ATE317693T1 - Substituierte stilbene mit gefässschädigender aktivität - Google Patents
Substituierte stilbene mit gefässschädigender aktivitätInfo
- Publication number
- ATE317693T1 ATE317693T1 AT00903824T AT00903824T ATE317693T1 AT E317693 T1 ATE317693 T1 AT E317693T1 AT 00903824 T AT00903824 T AT 00903824T AT 00903824 T AT00903824 T AT 00903824T AT E317693 T1 ATE317693 T1 AT E317693T1
- Authority
- AT
- Austria
- Prior art keywords
- animal
- substituted stilbenes
- moiety
- vascular damaged
- activity
- Prior art date
Links
- 230000002792 vascular Effects 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title 1
- 150000001629 stilbenes Chemical class 0.000 title 1
- 235000021286 stilbenes Nutrition 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000001939 inductive effect Effects 0.000 abstract 3
- 230000017074 necrotic cell death Effects 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- PJANXHGTPQOBST-QXMHVHEDSA-N cis-stilbene Chemical group C=1C=CC=CC=1/C=C\C1=CC=CC=C1 PJANXHGTPQOBST-QXMHVHEDSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 210000005166 vasculature Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9903403.5A GB9903403D0 (en) | 1999-02-16 | 1999-02-16 | Substituted stilbene compounds with vascular damaging activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE317693T1 true ATE317693T1 (de) | 2006-03-15 |
Family
ID=10847790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00903824T ATE317693T1 (de) | 1999-02-16 | 2000-02-15 | Substituierte stilbene mit gefässschädigender aktivität |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7265136B1 (de) |
| EP (1) | EP1154767B9 (de) |
| JP (1) | JP2002537250A (de) |
| AT (1) | ATE317693T1 (de) |
| AU (1) | AU2558300A (de) |
| DE (1) | DE60026010T2 (de) |
| ES (1) | ES2258444T4 (de) |
| GB (1) | GB9903403D0 (de) |
| WO (1) | WO2000048590A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100598474B1 (ko) | 1998-04-03 | 2006-07-11 | 아지노모토 가부시키가이샤 | 항종양제 |
| GB9918912D0 (en) * | 1999-08-12 | 1999-10-13 | Angiogene Pharm Ltd | New stilbenes with vascular damaging activity |
| PT1278758E (pt) | 2000-04-27 | 2011-12-22 | Univ Arizona | Pró-fármacos de fosfato de combretastatina a-1 e fosfato de combretastatina b-1 |
| US6670344B2 (en) | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
| US20050153939A1 (en) | 2003-09-10 | 2005-07-14 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts |
| WO2002050007A2 (en) * | 2000-12-21 | 2002-06-27 | Cancer Research Technology Limited | Substituted stilbenes, their reactions and anticancer activity |
| GB0306908D0 (en) * | 2003-03-26 | 2003-04-30 | Angiogene Pharm Ltd | Bioreductively activated stilbene prodrugs |
| CN1723884A (zh) | 2004-07-21 | 2006-01-25 | 中国人民解放军军事医学科学院放射医学研究所 | 顺式－1，2－取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途 |
| US20090264382A1 (en) | 2007-11-21 | 2009-10-22 | David Chaplin | Methods for Treating Hematopoietic Neoplasms |
| FR2953518B1 (fr) | 2009-12-03 | 2012-01-20 | Sanofi Aventis | Procede de preparation d'un derive de combretastatine |
| WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
| AU2014228822A1 (en) | 2013-03-15 | 2015-10-01 | Memorial Sloan-Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
| US11419934B2 (en) | 2015-08-18 | 2022-08-23 | Oncotelic Therapeutics, Inc. | Use of VDAS to enhance immunomodulating therapies against tumors |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| CN112225673B (zh) * | 2020-11-13 | 2022-08-02 | 义乌市华耀医药科技有限公司 | 氨基康普立停衍生物及其应用 |
| US12030888B2 (en) | 2021-02-24 | 2024-07-09 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9106177D0 (en) * | 1991-03-22 | 1991-05-08 | Aston Molecules Ltd | Substituted diphenylethylenes and analogues or derivatives thereof |
| TW325458B (en) | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| JP3163391B2 (ja) * | 1995-03-07 | 2001-05-08 | 味の素株式会社 | スチルベン誘導体及びそれを含有する制癌剤 |
-
1999
- 1999-02-16 GB GBGB9903403.5A patent/GB9903403D0/en not_active Ceased
-
2000
- 2000-02-15 EP EP00903824A patent/EP1154767B9/de not_active Expired - Lifetime
- 2000-02-15 US US09/890,990 patent/US7265136B1/en not_active Expired - Fee Related
- 2000-02-15 JP JP2000599382A patent/JP2002537250A/ja active Pending
- 2000-02-15 AT AT00903824T patent/ATE317693T1/de not_active IP Right Cessation
- 2000-02-15 WO PCT/GB2000/000503 patent/WO2000048590A1/en not_active Ceased
- 2000-02-15 AU AU25583/00A patent/AU2558300A/en not_active Abandoned
- 2000-02-15 DE DE60026010T patent/DE60026010T2/de not_active Expired - Lifetime
- 2000-02-15 ES ES00903824T patent/ES2258444T4/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000048590A1 (en) | 2000-08-24 |
| EP1154767B9 (de) | 2006-06-28 |
| GB9903403D0 (en) | 1999-04-07 |
| ES2258444T4 (es) | 2007-04-01 |
| US7265136B1 (en) | 2007-09-04 |
| JP2002537250A (ja) | 2002-11-05 |
| EP1154767B1 (de) | 2006-02-15 |
| AU2558300A (en) | 2000-09-04 |
| EP1154767A1 (de) | 2001-11-21 |
| DE60026010D1 (de) | 2006-04-20 |
| ES2258444T3 (es) | 2006-09-01 |
| DE60026010T2 (de) | 2006-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |