ECSP045310A - Material micronizado cristalino del bromuro de tiotropio - Google Patents

Material micronizado cristalino del bromuro de tiotropio

Info

Publication number
ECSP045310A
ECSP045310A EC2004005310A ECSP045310A ECSP045310A EC SP045310 A ECSP045310 A EC SP045310A EC 2004005310 A EC2004005310 A EC 2004005310A EC SP045310 A ECSP045310 A EC SP045310A EC SP045310 A ECSP045310 A EC SP045310A
Authority
EC
Ecuador
Prior art keywords
tiotrope
bromide material
crystalline micronized
preparation
micronized
Prior art date
Application number
EC2004005310A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27797948&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP045310(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of ECSP045310A publication Critical patent/ECSP045310A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Catalysts (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Hybrid Cells (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

El invento se refiere a un material micronizado cristalino de bromuro de (1a,2b,4b,5a,7b)-7-[(hidroxi-di-2-tienil-acetil)oxi]-9,9-dimetil-3-oxa-9-azonia-triciclo-[3.3.1.02,4]nonano, a procedimientos para su preparación así como a su utilización para la preparación de un medicamento, en particular para la preparación de un medicamento con efecto anticolinérgico.
EC2004005310A 2002-03-20 2004-09-23 Material micronizado cristalino del bromuro de tiotropio ECSP045310A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10212264A DE10212264A1 (de) 2002-03-20 2002-03-20 Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels

Publications (1)

Publication Number Publication Date
ECSP045310A true ECSP045310A (es) 2004-10-26

Family

ID=27797948

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005310A ECSP045310A (es) 2002-03-20 2004-09-23 Material micronizado cristalino del bromuro de tiotropio

Country Status (36)

Country Link
EP (3) EP3053921A1 (es)
JP (1) JP4331619B2 (es)
KR (2) KR101021430B1 (es)
CN (2) CN100368410C (es)
AR (1) AR039017A1 (es)
AT (1) ATE369365T1 (es)
AU (1) AU2003212327B2 (es)
BR (1) BRPI0308513B8 (es)
CA (1) CA2479652C (es)
CO (1) CO5611105A2 (es)
CY (2) CY1106923T1 (es)
DE (2) DE10212264A1 (es)
DK (2) DK1487832T4 (es)
EA (1) EA007064B1 (es)
EC (1) ECSP045310A (es)
ES (2) ES2291619T5 (es)
HR (1) HRP20040855B1 (es)
HU (1) HUE031876T2 (es)
IL (2) IL163841A0 (es)
LT (1) LT1785422T (es)
ME (1) ME02764B (es)
MX (1) MXPA04009056A (es)
MY (1) MY139720A (es)
NO (2) NO346754B1 (es)
NZ (1) NZ535808A (es)
PE (1) PE20030838A1 (es)
PL (1) PL220730B1 (es)
PT (2) PT1785422T (es)
RS (1) RS57551B1 (es)
SA (1) SA03240098B1 (es)
SI (1) SI1487832T2 (es)
TW (1) TWI345975B (es)
UA (1) UA78295C2 (es)
UY (1) UY27725A1 (es)
WO (1) WO2003078429A1 (es)
ZA (1) ZA200405636B (es)

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UY28590A1 (es) 2003-11-03 2005-06-30 Boehringer Ingelheim Int Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen.
EP2083007B1 (de) 2003-11-03 2013-04-24 Boehringer Ingelheim International Gmbh Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024451A1 (de) 2004-05-14 2005-12-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierungen für die Inhalation, die Enantiomerenreine Betaagonisten enthalten
JP5227790B2 (ja) 2005-05-02 2013-07-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規結晶性臭化チオトロピウム
EP1879888A2 (en) * 2005-05-02 2008-01-23 Boehringer Ingelheim International GmbH Crystalline forms of tiotropium bromide
KR101360803B1 (ko) 2005-08-15 2014-02-11 베링거 인겔하임 인터내셔날 게엠베하 베타모방제의 제조방법
TWI396541B (zh) * 2005-10-10 2013-05-21 Boehringer Ingelheim Int 用於治療呼吸疾病之新穎藥物組合
DE102005059602A1 (de) * 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
KR101395881B1 (ko) * 2005-12-19 2014-05-21 시코르, 인크. 브롬화 티오트로피움의 신규한 형태 및 이의 제조 방법
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
WO2011093815A2 (en) * 2010-01-29 2011-08-04 Mahmut Bilgic Pharmaceutical compositions comprising formoterol and mometasone
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
UA115989C2 (uk) 2012-07-05 2018-01-25 Арвен Айлак Санайі Ве Тіджарет А.С. Фармацевтична композиція для інгалятора сухого порошку, що містить антагоністи мускаринових рецепторів тривалої дії
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
SG11201700536XA (en) 2014-09-09 2017-02-27 Vectura Ltd Formulation comprising glycopyrrolate, method and apparatus
JP2019500916A (ja) * 2015-10-23 2019-01-17 アーヴェン イラチュ サナイ ヴェ ティヂャレット エー． エス．Ａｒｖｅｎ Ｉｌａｃ Ｓａｎａｙｉ Ｖｅ Ｔｉｃａｒｅｔ Ａ．Ｓ． 臭化チオトロピウムの吸入製剤のためのブリスター
EP3159278A1 (en) * 2015-10-23 2017-04-26 Arven Ilac Sanayi Ve Ticaret A.S. Blister for tiotropium bromide inhalable formulation
CN115737610B (zh) * 2021-12-13 2024-02-27 苏州欧米尼医药有限公司 一种噻托溴铵吸入粉雾剂及其活性成分的气流粉碎方法

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Also Published As

Publication number Publication date
ES2615460T3 (es) 2017-06-07
KR101021430B1 (ko) 2011-03-15
PT1487832E (pt) 2007-08-27
HRP20040855A2 (en) 2005-06-30
CA2479652A1 (en) 2003-09-25
AU2003212327B2 (en) 2009-02-05
NO346754B1 (no) 2022-12-12
DK1487832T3 (da) 2007-11-05
WO2003078429A1 (de) 2003-09-25
SI1487832T1 (sl) 2007-12-31
UY27725A1 (es) 2003-10-31
IL163841A0 (en) 2005-12-18
PL220730B1 (pl) 2015-12-31
KR101094091B1 (ko) 2011-12-15
UA78295C2 (en) 2007-03-15
EP1785422B1 (de) 2016-11-16
NO344427B1 (no) 2019-12-02
EP1487832B2 (de) 2018-08-29
DE10212264A1 (de) 2003-10-02
CA2479652C (en) 2012-07-10
NZ535808A (en) 2005-09-30
EA200401142A1 (ru) 2005-04-28
MEP46708A (en) 2011-02-10
PE20030838A1 (es) 2003-11-21
HUE031876T2 (en) 2017-08-28
MY139720A (en) 2009-10-30
ES2291619T3 (es) 2008-03-01
TWI345975B (en) 2011-08-01
NO20190824A1 (no) 2004-10-14
CN100368410C (zh) 2008-02-13
EA007064B1 (ru) 2006-06-30
BRPI0308513B1 (pt) 2016-04-19
CO5611105A2 (es) 2006-02-28
CY1106923T1 (el) 2012-09-26
BR0308513A (pt) 2005-01-04
BRPI0308513B8 (pt) 2021-05-25
HK1078871A1 (zh) 2006-03-24
DK1487832T4 (en) 2018-12-10
LT1785422T (lt) 2017-02-10
CN101220025A (zh) 2008-07-16
SA03240098B1 (ar) 2008-03-24
DE50307883D1 (de) 2007-09-20
CN1642952A (zh) 2005-07-20
ME02764B (me) 2011-05-10
MXPA04009056A (es) 2005-01-25
NO20044003L (no) 2004-10-14
ES2291619T5 (es) 2018-12-07
DK1785422T3 (en) 2017-02-27
EP1487832B1 (de) 2007-08-08
HRP20040855B1 (en) 2012-11-30
EP1487832B9 (de) 2019-01-23
KR20100135983A (ko) 2010-12-27
TW200305421A (en) 2003-11-01
JP4331619B2 (ja) 2009-09-16
EP1785422A8 (de) 2010-06-23
CY1118855T1 (el) 2018-01-10
PT1785422T (pt) 2017-02-17
ZA200405636B (en) 2006-01-25
AU2003212327A1 (en) 2003-09-29
EP3053921A1 (de) 2016-08-10
EP1785422A1 (de) 2007-05-16
PL371799A1 (en) 2005-06-27
RS57551B1 (sr) 2018-10-31
EP1487832A1 (de) 2004-12-22
IL163841A (en) 2015-10-29
SI1487832T2 (sl) 2018-11-30
KR20050008662A (ko) 2005-01-21
JP2005526776A (ja) 2005-09-08
AR039017A1 (es) 2005-02-02
ATE369365T1 (de) 2007-08-15

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