MX2008010035A - Compuestos de n-hidroxiacrilamida. - Google Patents

Compuestos de n-hidroxiacrilamida.

Info

Publication number
MX2008010035A
MX2008010035A MX2008010035A MX2008010035A MX2008010035A MX 2008010035 A MX2008010035 A MX 2008010035A MX 2008010035 A MX2008010035 A MX 2008010035A MX 2008010035 A MX2008010035 A MX 2008010035A MX 2008010035 A MX2008010035 A MX 2008010035A
Authority
MX
Mexico
Prior art keywords
hydroxyacrylamide
hydroxyacrylamide compounds
compounds
novel
pharmaceutically acceptable
Prior art date
Application number
MX2008010035A
Other languages
English (en)
Inventor
Fumiyuki Shirai
Hideo Tsutsumi
Yoshiteru Eikyu
Yoshihiro Kozuki
Taro Masunaga
Hiromichi Itani
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2006900588A external-priority patent/AU2006900588A0/en
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2008010035A publication Critical patent/MX2008010035A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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Abstract

Esta invención se refiere a nuevos compuestos de N-hidroxiacrilamida de la fórmula (I) y a sus sales farmacéuticamente aceptables. Más particularmente, se refiere a nuevos compuestos de N-hidroxiacrilamida y a sus sales farmacéuticamente aceptables, que actúan como un inhibidor de HDAC, a una composición farmacéutica que los comprende y a un método de uso de los mismos terapéuticamente en el tratamiento y/o prevención de enfermedades relacionadas con HDAC.
MX2008010035A 2006-02-07 2007-02-06 Compuestos de n-hidroxiacrilamida. MX2008010035A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2006900588A AU2006900588A0 (en) 2006-02-07 HDAC inhibitor
PCT/JP2007/052447 WO2007091703A1 (en) 2006-02-07 2007-02-06 N-hydroxyacrylamide compounds

Publications (1)

Publication Number Publication Date
MX2008010035A true MX2008010035A (es) 2008-10-17

Family

ID=38038616

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008010035A MX2008010035A (es) 2006-02-07 2007-02-06 Compuestos de n-hidroxiacrilamida.

Country Status (19)

Country Link
US (1) US7750155B2 (es)
EP (1) EP1981877B1 (es)
JP (1) JP5218057B2 (es)
KR (1) KR20080091297A (es)
CN (1) CN101379059A (es)
AT (1) ATE554084T1 (es)
AU (1) AU2007213018A1 (es)
BR (1) BRPI0707693A2 (es)
CA (1) CA2641579A1 (es)
ES (1) ES2384121T3 (es)
IL (1) IL193252A0 (es)
MX (1) MX2008010035A (es)
NO (1) NO20083836L (es)
PL (1) PL1981877T3 (es)
PT (1) PT1981877E (es)
RU (1) RU2008135979A (es)
TW (1) TW200806652A (es)
WO (1) WO2007091703A1 (es)
ZA (1) ZA200806778B (es)

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NZ588069A (en) * 2008-03-26 2012-06-29 Novartis Ag Hydroxamate-based inhibitors of deacetylases b
ES2395347T3 (es) 2008-03-27 2013-02-12 Janssen Pharmaceutica, N.V. Derivados de indolilalquilamino sustituidos con aza-biciclohexilo como inhibidores novedosos de histona desacetilasa
WO2011017448A1 (en) * 2009-08-05 2011-02-10 The Trustees Of The University Of Pennsylvania Use of histone deacetylase inhibitors for treatment of autoimmune diseases
US8614223B2 (en) * 2010-11-16 2013-12-24 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
US9403779B2 (en) 2013-10-08 2016-08-02 Acetylon Pharmaceuticals, Inc. Combinations of histone deacetylase inhibitors and either Her2 inhibitors or PI3K inhibitors
US9278963B2 (en) 2013-10-10 2016-03-08 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
WO2015061684A1 (en) 2013-10-24 2015-04-30 Mayo Foundation For Medical Education And Research Treatment of polycystic diseases with an hdac6 inhibitor
EP3076973B1 (en) 2013-12-03 2020-04-29 Acetylon Pharmaceuticals, Inc. Combinations of histone deacetylase inhibitors and immunomodulatory drugs
US9464073B2 (en) 2014-02-26 2016-10-11 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
EP3166603B1 (en) 2014-07-07 2020-02-12 Acetylon Pharmaceuticals, Inc. Treatment of leukemia with histone deacetylase inhibitors
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