NO20044003L - Crystalline micronisate of tiotropium bromide - Google Patents

Crystalline micronisate of tiotropium bromide

Info

Publication number
NO20044003L
NO20044003L NO20044003A NO20044003A NO20044003L NO 20044003 L NO20044003 L NO 20044003L NO 20044003 A NO20044003 A NO 20044003A NO 20044003 A NO20044003 A NO 20044003A NO 20044003 L NO20044003 L NO 20044003L
Authority
NO
Norway
Prior art keywords
tiotropium bromide
micronisate
crystalline
crystalline micronisate
tiotropium
Prior art date
Application number
NO20044003A
Other languages
Norwegian (no)
Other versions
NO344427B1 (en
Inventor
Michael Walz
Michael Trunk
Helmut Bender
Hagen Grabner
Konrad Schindler
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27797948&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20044003(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20044003L publication Critical patent/NO20044003L/en
Publication of NO344427B1 publication Critical patent/NO344427B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hybrid Cells (AREA)
NO20044003A 2002-03-20 2004-09-23 Process for the preparation of crystalline tiotropium bromide micronisate NO344427B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10212264A DE10212264A1 (en) 2002-03-20 2002-03-20 Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament
PCT/EP2003/002422 WO2003078429A1 (en) 2002-03-20 2003-03-10 Micronized crystalline tiotropium bromide

Publications (2)

Publication Number Publication Date
NO20044003L true NO20044003L (en) 2004-10-14
NO344427B1 NO344427B1 (en) 2019-12-02

Family

ID=27797948

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20190824A NO346754B1 (en) 2002-03-20 2003-03-10 Crystalline micronisate of tiotropium bromide
NO20044003A NO344427B1 (en) 2002-03-20 2004-09-23 Process for the preparation of crystalline tiotropium bromide micronisate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20190824A NO346754B1 (en) 2002-03-20 2003-03-10 Crystalline micronisate of tiotropium bromide

Country Status (37)

Country Link
EP (3) EP3053921A1 (en)
JP (1) JP4331619B2 (en)
KR (2) KR101021430B1 (en)
CN (2) CN100368410C (en)
AR (1) AR039017A1 (en)
AT (1) ATE369365T1 (en)
AU (1) AU2003212327B2 (en)
BR (1) BRPI0308513B8 (en)
CA (1) CA2479652C (en)
CO (1) CO5611105A2 (en)
CY (2) CY1106923T1 (en)
DE (2) DE10212264A1 (en)
DK (2) DK1785422T3 (en)
EA (1) EA007064B1 (en)
EC (1) ECSP045310A (en)
ES (2) ES2615460T3 (en)
HK (1) HK1078871A1 (en)
HR (1) HRP20040855B1 (en)
HU (1) HUE031876T2 (en)
IL (2) IL163841A0 (en)
LT (1) LT1785422T (en)
ME (1) ME02764B (en)
MX (1) MXPA04009056A (en)
MY (1) MY139720A (en)
NO (2) NO346754B1 (en)
NZ (1) NZ535808A (en)
PE (1) PE20030838A1 (en)
PL (1) PL220730B1 (en)
PT (2) PT1487832E (en)
RS (1) RS57551B1 (en)
SA (1) SA03240098B1 (en)
SI (1) SI1487832T2 (en)
TW (1) TWI345975B (en)
UA (1) UA78295C2 (en)
UY (1) UY27725A1 (en)
WO (1) WO2003078429A1 (en)
ZA (1) ZA200405636B (en)

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RS51758B (en) 2003-11-03 2011-12-31 Boehringer Ingelheim International Gmbh. Method for producing tiotropium salts
ATE478071T1 (en) 2003-11-03 2010-09-15 Boehringer Ingelheim Int METHOD FOR PRODUCING NEW TIOTROPIUM SALTS
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024451A1 (en) 2004-05-14 2005-12-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder formulations for inhalation containing enantiomerically pure beta agonists
DK1881980T3 (en) 2005-05-02 2012-10-01 Boehringer Ingelheim Int New crystalline forms of tiotropium bromide
JP2008540367A (en) * 2005-05-02 2008-11-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング New crystalline tiotropium bromide
CN101208316B (en) 2005-08-15 2012-05-09 贝林格尔·英格海姆国际有限公司 Method for producing betamimetics
US20070086957A1 (en) * 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
DE102005059602A1 (en) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Micronization process
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
MX2007009988A (en) * 2005-12-19 2008-02-22 Sicor Inc Novel forms of tiotropium bromide and processes for preparation thereof.
CN100999521B (en) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 Crystal anti-choline medicine thiatropic bromoammonium
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
WO2011093815A2 (en) * 2010-01-29 2011-08-04 Mahmut Bilgic Pharmaceutical compositions comprising formoterol and mometasone
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (en) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A PROCESS FOR THE PREPARATION OF TIOTROPE BROMIDE
WO2014007768A1 (en) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Dry powder inhaler compositions comprising long acting muscorinic antagonists
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
UA115958C2 (en) 2014-09-09 2018-01-10 Вектура Лімітед Formulation comprising glycopyrrolate, method and apparatus
US20180236188A1 (en) * 2015-10-23 2018-08-23 Arven Ilac Sanayi Ve Ticaret A.S. Blister for inhalable formulation of tiotropium bromide
EP3159278A1 (en) * 2015-10-23 2017-04-26 Arven Ilac Sanayi Ve Ticaret A.S. Blister for tiotropium bromide inhalable formulation
CN115737610B (en) * 2021-12-13 2024-02-27 苏州欧米尼医药有限公司 Air flow crushing method for tiotropium bromide inhalation powder fog agent and active ingredient thereof

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Also Published As

Publication number Publication date
BR0308513A (en) 2005-01-04
ZA200405636B (en) 2006-01-25
EP3053921A1 (en) 2016-08-10
ME02764B (en) 2011-05-10
DK1487832T4 (en) 2018-12-10
NO344427B1 (en) 2019-12-02
BRPI0308513B1 (en) 2016-04-19
AR039017A1 (en) 2005-02-02
MY139720A (en) 2009-10-30
TWI345975B (en) 2011-08-01
PE20030838A1 (en) 2003-11-21
ES2291619T3 (en) 2008-03-01
HRP20040855A2 (en) 2005-06-30
UY27725A1 (en) 2003-10-31
NZ535808A (en) 2005-09-30
MXPA04009056A (en) 2005-01-25
RS57551B1 (en) 2018-10-31
ECSP045310A (en) 2004-10-26
JP2005526776A (en) 2005-09-08
ES2291619T5 (en) 2018-12-07
EP1487832A1 (en) 2004-12-22
EP1487832B9 (en) 2019-01-23
HRP20040855B1 (en) 2012-11-30
CN101220025A (en) 2008-07-16
IL163841A0 (en) 2005-12-18
CA2479652A1 (en) 2003-09-25
DK1487832T3 (en) 2007-11-05
ATE369365T1 (en) 2007-08-15
HUE031876T2 (en) 2017-08-28
CO5611105A2 (en) 2006-02-28
MEP46708A (en) 2011-02-10
CY1106923T1 (en) 2012-09-26
KR20050008662A (en) 2005-01-21
ES2615460T3 (en) 2017-06-07
DE50307883D1 (en) 2007-09-20
AU2003212327A1 (en) 2003-09-29
AU2003212327B2 (en) 2009-02-05
CA2479652C (en) 2012-07-10
UA78295C2 (en) 2007-03-15
SI1487832T1 (en) 2007-12-31
PL371799A1 (en) 2005-06-27
CY1118855T1 (en) 2018-01-10
BRPI0308513B8 (en) 2021-05-25
KR101021430B1 (en) 2011-03-15
TW200305421A (en) 2003-11-01
EP1785422A1 (en) 2007-05-16
KR20100135983A (en) 2010-12-27
WO2003078429A1 (en) 2003-09-25
JP4331619B2 (en) 2009-09-16
KR101094091B1 (en) 2011-12-15
LT1785422T (en) 2017-02-10
CN1642952A (en) 2005-07-20
NO346754B1 (en) 2022-12-12
EP1487832B1 (en) 2007-08-08
EA007064B1 (en) 2006-06-30
EP1785422B1 (en) 2016-11-16
IL163841A (en) 2015-10-29
PT1785422T (en) 2017-02-17
DK1785422T3 (en) 2017-02-27
HK1078871A1 (en) 2006-03-24
PL220730B1 (en) 2015-12-31
EP1785422A8 (en) 2010-06-23
DE10212264A1 (en) 2003-10-02
SA03240098B1 (en) 2008-03-24
EP1487832B2 (en) 2018-08-29
PT1487832E (en) 2007-08-27
NO20190824A1 (en) 2004-10-14
CN100368410C (en) 2008-02-13
SI1487832T2 (en) 2018-11-30
EA200401142A1 (en) 2005-04-28

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