AU2011329028B2 - Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof - Google Patents

Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof Download PDF

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Publication number
AU2011329028B2
AU2011329028B2 AU2011329028A AU2011329028A AU2011329028B2 AU 2011329028 B2 AU2011329028 B2 AU 2011329028B2 AU 2011329028 A AU2011329028 A AU 2011329028A AU 2011329028 A AU2011329028 A AU 2011329028A AU 2011329028 B2 AU2011329028 B2 AU 2011329028B2
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compound
disease
cancer
optionally substituted
pharmaceutically acceptable
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AU2011329028A1 (en
Inventor
Yun Cao
Yanbing Ding
Yong Liu
Ralph Mazitschek
John H. Van Duzer
Nan Yu
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Acetylon Pharmaceuticals Inc
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Acetylon Pharmaceuticals Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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AU2011329028A 2010-11-16 2011-11-15 Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof Ceased AU2011329028B2 (en)

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US41415810P 2010-11-16 2010-11-16
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US201161503286P 2011-06-30 2011-06-30
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PCT/US2011/060791 WO2012068109A2 (en) 2010-11-16 2011-11-15 Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof

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NZ601655A (en) 2010-01-22 2014-10-31 Acetylon Pharmaceuticals Inc Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
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