EA201891417A1 - Амидное соединение и его применение в качестве средства для лечения и профилактики заболеваний, вызываемых рнк- и/или днк-содержащими вирусами, и сопутствующих заболеваний - Google Patents

Амидное соединение и его применение в качестве средства для лечения и профилактики заболеваний, вызываемых рнк- и/или днк-содержащими вирусами, и сопутствующих заболеваний

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EA201891417A1
EA201891417A1 EA201891417A EA201891417A EA201891417A1 EA 201891417 A1 EA201891417 A1 EA 201891417A1 EA 201891417 A EA201891417 A EA 201891417A EA 201891417 A EA201891417 A EA 201891417A EA 201891417 A1 EA201891417 A1 EA 201891417A1
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treatment
prevention
rna
dna
containing viruses
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EA201891417A
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EA035439B1 (ru
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Владимир Евгеньевич НЕБОЛЬСИН
Татьяна Александровна КРОМОВА
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Общество С Ограниченной Ответственностью "Фарминтерпрайсез"
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Publication of EA201891417A1 publication Critical patent/EA201891417A1/ru
Publication of EA035439B1 publication Critical patent/EA035439B1/ru

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    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
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    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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Abstract

Изобретение относится к медицине и включает способ профилактики или лечения заболеваний, вызываемых РНК- и ДНК-содержащими вирусами, и сопутствующих заболеваний, предусматривающий использование эффективного количества соединения общей формулы I или его фармацевтически приемлемой соли. Изобретение также относится к способам получения указанных соединений, фармацевтическим композициям для профилактики или лечения заболеваний, вызываемых РНК- и ДНК-содержащими вирусами, содержащими эффективное количество соединения общей формулы I или его фармацевтически приемлемой соли. Посредством данного изобретения решена задача предоставления нового средства, эффективного в лечении заболеваний, вызываемых РНК-содержащими вирусами, принадлежащими роду энтеровирусов, роду метапневмовирусов, роду пневмовирусов, роду респировирусов или роду альфа-коронавирусов, ДНК-содержащими вирусами, принадлежащими семейству аденовирусов и семейству герпесвирусов, а также в профилактике и лечении обострения астмы, хронической обструктивной болезни легких, муковисцидоза, конъюнктивита, гастроэнтерита, гепатита, миокардита; в профилактике и лечении ринореи, острого и инфекционного ринита, фарингита, назофарингита, тонзиллита, ларингита, ларинготрахеита, ларинготрахеобронхита, бронхита, бронхиолита, пневмонии или обструктивного синдрома дыхательных путей.
EA201891417A 2014-03-12 2015-02-27 Амидное соединение и его применение в качестве средства для лечения и профилактики заболеваний, вызываемых рнк- и/или днк-содержащими вирусами, и сопутствующих заболеваний EA035439B1 (ru)

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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018011216A (es) 2016-03-16 2019-08-29 H Lee Moffitt Cancer Ct & Res Moléculas pequeñas contra cereblon para mejorar la función efectora de los linfocitos t.
EP3594205A1 (en) 2018-07-09 2020-01-15 Abivax Phenyl-n-aryl derivatives for treating a rna virus infection
US11730726B2 (en) 2018-07-11 2023-08-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. Dimeric immuno-modulatory compounds against cereblon-based mechanisms
US20210380538A1 (en) * 2018-11-01 2021-12-09 Ahammune Biosciences Private Limited Novel imidazole compounds, process for the synthesis and uses thereof
RU2726119C1 (ru) * 2019-11-22 2020-07-09 Общество С Ограниченной Ответственностью "Валента - Интеллект" Новые производные полиолов, их применение, фармацевтическая композиция на их основе
CN111467338B (zh) * 2020-04-07 2021-04-23 中国科学院深圳先进技术研究院 焦谷氨酸在制备预防和治疗抗新冠肺炎新型冠状病毒的药物中的应用
CN113105504A (zh) * 2021-03-30 2021-07-13 澳门科技大学 Remdesivir衍生物、其类似物及其制备方法与应用
CN114213336A (zh) * 2021-12-24 2022-03-22 深圳瑞德林生物技术有限公司 β-丙氨酰-L-组氨的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61194099A (ja) * 1985-02-20 1986-08-28 チバ‐ガイギー アクチエンゲゼルシヤフト アシル化ヘキソース誘導体及び該誘導体を含む医薬製剤
RU2141483C1 (ru) * 1997-07-04 1999-11-20 Небольсин Владимир Евгеньевич Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция
RU2217196C2 (ru) * 2002-02-28 2003-11-27 Небольсин Владимир Евгеньевич Способ индукции дифференцировки клеток
ES2386272T3 (es) * 2004-09-09 2012-08-16 Novartis Vaccines And Diagnostics Gmbh Reducción de riesgos iatrogénicos potenciales asociados a las vacunas antigripales
RU2335495C2 (ru) * 2005-06-15 2008-10-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств
RU2373934C1 (ru) * 2008-03-19 2009-11-27 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств
EP2350277A1 (en) * 2008-10-23 2011-08-03 Alnylam Pharmaceuticals, Inc. Methods and compositions for prevention or treatment of rsv infection using modified duplex rna molecules
AU2010229730A1 (en) * 2009-03-26 2011-10-06 Pulmatrix, Inc. Calcium citrate and calcium lactate formulations for alteration of biophysical properties of mucosal lining
KR20120068235A (ko) * 2010-12-17 2012-06-27 한국식품연구원 포도상구균의 테이코산에 대한 rna 앱타머
US9204641B2 (en) * 2011-08-24 2015-12-08 Sumitomo Chemical Company, Limited Composition and method for controlling plant diseases
UA115431C2 (ru) * 2011-10-11 2017-11-10 Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" Применение глутарилгистамина для лечения заболеваний дыхательных путей
CN102757387B (zh) * 2012-07-04 2015-10-28 四川百利药业有限责任公司 一种英加韦林的合成方法
RU2518314C2 (ru) * 2012-08-30 2014-06-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Способ и средство активации irf-3 для лечения и профилактики заболеваний, вызываемых (+) phk-содержащими вирусами
EA032951B1 (ru) * 2013-04-12 2019-08-30 Общество С Ограниченной Ответственностью "Рсв Терапевтикс" Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения

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