DE60026010D1 - Substituierte stilbene mit gefässschädigender aktivität - Google Patents
Substituierte stilbene mit gefässschädigender aktivitätInfo
- Publication number
- DE60026010D1 DE60026010D1 DE60026010T DE60026010T DE60026010D1 DE 60026010 D1 DE60026010 D1 DE 60026010D1 DE 60026010 T DE60026010 T DE 60026010T DE 60026010 T DE60026010 T DE 60026010T DE 60026010 D1 DE60026010 D1 DE 60026010D1
- Authority
- DE
- Germany
- Prior art keywords
- vulnerable
- substituted
- activity
- animal
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9903403 | 1999-02-16 | ||
GBGB9903403.5A GB9903403D0 (en) | 1999-02-16 | 1999-02-16 | Substituted stilbene compounds with vascular damaging activity |
PCT/GB2000/000503 WO2000048590A1 (en) | 1999-02-16 | 2000-02-15 | Substituted stilbene compounds with vascular damaging activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60026010D1 true DE60026010D1 (de) | 2006-04-20 |
DE60026010T2 DE60026010T2 (de) | 2006-09-14 |
Family
ID=10847790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60026010T Expired - Lifetime DE60026010T2 (de) | 1999-02-16 | 2000-02-15 | Substituierte stilbene mit gefässschädigender aktivität |
Country Status (9)
Country | Link |
---|---|
US (1) | US7265136B1 (de) |
EP (1) | EP1154767B9 (de) |
JP (1) | JP2002537250A (de) |
AT (1) | ATE317693T1 (de) |
AU (1) | AU2558300A (de) |
DE (1) | DE60026010T2 (de) |
ES (1) | ES2258444T4 (de) |
GB (1) | GB9903403D0 (de) |
WO (1) | WO2000048590A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4470321B2 (ja) | 1998-04-03 | 2010-06-02 | 味の素株式会社 | 抗腫瘍剤 |
GB9918912D0 (en) * | 1999-08-12 | 1999-10-13 | Angiogene Pharm Ltd | New stilbenes with vascular damaging activity |
DK1278758T3 (da) * | 2000-04-27 | 2012-01-23 | Univ Arizona | Combretastatin A-1-phosphat- og combretastatin B-1-phosphat-prodrugs |
US6670344B2 (en) | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
US20050153939A1 (en) | 2003-09-10 | 2005-07-14 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts |
AU2002216228A1 (en) | 2000-12-21 | 2002-07-01 | Cancer Research Ventures Limited | Substituted stilbenes, their reactions and anticancer activity |
GB0306908D0 (en) * | 2003-03-26 | 2003-04-30 | Angiogene Pharm Ltd | Bioreductively activated stilbene prodrugs |
CN1723884A (zh) | 2004-07-21 | 2006-01-25 | 中国人民解放军军事医学科学院放射医学研究所 | 顺式-1,2-取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途 |
DK2219451T3 (en) | 2007-11-21 | 2015-01-12 | Oxigene Inc | A method for the treatment of hematopoietic neoplasms |
FR2953518B1 (fr) | 2009-12-03 | 2012-01-20 | Sanofi Aventis | Procede de preparation d'un derive de combretastatine |
US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
AU2014228822A1 (en) | 2013-03-15 | 2015-10-01 | Memorial Sloan-Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
EP3337495A4 (de) | 2015-08-18 | 2019-04-10 | Mateon Therapeutics, Inc. | Verwendung von vdas zur verbesserung von immunmodulierenden therapien gegen tumoren |
WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
CN112225673B (zh) * | 2020-11-13 | 2022-08-02 | 义乌市华耀医药科技有限公司 | 氨基康普立停衍生物及其应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9106177D0 (en) * | 1991-03-22 | 1991-05-08 | Aston Molecules Ltd | Substituted diphenylethylenes and analogues or derivatives thereof |
TW325458B (en) | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
JP3163391B2 (ja) * | 1995-03-07 | 2001-05-08 | 味の素株式会社 | スチルベン誘導体及びそれを含有する制癌剤 |
-
1999
- 1999-02-16 GB GBGB9903403.5A patent/GB9903403D0/en not_active Ceased
-
2000
- 2000-02-15 AT AT00903824T patent/ATE317693T1/de not_active IP Right Cessation
- 2000-02-15 US US09/890,990 patent/US7265136B1/en not_active Expired - Fee Related
- 2000-02-15 DE DE60026010T patent/DE60026010T2/de not_active Expired - Lifetime
- 2000-02-15 WO PCT/GB2000/000503 patent/WO2000048590A1/en active IP Right Grant
- 2000-02-15 JP JP2000599382A patent/JP2002537250A/ja active Pending
- 2000-02-15 ES ES00903824T patent/ES2258444T4/es not_active Expired - Lifetime
- 2000-02-15 EP EP00903824A patent/EP1154767B9/de not_active Expired - Lifetime
- 2000-02-15 AU AU25583/00A patent/AU2558300A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1154767B9 (de) | 2006-06-28 |
ES2258444T3 (es) | 2006-09-01 |
ATE317693T1 (de) | 2006-03-15 |
US7265136B1 (en) | 2007-09-04 |
JP2002537250A (ja) | 2002-11-05 |
GB9903403D0 (en) | 1999-04-07 |
EP1154767B1 (de) | 2006-02-15 |
ES2258444T4 (es) | 2007-04-01 |
AU2558300A (en) | 2000-09-04 |
WO2000048590A1 (en) | 2000-08-24 |
DE60026010T2 (de) | 2006-09-14 |
EP1154767A1 (de) | 2001-11-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |