PT1981877E - Compostos de n-hidroxiacrilamida - Google Patents

Compostos de n-hidroxiacrilamida Download PDF

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Publication number
PT1981877E
PT1981877E PT07708338T PT07708338T PT1981877E PT 1981877 E PT1981877 E PT 1981877E PT 07708338 T PT07708338 T PT 07708338T PT 07708338 T PT07708338 T PT 07708338T PT 1981877 E PT1981877 E PT 1981877E
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PT
Portugal
Prior art keywords
hydroxyacrylamide
hydroxyacrylamide compounds
compounds
novel
pharmaceutically acceptable
Prior art date
Application number
PT07708338T
Other languages
English (en)
Inventor
Fumiyuki Shirai
Hideo Tsutsumi
Hiromichi Itani
Yoshihiro Kozuki
Yoshiteru Eikyu
Taro Masunaga
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2006900588A external-priority patent/AU2006900588A0/en
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of PT1981877E publication Critical patent/PT1981877E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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PT07708338T 2006-02-07 2007-02-06 Compostos de n-hidroxiacrilamida PT1981877E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AU2006900588A AU2006900588A0 (en) 2006-02-07 HDAC inhibitor

Publications (1)

Publication Number Publication Date
PT1981877E true PT1981877E (pt) 2012-05-24

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Family Applications (1)

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PT07708338T PT1981877E (pt) 2006-02-07 2007-02-06 Compostos de n-hidroxiacrilamida

Country Status (19)

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US (1) US7750155B2 (pt)
EP (1) EP1981877B1 (pt)
JP (1) JP5218057B2 (pt)
KR (1) KR20080091297A (pt)
CN (1) CN101379059A (pt)
AT (1) ATE554084T1 (pt)
AU (1) AU2007213018A1 (pt)
BR (1) BRPI0707693A2 (pt)
CA (1) CA2641579A1 (pt)
ES (1) ES2384121T3 (pt)
IL (1) IL193252A0 (pt)
MX (1) MX2008010035A (pt)
NO (1) NO20083836L (pt)
PL (1) PL1981877T3 (pt)
PT (1) PT1981877E (pt)
RU (1) RU2008135979A (pt)
TW (1) TW200806652A (pt)
WO (1) WO2007091703A1 (pt)
ZA (1) ZA200806778B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2628726A1 (en) * 2008-03-26 2013-08-21 Novartis AG Hydroxamate-based inhibitors of deacetylases b
WO2009118370A1 (en) 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
WO2011017448A1 (en) * 2009-08-05 2011-02-10 The Trustees Of The University Of Pennsylvania Use of histone deacetylase inhibitors for treatment of autoimmune diseases
US8614223B2 (en) * 2010-11-16 2013-12-24 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
ES2929576T3 (es) 2013-10-08 2022-11-30 Acetylon Pharmaceuticals Inc Combinaciones de inhibidores de histona deacetilasa 6 y el inhibidor de Her2 lapatinib para el uso en el tratamiento del cáncer de mama
EP3055299B1 (en) 2013-10-10 2021-01-06 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
JP2016534069A (ja) 2013-10-24 2016-11-04 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ Ｈｄａｃ６阻害剤での多嚢胞性疾患の治療
PE20161030A1 (es) 2013-12-03 2016-11-06 Acetylon Pharmaceuticals Inc Combinaciones de inhibidores de histona deacetilasa y farmacos inmunomoduladores
US9464073B2 (en) 2014-02-26 2016-10-11 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
EP3166603B1 (en) 2014-07-07 2020-02-12 Acetylon Pharmaceuticals, Inc. Treatment of leukemia with histone deacetylase inhibitors
CA2969790A1 (en) 2014-12-05 2016-06-09 University of Modena and Reggio Emilia Combinations of histone deacetylase inhibitors and bendamustine
US10272084B2 (en) 2015-06-01 2019-04-30 Regenacy Pharmaceuticals, Llc Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy
JP2019515909A (ja) 2016-04-19 2019-06-13 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 慢性リンパ性白血病の治療を目的とするｈｄａｃ阻害剤単独またはｂｔｋ阻害剤との配合物
MX2020006587A (es) 2017-12-22 2020-12-10 Ravenna Pharmaceuticals Inc Derivados de aminopiridina como inhibidores de fosfatidilinositol fosfato cinasa.

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0570594T3 (pt) 1991-12-10 1997-08-25 Shionogi & Co
WO1995013264A1 (fr) 1993-11-08 1995-05-18 Terumo Kabushiki Kaisha Derive d'acide hydroxamique et preparation medicamenteuse contenant ledit derive
ES2217386T3 (es) 1996-01-02 2004-11-01 Aventis Pharmaceuticals Inc. Compuestos de acido(aril, heteroaril, arilmetil o heteroarilmetil) hidroxamico sustituido.
US6593322B1 (en) 1999-03-17 2003-07-15 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
UA74345C2 (uk) 1999-09-08 2005-12-15 Слоан-Кеттерінг Інстітьют Фо Кансер Рісерч Засоби клітинної диференціації і інгібітори гістонової деацетилази та способи їх використання
KR20100035666A (ko) 1999-11-23 2010-04-05 메틸진 인크. 히스톤 디아세틸라제의 억제제
EP1314721A1 (en) 2000-08-31 2003-05-28 Wakunaga Pharmaceutical Co., Ltd. Novel propenohydroxamic acid derivatives
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
WO2002030872A1 (fr) 2000-10-12 2002-04-18 Maruha Corporation Nouveaux composes aliphatiques, procede de preparation et utilisation associes
BR0007130A (pt) * 2000-12-22 2002-08-13 Olivier Marie Marcel Autran Método de envio e coleta de dados através de sistema de comunicação móvel
WO2002074298A1 (fr) 2001-03-21 2002-09-26 Ono Pharmaceutical Co., Ltd. Inhibiteurs de production d'il-6
US7148257B2 (en) 2002-03-04 2006-12-12 Merck Hdac Research, Llc Methods of treating mesothelioma with suberoylanilide hydroxamic acid
AU2003229883B2 (en) 2002-04-03 2009-06-11 Topotarget Uk Limited Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors
US7495022B2 (en) 2002-04-11 2009-02-24 Sk Chemicals Co., Ltd. α,β-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors
EP1553948B1 (en) 2002-09-13 2011-08-24 Virginia Commonwealth University Combination of imatnib and a histone deacetylase inhibitor for the treatment of leukemia
WO2004043352A2 (en) 2002-11-12 2004-05-27 Alcon, Inc. Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases
US7135493B2 (en) 2003-01-13 2006-11-14 Astellas Pharma Inc. HDAC inhibitor
US20050159470A1 (en) * 2003-12-19 2005-07-21 Syrrx, Inc. Histone deacetylase inhibitors
US20050197336A1 (en) 2004-03-08 2005-09-08 Miikana Therapeutics Corporation Inhibitors of histone deacetylase
MX2007001550A (es) 2004-08-09 2007-04-10 Astellas Pharma Inc Compuestos de hidroxiamida que tienen actividad como inhibidores de histona desacetilasa (hdac).

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ATE554084T1 (de) 2012-05-15
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JP5218057B2 (ja) 2013-06-26
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ES2384121T3 (es) 2012-06-29
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JP2009525945A (ja) 2009-07-16
US7750155B2 (en) 2010-07-06
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CA2641579A1 (en) 2007-08-16

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