EA201390403A1 - Способы получения фенилацетата l-орнитина - Google Patents

Способы получения фенилацетата l-орнитина

Info

Publication number
EA201390403A1
EA201390403A1 EA201390403A EA201390403A EA201390403A1 EA 201390403 A1 EA201390403 A1 EA 201390403A1 EA 201390403 A EA201390403 A EA 201390403A EA 201390403 A EA201390403 A EA 201390403A EA 201390403 A1 EA201390403 A1 EA 201390403A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phenylacetate
methods
ornitin
obtaining
ornithine
Prior art date
Application number
EA201390403A
Other languages
English (en)
Other versions
EA028395B1 (ru
Inventor
Кейт Х. Андерсон
Джим Белинг
Кристин Хендерсон Дуган
Стивен Уильям Ватт
Питер Манини
Аттилия Фиджини
Original Assignee
Осера Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Осера Терапьютикс, Инк. filed Critical Осера Терапьютикс, Инк.
Publication of EA201390403A1 publication Critical patent/EA201390403A1/ru
Publication of EA028395B1 publication Critical patent/EA028395B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32—Phenylacetic acid

Abstract

В изобретении предложены способы получения фенилацетата L-орнитина. Указанный способ может включать, например, смешивание галогенидной соли L-орнитина с фенилацетатом серебра. Способ также может включать получение фенилацетатной соли in situ.Заявка также относится к различным композициям, полученным согласно данным способам, содержащим кристаллические формы.
EA201390403A 2010-10-06 2011-10-05 Способы получения фенилацетата l-орнитина EA028395B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39058510P 2010-10-06 2010-10-06
PCT/US2011/054983 WO2012048043A1 (en) 2010-10-06 2011-10-05 Methods of making l-ornithine phenyl acetate

Publications (2)

Publication Number Publication Date
EA201390403A1 true EA201390403A1 (ru) 2013-09-30
EA028395B1 EA028395B1 (ru) 2017-11-30

Family

ID=45928120

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390403A EA028395B1 (ru) 2010-10-06 2011-10-05 Способы получения фенилацетата l-орнитина

Country Status (16)

Country Link
US (2) US8946473B2 (ru)
EP (1) EP2625162B1 (ru)
JP (1) JP6087284B2 (ru)
KR (1) KR101888215B1 (ru)
CN (1) CN103502203B (ru)
AU (1) AU2011312042B2 (ru)
BR (1) BR112013008054B1 (ru)
CA (1) CA2813563C (ru)
EA (1) EA028395B1 (ru)
ES (1) ES2720148T3 (ru)
IL (1) IL225512A (ru)
MX (1) MX360062B (ru)
NZ (1) NZ609191A (ru)
SG (1) SG189231A1 (ru)
TR (1) TR201903978T4 (ru)
WO (1) WO2012048043A1 (ru)

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DK2799067T3 (da) 2009-06-08 2019-06-03 Ucl Business Plc Behandling af hjerneinflammation ved anvendelse af L-Ornithin-phenylacetat
EA028395B1 (ru) * 2010-10-06 2017-11-30 Осера Терапьютикс, Инк. Способы получения фенилацетата l-орнитина
CA2968544A1 (en) 2014-11-24 2016-06-02 Ucl Business Plc Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
JP2018513171A (ja) * 2015-04-20 2018-05-24 オセラ セラピューティクス， インコーポレイテッド Ｌ−オルニチンフェニルアセテート製剤
CA2995823A1 (en) * 2015-08-18 2017-02-23 Ocera Therapeutics, Inc. Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
BR112018009349A8 (pt) * 2015-11-13 2019-02-26 Ocera Therapeutics Inc formulações de fenilacetato de l-ornitina
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
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AR115585A1 (es) 2018-06-20 2021-02-03 Axcella Health Inc Composiciones y métodos para el tratamiento de la infiltración de grasa en músculo

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Also Published As

Publication number Publication date
IL225512A (en) 2017-12-31
MX360062B (es) 2018-10-22
AU2011312042B2 (en) 2015-08-20
CA2813563C (en) 2019-02-26
US9260379B2 (en) 2016-02-16
KR20140053807A (ko) 2014-05-08
MX2013003764A (es) 2013-05-20
EP2625162B1 (en) 2019-03-13
WO2012048043A1 (en) 2012-04-12
ES2720148T3 (es) 2019-07-18
CN103502203B (zh) 2016-09-07
NZ609191A (en) 2015-06-26
IL225512A0 (en) 2013-06-27
US20130211135A1 (en) 2013-08-15
TR201903978T4 (tr) 2019-04-22
CA2813563A1 (en) 2012-04-12
EP2625162A1 (en) 2013-08-14
JP6087284B2 (ja) 2017-03-01
BR112013008054A2 (pt) 2016-06-14
JP2013542935A (ja) 2013-11-28
AU2011312042A1 (en) 2013-05-02
EA028395B1 (ru) 2017-11-30
BR112013008054B1 (pt) 2019-04-09
SG189231A1 (en) 2013-05-31
EP2625162A4 (en) 2014-06-25
CN103502203A (zh) 2014-01-08
KR101888215B1 (ko) 2018-09-20
US20150133684A1 (en) 2015-05-14
US8946473B2 (en) 2015-02-03

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM