ECSP034839A - Sulfona-hidroxamatos aromáticos y su uso como inhibidores de proteasas - Google Patents

Sulfona-hidroxamatos aromáticos y su uso como inhibidores de proteasas

Info

Publication number
ECSP034839A
ECSP034839A EC2003004839A ECSP034839A ECSP034839A EC SP034839 A ECSP034839 A EC SP034839A EC 2003004839 A EC2003004839 A EC 2003004839A EC SP034839 A ECSP034839 A EC SP034839A EC SP034839 A ECSP034839 A EC SP034839A
Authority
EC
Ecuador
Prior art keywords
hydroxamates
aromatic
activity
aggrecanase
mmp
Prior art date
Application number
EC2003004839A
Other languages
English (en)
Spanish (es)
Inventor
John Freskos
Stephen A Kolodziej
John J Talley
Thomas Barta
Deborah Aileen Mischke
Daniel P Becker
Louis Bedell
Jeffrey N Carroll
Gary A Decrescenzo
Yvette M Fobian
Joseph J Mcdonald
Joseph G Rico
Susan L Hockerman
Clara I Villamil
Terri BOEHM
Monica Norton
Lijuan Jane Wang
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of ECSP034839A publication Critical patent/ECSP034839A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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AP2003002908A0 (en) 2003-12-31
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PL367487A1 (en) 2005-02-21
US20040110805A1 (en) 2004-06-10
IS7003A (is) 2003-10-29
US20040010019A1 (en) 2004-01-15
HUP0304069A2 (hu) 2004-04-28
EP1385836A2 (en) 2004-02-04
CN1764655A (zh) 2006-04-26
US20050101641A1 (en) 2005-05-12
US6689794B2 (en) 2004-02-10
YU85403A (sh) 2006-03-03
OA12602A (en) 2006-06-09
NO20034995D0 (no) 2003-11-10
US6890928B2 (en) 2005-05-10
CO5540386A2 (es) 2005-07-29
CR7146A (es) 2008-02-11
CZ20032913A3 (cs) 2004-05-12
EA200301116A1 (ru) 2004-06-24
MXPA03010326A (es) 2004-07-30
AR040928A1 (es) 2005-04-27
IL158454A0 (en) 2004-05-12
WO2002092588A2 (en) 2002-11-21
ZA200308525B (en) 2005-02-17
CA2446586A1 (en) 2002-11-21
KR20040018368A (ko) 2004-03-03
JP2004530691A (ja) 2004-10-07
BG108285A (bg) 2004-09-30
BR0209525A (pt) 2004-03-09

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