EA201890428A1 - Ингибиторы контрольных точек иммунного ответа для применения в лечении различных видов рака крови - Google Patents

Ингибиторы контрольных точек иммунного ответа для применения в лечении различных видов рака крови

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EA201890428A1
EA201890428A1 EA201890428A EA201890428A EA201890428A1 EA 201890428 A1 EA201890428 A1 EA 201890428A1 EA 201890428 A EA201890428 A EA 201890428A EA 201890428 A EA201890428 A EA 201890428A EA 201890428 A1 EA201890428 A1 EA 201890428A1
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Eurasian Patent Office
Prior art keywords
cancer
inhibitors
blood
treatment
application
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EA201890428A
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English (en)
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EA039307B1 (ru
Inventor
Вальтер Фидлер
Ясмин Веллброк
Хауке Штамм
Феликс Клинглер
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Эмджен Рисерч (Мюник) Гмбх
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Publication of EA201890428A1 publication Critical patent/EA201890428A1/ru
Publication of EA039307B1 publication Critical patent/EA039307B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

В настоящем изобретении предложен ингибитор против CD112 (нектин-2, PVRL2), CD155 (PVR), галектин-9, TIM-3 и/или TIGIT для применения в способе лечения рака крови, в частности острого миелоидного лейкоза (ОМЛ). Кроме того, в настоящем изобретении предложена фармацевтическая композиция, содержащая ингибитор против CD112 (нектин-2, PVRL2), CD155 (PVR), галектина-9, TIM-3 и/или TIGIT и CAR T-клетку. В настоящем изобретении дополнительно предложена фармацевтическая композиция, содержащая ингибитор против CD112 (нектин-2, PVRL2), CD155(PVR), галектина-9, TIM-3 и/или TIGIT и конструкцию антитела, способную к привлечению T-клеток.
EA201890428A 2015-08-05 2016-08-05 Применение фармацевтической композиции, содержащей ингибиторы контрольных точек иммунного ответа, для лечения острого миелоидного лейкоза EA039307B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562201461P 2015-08-05 2015-08-05
PCT/EP2016/068726 WO2017021526A1 (en) 2015-08-05 2016-08-05 Immune-checkpoint inhibitors for use in the treatment of blood-borne cancers

Publications (2)

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EA201890428A1 true EA201890428A1 (ru) 2018-07-31
EA039307B1 EA039307B1 (ru) 2022-01-12

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EA201890428A EA039307B1 (ru) 2015-08-05 2016-08-05 Применение фармацевтической композиции, содержащей ингибиторы контрольных точек иммунного ответа, для лечения острого миелоидного лейкоза

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US (2) US20170037133A1 (ru)
EP (1) EP3331915B1 (ru)
JP (1) JP7170532B2 (ru)
CN (1) CN108473572B (ru)
AU (1) AU2016301961B2 (ru)
CA (1) CA2996015A1 (ru)
DK (1) DK3331915T3 (ru)
EA (1) EA039307B1 (ru)
ES (1) ES2861436T3 (ru)
HK (1) HK1249524A1 (ru)
HU (1) HUE053763T2 (ru)
IL (1) IL256874B (ru)
JO (1) JO3620B1 (ru)
LT (1) LT3331915T (ru)
MX (1) MX2018001351A (ru)
MY (1) MY186582A (ru)
PH (1) PH12018500120A1 (ru)
SG (1) SG10202000914VA (ru)
SI (1) SI3331915T1 (ru)
TW (1) TWI719041B (ru)
UA (1) UA125375C2 (ru)
WO (1) WO2017021526A1 (ru)
ZA (1) ZA201708598B (ru)

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