CY1124817T1 - Μεθοδος για την αναλυση γλυκοζαμινογλυκανων, ηπαρινων καi των παραγωγων τους με πυρηνικο μαγνητικο συντονισμο - Google Patents

Μεθοδος για την αναλυση γλυκοζαμινογλυκανων, ηπαρινων καi των παραγωγων τους με πυρηνικο μαγνητικο συντονισμο

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Publication number
CY1124817T1
CY1124817T1 CY20211100927T CY211100927T CY1124817T1 CY 1124817 T1 CY1124817 T1 CY 1124817T1 CY 20211100927 T CY20211100927 T CY 20211100927T CY 211100927 T CY211100927 T CY 211100927T CY 1124817 T1 CY1124817 T1 CY 1124817T1
Authority
CY
Cyprus
Prior art keywords
glycosaminoglycans
derivatives
nuclear magnetic
heperins
analysis
Prior art date
Application number
CY20211100927T
Other languages
English (en)
Inventor
Guillermo Franco
Ibon Gutierro
Original Assignee
Laboratorios Farmacéuticos Rovi, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Farmacéuticos Rovi, S.A. filed Critical Laboratorios Farmacéuticos Rovi, S.A.
Publication of CY1124817T1 publication Critical patent/CY1124817T1/el

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/087—Structure determination of a chemical compound, e.g. of a biomolecule such as a protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4633—Sequences for multi-dimensional NMR

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Signal Processing (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση περιγράφει μία αναλυτική μέθοδο με πυρηνικό μαγνητικό συντονισμό γλυκοζαμινογλυκανών γενικά, και ηπαρινών και ηπαρινών χαμηλού μοριακού βάρους και των παραγώγων τους συγκεκριμένα, η οποία (μέθοδος) επιτρέπει την ταυτοποίηση τους και τη σχετική ποσοτικοποίηση των χαρακτηριστικών σημάτων της με 1H-NMR και 1H-13HSQC.
CY20211100927T 2016-07-19 2021-10-26 Μεθοδος για την αναλυση γλυκοζαμινογλυκανων, ηπαρινων καi των παραγωγων τους με πυρηνικο μαγνητικο συντονισμο CY1124817T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16382350.3A EP3273239A1 (en) 2016-07-19 2016-07-19 Procedure of analysis of glycosaminoglycans, heparins and their derivatives by nuclear magnetic resonance
PCT/EP2017/068285 WO2018015463A1 (en) 2016-07-19 2017-07-19 Method for the analysis of glycosaminoglycans, heparins and their derivatives by nuclear magnetic resonance

Publications (1)

Publication Number Publication Date
CY1124817T1 true CY1124817T1 (el) 2022-11-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100927T CY1124817T1 (el) 2016-07-19 2021-10-26 Μεθοδος για την αναλυση γλυκοζαμινογλυκανων, ηπαρινων καi των παραγωγων τους με πυρηνικο μαγνητικο συντονισμο

Country Status (27)

Country Link
US (2) US10705037B2 (el)
EP (2) EP3273239A1 (el)
JP (1) JP7035007B2 (el)
CN (1) CN109477829B (el)
AR (1) AR109099A1 (el)
AU (1) AU2017299186C1 (el)
BR (1) BR112019000437A2 (el)
CA (1) CA3029924A1 (el)
CL (1) CL2019000038A1 (el)
CO (1) CO2019000087A2 (el)
CR (1) CR20190016A (el)
CY (1) CY1124817T1 (el)
DK (1) DK3452827T3 (el)
DO (1) DOP2019000003A (el)
EA (1) EA037102B1 (el)
ES (1) ES2894898T3 (el)
HR (1) HRP20211649T1 (el)
HU (1) HUE056604T2 (el)
LT (1) LT3452827T (el)
MA (1) MA44876A (el)
PL (1) PL3452827T3 (el)
PT (1) PT3452827T (el)
SI (1) SI3452827T1 (el)
UA (1) UA124466C2 (el)
UY (1) UY37337A (el)
WO (1) WO2018015463A1 (el)
ZA (1) ZA201900143B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102018203434B4 (de) * 2018-03-07 2019-12-05 Bernd Willi Karl-Heinz Diehl Verfahren zur heteronuklearen quantitativen Bestimmung mittels NMR-Spektroskopie, Referenzsubstanzen hierfür und Verfahren zur Bestimmung des Deuterierungsgrades einer deuterierten Verbindung
CN112816566A (zh) * 2019-11-17 2021-05-18 烟台东诚药业集团股份有限公司 一种那屈肝素钙末端结构确认方法
CN111337529B (zh) * 2020-03-12 2023-06-16 青岛科技大学 一种降低粘度、使水峰偏移的多糖样品制备和测试方法
JP7377937B2 (ja) * 2021-10-20 2023-11-10 シオノギヘルスケア株式会社 オリゴ糖の還元末端糖の定量的分析方法
CN114018965A (zh) * 2021-11-04 2022-02-08 五源本草(山东)健康科技有限公司 一种多糖核磁共振氢谱法定量检测技术
CN117990732B (zh) * 2024-04-02 2024-06-25 浙江大学 一种基于分离的分段同源多糖组的多糖结构解析方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020071931A (ko) 2000-01-07 2002-09-13 트렌스폼 파마수티컬스 인코퍼레이티드 다양한 고체-형태들의 고도의 자료 처리 편성, 확인 및분석
CA2486456C (en) 2002-05-20 2012-07-17 Massachusetts Institute Of Technology Method for sequence determination using nmr
JP2004339083A (ja) 2003-05-13 2004-12-02 Bioserentack Co Ltd ムコ多糖類製剤
JP2005337958A (ja) 2004-05-28 2005-12-08 Kao Corp 水溶性の糖骨格を有する化合物の分析法
JP2005345193A (ja) 2004-06-01 2005-12-15 Shiseido Co Ltd 核磁気共鳴法及び／又は核磁気共鳴による拡散係数測定法を用いた定量方法
JP2006291028A (ja) 2005-04-11 2006-10-26 Q P Corp 低分子ヘパリンまたはその塩、ならびにその製造方法
US7968082B1 (en) * 2007-01-26 2011-06-28 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by NMR
EP2213282A1 (en) 2009-01-30 2010-08-04 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
US8802156B2 (en) 2007-11-14 2014-08-12 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
ES2340902B1 (es) 2008-07-01 2011-05-03 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
ES2336297B1 (es) 2008-10-08 2011-01-24 Laboratorios Farmaceuticos Rovi, S.A. Procedimiento de sintesis de pentasacaridos desprotegidos a partir deun pentasacarido precursos protegido.
JP5372696B2 (ja) 2009-10-20 2013-12-18 杏林製薬株式会社 ジメチルアミノエチルメタクリレート含有共重合体の定量法
CN105452479B (zh) 2013-06-17 2021-05-18 北卡罗来纳大学查珀尔希尔分校 可逆肝素分子

Also Published As

Publication number Publication date
BR112019000437A2 (pt) 2019-04-30
US20200271601A1 (en) 2020-08-27
WO2018015463A1 (en) 2018-01-25
EA037102B1 (ru) 2021-02-05
DK3452827T3 (da) 2021-10-11
ES2894898T3 (es) 2022-02-16
MA44876A (fr) 2021-04-21
US20190154601A1 (en) 2019-05-23
JP7035007B2 (ja) 2022-03-14
UA124466C2 (uk) 2021-09-22
AU2017299186C1 (en) 2023-07-06
WO2018015463A9 (en) 2018-05-11
EA201990005A1 (ru) 2019-06-28
DOP2019000003A (es) 2019-06-30
CR20190016A (es) 2019-05-17
SI3452827T1 (sl) 2022-01-31
HRP20211649T1 (hr) 2022-02-04
AU2017299186A1 (en) 2019-01-24
CA3029924A1 (en) 2018-01-25
CL2019000038A1 (es) 2019-05-10
CN109477829A (zh) 2019-03-15
JP2019525166A (ja) 2019-09-05
CO2019000087A2 (es) 2019-04-30
US10705037B2 (en) 2020-07-07
PL3452827T3 (pl) 2022-02-14
EP3452827A1 (en) 2019-03-13
ZA201900143B (en) 2019-09-25
UY37337A (es) 2018-01-31
CN109477829B (zh) 2022-06-21
HUE056604T2 (hu) 2022-02-28
AR109099A1 (es) 2018-10-31
EP3452827B1 (en) 2021-08-25
LT3452827T (lt) 2021-11-25
EP3273239A1 (en) 2018-01-24
US10809212B2 (en) 2020-10-20
AU2017299186B2 (en) 2023-04-13
PT3452827T (pt) 2021-11-10

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