CN103429574B - 作为蛋白质去乙酰化酶抑制剂的嘧啶羟基酰胺化合物和其使用方法 - Google Patents
作为蛋白质去乙酰化酶抑制剂的嘧啶羟基酰胺化合物和其使用方法 Download PDFInfo
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- CN103429574B CN103429574B CN201180055168.7A CN201180055168A CN103429574B CN 103429574 B CN103429574 B CN 103429574B CN 201180055168 A CN201180055168 A CN 201180055168A CN 103429574 B CN103429574 B CN 103429574B
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- 0 *C(*)(C1=CC=*=CC=C1)Nc(nc1)ncc1C(NO)=O Chemical compound *C(*)(C1=CC=*=CC=C1)Nc(nc1)ncc1C(NO)=O 0.000 description 2
- WYAAHXSECXWBTJ-CLFYSBASSA-N CC(C=C=N/C(/C)=N\C)C(NO)=O Chemical compound CC(C=C=N/C(/C)=N\C)C(NO)=O WYAAHXSECXWBTJ-CLFYSBASSA-N 0.000 description 1
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- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610911460.9A CN107011270A (zh) | 2010-11-16 | 2011-11-15 | 作为蛋白质去乙酰化酶抑制剂的嘧啶羟基酰胺化合物和其使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41415810P | 2010-11-16 | 2010-11-16 | |
| US61/414,158 | 2010-11-16 | ||
| US201161503286P | 2011-06-30 | 2011-06-30 | |
| US61/503,286 | 2011-06-30 | ||
| PCT/US2011/060791 WO2012068109A2 (en) | 2010-11-16 | 2011-11-15 | Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610911460.9A Division CN107011270A (zh) | 2010-11-16 | 2011-11-15 | 作为蛋白质去乙酰化酶抑制剂的嘧啶羟基酰胺化合物和其使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103429574A CN103429574A (zh) | 2013-12-04 |
| CN103429574B true CN103429574B (zh) | 2016-11-16 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180055168.7A Expired - Fee Related CN103429574B (zh) | 2010-11-16 | 2011-11-15 | 作为蛋白质去乙酰化酶抑制剂的嘧啶羟基酰胺化合物和其使用方法 |
| CN201610911460.9A Pending CN107011270A (zh) | 2010-11-16 | 2011-11-15 | 作为蛋白质去乙酰化酶抑制剂的嘧啶羟基酰胺化合物和其使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610911460.9A Pending CN107011270A (zh) | 2010-11-16 | 2011-11-15 | 作为蛋白质去乙酰化酶抑制剂的嘧啶羟基酰胺化合物和其使用方法 |
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| EP (2) | EP3067346A1 (enExample) |
| JP (2) | JP6041808B2 (enExample) |
| KR (1) | KR20130115300A (enExample) |
| CN (2) | CN103429574B (enExample) |
| AU (2) | AU2011329028B2 (enExample) |
| BR (1) | BR112013011868A2 (enExample) |
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| IL (2) | IL226326A0 (enExample) |
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Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2526093T (lt) | 2010-01-22 | 2016-10-10 | Acetylon Pharmaceuticals, Inc. | Grįžtamieji amido junginiai kaip baltymo deacetilazės inhibitoriai ir jų panaudojimo būdai |
| JP6041808B2 (ja) * | 2010-11-16 | 2016-12-14 | アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. | 蛋白質脱アセチル化酵素抑制剤としてのピリミジン水酸基アミド化合物およびその利用方法 |
| CA2868302A1 (en) | 2012-03-23 | 2013-09-26 | Dennis M. Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
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