DK2799067T3 - Behandling af hjerneinflammation ved anvendelse af L-Ornithin-phenylacetat - Google Patents
Behandling af hjerneinflammation ved anvendelse af L-Ornithin-phenylacetat Download PDFInfo
- Publication number
- DK2799067T3 DK2799067T3 DK14175859.9T DK14175859T DK2799067T3 DK 2799067 T3 DK2799067 T3 DK 2799067T3 DK 14175859 T DK14175859 T DK 14175859T DK 2799067 T3 DK2799067 T3 DK 2799067T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- brain inflammation
- ornithine phenylacetate
- phenylacetate
- ornithine
- Prior art date
Links
- LRSYFEZBIMVWRY-VWMHFEHESA-N (2s)-2,5-diaminopentanoic acid;2-phenylacetic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)CC1=CC=CC=C1 LRSYFEZBIMVWRY-VWMHFEHESA-N 0.000 title 1
- 208000025698 brain inflammatory disease Diseases 0.000 title 1
- 206010014599 encephalitis Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Physiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18515809P | 2009-06-08 | 2009-06-08 | |
US24074809P | 2009-09-09 | 2009-09-09 | |
US29637710P | 2010-01-19 | 2010-01-19 | |
EP10786721.0A EP2440200B8 (en) | 2009-06-08 | 2010-06-08 | Treatment of portal hypertension using l-ornithine phenylacetate |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2799067T3 true DK2799067T3 (da) | 2019-06-03 |
Family
ID=43309444
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10786721.0T DK2440200T3 (da) | 2009-06-08 | 2010-06-08 | Behandling af portal hypertension ved anvendelse af l-ornithinphenylacetat |
DK14175859.9T DK2799067T3 (da) | 2009-06-08 | 2010-06-08 | Behandling af hjerneinflammation ved anvendelse af L-Ornithin-phenylacetat |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10786721.0T DK2440200T3 (da) | 2009-06-08 | 2010-06-08 | Behandling af portal hypertension ved anvendelse af l-ornithinphenylacetat |
Country Status (19)
Country | Link |
---|---|
US (2) | US20120157526A1 (da) |
EP (3) | EP2440200B8 (da) |
JP (3) | JP5749255B2 (da) |
KR (2) | KR20170026672A (da) |
CN (2) | CN104434894A (da) |
AU (1) | AU2010258888B2 (da) |
BR (1) | BRPI1012956A8 (da) |
CA (2) | CA2764587C (da) |
DK (2) | DK2440200T3 (da) |
EA (2) | EA025735B1 (da) |
ES (2) | ES2728948T3 (da) |
HK (2) | HK1174264A1 (da) |
IL (2) | IL216811A (da) |
MX (2) | MX2011013129A (da) |
NZ (2) | NZ615091A (da) |
PL (1) | PL2440200T3 (da) |
SG (1) | SG176675A1 (da) |
WO (1) | WO2010144498A2 (da) |
ZA (1) | ZA201108988B (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2319581T1 (sl) | 2004-11-26 | 2015-10-30 | Ucl Business Plc | Pripravki, ki obsegajo ornitin in fenilacetat ali fenilbutirat za zdravljenje hepatične encefalopatije |
NO2413924T3 (da) | 2009-04-03 | 2018-02-24 | ||
BRPI1012956A8 (pt) | 2009-06-08 | 2021-11-03 | Ocera Therapeutics Inc | Usos da l-ornitina e de pelo menos um de fenilacetato e fenilbutirato |
JP6087284B2 (ja) | 2010-10-06 | 2017-03-01 | オセラ セラピューティクス, インコーポレイテッド | L−オルニチンフェニルアセテートを製造するための方法 |
CN102993037B (zh) * | 2012-11-20 | 2015-03-04 | 南京工业大学 | 一种l-鸟氨酸苯乙酸盐的制备方法 |
CN106163528A (zh) | 2014-01-29 | 2016-11-23 | 梅克芳识别有限公司 | 用于治疗肝脑病的甾族化合物 |
CA2965325A1 (en) | 2014-10-24 | 2016-04-28 | Mallinckrodt Hospital Products IP Limited | Method of treating patients with hepatorenal syndrome type 1 |
CN107206021B (zh) * | 2014-11-24 | 2021-09-03 | Ucl商业有限公司 | 使用降氨疗法治疗与肝星状细胞激活相关的疾病 |
AR103384A1 (es) | 2015-01-12 | 2017-05-03 | Umecrine Cognition Ab | 3a-ETINILO, 3b-HIDROXI, 5a-PREGNAN-20-OXIMA COMO MODULADOR DE GABA |
MX2017013170A (es) * | 2015-04-20 | 2018-04-11 | Ocera Therapeutics Inc | Formulaciones de fenilacetato de l-ornitina. |
JP2017014206A (ja) * | 2015-06-30 | 2017-01-19 | ナノアンティバイオティクス,インコーポレイテッド | 腹水の治療 |
AU2016308641B2 (en) * | 2015-08-18 | 2022-02-03 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
WO2017053613A1 (en) * | 2015-09-25 | 2017-03-30 | Ocera Therapeutics, Inc. | Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
CN108366983A (zh) * | 2015-11-13 | 2018-08-03 | 欧塞拉治疗有限公司 | L-鸟氨酸苯乙酸盐制剂 |
US11219611B2 (en) * | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
CN106109429A (zh) * | 2016-07-26 | 2016-11-16 | 北京百奥药业有限责任公司 | 一种苯丁酸钠片剂及其制备方法 |
JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
US11160826B1 (en) | 2017-03-03 | 2021-11-02 | United States Government As Represented By The Department Of Veterans Affairs | Cholesterol lowering drugs for the treatment of hepatic encephalopathy |
AU2018266357B2 (en) | 2017-05-11 | 2022-12-08 | Ocera Therapeutics, Inc. | Processes of making L-ornithine phenylacetate |
CN111295187A (zh) | 2017-08-14 | 2020-06-16 | 胺细拉健康公司 | 用于治疗肝脏疾病的氨基酸组合物 |
WO2019173148A1 (en) * | 2018-03-05 | 2019-09-12 | The United States Government As Represented By The United States Department Of Veterans Affairs | Cholesterol lowering drugs for the treatment of hepatic encephalopathy |
CN112839643A (zh) | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | 用于治疗肌肉中脂肪浸润的组合物及方法 |
KR102237526B1 (ko) * | 2019-11-07 | 2021-04-07 | 한국식품연구원 | 오르니틴 생성능이 우수한 락토바실러스 브레비스 wikim47를 이용한 마늘 발효 조성물 |
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SI2319581T1 (sl) * | 2004-11-26 | 2015-10-30 | Ucl Business Plc | Pripravki, ki obsegajo ornitin in fenilacetat ali fenilbutirat za zdravljenje hepatične encefalopatije |
GB0426141D0 (en) * | 2004-11-26 | 2004-12-29 | Ucl Biomedica Plc | Treatment |
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BRPI1012956A8 (pt) | 2009-06-08 | 2021-11-03 | Ocera Therapeutics Inc | Usos da l-ornitina e de pelo menos um de fenilacetato e fenilbutirato |
AU2014250643B2 (en) | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
JP2011236160A (ja) | 2010-05-11 | 2011-11-24 | Shinshu Univ | 非アルコール性肝疾患治療薬 |
JP6087284B2 (ja) | 2010-10-06 | 2017-03-01 | オセラ セラピューティクス, インコーポレイテッド | L−オルニチンフェニルアセテートを製造するための方法 |
JP2016506378A (ja) | 2012-11-21 | 2016-03-03 | ハイペリオン セラピューティクス,インコーポレイテッド | 肝性脳症の治療のための窒素除去薬の投与方法および評価方法 |
CN103705490B (zh) | 2013-10-31 | 2016-08-17 | 蚌埠丰原医药科技发展有限公司 | 一种门冬氨酸鸟氨酸的缓释制剂及其制备工艺 |
CN107206021B (zh) | 2014-11-24 | 2021-09-03 | Ucl商业有限公司 | 使用降氨疗法治疗与肝星状细胞激活相关的疾病 |
MX2017013170A (es) | 2015-04-20 | 2018-04-11 | Ocera Therapeutics Inc | Formulaciones de fenilacetato de l-ornitina. |
AU2016308641B2 (en) | 2015-08-18 | 2022-02-03 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
WO2017053613A1 (en) | 2015-09-25 | 2017-03-30 | Ocera Therapeutics, Inc. | Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
-
2010
- 2010-06-08 BR BRPI1012956A patent/BRPI1012956A8/pt not_active Application Discontinuation
- 2010-06-08 EP EP10786721.0A patent/EP2440200B8/en active Active
- 2010-06-08 PL PL10786721T patent/PL2440200T3/pl unknown
- 2010-06-08 CN CN201410350083.7A patent/CN104434894A/zh active Pending
- 2010-06-08 EP EP19158338.4A patent/EP3517110A1/en not_active Withdrawn
- 2010-06-08 EA EA201171396A patent/EA025735B1/ru not_active IP Right Cessation
- 2010-06-08 ES ES14175859T patent/ES2728948T3/es active Active
- 2010-06-08 JP JP2012515079A patent/JP5749255B2/ja active Active
- 2010-06-08 DK DK10786721.0T patent/DK2440200T3/da active
- 2010-06-08 DK DK14175859.9T patent/DK2799067T3/da active
- 2010-06-08 EA EA201691430A patent/EA201691430A1/ru unknown
- 2010-06-08 CA CA2764587A patent/CA2764587C/en active Active
- 2010-06-08 CA CA2997484A patent/CA2997484C/en active Active
- 2010-06-08 NZ NZ61509110A patent/NZ615091A/en unknown
- 2010-06-08 US US13/375,463 patent/US20120157526A1/en not_active Abandoned
- 2010-06-08 EP EP14175859.9A patent/EP2799067B1/en active Active
- 2010-06-08 KR KR1020177005930A patent/KR20170026672A/ko not_active Application Discontinuation
- 2010-06-08 SG SG2011089828A patent/SG176675A1/en unknown
- 2010-06-08 NZ NZ596916A patent/NZ596916A/xx unknown
- 2010-06-08 AU AU2010258888A patent/AU2010258888B2/en active Active
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