NO20044003L - Crystalline micronisate of tiotropium bromide - Google Patents
Crystalline micronisate of tiotropium bromideInfo
- Publication number
- NO20044003L NO20044003L NO20044003A NO20044003A NO20044003L NO 20044003 L NO20044003 L NO 20044003L NO 20044003 A NO20044003 A NO 20044003A NO 20044003 A NO20044003 A NO 20044003A NO 20044003 L NO20044003 L NO 20044003L
- Authority
- NO
- Norway
- Prior art keywords
- tiotropium bromide
- micronisate
- crystalline
- crystalline micronisate
- tiotropium
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Glass Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hybrid Cells (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10212264A DE10212264A1 (en) | 2002-03-20 | 2002-03-20 | Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament |
PCT/EP2003/002422 WO2003078429A1 (en) | 2002-03-20 | 2003-03-10 | Micronized crystalline tiotropium bromide |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20044003L true NO20044003L (en) | 2004-10-14 |
NO344427B1 NO344427B1 (en) | 2019-12-02 |
Family
ID=27797948
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20190824A NO346754B1 (en) | 2002-03-20 | 2003-03-10 | Crystalline micronisate of tiotropium bromide |
NO20044003A NO344427B1 (en) | 2002-03-20 | 2004-09-23 | Process for the preparation of crystalline tiotropium bromide micronisate |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20190824A NO346754B1 (en) | 2002-03-20 | 2003-03-10 | Crystalline micronisate of tiotropium bromide |
Country Status (37)
Country | Link |
---|---|
EP (3) | EP3053921A1 (en) |
JP (1) | JP4331619B2 (en) |
KR (2) | KR101021430B1 (en) |
CN (2) | CN100368410C (en) |
AR (1) | AR039017A1 (en) |
AT (1) | ATE369365T1 (en) |
AU (1) | AU2003212327B2 (en) |
BR (1) | BRPI0308513B8 (en) |
CA (1) | CA2479652C (en) |
CO (1) | CO5611105A2 (en) |
CY (2) | CY1106923T1 (en) |
DE (2) | DE10212264A1 (en) |
DK (2) | DK1785422T3 (en) |
EA (1) | EA007064B1 (en) |
EC (1) | ECSP045310A (en) |
ES (2) | ES2615460T3 (en) |
HK (1) | HK1078871A1 (en) |
HR (1) | HRP20040855B1 (en) |
HU (1) | HUE031876T2 (en) |
IL (2) | IL163841A0 (en) |
LT (1) | LT1785422T (en) |
ME (1) | ME02764B (en) |
MX (1) | MXPA04009056A (en) |
MY (1) | MY139720A (en) |
NO (2) | NO346754B1 (en) |
NZ (1) | NZ535808A (en) |
PE (1) | PE20030838A1 (en) |
PL (1) | PL220730B1 (en) |
PT (2) | PT1487832E (en) |
RS (1) | RS57551B1 (en) |
SA (1) | SA03240098B1 (en) |
SI (1) | SI1487832T2 (en) |
TW (1) | TWI345975B (en) |
UA (1) | UA78295C2 (en) |
UY (1) | UY27725A1 (en) |
WO (1) | WO2003078429A1 (en) |
ZA (1) | ZA200405636B (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
RS51758B (en) | 2003-11-03 | 2011-12-31 | Boehringer Ingelheim International Gmbh. | Method for producing tiotropium salts |
ATE478071T1 (en) | 2003-11-03 | 2010-09-15 | Boehringer Ingelheim Int | METHOD FOR PRODUCING NEW TIOTROPIUM SALTS |
US7220742B2 (en) | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
DE102004024451A1 (en) | 2004-05-14 | 2005-12-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder formulations for inhalation containing enantiomerically pure beta agonists |
DK1881980T3 (en) | 2005-05-02 | 2012-10-01 | Boehringer Ingelheim Int | New crystalline forms of tiotropium bromide |
JP2008540367A (en) * | 2005-05-02 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | New crystalline tiotropium bromide |
CN101208316B (en) | 2005-08-15 | 2012-05-09 | 贝林格尔·英格海姆国际有限公司 | Method for producing betamimetics |
US20070086957A1 (en) * | 2005-10-10 | 2007-04-19 | Thierry Bouyssou | Combination of medicaments for the treatment of respiratory diseases |
DE102005059602A1 (en) | 2005-12-14 | 2007-06-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Micronization process |
US9108962B2 (en) | 2005-12-19 | 2015-08-18 | Sicor, Inc. | Forms of tiotropium bromide and processes for preparation thereof |
MX2007009988A (en) * | 2005-12-19 | 2008-02-22 | Sicor Inc | Novel forms of tiotropium bromide and processes for preparation thereof. |
CN100999521B (en) * | 2006-01-13 | 2010-12-08 | 江苏正大天晴药业股份有限公司 | Crystal anti-choline medicine thiatropic bromoammonium |
GB0716026D0 (en) | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
WO2011093815A2 (en) * | 2010-01-29 | 2011-08-04 | Mahmut Bilgic | Pharmaceutical compositions comprising formoterol and mometasone |
GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
PT106142B (en) * | 2012-02-10 | 2014-07-18 | Hovione Farmaci Ncia S A | PROCESS FOR THE PREPARATION OF TIOTROPE BROMIDE |
WO2014007768A1 (en) | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Dry powder inhaler compositions comprising long acting muscorinic antagonists |
EP2705838A1 (en) * | 2012-09-06 | 2014-03-12 | Xspray Microparticles Ab | Tiotropium preparations |
EP2897955B1 (en) * | 2012-09-11 | 2019-11-06 | Bilgic, Mahmut | New tiotropium bromide crystalline form |
US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
UA115958C2 (en) | 2014-09-09 | 2018-01-10 | Вектура Лімітед | Formulation comprising glycopyrrolate, method and apparatus |
US20180236188A1 (en) * | 2015-10-23 | 2018-08-23 | Arven Ilac Sanayi Ve Ticaret A.S. | Blister for inhalable formulation of tiotropium bromide |
EP3159278A1 (en) * | 2015-10-23 | 2017-04-26 | Arven Ilac Sanayi Ve Ticaret A.S. | Blister for tiotropium bromide inhalable formulation |
CN115737610B (en) * | 2021-12-13 | 2024-02-27 | 苏州欧米尼医药有限公司 | Air flow crushing method for tiotropium bromide inhalation powder fog agent and active ingredient thereof |
Family Cites Families (23)
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US4570630A (en) | 1983-08-03 | 1986-02-18 | Miles Laboratories, Inc. | Medicament inhalation device |
DK163640C (en) | 1985-07-30 | 1992-08-17 | Glaxo Group Ltd | DEVICE FOR ADMINISTRATING MEDICINES |
DE3931041C2 (en) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them |
US5610163A (en) | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
SE9302777D0 (en) | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
US5874063A (en) | 1991-04-11 | 1999-02-23 | Astra Aktiebolag | Pharmaceutical formulation |
DE4318455A1 (en) | 1993-06-03 | 1994-12-08 | Boehringer Ingelheim Kg | Capsule holder |
DE19515625C2 (en) * | 1995-04-28 | 1998-02-19 | Boehringer Ingelheim Kg | Process for the production of enantiomerically pure tropic acid esters |
FR2779347A1 (en) * | 1998-06-05 | 1999-12-03 | Arlette Guerry | Micronization of medicaments to improve homogeneity and bioavailability of active compound |
US6475467B1 (en) | 1998-08-04 | 2002-11-05 | Jago Research Ag | Medicinal aerosol formulations |
NZ511527A (en) * | 1998-11-13 | 2002-10-25 | Jago Res A | Dry powder for inhalation |
GB9902689D0 (en) * | 1999-02-08 | 1999-03-31 | Novartis Ag | Organic compounds |
DE19921693A1 (en) † | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Pharmaceutical composition for treating respiratory disorders, e.g. asthma, comprises combination of anticholinergic and beta-mimetic agents having synergistic bronchospasmolytic activity and reduced side-effects |
JP2002542297A (en) † | 1999-04-23 | 2002-12-10 | リサーチ コーポレイション テクノロジーズ,インコーポレイテッド | Therapeutic compositions and methods for enhancing angiogenesis |
CA2387212A1 (en) | 1999-10-12 | 2001-04-19 | Kaken Pharmaceutical Co., Ltd. | Dry powder inhalation and a method for the preparation thereof |
RS50197B (en) | 2000-10-12 | 2009-05-06 | Boehringer Ingelheim Pharma Gmbh. & Co.Kg., | Novel tiotropium-containing inhalation powder |
TR200402579T4 (en) | 2000-10-12 | 2004-12-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Crystalline monohydrate, its method of manufacture and its use in the manufacture of a drug substance |
DE10126924A1 (en) | 2001-06-01 | 2002-12-05 | Boehringer Ingelheim Pharma | Inhalation capsule contains powdered mixture of tiotropium and auxiliary, for treating asthma or chronic obstructive pulmonary disease, having capsule material of low moisture content to improve stability |
SK287262B6 (en) | 2001-06-22 | 2010-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anhydrous crystalline tiotropium bromide, method for its production, pharmaceutical composition containing it and use thereof |
US7309707B2 (en) | 2002-03-20 | 2007-12-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament |
AU2003276525A1 (en) | 2002-11-15 | 2004-06-15 | Orchid Chemicals And Pharmaceuticals Ltd | Novel amorphous hydrate of a cephalosporin antibiotic |
DE102005059602A1 (en) | 2005-12-14 | 2007-06-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Micronization process |
CN102127069A (en) | 2010-01-20 | 2011-07-20 | 鲁南制药集团股份有限公司 | Tiotropium bromide crystal |
-
2002
- 2002-03-20 DE DE10212264A patent/DE10212264A1/en not_active Withdrawn
-
2003
- 2003-03-10 PT PT03708206T patent/PT1487832E/en unknown
- 2003-03-10 WO PCT/EP2003/002422 patent/WO2003078429A1/en active IP Right Grant
- 2003-03-10 KR KR1020047014831A patent/KR101021430B1/en active IP Right Grant
- 2003-03-10 EP EP16159836.2A patent/EP3053921A1/en not_active Withdrawn
- 2003-03-10 ES ES07102206.5T patent/ES2615460T3/en not_active Expired - Lifetime
- 2003-03-10 CA CA2479652A patent/CA2479652C/en not_active Expired - Fee Related
- 2003-03-10 LT LTEP07102206.5T patent/LT1785422T/en unknown
- 2003-03-10 DK DK07102206.5T patent/DK1785422T3/en active
- 2003-03-10 ME MEP-2008-467A patent/ME02764B/en unknown
- 2003-03-10 CN CNB038065169A patent/CN100368410C/en not_active Ceased
- 2003-03-10 MX MXPA04009056A patent/MXPA04009056A/en active IP Right Grant
- 2003-03-10 EP EP03708206.2A patent/EP1487832B9/en not_active Expired - Lifetime
- 2003-03-10 EP EP07102206.5A patent/EP1785422B1/en not_active Expired - Lifetime
- 2003-03-10 DK DK03708206.2T patent/DK1487832T4/en active
- 2003-03-10 PT PT71022065T patent/PT1785422T/en unknown
- 2003-03-10 AU AU2003212327A patent/AU2003212327B2/en not_active Expired
- 2003-03-10 KR KR1020107028543A patent/KR101094091B1/en active IP Right Grant
- 2003-03-10 JP JP2003576434A patent/JP4331619B2/en not_active Expired - Lifetime
- 2003-03-10 SI SI200330973T patent/SI1487832T2/en unknown
- 2003-03-10 EA EA200401142A patent/EA007064B1/en not_active IP Right Cessation
- 2003-03-10 AT AT03708206T patent/ATE369365T1/en active
- 2003-03-10 BR BRPI0308513A patent/BRPI0308513B8/en not_active IP Right Cessation
- 2003-03-10 PL PL371799A patent/PL220730B1/en unknown
- 2003-03-10 RS RS82604A patent/RS57551B1/en unknown
- 2003-03-10 NZ NZ535808A patent/NZ535808A/en not_active IP Right Cessation
- 2003-03-10 DE DE50307883T patent/DE50307883D1/en not_active Expired - Lifetime
- 2003-03-10 IL IL16384103A patent/IL163841A0/en unknown
- 2003-03-10 ES ES03708206.2T patent/ES2291619T5/en not_active Expired - Lifetime
- 2003-03-10 NO NO20190824A patent/NO346754B1/en not_active IP Right Cessation
- 2003-03-10 CN CNA2008100024354A patent/CN101220025A/en active Pending
- 2003-03-10 HU HUE07102206A patent/HUE031876T2/en unknown
- 2003-03-18 UY UY27725A patent/UY27725A1/en not_active Application Discontinuation
- 2003-03-18 MY MYPI20030947A patent/MY139720A/en unknown
- 2003-03-18 PE PE2003000268A patent/PE20030838A1/en not_active Application Discontinuation
- 2003-03-18 TW TW092105919A patent/TWI345975B/en not_active IP Right Cessation
- 2003-03-19 AR ARP030100957A patent/AR039017A1/en not_active Suspension/Interruption
- 2003-04-29 SA SA03240098A patent/SA03240098B1/en unknown
- 2003-10-03 UA UA20041008391A patent/UA78295C2/en unknown
-
2004
- 2004-07-15 ZA ZA2004/05636A patent/ZA200405636B/en unknown
- 2004-08-31 IL IL163841A patent/IL163841A/en not_active IP Right Cessation
- 2004-09-17 HR HR20040855 patent/HRP20040855B1/en not_active IP Right Cessation
- 2004-09-23 EC EC2004005310A patent/ECSP045310A/en unknown
- 2004-09-23 NO NO20044003A patent/NO344427B1/en not_active IP Right Cessation
- 2004-10-15 CO CO04104123A patent/CO5611105A2/en not_active Application Discontinuation
-
2005
- 2005-12-01 HK HK05110949A patent/HK1078871A1/en not_active IP Right Cessation
-
2007
- 2007-10-10 CY CY20071101300T patent/CY1106923T1/en unknown
-
2017
- 2017-02-13 CY CY20171100194T patent/CY1118855T1/en unknown
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Legal Events
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MK1K | Patent expired |