JP6041808B2 - 蛋白質脱アセチル化酵素抑制剤としてのピリミジン水酸基アミド化合物およびその利用方法 - Google Patents

蛋白質脱アセチル化酵素抑制剤としてのピリミジン水酸基アミド化合物およびその利用方法 Download PDF

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JP6041808B2
JP6041808B2 JP2013539949A JP2013539949A JP6041808B2 JP 6041808 B2 JP6041808 B2 JP 6041808B2 JP 2013539949 A JP2013539949 A JP 2013539949A JP 2013539949 A JP2013539949 A JP 2013539949A JP 6041808 B2 JP6041808 B2 JP 6041808B2
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JP2013542994A5 (enExample
JP2013542994A (ja
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ヴァン・ダザー，ジョン，エイチ
マジッチェック，ラルフ
ディン，ヤンビン
ユ，ナン
カオ，ユン
リュー，ヨン
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Acetylon Pharmaceuticals Inc
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Acetylon Pharmaceuticals Inc
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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JP2013539949A 2010-11-16 2011-11-15 蛋白質脱アセチル化酵素抑制剤としてのピリミジン水酸基アミド化合物およびその利用方法 Active JP6041808B2 (ja)

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US41415810P 2010-11-16 2010-11-16
US61/414,158 2010-11-16
US201161503286P 2011-06-30 2011-06-30
US61/503,286 2011-06-30
PCT/US2011/060791 WO2012068109A2 (en) 2010-11-16 2011-11-15 Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof

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JP2013542994A5 JP2013542994A5 (enExample) 2015-01-08
JP6041808B2 true JP6041808B2 (ja) 2016-12-14

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JP2016157532A Pending JP2017019820A (ja) 2010-11-16 2016-08-10 蛋白質脱アセチル化酵素抑制剤としてのピリミジン水酸基アミド化合物およびその利用方法

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US (3) US8614223B2 (enExample)
EP (2) EP3067346A1 (enExample)
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KR (1) KR20130115300A (enExample)
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AU (2) AU2011329028B2 (enExample)
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JP2017019820A (ja) * 2010-11-16 2017-01-26 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 蛋白質脱アセチル化酵素抑制剤としてのピリミジン水酸基アミド化合物およびその利用方法

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201500444TA (en) 2010-01-22 2015-03-30 Acetylon Pharmaceuticals Inc Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
WO2013142817A2 (en) 2012-03-23 2013-09-26 Dennis Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
WO2013158984A1 (en) 2012-04-19 2013-10-24 Acetylon Pharmaceuticals, Inc. Biomarkers to identify patients that will respond to treatment and treating such patients
HK1213471A1 (zh) * 2012-10-12 2016-07-08 The Trustees Of The University Of Pennsylvania 作為蛋白脫乙酰基酶抑制劑的嘧啶羥基酰胺化合物及其使用方法
US9145412B2 (en) 2012-11-02 2015-09-29 Acetylon Pharmaceuticals, Inc. Selective HDAC1 and HDAC2 inhibitors
WO2014159224A1 (en) 2013-03-14 2014-10-02 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
HK1220406A1 (zh) 2013-03-14 2017-05-05 Chdi Foundation, Inc. 组蛋白去乙酰酶抑制剂及组合物
WO2015042418A1 (en) * 2013-09-20 2015-03-26 Acetylon Pharmaceuticals, Inc. Treatment of diseases caused by abnormal lymphocyte function with an hdac6 inhibitor
EP3054952B1 (en) 2013-10-08 2022-10-26 Acetylon Pharmaceuticals, Inc. Combinations of histone deacetylase 6 inhibitors and the her2 inhibitor lapatinib for use in the treatment of breast cancer
JP2016536354A (ja) * 2013-10-10 2016-11-24 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 非ホジキンリンパ腫を治療するための、ｈｄａｃ阻害剤単独またはｂｔｋ阻害剤との組み合わせ
EP3055299B1 (en) * 2013-10-10 2021-01-06 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
ES2818933T3 (es) * 2013-10-10 2021-04-14 Acetylon Pharmaceuticals Inc Inhibidores de la HDAC en combinación con los inhibidores de la pi3k, para el tratamiento del linfoma no Hodgkin
CN105722507A (zh) * 2013-10-11 2016-06-29 埃斯泰隆制药公司 组蛋白脱乙酰酶抑制剂与免疫调节药物的组合
WO2015061684A1 (en) 2013-10-24 2015-04-30 Mayo Foundation For Medical Education And Research Treatment of polycystic diseases with an hdac6 inhibitor
CN105939716A (zh) * 2013-12-03 2016-09-14 埃斯泰隆制药公司 组蛋白脱乙酰基酶抑制剂和免疫调节药物的组合
ES2936812T3 (es) 2013-12-20 2023-03-22 Acetylon Pharmaceuticals Inc Biomarcadores de histona desacetilasa 6 (HDAC6) en mieloma múltiple
US9464073B2 (en) * 2014-02-26 2016-10-11 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
CN104974108B (zh) * 2014-04-04 2017-11-17 中国科学院上海药物研究所 一类2,2’‑串联双噻唑类化合物及其制备方法和用途
CA2951026A1 (en) 2014-06-02 2015-12-10 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
CA2954522A1 (en) 2014-07-07 2016-01-14 Acetylon Pharmaceuticals, Inc. Treatment of leukemia with histone deacetylase inhibitors
WO2016090230A1 (en) * 2014-12-05 2016-06-09 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds for treating peripheral neuropathy
US9937174B2 (en) 2014-12-05 2018-04-10 University of Modena and Reggio Emilia Combinations of histone deacetylase inhibitors and bendamustine
BR112017012504A2 (pt) 2014-12-12 2018-01-09 Acetylon Pharmaceuticals, Inc. derivados de piperidina como inibidores de hdac1/2
CN104503831B (zh) * 2014-12-22 2017-10-13 北京奇虎科技有限公司 设备优化方法及装置
US10183934B2 (en) 2015-02-02 2019-01-22 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors
PL3292116T3 (pl) 2015-02-02 2022-02-21 Valo Health, Inc. 3-arylo-4-amidobicykliczne kwasy [4,5,0]hydroksamowe jako inhibitory hdac
ES2833473T3 (es) * 2015-04-21 2021-06-15 Chengdu Zenitar Biomedical Tech Co Ltd Derivados de purinil-N-hidroxil pirimidin formamida, método de preparación y uso de los mismos
US10272084B2 (en) 2015-06-01 2019-04-30 Regenacy Pharmaceuticals, Llc Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy
CN107922352B (zh) 2015-06-08 2021-08-06 埃斯泰隆制药公司 制备蛋白质脱乙酰酶抑制剂的方法
US10464906B2 (en) 2015-06-08 2019-11-05 Acetylon Pharmaceuticals, Inc. Crystalline forms of a histone deacetylase inhibitor
US10040769B2 (en) 2015-10-27 2018-08-07 Regenacy Pharmaceuticals, Llc HDAC inhibitors for the treatment of diabetic peripheral neuropathy
WO2017184774A1 (en) 2016-04-19 2017-10-26 Acetylon Pharmaceuticals, Inc. Hdac inhibitors, alone or in combination with btk inhibitors, for treating chronic lymphocytic leukemia
JP2019519543A (ja) * 2016-06-07 2019-07-11 デルマヴァント サイエンシーズ ゲーエムベーハーＤｅｒｍａｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ Ｐｄｅ−４阻害剤の局所処方物およびそれらの使用方法
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors
US11324744B2 (en) 2016-08-08 2022-05-10 Acetylon Pharmaceuticals Inc. Methods of use and pharmaceutical combinations of histone deacetylase inhibitors and CD20 inhibitory antibodies
JP7068297B2 (ja) * 2016-11-10 2022-05-16 アセチロン ファーマシューティカルズ インコーポレイテッド フェニル及びピリジニルヒドロキサム酸
EP3544600A4 (en) 2016-11-23 2020-06-17 Acetylon Pharmaceuticals, Inc. Pharmaceutical combinations comprising a histone deacetylase inhibitor and a programmed death-ligand 1 (pd-l1) inhibitor and methods of use thereof
WO2018130155A1 (zh) * 2017-01-10 2018-07-19 南京明德新药研发股份有限公司 Hdac6选择性抑制剂及其制备方法和应用
US10357493B2 (en) 2017-03-10 2019-07-23 Selenity Therapeutics (Bermuda), Ltd. Metalloenzyme inhibitor compounds
EP4397656A3 (en) * 2017-04-11 2024-10-09 The General Hospital Corporation Hdac6 inhibitors and imaging agents
IT201700041723A1 (it) * 2017-04-14 2018-10-14 Italfarmaco Spa Nuovi inibitori selettivi di HDAC6
KR102236356B1 (ko) 2017-11-24 2021-04-05 주식회사 종근당 루푸스의 예방 또는 치료를 위한 조성물
CN108299313B (zh) * 2018-01-16 2020-10-02 长沙霍滋生物科技有限公司 一种化合物及其在药学上的应用
CN108129367B (zh) * 2018-02-05 2020-10-02 南开大学 一种构建手性亚磺酰亚胺α位手性四级碳的构建方法及其产品与应用
KR20190099952A (ko) * 2018-02-20 2019-08-28 주식회사 종근당 포도막염의 예방 또는 치료를 위한 조성물
CN112703190B (zh) * 2018-07-04 2022-08-05 基石药业（苏州）有限公司 Hdac6选择性抑制剂的晶型及其应用
KR20200041812A (ko) * 2018-10-12 2020-04-22 주식회사 종근당 히스톤 탈아세틸화 효소 억제제 및 메토트렉세이트를 포함하는 약학적 조성물
CN111848454B (zh) * 2019-04-28 2021-05-07 山东大学 一种组蛋白去乙酰化酶6抑制剂及其制备方法和应用
WO2021110121A1 (zh) * 2019-12-05 2021-06-10 基石药业（苏州）有限公司 Hdac6选择性抑制剂及其组合疗法
CN114315736B (zh) * 2020-03-30 2025-11-18 甫康（上海）健康科技有限责任公司 二氢化茚胺类衍生物、其制备方法和用途
AU2021288568B2 (en) * 2020-06-08 2025-03-27 Annji Pharmaceutical Co., Ltd. Quinazoline derivatives useful as selective HDAC6 inhibitors
CN112029738B (zh) * 2020-08-18 2022-04-29 浙江省人民医院 人parkin蛋白乙酰化及其在药物制备中的应用
CN113024536B (zh) * 2021-03-12 2022-05-27 湖南师范大学 含嘧啶-哌嗪环的5-氨基噻唑甲酰胺类化合物及其制备方法和用途
US20250179065A1 (en) * 2022-02-03 2025-06-05 Eikonizo Therapeutics, Inc. Hdac6 inhibitors and uses thereof

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3549633A (en) * 1968-11-20 1970-12-22 Merck & Co Inc Process for preparation of 1-h-imidazo (4,5-b)pyrazin-2-ones
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US5891507A (en) 1997-07-28 1999-04-06 Iowa-India Investments Company Limited Process for coating a surface of a metallic stent
US6153252A (en) 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US6248127B1 (en) 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6203551B1 (en) 1999-10-04 2001-03-20 Advanced Cardiovascular Systems, Inc. Chamber for applying therapeutic substances to an implant device
US6251136B1 (en) 1999-12-08 2001-06-26 Advanced Cardiovascular Systems, Inc. Method of layering a three-coated stent using pharmacological and polymeric agents
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
HUP0402330A3 (en) 2001-11-01 2010-03-29 Janssen Pharmaceutica Nv Amide derivatives as glycogen synthase kinase 3-beta inhibitors, process for producing them, pharmaceutical compositions containing them and use thereof
US6517889B1 (en) 2001-11-26 2003-02-11 Swaminathan Jayaraman Process for coating a surface of a stent
MY140390A (en) 2002-03-13 2009-12-31 Janssen Pharmaceutica Nv Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
PL212089B1 (pl) * 2002-03-13 2012-08-31 Janssen Pharmaceutica Nv Związki heterocykliczne jako inhibitory deacetylazy histonowej, kompozycja farmaceutyczna je zawierająca, ich zastosowanie, sposób wytwarzania, sposób wykrywania lub identyfikacji HDAC oraz kompozycja
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
MY141521A (en) * 2002-12-12 2010-05-14 Hoffmann La Roche 5-substituted-six-membered heteroaromatic glucokinase activators
US7375228B2 (en) 2003-03-17 2008-05-20 Takeda San Diego, Inc. Histone deacetylase inhibitors
AU2004261373B8 (en) * 2003-07-24 2010-11-04 Basf Se 2-substituted pyrimidines
JP4809228B2 (ja) * 2003-09-24 2011-11-09 メチルジーン インコーポレイテッド ヒストンデアセチラーゼの阻害剤
JP4993374B2 (ja) 2004-04-05 2012-08-08 メルク エイチディーエーシー リサーチ エルエルシー ヒストン脱アセチル化酵素インヒビタープロドラッグ
EP3354265A1 (en) 2005-03-22 2018-08-01 President and Fellows of Harvard College Treatment of solid tumors
GB0510204D0 (en) * 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
US20070155730A1 (en) * 2005-08-26 2007-07-05 Methylgene, Inc. Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase
AU2007213018A1 (en) * 2006-02-07 2007-08-16 Astellas Pharma Inc. N-hydroxyacrylamide compounds
CA2642273C (en) 2006-02-14 2016-09-20 President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
US8304451B2 (en) 2006-05-03 2012-11-06 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
US8399452B2 (en) * 2006-10-28 2013-03-19 Methylgene Inc. Dibenzo[b,f][1,4]oxazepin-11-yl-N-hydroxybenzamides as HDAC inhibitors
CA2703718A1 (en) * 2007-11-02 2009-05-07 Tammy Mallais Inhibitors of histone deacetylase
US20110288070A1 (en) * 2008-05-05 2011-11-24 ROGERS Kathryn Methods for treating cognitive disorders using inhibitors of histone deacetylase
WO2009137503A1 (en) * 2008-05-05 2009-11-12 Envivo Pharmaceuticals, Inc. Hdac inhibitors and uses thereof
NZ602832A (en) * 2008-07-14 2014-04-30 Gilead Sciences Inc Fused heterocyclic hdac inhibitor compounds
AU2009274549B2 (en) 2008-07-23 2014-05-01 Dana-Farber Cancer Institute, Inc. Deacetylase inhibitors and uses thereof
RS54230B1 (sr) 2009-01-08 2015-12-31 Curis Inc. Inhibitori fosfoinozitid 3-kinaze sa delom koji vezuje cink
EP2401123A4 (en) 2009-02-26 2013-08-28 Arkema Inc ROTOMOULE ARTICLE FORMED FROM HIGH MOLECULAR WEIGHT POLYAMIDES
JP5838157B2 (ja) * 2009-07-22 2015-12-24 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ Ｈｄａｃ阻害剤およびそれを用いる治療法
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
EP2638009A4 (en) 2010-01-08 2014-06-11 Harvard College FLUORINATED HDAC HEMMER AND USES THEREOF
SG10201500444TA (en) 2010-01-22 2015-03-30 Acetylon Pharmaceuticals Inc Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
WO2012018499A2 (en) * 2010-08-05 2012-02-09 Acetylon Pharmaceuticals Specific regulation of cytokine levels by hdac6 inhibitors
ES2568260T3 (es) 2010-11-16 2016-04-28 Acetylon Pharmaceuticals, Inc. Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos
EP2524918A1 (en) * 2011-05-19 2012-11-21 Centro Nacional de Investigaciones Oncológicas (CNIO) Imidazopyrazines derivates as kinase inhibitors
WO2013158984A1 (en) 2012-04-19 2013-10-24 Acetylon Pharmaceuticals, Inc. Biomarkers to identify patients that will respond to treatment and treating such patients
US9145412B2 (en) 2012-11-02 2015-09-29 Acetylon Pharmaceuticals, Inc. Selective HDAC1 and HDAC2 inhibitors
WO2014121062A1 (en) 2013-02-01 2014-08-07 Acetylon Pharmaceuticals, Inc. Selective hdac3 inhibitors
US9139583B2 (en) 2013-02-01 2015-09-22 Acetylon Pharmaceuticals, Inc. Selective HDAC3 inhibitors
EP3004141A4 (en) 2013-06-03 2017-05-31 Acetylon Pharmaceuticals, Inc. Histone deacetylase ( hdac) biomarkers in multiple myeloma
EP3054952B1 (en) 2013-10-08 2022-10-26 Acetylon Pharmaceuticals, Inc. Combinations of histone deacetylase 6 inhibitors and the her2 inhibitor lapatinib for use in the treatment of breast cancer
JP2016536354A (ja) 2013-10-10 2016-11-24 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 非ホジキンリンパ腫を治療するための、ｈｄａｃ阻害剤単独またはｂｔｋ阻害剤との組み合わせ
EP3055299B1 (en) 2013-10-10 2021-01-06 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
ES2818933T3 (es) 2013-10-10 2021-04-14 Acetylon Pharmaceuticals Inc Inhibidores de la HDAC en combinación con los inhibidores de la pi3k, para el tratamiento del linfoma no Hodgkin
CN105722507A (zh) 2013-10-11 2016-06-29 埃斯泰隆制药公司 组蛋白脱乙酰酶抑制剂与免疫调节药物的组合
CN105939716A (zh) 2013-12-03 2016-09-14 埃斯泰隆制药公司 组蛋白脱乙酰基酶抑制剂和免疫调节药物的组合

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017019820A (ja) * 2010-11-16 2017-01-26 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 蛋白質脱アセチル化酵素抑制剤としてのピリミジン水酸基アミド化合物およびその利用方法

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