EA201990005A1 - Способ анализа гликозаминогликанов, гепаринов и их производных методом ямр (ядерного магнитного резонанса) - Google Patents

Способ анализа гликозаминогликанов, гепаринов и их производных методом ямр (ядерного магнитного резонанса)

Info

Publication number
EA201990005A1
EA201990005A1 EA201990005A EA201990005A EA201990005A1 EA 201990005 A1 EA201990005 A1 EA 201990005A1 EA 201990005 A EA201990005 A EA 201990005A EA 201990005 A EA201990005 A EA 201990005A EA 201990005 A1 EA201990005 A1 EA 201990005A1
Authority
EA
Eurasian Patent Office
Prior art keywords
magnetic resonance
nuclear magnetic
heparins
glycosaminoglycans
derivatives
Prior art date
Application number
EA201990005A
Other languages
English (en)
Other versions
EA037102B1 (ru
Inventor
Гильермо Франко
Ибон Гутьерро
Original Assignee
Лабораториос Фармасеутикос Рови, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лабораториос Фармасеутикос Рови, С.А. filed Critical Лабораториос Фармасеутикос Рови, С.А.
Publication of EA201990005A1 publication Critical patent/EA201990005A1/ru
Publication of EA037102B1 publication Critical patent/EA037102B1/ru

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/087—Structure determination of a chemical compound, e.g. of a biomolecule such as a protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4633—Sequences for multi-dimensional NMR

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Signal Processing (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Настоящее изобретение описывает аналитический метод ядерного магнитного резонанса гликозаминогликанов в целом и гепаринов и низкомолекулярных гепаринов, а также их производных, в частности, что позволяет идентифицировать их и произвести относительное количественное определение их характерных сигналов с помощьюН ЯМР иН-С HSQC.
EA201990005A 2016-07-19 2017-07-19 Способ анализа гликозаминогликанов, гепаринов и их производных методом ямр (ядерного магнитного резонанса) EA037102B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16382350.3A EP3273239A1 (en) 2016-07-19 2016-07-19 Procedure of analysis of glycosaminoglycans, heparins and their derivatives by nuclear magnetic resonance
PCT/EP2017/068285 WO2018015463A1 (en) 2016-07-19 2017-07-19 Method for the analysis of glycosaminoglycans, heparins and their derivatives by nuclear magnetic resonance

Publications (2)

Publication Number Publication Date
EA201990005A1 true EA201990005A1 (ru) 2019-06-28
EA037102B1 EA037102B1 (ru) 2021-02-05

Family

ID=56682072

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990005A EA037102B1 (ru) 2016-07-19 2017-07-19 Способ анализа гликозаминогликанов, гепаринов и их производных методом ямр (ядерного магнитного резонанса)

Country Status (27)

Country Link
US (2) US10705037B2 (ru)
EP (2) EP3273239A1 (ru)
JP (1) JP7035007B2 (ru)
CN (1) CN109477829B (ru)
AR (1) AR109099A1 (ru)
AU (1) AU2017299186C1 (ru)
BR (1) BR112019000437A2 (ru)
CA (1) CA3029924A1 (ru)
CL (1) CL2019000038A1 (ru)
CO (1) CO2019000087A2 (ru)
CR (1) CR20190016A (ru)
CY (1) CY1124817T1 (ru)
DK (1) DK3452827T3 (ru)
DO (1) DOP2019000003A (ru)
EA (1) EA037102B1 (ru)
ES (1) ES2894898T3 (ru)
HR (1) HRP20211649T1 (ru)
HU (1) HUE056604T2 (ru)
LT (1) LT3452827T (ru)
MA (1) MA44876A (ru)
PL (1) PL3452827T3 (ru)
PT (1) PT3452827T (ru)
SI (1) SI3452827T1 (ru)
UA (1) UA124466C2 (ru)
UY (1) UY37337A (ru)
WO (1) WO2018015463A1 (ru)
ZA (1) ZA201900143B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102018203434B4 (de) * 2018-03-07 2019-12-05 Bernd Willi Karl-Heinz Diehl Verfahren zur heteronuklearen quantitativen Bestimmung mittels NMR-Spektroskopie, Referenzsubstanzen hierfür und Verfahren zur Bestimmung des Deuterierungsgrades einer deuterierten Verbindung
CN112816566A (zh) * 2019-11-17 2021-05-18 烟台东诚药业集团股份有限公司 一种那屈肝素钙末端结构确认方法
CN111337529B (zh) * 2020-03-12 2023-06-16 青岛科技大学 一种降低粘度、使水峰偏移的多糖样品制备和测试方法
JP7377937B2 (ja) 2021-10-20 2023-11-10 シオノギヘルスケア株式会社 オリゴ糖の還元末端糖の定量的分析方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2396079A1 (en) 2000-01-07 2001-07-19 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
EP1590648A4 (en) 2002-05-20 2007-04-18 Massachusetts Inst Technology NEW TECHNIQUE FOR MRI SEQUENCE DETERMINATION
JP2004339083A (ja) 2003-05-13 2004-12-02 Bioserentack Co Ltd ムコ多糖類製剤
JP2005337958A (ja) 2004-05-28 2005-12-08 Kao Corp 水溶性の糖骨格を有する化合物の分析法
JP2005345193A (ja) 2004-06-01 2005-12-15 Shiseido Co Ltd 核磁気共鳴法及び／又は核磁気共鳴による拡散係数測定法を用いた定量方法
JP2006291028A (ja) 2005-04-11 2006-10-26 Q P Corp 低分子ヘパリンまたはその塩、ならびにその製造方法
US7968082B1 (en) * 2007-01-26 2011-06-28 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by NMR
EP2213282A1 (en) 2009-01-30 2010-08-04 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
US8802156B2 (en) 2007-11-14 2014-08-12 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
ES2340902B1 (es) * 2008-07-01 2011-05-03 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
ES2336297B1 (es) 2008-10-08 2011-01-24 Laboratorios Farmaceuticos Rovi, S.A. Procedimiento de sintesis de pentasacaridos desprotegidos a partir deun pentasacarido precursos protegido.
JP5372696B2 (ja) 2009-10-20 2013-12-18 杏林製薬株式会社 ジメチルアミノエチルメタクリレート含有共重合体の定量法
ES2924830T3 (es) 2013-06-17 2022-10-11 Univ North Carolina Chapel Hill Moléculas de heparina reversibles

Also Published As

Publication number Publication date
HRP20211649T1 (hr) 2022-02-04
AU2017299186C1 (en) 2023-07-06
SI3452827T1 (sl) 2022-01-31
CY1124817T1 (el) 2022-11-25
CO2019000087A2 (es) 2019-04-30
DOP2019000003A (es) 2019-06-30
WO2018015463A1 (en) 2018-01-25
MA44876A (fr) 2021-04-21
US20200271601A1 (en) 2020-08-27
EP3452827B1 (en) 2021-08-25
ES2894898T3 (es) 2022-02-16
UY37337A (es) 2018-01-31
PT3452827T (pt) 2021-11-10
US10705037B2 (en) 2020-07-07
ZA201900143B (en) 2019-09-25
HUE056604T2 (hu) 2022-02-28
US10809212B2 (en) 2020-10-20
CR20190016A (es) 2019-05-17
AR109099A1 (es) 2018-10-31
EP3452827A1 (en) 2019-03-13
UA124466C2 (uk) 2021-09-22
PL3452827T3 (pl) 2022-02-14
US20190154601A1 (en) 2019-05-23
DK3452827T3 (da) 2021-10-11
AU2017299186B2 (en) 2023-04-13
CN109477829B (zh) 2022-06-21
WO2018015463A9 (en) 2018-05-11
CA3029924A1 (en) 2018-01-25
JP2019525166A (ja) 2019-09-05
JP7035007B2 (ja) 2022-03-14
LT3452827T (lt) 2021-11-25
AU2017299186A1 (en) 2019-01-24
CL2019000038A1 (es) 2019-05-10
CN109477829A (zh) 2019-03-15
EA037102B1 (ru) 2021-02-05
EP3273239A1 (en) 2018-01-24
BR112019000437A2 (pt) 2019-04-30

Similar Documents

Publication Publication Date Title
EA201990005A1 (ru) Способ анализа гликозаминогликанов, гепаринов и их производных методом ямр (ядерного магнитного резонанса)
MX2021009297A (es) Composiciones, dispositivos, y metodos de pruebas de sensibilidad del ibs.
EA201890611A1 (ru) Библиотеки модульных полипептидов и способы их получения и применения
MX341892B (es) Metodos para investigar muestras de formacion utilizando datos de nmr.
MX2016013261A (es) Metodo para la cuantificacion de huevos de parasitos en las heces.
EA201790769A1 (ru) Определение уровней гликозаминогликанов методом масс-спектрометрии
EA201691168A1 (ru) Способы исследования бета-глюкана
WO2014179521A3 (en) Method for identifying chemical species in a substance using nqr
MX2018002947A (es) Composiciones, dispositivos, y métodos de pruebas de sensibilidad a la osteoartritis.
AR103745A1 (es) Inmunoensayo homogéneo con compensación de la señal de fondo
MX2018010856A (es) Composiciones, dispositivos y metodos de pruebas de sensibilidad de dispepsia funcional.
NZ717872A (en) Nmr sample analysis
EA201401101A1 (ru) Способ лабораторной диагностики пневмонии
MX2018007566A (es) Composiciones, dispositivos y métodos de prueba de sensibilidad a los alimentos de personas con dolor de cabeza por migraña.
RU2014122707A (ru) Способ адаптивной коррекции с компенсацией защитных интервалов
RU2014140901A (ru) Способ оценки структурного состояния воды
BR112015031292A2 (pt) método e sistema para monitorar a qualidade de fluidos
UA115190U (xx) Спосіб оцінки активності ювенільного ревматоїдного артриту
EA202092574A1 (ru) Композиции и способы обнаружения и лечения рака яичников
UA123429U (uk) Спосіб тризондового несиметричного індукційного каротажу
UA87368U (ru) Способ определения коэффициента самодиффузии молекул воды в пищевых продуктах методом ямр с использованием эталонного образца
UA66358U (ru) Способ дополнительного стробирования цифровых отсчетов сигналов
EA201890103A1 (ru) Система и способ калибровки
TH14566A3 (th) กรรมวิธีการวัดปริมาณไมโครอาร์เอ็นเอโดยใช้ดีเอ็นเอแม่แบบปลายเปิดร่วมกับการยับยั้งการส่งสัญญาณฟลูออเรสเซนต์ของกราฟีนออกไซด์
TH14566C3 (th) กรรมวิธีการวัดปริมาณไมโครอาร์เอ็นเอโดยใช้ดีเอ็นเอแม่แบบปลายเปิดร่วมกับการยับยั้งการส่งสัญญาณฟลูออเรสเซนต์ของกราฟีนออกไซด์