EP10183135A patent/EP2354118A1/fr not_active Withdrawn
- 2003-04-09 JP JP2003582118A patent/JP4299677B2/ja not_active Expired - Fee Related
- 2003-04-09 PL PL371629A patent/PL213708B1/pl not_active IP Right Cessation
- 2003-04-10 TW TW092108184A patent/TWI262179B/zh not_active IP Right Cessation
- 2003-09-04 UA UA20041109227A patent/UA76079C2/uk unknown
-
2004
- 2004-09-14 CR CR7481A patent/CR7481A/es unknown
- 2004-09-15 ZA ZA200407417A patent/ZA200407417B/en unknown
- 2004-09-20 MA MA27868A patent/MA26407A1/fr unknown
- 2004-10-07 HR HR20040935A patent/HRP20040935A2/hr not_active Application Discontinuation
- 2004-10-08 EC EC2004005348A patent/ECSP045348A/es unknown
- 2004-10-08 TN TNP2004000201A patent/TNSN04201A1/fr unknown
- 2004-11-05 NO NO20044814A patent/NO329701B1/no not_active IP Right Cessation
-
2005
- 2005-09-05 HK HK05107764A patent/HK1075651A1/xx not_active IP Right Cessation
-
2010
- 2010-09-01 NO NO20101215A patent/NO331372B1/no not_active IP Right Cessation
-
2011
- 2011-08-05 AR ARP110102854A patent/AR082581A2/es unknown
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