RS52331B - Method for preparing combretastatins - Google Patents

Method for preparing combretastatins

Info

Publication number
RS52331B
RS52331B YU86504A YUP86504A RS52331B RS 52331 B RS52331 B RS 52331B YU 86504 A YU86504 A YU 86504A YU P86504 A YUP86504 A YU P86504A RS 52331 B RS52331 B RS 52331B
Authority
RS
Serbia
Prior art keywords
formula
combretastatins
preparing
derivatives
serine
Prior art date
Application number
YU86504A
Other languages
Serbian (sr)
Inventor
Stéphane Mutti
Michel Lavigne
Irina Malejonock
Jean-Paul Casimir
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of RS86504A publication Critical patent/RS86504A/en
Publication of RS52331B publication Critical patent/RS52331B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Magnetic Ceramics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Postupak dobijanja jedinjenjau obliku soli serina kuplovanjem derivata formule (IIа)sa zaštićenim cikličnim derivatima serina formule (IIb)gde PG predstavlja zaštitnu grupu za amino funkcionalnu grupu, i daje novi intermedijer, sledeće opšte formule:sa kojeg se zatim uklanja zaštita.Prijava sadrži još 6 patentnih zahteva.A process for the preparation of compounds in the form of serine salts by coupling derivatives of formula (IIa) with protected cyclic serine derivatives of formula (IIb) wherein PG represents a protecting group for an amino functional group, and gives a new intermediate of the following general formula: from which protection is then removed. 6 patent claims.

YU86504A 2002-04-11 2003-04-09 Method for preparing combretastatins RS52331B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0204499A FR2838437B1 (en) 2002-04-11 2002-04-11 PROCESSES FOR THE PREPARATION OF COMBRETASTATINS
PCT/FR2003/001117 WO2003084919A2 (en) 2002-04-11 2003-04-09 Method for preparing combretastatins

Publications (2)

Publication Number Publication Date
RS86504A RS86504A (en) 2007-02-05
RS52331B true RS52331B (en) 2012-12-31

Family

ID=28459732

Family Applications (3)

Application Number Title Priority Date Filing Date
RS20110561A RS20110561A3 (en) 2002-04-11 2003-04-09 Methods for preparing combretastatin
RS20110562A RS20110562A3 (en) 2002-04-11 2003-04-09 Methods for preparing combretastatin
YU86504A RS52331B (en) 2002-04-11 2003-04-09 Method for preparing combretastatins

Family Applications Before (2)

Application Number Title Priority Date Filing Date
RS20110561A RS20110561A3 (en) 2002-04-11 2003-04-09 Methods for preparing combretastatin
RS20110562A RS20110562A3 (en) 2002-04-11 2003-04-09 Methods for preparing combretastatin

Country Status (28)

Country Link
EP (3) EP2354118A1 (en)
JP (1) JP4299677B2 (en)
KR (1) KR101018983B1 (en)
CN (1) CN1291970C (en)
AR (2) AR039198A1 (en)
AU (1) AU2003260026B2 (en)
BR (1) BR0309087A (en)
CA (1) CA2481742C (en)
CR (1) CR7481A (en)
EA (1) EA007965B1 (en)
EC (1) ECSP045348A (en)
FR (1) FR2838437B1 (en)
HK (1) HK1075651A1 (en)
HR (1) HRP20040935A2 (en)
IL (1) IL164247A0 (en)
MA (1) MA26407A1 (en)
ME (1) MEP91508A (en)
MX (1) MXPA04009112A (en)
NO (2) NO329701B1 (en)
NZ (1) NZ535318A (en)
OA (1) OA12804A (en)
PL (3) PL213967B1 (en)
RS (3) RS20110561A3 (en)
TN (1) TNSN04201A1 (en)
TW (1) TWI262179B (en)
UA (1) UA76079C2 (en)
WO (1) WO2003084919A2 (en)
ZA (1) ZA200407417B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235688B1 (en) 2004-11-04 2007-06-26 University Of Notre Dame Du Lac Process for preparing histone deacetylase inhibitors and intermediates thereof
FR2928148B1 (en) * 2008-02-28 2013-01-18 Sanofi Aventis PROCESS FOR PREPARING COMBRETASTATIN
FR2939665B1 (en) 2008-12-12 2011-10-07 Sanofi Aventis ANTITUMOR COMBINATION ASSOCIATING WITH AVE8062A AND DOCETAXEL
FR2945210B1 (en) 2009-05-07 2011-07-01 Sanofi Aventis ANTITUMOR COMBINATION COMPRISING AVE8062 AND SORAFENIB
FR2953518B1 (en) * 2009-12-03 2012-01-20 Sanofi Aventis PROCESS FOR PREPARING A COMBRETASTATIN DERIVATIVE
EP2481404A1 (en) 2010-11-15 2012-08-01 Sanofi An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
SG186376A1 (en) 2010-06-18 2013-01-30 Sanofi Sa An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
EP2397135A1 (en) 2010-06-18 2011-12-21 Sanofi An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
EP2407161A1 (en) 2010-07-13 2012-01-18 Sanofi An antitumoral combination comprising ombrabulin and bevacizumab
FR2968557A1 (en) 2010-12-09 2012-06-15 Sanofi Aventis ANTITUMOR COMBINATION COMPRISING A DRIFT OF THE COMBRETASTATIN FAMILY AND THE CETUXIMAB
FR2978662A1 (en) 2011-08-01 2013-02-08 Sanofi Sa ANTITUMOR COMBINATION COMPRISING OMBRABULIN AND CISPLATIN ASSOCIATED WITH RADIOTHERAPY
FR2978663A1 (en) 2011-08-01 2013-02-08 Sanofi Sa ANTITUMOR COMBINATION COMPRISING OMBRABULIN AND CETUXIMAB ASSOCIATED WITH RADIOTHERAPY
CN103012248B (en) * 2013-01-11 2014-11-05 浙江大德药业集团有限公司 Synthesis of amino combretastatin derivative and application of amino combretastatin derivative as oral antitumour drug
EP2805705B1 (en) 2013-05-23 2016-11-09 IP Gesellschaft für Management mbH Packaging with one or more administration units comprising a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1 H-imidazol-4-yl)-propionic acid
EP4079327A1 (en) 2021-04-22 2022-10-26 Centaurus Polytherapeutics Payloads for drug-conjugates and their use for treating cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996237A (en) 1987-01-06 1991-02-26 Arizona Board Of Regents Combretastatin A-4
UA18265A (en) * 1988-02-24 1997-12-25 Ф.Хоффманн-Ля Рош Аг a process for preparation of derivatives of toluylene
NZ232897A (en) * 1989-04-03 1992-12-23 Squibb & Sons Inc Interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogues, preparation and pharmaceutical compositions thereof
TW325458B (en) 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
US5731353A (en) * 1993-09-08 1998-03-24 Ajinomoto Co., Inc. Stilbene derivatives and pharmaceutical compositions containing them
CN1053658C (en) * 1994-04-06 2000-06-21 日本新药株式会社 Aminostilbazole derivative and medicine
TW334418B (en) * 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
JP4551514B2 (en) * 1999-07-23 2010-09-29 住友化学株式会社 Process for producing unsaturated hydrocarbon residue-substituted anilines
GB9918912D0 (en) 1999-08-12 1999-10-13 Angiogene Pharm Ltd New stilbenes with vascular damaging activity

Also Published As

Publication number Publication date
RS20110561A2 (en) 2012-10-31
JP4299677B2 (en) 2009-07-22
AR082581A2 (en) 2012-12-19
ECSP045348A (en) 2004-11-26
AR039198A1 (en) 2005-02-09
KR20040108717A (en) 2004-12-24
AU2003260026B2 (en) 2008-01-03
CA2481742C (en) 2012-06-19
PL214129B1 (en) 2013-06-28
PL394820A1 (en) 2011-09-12
PL394821A1 (en) 2011-09-12
AU2003260026A1 (en) 2003-10-20
RS20110562A2 (en) 2012-10-31
JP2005522478A (en) 2005-07-28
OA12804A (en) 2006-07-11
MXPA04009112A (en) 2004-12-07
CR7481A (en) 2008-11-25
BR0309087A (en) 2005-02-09
PL213967B1 (en) 2013-05-31
PL371629A1 (en) 2005-06-27
ZA200407417B (en) 2006-04-26
TWI262179B (en) 2006-09-21
EP2354118A1 (en) 2011-08-10
NZ535318A (en) 2007-02-23
MEP91508A (en) 2011-12-20
EP1497255A2 (en) 2005-01-19
CA2481742A1 (en) 2003-10-16
HK1075651A1 (en) 2005-12-23
CN1646476A (en) 2005-07-27
FR2838437B1 (en) 2004-06-04
EP2348012A1 (en) 2011-07-27
NO331372B1 (en) 2011-12-12
FR2838437A1 (en) 2003-10-17
RS20110561A3 (en) 2013-10-31
EA200401350A1 (en) 2005-02-24
MA26407A1 (en) 2004-12-01
UA76079C2 (en) 2006-06-15
PL213708B1 (en) 2013-04-30
NO20101215L (en) 2004-01-07
RS86504A (en) 2007-02-05
CN1291970C (en) 2006-12-27
NO329701B1 (en) 2010-12-06
WO2003084919A2 (en) 2003-10-16
IL164247A0 (en) 2005-12-18
TW200401762A (en) 2004-02-01
HRP20040935A2 (en) 2005-10-31
TNSN04201A1 (en) 2007-03-12
KR101018983B1 (en) 2011-03-07
EA007965B1 (en) 2007-02-27
RS20110562A3 (en) 2013-12-31
WO2003084919A3 (en) 2004-04-08
NO20044814L (en) 2004-01-07

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