ECSP045310A - Material micronizado cristalino del bromuro de tiotropio - Google Patents

Material micronizado cristalino del bromuro de tiotropio

Info

Publication number
ECSP045310A
ECSP045310A EC2004005310A ECSP045310A ECSP045310A EC SP045310 A ECSP045310 A EC SP045310A EC 2004005310 A EC2004005310 A EC 2004005310A EC SP045310 A ECSP045310 A EC SP045310A EC SP045310 A ECSP045310 A EC SP045310A
Authority
EC
Ecuador
Prior art keywords
tiotrope
bromide material
crystalline micronized
preparation
micronized
Prior art date
Application number
EC2004005310A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27797948&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP045310(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of ECSP045310A publication Critical patent/ECSP045310A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hybrid Cells (AREA)

Abstract

El invento se refiere a un material micronizado cristalino de bromuro de (1a,2b,4b,5a,7b)-7-[(hidroxi-di-2-tienil-acetil)oxi]-9,9-dimetil-3-oxa-9-azonia-triciclo-[3.3.1.02,4]nonano, a procedimientos para su preparación así como a su utilización para la preparación de un medicamento, en particular para la preparación de un medicamento con efecto anticolinérgico.
EC2004005310A 2002-03-20 2004-09-23 Material micronizado cristalino del bromuro de tiotropio ECSP045310A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10212264A DE10212264A1 (de) 2002-03-20 2002-03-20 Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels

Publications (1)

Publication Number Publication Date
ECSP045310A true ECSP045310A (es) 2004-10-26

Family

ID=27797948

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005310A ECSP045310A (es) 2002-03-20 2004-09-23 Material micronizado cristalino del bromuro de tiotropio

Country Status (37)

Country Link
EP (3) EP1785422B1 (es)
JP (1) JP4331619B2 (es)
KR (2) KR101021430B1 (es)
CN (2) CN100368410C (es)
AR (1) AR039017A1 (es)
AT (1) ATE369365T1 (es)
AU (1) AU2003212327B2 (es)
BR (1) BRPI0308513B8 (es)
CA (1) CA2479652C (es)
CO (1) CO5611105A2 (es)
CY (2) CY1106923T1 (es)
DE (2) DE10212264A1 (es)
DK (2) DK1785422T3 (es)
EA (1) EA007064B1 (es)
EC (1) ECSP045310A (es)
ES (2) ES2291619T5 (es)
HK (1) HK1078871A1 (es)
HR (1) HRP20040855B1 (es)
HU (1) HUE031876T2 (es)
IL (2) IL163841A0 (es)
LT (1) LT1785422T (es)
ME (1) ME02764B (es)
MX (1) MXPA04009056A (es)
MY (1) MY139720A (es)
NO (2) NO346754B1 (es)
NZ (1) NZ535808A (es)
PE (1) PE20030838A1 (es)
PL (1) PL220730B1 (es)
PT (2) PT1487832E (es)
RS (1) RS57551B1 (es)
SA (1) SA03240098B1 (es)
SI (1) SI1487832T2 (es)
TW (1) TWI345975B (es)
UA (1) UA78295C2 (es)
UY (1) UY27725A1 (es)
WO (1) WO2003078429A1 (es)
ZA (1) ZA200405636B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
PT1682541E (pt) 2003-11-03 2010-04-14 Boehringer Ingelheim Int Processo para a preparação de sais de tiotrópio
ES2422730T3 (es) 2003-11-03 2013-09-13 Boehringer Ingelheim Int Sales de tiotropio, procedimiento para su preparación, así como formulaciones de medicamentos que las contienen
DE102004024451A1 (de) 2004-05-14 2005-12-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierungen für die Inhalation, die Enantiomerenreine Betaagonisten enthalten
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
EP2085396A3 (en) 2005-05-02 2009-11-25 Boehringer Ingelheim International Gmbh Novel crystalline forms of tiotropium bromide
CN101203513A (zh) * 2005-05-02 2008-06-18 贝林格尔·英格海姆国际有限公司 噻托溴铵的晶型
BRPI0614410A2 (pt) 2005-08-15 2011-03-29 Boehringer Ingelheim Int processo para preparação de betamiméticos
US20070086957A1 (en) * 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
EP2123650B1 (en) 2005-12-19 2012-04-04 Sicor, Inc. Novel form of tiotropium bromide and process for preparation thereof
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
EP2533765A2 (en) * 2010-01-29 2012-12-19 Mahmut Bilgic Pharmaceutical compositions comprising formoterol and mometasone
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
GEP201706672B (en) 2012-07-05 2017-05-25 Arven Ilac Sanayi Ve Ticaret As Dry powder inhaler compositions comprising long acting muscorinic antagonists
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
HUE049339T2 (hu) 2014-09-09 2020-09-28 Vectura Ltd Glikopirrolátot tartalmazó készítmény, eljárás és berendezés
CA3002300A1 (en) * 2015-10-23 2017-04-27 Arven Ilac Sanayi Ve Ticaret A.S. Blister for inhalable formulation of tiotropium bromide
EP3159278A1 (en) * 2015-10-23 2017-04-26 Arven Ilac Sanayi Ve Ticaret A.S. Blister for tiotropium bromide inhalable formulation
CN115737610B (zh) * 2021-12-13 2024-02-27 苏州欧米尼医药有限公司 一种噻托溴铵吸入粉雾剂及其活性成分的气流粉碎方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
IE59026B1 (en) 1985-07-30 1993-12-15 Glaxo Group Ltd Devices for administering medicaments to patients
US5610163A (en) 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
US5874063A (en) 1991-04-11 1999-02-23 Astra Aktiebolag Pharmaceutical formulation
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19515625C2 (de) * 1995-04-28 1998-02-19 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern
FR2779347A1 (fr) * 1998-06-05 1999-12-03 Arlette Guerry Procede de micronisation de substances medicamenteuses
CN1150890C (zh) 1998-08-04 2004-05-26 杰格研究股份公司 药用气溶胶制剂
DK1131059T3 (da) * 1998-11-13 2003-06-30 Jago Res Ag Tørpulver til inhalation
GB9902689D0 (en) * 1999-02-08 1999-03-31 Novartis Ag Organic compounds
DE19921693A1 (de) 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
WO2000064468A2 (en) † 1999-04-23 2000-11-02 Research Corporation Technologies Therapeutic compositions and methods for enhancing angiogenesis
WO2001026630A1 (fr) 1999-10-12 2001-04-19 Kaken Pharmaceutical Co., Ltd. Preparations pour inhalation en poudre et leur procede de production
EE04414B1 (et) 2000-10-12 2005-02-15 Boehringer Ingelheim Pharma Kg Tiotroopiumi sisaldav inhalatsioonipulber, meetodselle valmistamiseks ja selle kasutamine ravimi valmistamiseks
PL207870B1 (pl) 2000-10-12 2011-02-28 Boehringer Ingelheim Pharma Krystaliczny monohydrat bromku tiotropium, sposób jego wytwarzania, środek leczniczy i zastosowanie
DE10126924A1 (de) 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
PL208137B1 (pl) 2001-06-22 2011-03-31 Boehringer Ingelheim Pharma Bezwodny krystaliczny bromek tiotropium, sposób jego wytwarzania i zastosowanie krystalicznego monohydratu bromku tiotropium do wytwarzania krystalicznego bezwodnego bromku tiotropium
US7309707B2 (en) 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
AU2003276525A1 (en) 2002-11-15 2004-06-15 Orchid Chemicals And Pharmaceuticals Ltd Novel amorphous hydrate of a cephalosporin antibiotic
DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
CN102127069A (zh) 2010-01-20 2011-07-20 鲁南制药集团股份有限公司 噻托溴铵晶体

Also Published As

Publication number Publication date
CY1106923T1 (el) 2012-09-26
NO20190824A1 (no) 2004-10-14
EP1785422B1 (de) 2016-11-16
EP1487832B2 (de) 2018-08-29
SA03240098B1 (ar) 2008-03-24
EP1487832B1 (de) 2007-08-08
IL163841A0 (en) 2005-12-18
SI1487832T1 (sl) 2007-12-31
CN101220025A (zh) 2008-07-16
DK1487832T4 (en) 2018-12-10
CO5611105A2 (es) 2006-02-28
LT1785422T (lt) 2017-02-10
UY27725A1 (es) 2003-10-31
ES2615460T3 (es) 2017-06-07
PT1487832E (pt) 2007-08-27
DE50307883D1 (de) 2007-09-20
PL371799A1 (en) 2005-06-27
UA78295C2 (en) 2007-03-15
JP2005526776A (ja) 2005-09-08
NO20044003L (no) 2004-10-14
TW200305421A (en) 2003-11-01
HK1078871A1 (en) 2006-03-24
AU2003212327A1 (en) 2003-09-29
KR20050008662A (ko) 2005-01-21
PE20030838A1 (es) 2003-11-21
CN1642952A (zh) 2005-07-20
TWI345975B (en) 2011-08-01
ES2291619T3 (es) 2008-03-01
EP3053921A1 (de) 2016-08-10
EP1487832A1 (de) 2004-12-22
HRP20040855B1 (en) 2012-11-30
PT1785422T (pt) 2017-02-17
HUE031876T2 (en) 2017-08-28
HRP20040855A2 (en) 2005-06-30
BR0308513A (pt) 2005-01-04
AU2003212327B2 (en) 2009-02-05
NZ535808A (en) 2005-09-30
CA2479652C (en) 2012-07-10
WO2003078429A1 (de) 2003-09-25
BRPI0308513B8 (pt) 2021-05-25
SI1487832T2 (sl) 2018-11-30
JP4331619B2 (ja) 2009-09-16
NO344427B1 (no) 2019-12-02
MY139720A (en) 2009-10-30
EP1785422A1 (de) 2007-05-16
EA200401142A1 (ru) 2005-04-28
KR101021430B1 (ko) 2011-03-15
EP1785422A8 (de) 2010-06-23
DK1785422T3 (en) 2017-02-27
MEP46708A (en) 2011-02-10
CN100368410C (zh) 2008-02-13
ES2291619T5 (es) 2018-12-07
DE10212264A1 (de) 2003-10-02
NO346754B1 (no) 2022-12-12
KR20100135983A (ko) 2010-12-27
ZA200405636B (en) 2006-01-25
EA007064B1 (ru) 2006-06-30
IL163841A (en) 2015-10-29
RS57551B1 (sr) 2018-10-31
EP1487832B9 (de) 2019-01-23
MXPA04009056A (es) 2005-01-25
ME02764B (me) 2011-05-10
ATE369365T1 (de) 2007-08-15
BRPI0308513B1 (pt) 2016-04-19
DK1487832T3 (da) 2007-11-05
PL220730B1 (pl) 2015-12-31
AR039017A1 (es) 2005-02-02
KR101094091B1 (ko) 2011-12-15
CY1118855T1 (el) 2018-01-10
CA2479652A1 (en) 2003-09-25

Similar Documents

Publication Publication Date Title
ECSP045310A (es) Material micronizado cristalino del bromuro de tiotropio
UY26962A1 (es) Monohidrato cristalino, procedimiento para su preparación y su utilización para la preparación de un medicamento
UY27342A1 (es) Agente anticolinérgico cristalino, procedimiento para su preparación y su utilización para la preparación de un medicamento
AR054347A1 (es) Combinaciones terapeuticas para el tratamiento o la prevencion de la depresion
ECSP055528A (es) Composicion farmaceutica que tiene una distribución y potencia uniforme de farmaco
BRPI0514474A (pt) multiparticulados
CL2008001813A1 (es) Compuestos derivados de quinolin-3-carbonitrilo sustituidos con piperazina; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como artritis, inflamacion, cancer entre otras (div. sol. 266-04).
CO5640037A2 (es) Derivados de la quinazolina para el tratamiento del cancer
SV2006002473A (es) Forma cristalina ortorrombica del maleato de asenapina y su uso en el tratamiento de trastornos mentales ref. 2005.893 (806.671)
BR0308429A (pt) Aroilpiridinonas monocìclicas como agentes antiinflamatórios
CR10327A (es) &#34;PIRIDIN(3-4-b) PIRAZINONAS&#34;
RS51569B (en) COMPOSITIONS CONTAINING CRYSTAL TRANS - (+/-) - DELTA-9-TETRAHYDROCANABINOL
PA8587101A1 (es) Nuevos derivados de dihidropirimido [4,5-d] pirimidinona sustituida por amiino, fabricacion y uso de los mismos como agentes farmaceuticos
UY26992A1 (es) Nuevas composiciones de medicamentos sobre la base de agentes anticolinérgicos y corticoesteroides
TW200626527A (en) Novel hexafluoroisopropanol derivatives
SG165404A1 (en) Fulvestrant formulation
BRPI0311189B8 (pt) composições farmacêuticas contendo polimorfo a de flibanserin, bem como seu uso
AR053775A1 (es) Nonadepsipeptidos acilados ii
SI1893237T1 (sl) Farmacevtska zmes ki vsebuje organopolisiloksan elastomer in učinkovino v obliki raztopine
MX2012007225A (es) Composicion farmaceutica que comprende mezcla de solventes y derivado o analogo de vitamina d.
PE20070711A1 (es) Derivados de piperazina utiles como antagonistas de ccr5
PE20011080A1 (es) Uso de mirtazapina para el tratamiento de trastornos del sueno
UY27670A1 (es) Nuevas composiciones de medicamentos sobre la base de agentes anticolinérgicos y de agentes inhibidores de la cinasa del egfr
RU2008115908A (ru) Фармацевтическая композиция, содержащая гиалуронидазу и липосомы для наружного применения
ECSP067104A (es) Uso de lingados de receptor en terapia