AU2002216228A1 - Substituted stilbenes, their reactions and anticancer activity - Google Patents

Substituted stilbenes, their reactions and anticancer activity

Info

Publication number
AU2002216228A1
AU2002216228A1 AU2002216228A AU1622802A AU2002216228A1 AU 2002216228 A1 AU2002216228 A1 AU 2002216228A1 AU 2002216228 A AU2002216228 A AU 2002216228A AU 1622802 A AU1622802 A AU 1622802A AU 2002216228 A1 AU2002216228 A1 AU 2002216228A1
Authority
AU
Australia
Prior art keywords
reactions
anticancer activity
substituted stilbenes
stilbenes
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002216228A
Inventor
John Butler
Keira Gaukroger
John Anthony Hadfield
Ian Hamblett
Lucy Annette Hepworth
Edward John Land
Nicholas James Lawrence
Stephen Patrick Mayalarp
Alan Thomson Mcgown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Ventures Ltd
Original Assignee
Cancer Research Ventures Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0031262A external-priority patent/GB0031262D0/en
Priority claimed from GB0100295A external-priority patent/GB0100295D0/en
Application filed by Cancer Research Ventures Ltd filed Critical Cancer Research Ventures Ltd
Publication of AU2002216228A1 publication Critical patent/AU2002216228A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/30—Quinones containing groups having oxygen atoms singly bound to carbon atoms with polycyclic non-condensed quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2002216228A 2000-12-21 2001-12-20 Substituted stilbenes, their reactions and anticancer activity Abandoned AU2002216228A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0031262.9 2000-12-21
GB0031262A GB0031262D0 (en) 2000-12-21 2000-12-21 Substituted stilbenes and their reactions
GB0100295A GB0100295D0 (en) 2001-01-05 2001-01-05 Substituted stilbenes and their reactions
GB0100295.5 2001-01-05
PCT/GB2001/005702 WO2002050007A2 (en) 2000-12-21 2001-12-20 Substituted stilbenes, their reactions and anticancer activity

Publications (1)

Publication Number Publication Date
AU2002216228A1 true AU2002216228A1 (en) 2002-07-01

Family

ID=26245470

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002216228A Abandoned AU2002216228A1 (en) 2000-12-21 2001-12-20 Substituted stilbenes, their reactions and anticancer activity

Country Status (5)

Country Link
US (3) US7220784B2 (en)
EP (1) EP1351912A2 (en)
AU (1) AU2002216228A1 (en)
CA (1) CA2432640A1 (en)
WO (1) WO2002050007A2 (en)

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WO2002050007A2 (en) * 2000-12-21 2002-06-27 Cancer Research Technology Limited Substituted stilbenes, their reactions and anticancer activity
JP2005507912A (en) 2001-10-26 2005-03-24 オキシジーン， インコーポレイテッド Functionalized stilbene derivatives as improved vascular targeting agents
US7528165B2 (en) 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
US6933316B2 (en) 2001-12-13 2005-08-23 National Health Research Institutes Indole compounds
US7632955B2 (en) 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US8198302B2 (en) 2003-02-28 2012-06-12 Oxigene, Inc. Compositions and methods with enhanced therapeutic activity
GB0306908D0 (en) * 2003-03-26 2003-04-30 Angiogene Pharm Ltd Bioreductively activated stilbene prodrugs
GB0306907D0 (en) * 2003-03-26 2003-04-30 Angiogene Pharm Ltd Boireductively-activated prodrugs
GB2403949A (en) * 2003-07-18 2005-01-19 Sigma Tau Ind Farmaceuti Combretastatin derivatives
US20070191627A1 (en) * 2003-08-14 2007-08-16 Thomas Szekeres Stilbene derivatives and their use in medicaments
US7223747B2 (en) * 2003-09-24 2007-05-29 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Halocombstatins and methods of synthesis thereof
HRP20040645A2 (en) * 2004-07-14 2007-01-31 Institut "Ruđer Bošković"
CN1723884A (en) 2004-07-21 2006-01-25 中国人民解放军军事医学科学院放射医学研究所 Cis-1, the diphenyl ethylene derivatives that 2-replaces are used to prepare the purposes of the medicine of treatment or prevent diabetes
CA2582046A1 (en) * 2004-09-24 2006-04-06 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acti Ng For And On Behalf Of Arizona State University Halocombstatins and methods of synthesis thereof
US7456289B2 (en) 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
US7759527B2 (en) * 2006-03-28 2010-07-20 Council Of Scientific & Industrial Research Microwave induced one pot process for the preparation of arylethenes
DE112007000790T5 (en) 2006-03-28 2009-04-23 Council Of Scientific & Industrial Research Single stage microwave-induced process for the preparation of substituted stilbenes and their analogues
CN101085743B (en) * 2006-06-06 2012-02-15 浙江大德药业集团有限公司 Fluorine-containing alkoxy combretastatin derivative, preparation method and use thereof
TW200819409A (en) * 2006-10-19 2008-05-01 Univ Taipei Medical Z-stilbenes derivatives and the pharmaceutical composition thereof
EP2076124A4 (en) 2007-04-20 2011-08-03 Acucela Inc Styrenyl derivative compounds for treating ophthalmic diseases and disorders
WO2009059448A1 (en) * 2007-11-05 2009-05-14 Zhiquan Yong Styrene-acid derivative and use in manufacturing blood-vessel targeted-agent drugs
SI2219451T1 (en) 2007-11-21 2015-02-27 Oxigene, Inc. Method for treating hematopoietic neoplasms
EP2262519A4 (en) * 2008-03-05 2011-03-23 Edison Pharmaceuticals Inc Treatment of hearing and balance impairments with redox-active therapeutics
WO2010113005A2 (en) 2009-03-27 2010-10-07 Council Of Scientific & Industrial Research One pot multicomponent synthesis of some novel hydroxy stilbene derivatives with alpha, beta-carbonyl conjugation under microwave irradiation
KR20140147797A (en) 2011-06-27 2014-12-30 더 잭슨 래보라토리 Methods and compositions for treatment of cancer and autoimmune disease
CN105753787B (en) * 2011-07-05 2018-05-15 南京圣和药业股份有限公司 Tumor-targeting drug Combretastatin A4 derivatives
CN102863388B (en) * 2011-07-05 2015-04-29 南京圣和药业股份有限公司 Tumor targeted drug Combretastatin A4 derivatives
GB201113815D0 (en) * 2011-08-10 2011-09-28 Univ Salford The Multi-photon isomerisation of transcombretastatins
CN103030549B (en) * 2011-09-30 2016-09-14 中国科学院福建物质结构研究所 P-benzoquinone derivative and application thereof
PL220039B1 (en) 2012-03-29 2015-08-31 Univ Medyczny Im Karola Marcinkowskiego W Poznaniu New derivatives of (Z)-1,2-diphenylethan
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
CA2905509A1 (en) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center Hsp90-targeted cardiac imaging and therapy
EP3137554A1 (en) 2014-04-29 2017-03-08 Ecole Normale Superieure De Lyon Azoaryls as reversibly modulatable tubulin inhibitors
TW201702218A (en) 2014-12-12 2017-01-16 美國杰克森實驗室 Compositions and methods relating to the treatment of cancer, autoimmune disease, and neurodegenerative disease
WO2017031157A1 (en) 2015-08-18 2017-02-23 Mateon Therapeutics, Inc. Use of vdas to enhance immunomodulating therapies against tumors
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
CA3050255A1 (en) * 2017-01-20 2018-07-26 The Regents Of The University Of California Inhibitors of the n-terminal domain of the androgen receptor
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
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CN112759515B (en) * 2020-12-28 2023-06-13 广东药科大学 Novel FFA1 and PPAR alpha/gamma/delta quadruple agonist, preparation method thereof and application thereof as medicine
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WO2002050007A2 (en) * 2000-12-21 2002-06-27 Cancer Research Technology Limited Substituted stilbenes, their reactions and anticancer activity

Also Published As

Publication number Publication date
US8853270B2 (en) 2014-10-07
US7220784B2 (en) 2007-05-22
US20130023663A1 (en) 2013-01-24
WO2002050007A3 (en) 2002-10-17
CA2432640A1 (en) 2002-06-27
EP1351912A2 (en) 2003-10-15
WO2002050007A2 (en) 2002-06-27
US20070203217A1 (en) 2007-08-30
US20040152629A1 (en) 2004-08-05

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