BR112019000437A2 - método para análise de glicosaminoglicanos, heparinas e seus derivados por ressonância magnética nuclear - Google Patents
método para análise de glicosaminoglicanos, heparinas e seus derivados por ressonância magnética nuclearInfo
- Publication number
- BR112019000437A2 BR112019000437A2 BR112019000437-8A BR112019000437A BR112019000437A2 BR 112019000437 A2 BR112019000437 A2 BR 112019000437A2 BR 112019000437 A BR112019000437 A BR 112019000437A BR 112019000437 A2 BR112019000437 A2 BR 112019000437A2
- Authority
- BR
- Brazil
- Prior art keywords
- glycosaminoglycans
- derivatives
- magnetic resonance
- nuclear magnetic
- heparins
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
- G01N24/087—Structure determination of a chemical compound, e.g. of a biomolecule such as a protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/4633—Sequences for multi-dimensional NMR
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Signal Processing (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
a presente invenção descreve um método analítico por ressonância magnética nuclear de glicosaminoglicanos em geral, e de heparinas e heparinas de baixo peso molecular e seus derivados em particular, o que permite sua identificação e a quantificação relativa de seus sinais característicos por rmn 1h e hsqc 1h-13c.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382350.3A EP3273239A1 (en) | 2016-07-19 | 2016-07-19 | Procedure of analysis of glycosaminoglycans, heparins and their derivatives by nuclear magnetic resonance |
| EP16382350.3 | 2016-07-19 | ||
| PCT/EP2017/068285 WO2018015463A1 (en) | 2016-07-19 | 2017-07-19 | Method for the analysis of glycosaminoglycans, heparins and their derivatives by nuclear magnetic resonance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019000437A2 true BR112019000437A2 (pt) | 2019-04-30 |
Family
ID=56682072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019000437-8A BR112019000437A2 (pt) | 2016-07-19 | 2017-07-19 | método para análise de glicosaminoglicanos, heparinas e seus derivados por ressonância magnética nuclear |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US10705037B2 (pt) |
| EP (2) | EP3273239A1 (pt) |
| JP (1) | JP7035007B2 (pt) |
| CN (1) | CN109477829B (pt) |
| AR (1) | AR109099A1 (pt) |
| AU (1) | AU2017299186C1 (pt) |
| BR (1) | BR112019000437A2 (pt) |
| CA (1) | CA3029924A1 (pt) |
| CL (1) | CL2019000038A1 (pt) |
| CO (1) | CO2019000087A2 (pt) |
| CR (1) | CR20190016A (pt) |
| CY (1) | CY1124817T1 (pt) |
| DK (1) | DK3452827T3 (pt) |
| DO (1) | DOP2019000003A (pt) |
| EA (1) | EA037102B1 (pt) |
| ES (1) | ES2894898T3 (pt) |
| HR (1) | HRP20211649T1 (pt) |
| HU (1) | HUE056604T2 (pt) |
| LT (1) | LT3452827T (pt) |
| MA (1) | MA44876A (pt) |
| PL (1) | PL3452827T3 (pt) |
| PT (1) | PT3452827T (pt) |
| SI (1) | SI3452827T1 (pt) |
| UA (1) | UA124466C2 (pt) |
| UY (1) | UY37337A (pt) |
| WO (1) | WO2018015463A1 (pt) |
| ZA (1) | ZA201900143B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102018203434B4 (de) * | 2018-03-07 | 2019-12-05 | Bernd Willi Karl-Heinz Diehl | Verfahren zur heteronuklearen quantitativen Bestimmung mittels NMR-Spektroskopie, Referenzsubstanzen hierfür und Verfahren zur Bestimmung des Deuterierungsgrades einer deuterierten Verbindung |
| CN112816566A (zh) * | 2019-11-17 | 2021-05-18 | 烟台东诚药业集团股份有限公司 | 一种那屈肝素钙末端结构确认方法 |
| CN111337529B (zh) * | 2020-03-12 | 2023-06-16 | 青岛科技大学 | 一种降低粘度、使水峰偏移的多糖样品制备和测试方法 |
| JP7377937B2 (ja) | 2021-10-20 | 2023-11-10 | シオノギヘルスケア株式会社 | オリゴ糖の還元末端糖の定量的分析方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003519698A (ja) | 2000-01-07 | 2003-06-24 | トランスフォーム ファーマスーティカルズ，インコーポレイテッド | 多様な固体形態のハイスループットでの形成、同定および分析 |
| WO2004055491A2 (en) | 2002-05-20 | 2004-07-01 | Massachusetts Institute Of Technology | Novel method for sequence determination using nmr |
| JP2004339083A (ja) | 2003-05-13 | 2004-12-02 | Bioserentack Co Ltd | ムコ多糖類製剤 |
| JP2005337958A (ja) | 2004-05-28 | 2005-12-08 | Kao Corp | 水溶性の糖骨格を有する化合物の分析法 |
| JP2005345193A (ja) | 2004-06-01 | 2005-12-15 | Shiseido Co Ltd | 核磁気共鳴法及び／又は核磁気共鳴による拡散係数測定法を用いた定量方法 |
| JP2006291028A (ja) | 2005-04-11 | 2006-10-26 | Q P Corp | 低分子ヘパリンまたはその塩、ならびにその製造方法 |
| US7968082B1 (en) * | 2007-01-26 | 2011-06-28 | Momenta Pharmaceuticals, Inc. | Evaluating mixtures of low molecular weight heparins by NMR |
| EP2213282A1 (en) | 2009-01-30 | 2010-08-04 | Laboratorios Farmaceuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| US8802156B2 (en) | 2007-11-14 | 2014-08-12 | Laboratorios Farmacéuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| ES2340902B1 (es) | 2008-07-01 | 2011-05-03 | Laboratorios Farmaceuticos Rovi, S.A. | Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas. |
| ES2336297B1 (es) | 2008-10-08 | 2011-01-24 | Laboratorios Farmaceuticos Rovi, S.A. | Procedimiento de sintesis de pentasacaridos desprotegidos a partir deun pentasacarido precursos protegido. |
| JP5372696B2 (ja) | 2009-10-20 | 2013-12-18 | 杏林製薬株式会社 | ジメチルアミノエチルメタクリレート含有共重合体の定量法 |
| EP3011043B1 (en) | 2013-06-17 | 2022-05-11 | The University of North Carolina At Chapel Hill | Reversible heparin molecules |
-
2016
- 2016-07-19 EP EP16382350.3A patent/EP3273239A1/en not_active Ceased
-
2017
- 2017-07-19 EP EP17749132.1A patent/EP3452827B1/en active Active
- 2017-07-19 PT PT177491321T patent/PT3452827T/pt unknown
- 2017-07-19 DK DK17749132.1T patent/DK3452827T3/da active
- 2017-07-19 UY UY0001037337A patent/UY37337A/es active IP Right Grant
- 2017-07-19 HR HRP20211649TT patent/HRP20211649T1/hr unknown
- 2017-07-19 WO PCT/EP2017/068285 patent/WO2018015463A1/en unknown
- 2017-07-19 BR BR112019000437-8A patent/BR112019000437A2/pt unknown
- 2017-07-19 PL PL17749132T patent/PL3452827T3/pl unknown
- 2017-07-19 AR ARP170102020A patent/AR109099A1/es unknown
- 2017-07-19 EA EA201990005A patent/EA037102B1/ru unknown
- 2017-07-19 ES ES17749132T patent/ES2894898T3/es active Active
- 2017-07-19 SI SI201730971T patent/SI3452827T1/sl unknown
- 2017-07-19 HU HUE17749132A patent/HUE056604T2/hu unknown
- 2017-07-19 CA CA3029924A patent/CA3029924A1/en active Pending
- 2017-07-19 MA MA044876A patent/MA44876A/fr unknown
- 2017-07-19 UA UAA201900263A patent/UA124466C2/uk unknown
- 2017-07-19 CR CR20190016A patent/CR20190016A/es unknown
- 2017-07-19 CN CN201780041954.9A patent/CN109477829B/zh active Active
- 2017-07-19 LT LTEPPCT/EP2017/068285T patent/LT3452827T/lt unknown
- 2017-07-19 JP JP2019500842A patent/JP7035007B2/ja active Active
- 2017-07-19 AU AU2017299186A patent/AU2017299186C1/en active Active
-
2019
- 2019-01-04 DO DO2019000003A patent/DOP2019000003A/es unknown
- 2019-01-07 CL CL2019000038A patent/CL2019000038A1/es unknown
- 2019-01-08 CO CONC2019/0000087A patent/CO2019000087A2/es unknown
- 2019-01-09 ZA ZA2019/00143A patent/ZA201900143B/en unknown
- 2019-01-18 US US16/251,909 patent/US10705037B2/en active Active
-
2020
- 2020-03-20 US US16/824,895 patent/US10809212B2/en active Active
-
2021
- 2021-10-26 CY CY20211100927T patent/CY1124817T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |