ATE317693T1 - Substituierte stilbene mit gefässschädigender aktivität - Google Patents
Substituierte stilbene mit gefässschädigender aktivitätInfo
- Publication number
- ATE317693T1 ATE317693T1 AT00903824T AT00903824T ATE317693T1 AT E317693 T1 ATE317693 T1 AT E317693T1 AT 00903824 T AT00903824 T AT 00903824T AT 00903824 T AT00903824 T AT 00903824T AT E317693 T1 ATE317693 T1 AT E317693T1
- Authority
- AT
- Austria
- Prior art keywords
- animal
- substituted stilbenes
- moiety
- vascular damaged
- activity
- Prior art date
Links
- 230000002792 vascular Effects 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title 1
- 150000001629 stilbenes Chemical class 0.000 title 1
- 235000021286 stilbenes Nutrition 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000001939 inductive effect Effects 0.000 abstract 3
- 230000017074 necrotic cell death Effects 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- PJANXHGTPQOBST-QXMHVHEDSA-N cis-stilbene Chemical group C=1C=CC=CC=1/C=C\C1=CC=CC=C1 PJANXHGTPQOBST-QXMHVHEDSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 210000005166 vasculature Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9903403.5A GB9903403D0 (en) | 1999-02-16 | 1999-02-16 | Substituted stilbene compounds with vascular damaging activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE317693T1 true ATE317693T1 (de) | 2006-03-15 |
Family
ID=10847790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00903824T ATE317693T1 (de) | 1999-02-16 | 2000-02-15 | Substituierte stilbene mit gefässschädigender aktivität |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7265136B1 (de) |
| EP (1) | EP1154767B9 (de) |
| JP (1) | JP2002537250A (de) |
| AT (1) | ATE317693T1 (de) |
| AU (1) | AU2558300A (de) |
| DE (1) | DE60026010T2 (de) |
| ES (1) | ES2258444T4 (de) |
| GB (1) | GB9903403D0 (de) |
| WO (1) | WO2000048590A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69931766T2 (de) * | 1998-04-03 | 2007-05-31 | Ajinomoto Co., Inc. | Antitumorale mittel |
| GB9918912D0 (en) * | 1999-08-12 | 1999-10-13 | Angiogene Pharm Ltd | New stilbenes with vascular damaging activity |
| CA2407675C (en) | 2000-04-27 | 2012-07-10 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Combretastatin a-1 phosphate and combretastatin b-1 phosphate prodrugs |
| US20050153939A1 (en) | 2003-09-10 | 2005-07-14 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts |
| US6670344B2 (en) | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
| AU2002216228A1 (en) | 2000-12-21 | 2002-07-01 | Cancer Research Ventures Limited | Substituted stilbenes, their reactions and anticancer activity |
| GB0306908D0 (en) * | 2003-03-26 | 2003-04-30 | Angiogene Pharm Ltd | Bioreductively activated stilbene prodrugs |
| CN1723884A (zh) * | 2004-07-21 | 2006-01-25 | 中国人民解放军军事医学科学院放射医学研究所 | 顺式－1，2－取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途 |
| WO2009067706A1 (en) | 2007-11-21 | 2009-05-28 | Oxigene, Inc. | Method for treating hematopoietic neoplasms |
| FR2953518B1 (fr) * | 2009-12-03 | 2012-01-20 | Sanofi Aventis | Procede de preparation d'un derive de combretastatine |
| WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
| CA2905509A1 (en) | 2013-03-15 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | Hsp90-targeted cardiac imaging and therapy |
| JP2018523712A (ja) | 2015-08-18 | 2018-08-23 | マテオン セラピューティクス, インク.Mateon Therapeutics, Inc. | 腫瘍に対する免疫調節療法を向上させる為のｖｄａｓの使用 |
| WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| CN112225673B (zh) * | 2020-11-13 | 2022-08-02 | 义乌市华耀医药科技有限公司 | 氨基康普立停衍生物及其应用 |
| US12030888B2 (en) | 2021-02-24 | 2024-07-09 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9106177D0 (en) * | 1991-03-22 | 1991-05-08 | Aston Molecules Ltd | Substituted diphenylethylenes and analogues or derivatives thereof |
| TW325458B (en) * | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| JP3163391B2 (ja) * | 1995-03-07 | 2001-05-08 | 味の素株式会社 | スチルベン誘導体及びそれを含有する制癌剤 |
-
1999
- 1999-02-16 GB GBGB9903403.5A patent/GB9903403D0/en not_active Ceased
-
2000
- 2000-02-15 WO PCT/GB2000/000503 patent/WO2000048590A1/en not_active Ceased
- 2000-02-15 AT AT00903824T patent/ATE317693T1/de not_active IP Right Cessation
- 2000-02-15 JP JP2000599382A patent/JP2002537250A/ja active Pending
- 2000-02-15 US US09/890,990 patent/US7265136B1/en not_active Expired - Fee Related
- 2000-02-15 ES ES00903824T patent/ES2258444T4/es not_active Expired - Lifetime
- 2000-02-15 AU AU25583/00A patent/AU2558300A/en not_active Abandoned
- 2000-02-15 EP EP00903824A patent/EP1154767B9/de not_active Expired - Lifetime
- 2000-02-15 DE DE60026010T patent/DE60026010T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002537250A (ja) | 2002-11-05 |
| EP1154767B1 (de) | 2006-02-15 |
| DE60026010D1 (de) | 2006-04-20 |
| US7265136B1 (en) | 2007-09-04 |
| EP1154767A1 (de) | 2001-11-21 |
| ES2258444T3 (es) | 2006-09-01 |
| GB9903403D0 (en) | 1999-04-07 |
| WO2000048590A1 (en) | 2000-08-24 |
| AU2558300A (en) | 2000-09-04 |
| EP1154767B9 (de) | 2006-06-28 |
| ES2258444T4 (es) | 2007-04-01 |
| DE60026010T2 (de) | 2006-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE317693T1 (de) | Substituierte stilbene mit gefässschädigender aktivität | |
| ATE210440T1 (de) | Behandlung von tumoren mit verbindungen mit einer rxr-retinoid agonistische wirkung | |
| EA200100867A1 (ru) | Сульфаматогидроксамовая кислота как ингибитор металлопротеаз | |
| EA200200097A1 (ru) | Имидазоимидазолы и триазолы в качестве противовоспалительных агентов | |
| CY1110732T1 (el) | Χρησιμοποιηση ορισμενων αλκοολαλκοξυλικων σαν βοηθητικα μεσα για τον αγροτεχνικο τομεα | |
| MXPA03006855A (es) | Metodo para tratar insuficiencia cardiaca cronica y/o niveles elevados de colesterol, utilizando acido 3,5-diyodotiropropionico, y metodo para su preparacion. | |
| NO20060416L (no) | Ny anvendelse I | |
| ES2149776T3 (es) | Modulacion, inducida por un morfogeno, de la respuesta inflamatoria. | |
| AR044234A2 (es) | Uso de una composicion que comprende oocistos de eimeria vivos | |
| DE69205859D1 (de) | Verwendung von oberflächenaktiven Mitteln zur Verbesserung des Rückflusses von Venenkathetern. | |
| ES547630A0 (es) | Un metodo para producir una propioxantina | |
| ATE405282T1 (de) | Verwendung von il-13 inhibitoren zur behandlung von tumoren | |
| BR0112280A (pt) | Nova utilização para deferiprona | |
| ES2058646T3 (es) | Utilizacion de di-estiril-fenil-triglicoleter como inhibidor de la cristalizacion. | |
| ATE296827T1 (de) | Heteropolycyclische inhibitoren | |
| WO2002058535A3 (en) | Use of combretastatin a4 and its prodrugs as an immune enhancing therapy | |
| ES2191211T3 (es) | Uso de acido peracetico en piscicultura. | |
| SE0301883D0 (sv) | New use II | |
| EE9800315A (et) | Meetod südamepuudulikkuse käitlemiseks endoteliini antagonistide abil | |
| NO902157D0 (no) | Butensyrederivater for terapeutisk anvendelse. | |
| ES2150286T3 (es) | Terapia tumoral. | |
| ES2183158T3 (es) | Poli(acidos organicos) y sus analogos para aumentar la eficacia herbicida. | |
| BR8006042A (pt) | Composto farmaceutico, processo para aliviar inflamacao em um corpo de animal vivo, processo para produzir um efeito inibidor sobre a agreagacao de plaquetas do sangue, processo para produzir um efeito analgesico em um corpo de animal vivo afligido pela dor e composicao terapeutica | |
| DE50111407D1 (de) | Mittel enthaltend n-chlortaurin sowie dessen verwendung zur behandlung von schleimhautpolypen | |
| SE0301885D0 (sv) | New use IV |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |