MEP46708A - Micronized crystalline tiotropium bromide - Google Patents

Micronized crystalline tiotropium bromide

Info

Publication number
MEP46708A
MEP46708A MEP-467/08A MEP46708A MEP46708A ME P46708 A MEP46708 A ME P46708A ME P46708 A MEP46708 A ME P46708A ME P46708 A MEP46708 A ME P46708A
Authority
ME
Montenegro
Prior art keywords
tiotropium bromide
crystalline tiotropium
micronized crystalline
preparation
medicament
Prior art date
Application number
MEP-467/08A
Other languages
Bosnian (bs)
Inventor
Helmut Bender
Hagen Graebner
Konrad Schindler
Michael Josef Friedrich Trunk
Michael Walz
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27797948&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MEP46708(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MEP46708A publication Critical patent/MEP46708A/en
Publication of ME02764B publication Critical patent/ME02764B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Hybrid Cells (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Pronalazak se odnosi na kristalni mikronizat (1α, 2β, 4 β, 5 α, 7 β,)-7-[(hidroksidi-2-tienil-acetil)oksi]-9,9-dimetil-3-oksa-9-azoniatriciklo[3.3.1.02,4]nonan-bromida, na postupak za njegovo pripremanje, kao i na njegovu primjenu za pripremanje lijeka, naročito za pripremanje lijeka sa antiholingergijskim dejstvom.The invention relates to crystalline micronizate (1α, 2β, 4 β, 5 α, 7 β,) - 7 - [(hydroxides-2-thienyl-acetyl) oxy] -9,9-dimethyl-3-oxa-9-azoniatricyclo [3.3.1.02,4] nonan-bromide, to a process for its preparation as well as to its use for the preparation of a medicament, in particular for the preparation of a medicament with anticholingeric action.

MEP-2008-467A 2002-03-20 2003-03-10 Micronized crystalline tiotropium bromide ME02764B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10212264A DE10212264A1 (en) 2002-03-20 2002-03-20 Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament
PCT/EP2003/002422 WO2003078429A1 (en) 2002-03-20 2003-03-10 Micronized crystalline tiotropium bromide

Publications (2)

Publication Number Publication Date
MEP46708A true MEP46708A (en) 2011-02-10
ME02764B ME02764B (en) 2011-05-10

Family

ID=27797948

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-467A ME02764B (en) 2002-03-20 2003-03-10 Micronized crystalline tiotropium bromide

Country Status (37)

Country Link
EP (3) EP3053921A1 (en)
JP (1) JP4331619B2 (en)
KR (2) KR101094091B1 (en)
CN (2) CN100368410C (en)
AR (1) AR039017A1 (en)
AT (1) ATE369365T1 (en)
AU (1) AU2003212327B2 (en)
BR (1) BRPI0308513B8 (en)
CA (1) CA2479652C (en)
CO (1) CO5611105A2 (en)
CY (2) CY1106923T1 (en)
DE (2) DE10212264A1 (en)
DK (2) DK1487832T4 (en)
EA (1) EA007064B1 (en)
EC (1) ECSP045310A (en)
ES (2) ES2615460T3 (en)
HK (1) HK1078871A1 (en)
HR (1) HRP20040855B1 (en)
HU (1) HUE031876T2 (en)
IL (2) IL163841A0 (en)
LT (1) LT1785422T (en)
ME (1) ME02764B (en)
MX (1) MXPA04009056A (en)
MY (1) MY139720A (en)
NO (2) NO346754B1 (en)
NZ (1) NZ535808A (en)
PE (1) PE20030838A1 (en)
PL (1) PL220730B1 (en)
PT (2) PT1487832E (en)
RS (1) RS57551B1 (en)
SA (1) SA03240098B1 (en)
SI (1) SI1487832T2 (en)
TW (1) TWI345975B (en)
UA (1) UA78295C2 (en)
UY (1) UY27725A1 (en)
WO (1) WO2003078429A1 (en)
ZA (1) ZA200405636B (en)

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BRPI0609295A2 (en) 2005-05-02 2010-03-23 Boehringer Ingelheim Int crystalline forms of tiotropium bromide, pharmaceutical composition, use and method for preparing same
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GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
EP2533765A2 (en) * 2010-01-29 2012-12-19 Mahmut Bilgic Pharmaceutical compositions comprising formoterol and mometasone
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (en) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A PROCESS FOR THE PREPARATION OF TIOTROPE BROMIDE
EA036153B1 (en) 2012-07-05 2020-10-06 Арвен Айлак Санайи Ве Тиджарет А.С. Pharmaceutical composition for inhalation, packed dosage form, capsule, method of treating obstructive airway diseases and pharmaceutical kit
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
HUE049339T2 (en) 2014-09-09 2020-09-28 Vectura Ltd Formulation comprising glycopyrrolate, method and apparatus
EP3159278A1 (en) * 2015-10-23 2017-04-26 Arven Ilac Sanayi Ve Ticaret A.S. Blister for tiotropium bromide inhalable formulation
CN108137205A (en) * 2015-10-23 2018-06-08 阿尔文伊莱克工贸有限公司 For the bubble-cap of the inhalable formulations of Tiotropium Bromide
CN115737610B (en) * 2021-12-13 2024-02-27 苏州欧米尼医药有限公司 Air flow crushing method for tiotropium bromide inhalation powder fog agent and active ingredient thereof

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Also Published As

Publication number Publication date
DK1487832T4 (en) 2018-12-10
HRP20040855B1 (en) 2012-11-30
ZA200405636B (en) 2006-01-25
AU2003212327B2 (en) 2009-02-05
KR101021430B1 (en) 2011-03-15
KR101094091B1 (en) 2011-12-15
CN101220025A (en) 2008-07-16
PT1785422T (en) 2017-02-17
EP1487832B2 (en) 2018-08-29
AR039017A1 (en) 2005-02-02
JP2005526776A (en) 2005-09-08
CY1118855T1 (en) 2018-01-10
CA2479652C (en) 2012-07-10
MXPA04009056A (en) 2005-01-25
ATE369365T1 (en) 2007-08-15
ECSP045310A (en) 2004-10-26
DE50307883D1 (en) 2007-09-20
MY139720A (en) 2009-10-30
KR20100135983A (en) 2010-12-27
SA03240098B1 (en) 2008-03-24
EP3053921A1 (en) 2016-08-10
BRPI0308513B8 (en) 2021-05-25
CN100368410C (en) 2008-02-13
DE10212264A1 (en) 2003-10-02
SI1487832T2 (en) 2018-11-30
EA007064B1 (en) 2006-06-30
DK1785422T3 (en) 2017-02-27
UY27725A1 (en) 2003-10-31
NZ535808A (en) 2005-09-30
IL163841A (en) 2015-10-29
EP1487832B9 (en) 2019-01-23
EP1785422A1 (en) 2007-05-16
IL163841A0 (en) 2005-12-18
AU2003212327A1 (en) 2003-09-29
HUE031876T2 (en) 2017-08-28
NO20190824A1 (en) 2004-10-14
EP1785422B1 (en) 2016-11-16
PT1487832E (en) 2007-08-27
BR0308513A (en) 2005-01-04
ES2291619T3 (en) 2008-03-01
CA2479652A1 (en) 2003-09-25
LT1785422T (en) 2017-02-10
NO20044003L (en) 2004-10-14
CN1642952A (en) 2005-07-20
CY1106923T1 (en) 2012-09-26
CO5611105A2 (en) 2006-02-28
PL220730B1 (en) 2015-12-31
HRP20040855A2 (en) 2005-06-30
PE20030838A1 (en) 2003-11-21
JP4331619B2 (en) 2009-09-16
PL371799A1 (en) 2005-06-27
ME02764B (en) 2011-05-10
UA78295C2 (en) 2007-03-15
KR20050008662A (en) 2005-01-21
ES2615460T3 (en) 2017-06-07
TW200305421A (en) 2003-11-01
BRPI0308513B1 (en) 2016-04-19
SI1487832T1 (en) 2007-12-31
EP1785422A8 (en) 2010-06-23
EP1487832A1 (en) 2004-12-22
EA200401142A1 (en) 2005-04-28
RS57551B1 (en) 2018-10-31
EP1487832B1 (en) 2007-08-08
WO2003078429A1 (en) 2003-09-25
HK1078871A1 (en) 2006-03-24
NO346754B1 (en) 2022-12-12
DK1487832T3 (en) 2007-11-05
TWI345975B (en) 2011-08-01
NO344427B1 (en) 2019-12-02
ES2291619T5 (en) 2018-12-07

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