ES2568260T3 - Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos - Google Patents

Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos Download PDF

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Publication number
ES2568260T3
ES2568260T3 ES11840803.8T ES11840803T ES2568260T3 ES 2568260 T3 ES2568260 T3 ES 2568260T3 ES 11840803 T ES11840803 T ES 11840803T ES 2568260 T3 ES2568260 T3 ES 2568260T3
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compound
disease
cancer
optionally substituted
compounds
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Spanish (es)
Inventor
John H. Van Duzer
Ralph Mazitschek
Yanbing Ding
Nan Yu
Yun Cao
Yong Liu
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Acetylon Pharmaceuticals Inc
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Acetylon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
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ES11840803.8T 2010-11-16 2011-11-15 Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos Active ES2568260T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41415810P 2010-11-16 2010-11-16
US414158P 2010-11-16
US201161503286P 2011-06-30 2011-06-30
US201161503286P 2011-06-30
PCT/US2011/060791 WO2012068109A2 (en) 2010-11-16 2011-11-15 Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof

Publications (1)

Publication Number Publication Date
ES2568260T3 true ES2568260T3 (es) 2016-04-28

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ES11840803.8T Active ES2568260T3 (es) 2010-11-16 2011-11-15 Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos

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US (3) US8614223B2 (enExample)
EP (2) EP2640709B1 (enExample)
JP (2) JP6041808B2 (enExample)
KR (1) KR20130115300A (enExample)
CN (2) CN107011270A (enExample)
AU (2) AU2011329028B2 (enExample)
BR (1) BR112013011868A2 (enExample)
CA (1) CA2818125A1 (enExample)
CL (1) CL2013001381A1 (enExample)
EA (2) EA201691121A1 (enExample)
ES (1) ES2568260T3 (enExample)
IL (2) IL226326A0 (enExample)
MX (1) MX2013005392A (enExample)
NZ (2) NZ610225A (enExample)
PH (2) PH12013500964A1 (enExample)
PL (1) PL2640709T3 (enExample)
PT (1) PT2640709T (enExample)
SG (2) SG190211A1 (enExample)
WO (1) WO2012068109A2 (enExample)

Families Citing this family (58)

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Publication number Priority date Publication date Assignee Title
PH12012501492B1 (en) 2010-01-22 2020-01-24 Acetylon Pharmaceuticals Inc Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
NZ610225A (en) * 2010-11-16 2015-08-28 Acetylon Pharmaceuticals Inc Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
CA2868302A1 (en) 2012-03-23 2013-09-26 Dennis M. Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
WO2013158984A1 (en) 2012-04-19 2013-10-24 Acetylon Pharmaceuticals, Inc. Biomarkers to identify patients that will respond to treatment and treating such patients
EP2906211A4 (en) * 2012-10-12 2016-04-20 Univ Pennsylvania PYRIMIDINHYDROXY AMID COMPOUNDS AS A PROTEIN DEACETYLASE INHIBITOR AND METHOD OF USE THEREOF
US9145412B2 (en) 2012-11-02 2015-09-29 Acetylon Pharmaceuticals, Inc. Selective HDAC1 and HDAC2 inhibitors
HK1220407A1 (zh) 2013-03-14 2017-05-05 Chdi Foundation, Inc. 组蛋白去乙酰酶抑制剂，其组合物及其使用方法
US9617259B2 (en) 2013-03-14 2017-04-11 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
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