EA201691121A1 - Гидроксиамидные соединения пиримидина в качестве ингибиторов деацетилаз белков и способы их применения - Google Patents

Гидроксиамидные соединения пиримидина в качестве ингибиторов деацетилаз белков и способы их применения

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Publication number
EA201691121A1
EA201691121A1 EA201691121A EA201691121A EA201691121A1 EA 201691121 A1 EA201691121 A1 EA 201691121A1 EA 201691121 A EA201691121 A EA 201691121A EA 201691121 A EA201691121 A EA 201691121A EA 201691121 A1 EA201691121 A1 EA 201691121A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrimidine
inhibitors
methods
compounds
protein deacetylases
Prior art date
Application number
EA201691121A
Other languages
English (en)
Russian (ru)
Inventor
Джон Х. Ван Дюзер
Ральф Мацичек
Янбинг Динг
Нань Юй
Юн Цао
Юн Лю
Original Assignee
Эситайлон Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46047943&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201691121(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эситайлон Фармасьютикалз, Инк. filed Critical Эситайлон Фармасьютикалз, Инк.
Publication of EA201691121A1 publication Critical patent/EA201691121A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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EA201691121A 2010-11-16 2011-11-15 Гидроксиамидные соединения пиримидина в качестве ингибиторов деацетилаз белков и способы их применения EA201691121A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41415810P 2010-11-16 2010-11-16
US201161503286P 2011-06-30 2011-06-30

Publications (1)

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EA201691121A1 true EA201691121A1 (ru) 2016-10-31

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EA201390711A EA025345B1 (ru) 2010-11-16 2011-11-15 Гидроксиамидные соединения пиримидина в качестве ингибиторов деацетилаз белков и фармацевтические композиции для лечения заболевания, обусловленного hdac6, включающие эти соединения
EA201691121A EA201691121A1 (ru) 2010-11-16 2011-11-15 Гидроксиамидные соединения пиримидина в качестве ингибиторов деацетилаз белков и способы их применения

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EA201390711A EA025345B1 (ru) 2010-11-16 2011-11-15 Гидроксиамидные соединения пиримидина в качестве ингибиторов деацетилаз белков и фармацевтические композиции для лечения заболевания, обусловленного hdac6, включающие эти соединения

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BR (1) BR112013011868A2 (enExample)
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CN102933558B (zh) 2010-01-22 2016-03-16 埃斯泰隆制药公司 作为蛋白质去乙酰化酶抑制剂的反向酰胺化合物及其使用方法
NZ710405A (en) * 2010-11-16 2017-04-28 Acetylon Pharmaceuticals Inc Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
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