BRPI0412667A - sìntese regiosseletiva de cci - 779 - Google Patents

sìntese regiosseletiva de cci - 779

Info

Publication number
BRPI0412667A
BRPI0412667A BRPI0412667-0A BRPI0412667A BRPI0412667A BR PI0412667 A BRPI0412667 A BR PI0412667A BR PI0412667 A BRPI0412667 A BR PI0412667A BR PI0412667 A BRPI0412667 A BR PI0412667A
Authority
BR
Brazil
Prior art keywords
cci
regioselective synthesis
regioselective
synthesis
boronate
Prior art date
Application number
BRPI0412667-0A
Other languages
English (en)
Inventor
Warren Chew
Chia-Cheng Shaw
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0412667A publication Critical patent/BRPI0412667A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)

Abstract

"SìNTESE REGIOSSELETIVA DE CCI-779". A presente invenção proporciona um método para síntese regiosseletiva de CCI-779 baseada na química de boronato. Também proporcionados são novos intermediários úteis nesse método.
BRPI0412667-0A 2003-08-07 2004-07-15 sìntese regiosseletiva de cci - 779 BRPI0412667A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49324903P 2003-08-07 2003-08-07
PCT/US2004/022860 WO2005016935A2 (en) 2003-08-07 2004-07-15 Regioselective synthesis of cci-779

Publications (1)

Publication Number Publication Date
BRPI0412667A true BRPI0412667A (pt) 2006-09-26

Family

ID=34193170

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412667-0A BRPI0412667A (pt) 2003-08-07 2004-07-15 sìntese regiosseletiva de cci - 779

Country Status (27)

Country Link
US (1) US7153957B2 (pt)
EP (1) EP1658295B1 (pt)
JP (1) JP4227649B2 (pt)
KR (1) KR20060057605A (pt)
CN (1) CN1829722B (pt)
AR (1) AR045217A1 (pt)
AT (1) ATE365169T1 (pt)
AU (1) AU2004265267A1 (pt)
BR (1) BRPI0412667A (pt)
CA (1) CA2532988A1 (pt)
CO (1) CO5650251A2 (pt)
CR (1) CR8189A (pt)
DE (1) DE602004007145T2 (pt)
DK (1) DK1658295T3 (pt)
EC (1) ECSP066413A (pt)
ES (1) ES2287772T3 (pt)
HK (1) HK1085482A1 (pt)
IL (1) IL173134A0 (pt)
MX (1) MXPA06000951A (pt)
NO (1) NO20060494L (pt)
PL (1) PL1658295T3 (pt)
PT (1) PT1658295E (pt)
RU (1) RU2339639C2 (pt)
TW (1) TW200508241A (pt)
UA (1) UA83245C2 (pt)
WO (1) WO2005016935A2 (pt)
ZA (1) ZA200601055B (pt)

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EP1389209B1 (en) * 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
KR20040106547A (ko) * 2002-05-15 2004-12-17 엔도사이트, 인코포레이티드 비타민-마이토마이신 공액체
RU2344821C2 (ru) 2002-07-30 2009-01-27 Уайт Парентеральные композиции, содержащие гидроксиэфиры рапамицина
NZ541846A (en) 2003-01-27 2008-12-24 Endocyte Inc Vitamin receptor binding drug delivery conjugates
AU2004270154A1 (en) * 2003-09-03 2005-03-17 Wyeth Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions containing the same
KR20060130162A (ko) * 2004-01-08 2006-12-18 와이어쓰 Ｃｃｉ-779 의 경구 투여용, 직접 압축식 약학적 조성물
DE602005010228D1 (de) * 2004-04-14 2008-11-20 Wyeth Corp Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper
MXPA06011881A (es) 2004-04-14 2006-12-14 Wyeth Corp Sintesis regioespecifica de derivados de ester-42 de rapamicina.
US7202256B2 (en) 2004-04-14 2007-04-10 Wyeth Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
AU2005238493A1 (en) * 2004-04-27 2005-11-10 Wyeth Labeling of rapamycin using rapamycin-specific methylases
JP5149620B2 (ja) 2004-07-23 2013-02-20 エンドサイト，インコーポレイテッド ２価リンカーおよびその結合体
TW200616633A (en) * 2004-08-10 2006-06-01 Wyeth Corp CCI-779 derivatives and methods of making same
MX2007005153A (es) 2004-10-28 2007-06-26 Wyeth Corp Uso de un inhibidor del mtor en el tratamiento de leiomioma del utero.
WO2006086172A1 (en) 2005-02-09 2006-08-17 Wyeth Cci-779 polymorph and use thereof
BRPI0607390A2 (pt) * 2005-03-02 2017-08-22 Wyeth Corp Processo para recuperar cci-779 de licores mâe
MX2007010716A (es) 2005-03-02 2008-01-16 Wyeth Corp Purificacion de rapamicina.
CN101175757B (zh) 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
EP2382995A3 (en) * 2005-08-19 2013-09-25 Endocyte, Inc. Ligand conjugates of Vinca alkaloids, analogs and derivatives
BRPI0615354A2 (pt) 2005-08-19 2011-05-17 Endocyte Inc conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso
KR101354828B1 (ko) 2005-11-04 2014-02-18 와이어쓰 엘엘씨 ｍＴＯＲ 저해자, 헤르셉틴, 및/또는 ＨＫＩ-272의항신생물성 조합
US7538119B2 (en) * 2005-11-04 2009-05-26 Wyeth 41-Methoxy isotope labeled rapamycin 42-ester
BRPI0619578A2 (pt) * 2005-12-07 2011-10-04 Wyeth Corp processo para preparar um 42-éster de rapamicina, composto, método para isolar o boronato do 42-éster de rapamicina bruto a partir do licor mãe, método para purificação de um boronato do 42-éster de rapamicina, e, boronato de cci-779
JP2009518648A (ja) * 2005-12-07 2009-05-07 ワイス 結晶性ラパマイシンを調製するための方法およびを示差走査熱量測定使用してラパマイシン化合物の結晶化度を測定するための方法
AU2006322029A1 (en) * 2005-12-07 2007-06-14 Wyeth Process for the preparation of purified crystalline CCI-779
EP1962819A1 (en) * 2005-12-20 2008-09-03 Wyeth Control of cci-779 dosage form stability through control of drug substance impurities
US20070203169A1 (en) * 2006-02-28 2007-08-30 Zhao Jonathon Z Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same
TW200824713A (en) * 2006-10-18 2008-06-16 Wyeth Corp Processes for the synthesis of individual isomers of mono-PEG CCI-779
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US20100104626A1 (en) 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
NZ599239A (en) * 2007-03-14 2013-10-25 Endocyte Inc Binding ligand linked drug delivery conjugates of tubulysins
TW200845960A (en) * 2007-04-05 2008-12-01 Wyeth Corp Wortmannin-rapalog conjugate and uses thereof
TW200901989A (en) 2007-04-10 2009-01-16 Wyeth Corp Anti-tumor activity of CCI-779 in papillary renal cell cancer
WO2009002993A1 (en) 2007-06-25 2008-12-31 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
US9187521B2 (en) 2007-10-25 2015-11-17 Endocyte, Inc. Tubulysins and processes for preparing
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EP2528906A2 (en) * 2010-01-28 2012-12-05 Fresenius Kabi Oncology Ltd Process for the preparation of temsirolimus and its intermediates
CN102020662B (zh) 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔制备方法
CN102020661B (zh) * 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔合成方法
US9051336B2 (en) * 2011-04-01 2015-06-09 Sandoz Regioselective acylation of rapamycin at the C-42 position
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
IN2015DN04147A (pt) 2012-10-16 2015-10-16 Endocyte Inc
CN104086564B (zh) * 2014-07-30 2019-02-05 江苏奥赛康药业股份有限公司 一种高纯度坦罗莫司的制备方法

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US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
DE19857765A1 (de) * 1998-12-15 2000-06-21 Clariant Gmbh Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives

Also Published As

Publication number Publication date
EP1658295A2 (en) 2006-05-24
ECSP066413A (es) 2006-09-18
ATE365169T1 (de) 2007-07-15
AU2004265267A1 (en) 2005-02-24
RU2339639C2 (ru) 2008-11-27
IL173134A0 (en) 2006-06-11
US20050033046A1 (en) 2005-02-10
CO5650251A2 (es) 2006-06-30
ZA200601055B (en) 2008-07-30
RU2006106910A (ru) 2007-09-20
AR045217A1 (es) 2005-10-19
UA83245C2 (en) 2008-06-25
NO20060494L (no) 2006-03-06
JP4227649B2 (ja) 2009-02-18
MXPA06000951A (es) 2006-03-30
PT1658295E (pt) 2007-09-25
EP1658295B1 (en) 2007-06-20
DE602004007145T2 (de) 2008-02-28
CR8189A (es) 2006-10-04
PL1658295T3 (pl) 2007-11-30
CA2532988A1 (en) 2005-02-24
DE602004007145D1 (de) 2007-08-02
KR20060057605A (ko) 2006-05-26
CN1829722B (zh) 2010-10-27
HK1085482A1 (en) 2006-08-25
CN1829722A (zh) 2006-09-06
US7153957B2 (en) 2006-12-26
WO2005016935A2 (en) 2005-02-24
WO2005016935A3 (en) 2005-04-07
TW200508241A (en) 2005-03-01
ES2287772T3 (es) 2007-12-16
JP2007501783A (ja) 2007-02-01
DK1658295T3 (da) 2007-09-24

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.