DK2440200T3 - Behandling af portal hypertension ved anvendelse af l-ornithinphenylacetat - Google Patents
Behandling af portal hypertension ved anvendelse af l-ornithinphenylacetat Download PDFInfo
- Publication number
- DK2440200T3 DK2440200T3 DK10786721.0T DK10786721T DK2440200T3 DK 2440200 T3 DK2440200 T3 DK 2440200T3 DK 10786721 T DK10786721 T DK 10786721T DK 2440200 T3 DK2440200 T3 DK 2440200T3
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- DK
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- Prior art keywords
- liver
- administration
- composition
- subject
- portal hypertension
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Claims (9)
1. Sammensætning, der omfatter L-omithin og mindst én af phenylacetat og phenylbutyrat til anvendelse i behandling af en tilstand, der er udvalgt fra portal hypertension, portal hypertensionsrelateret variceal blødning og ascites hos et individ, hvor individet fortrinsvis lider af en leversygdom, en kronisk leversygdom, cirrose eller et akut leversvigt.
2. Sammensætning, der omfatter L-omithin og mindst én af phenylacetat og phenylbutyrat, til anvendelse i udskydelse eller reduktion af sandsynligheden for indtræden af portal hypertension hos et individ, hvor individet fortrinsvis lider af leversygdom, en kronisk leversygdom, cirrose eller et akut leversvigt.
3. Sammensætning til anvendelse ifølge krav 1 eller 2, hvor sammensætningen omfatter L-omithin og phenylacetat eller phenylbutyrat i en dosering mellem 20 g og 40 g.
4. Sammensætning, der omfatter L-omithin og mindst én af phenylacetat og phenylbutyrat til anvendelse i restituering af leveren hos et individ, hvor individet lider af portal hypertension.
5. Sammensætning til anvendelse ifølge krav 4, hvor restituering af leverfunktionen reducerer den portale hypertension hos individet.
6. Sammensætning til anvendelse ifølge krav 4, hvor restituering af leverfunktionen omfatter forhøjet leverperfusion.
7. Sammensætning til anvendelse ifølge krav 1, 2 eller 4, hvor behandlingen af portal hypertension, udskydelsen eller reduktionen i sandsynligheden for henholdsvis indtræden af portal hypertension eller restituering af leverfunktionen opnås ved reducering af niveauet af proinflammatoriske cytokiner eller forøgelse af endothelial nitrogenoxidsyntaseaktivitet hos individet.
8. Sammensætning til anvendelse ifølge krav 1, 2 eller 4, hvor sammensætningen omfatter L-omithinphenylacetat; separate fysiologisk acceptable salte af L-omithin og mindst én af phenylacetat og phenylbutyrat; en fri monomeraminosyre eller et fysiologisk acceptabelt salt af L-omithin; natriumphenylacetat eller natriumphenylbutyrat.
9. Sammensætning til anvendelse ifølge krav 1, 2 eller 4, hvor sammensætningen er til oral, intravenøs, intraperitoneal, intragastrisk eller intravaskulær administration, fortrinsvis til oral eller intravenøs administration.
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PCT/US2010/037838 WO2010144498A2 (en) | 2009-06-08 | 2010-06-08 | Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate |
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KR (2) | KR20170026672A (da) |
CN (2) | CN104434894A (da) |
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BR (1) | BRPI1012956A8 (da) |
CA (2) | CA2997484C (da) |
DK (2) | DK2440200T3 (da) |
EA (2) | EA025735B1 (da) |
ES (2) | ES2728948T3 (da) |
HK (2) | HK1174264A1 (da) |
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WO (1) | WO2010144498A2 (da) |
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ES2537974T3 (es) | 2004-11-26 | 2015-06-16 | Ucl Business Plc | Composiciones que comprenden ornitina y fenilacetato o fenilbutirato para el tratamiento de la encefalopatía hepática |
WO2010115055A1 (en) | 2009-04-03 | 2010-10-07 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
DK2440200T3 (da) | 2009-06-08 | 2014-12-08 | Ucl Business Plc | Behandling af portal hypertension ved anvendelse af l-ornithinphenylacetat |
NZ609191A (en) | 2010-10-06 | 2015-06-26 | Ocera Therapeutics Inc | Methods of making l-ornithine phenyl acetate |
CN102993037B (zh) * | 2012-11-20 | 2015-03-04 | 南京工业大学 | 一种l-鸟氨酸苯乙酸盐的制备方法 |
RS58375B1 (sr) | 2014-01-29 | 2019-03-29 | Umecrine Cognition Ab | Steroidno jedinjenje za upotrebu u lečenju hepatične encefalopatije |
EP3981420A1 (en) | 2014-10-24 | 2022-04-13 | Mallinckrodt Pharmaceuticals Ireland Limited | Method of treating patients with hepatorenal syndrome type 1 |
BR112017010761B1 (pt) | 2014-11-24 | 2022-10-18 | Ucl Business Plc | Tratamento de doenças associadas à ativação de célula estrelada hepática com o uso de terapias de redução de amônia |
AR103384A1 (es) | 2015-01-12 | 2017-05-03 | Umecrine Cognition Ab | 3a-ETINILO, 3b-HIDROXI, 5a-PREGNAN-20-OXIMA COMO MODULADOR DE GABA |
DK3285756T3 (da) * | 2015-04-20 | 2023-05-08 | Ocera Therapeutics Inc | Formuleringer af l-ornithinphenylacetat |
JP2017014206A (ja) * | 2015-06-30 | 2017-01-19 | ナノアンティバイオティクス,インコーポレイテッド | 腹水の治療 |
WO2017031131A1 (en) * | 2015-08-18 | 2017-02-23 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
EP3352748A4 (en) * | 2015-09-25 | 2019-06-05 | Ocera Therapeutics, Inc. | TREATMENT AND PREVENTION OF NEURONAL CELL LOSS BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE |
RU2018113801A (ru) | 2015-11-13 | 2019-12-16 | Осера Терапьютикс, Инк. | Составы l-орнитин фенилацетата |
US11219611B2 (en) * | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
CN106109429A (zh) * | 2016-07-26 | 2016-11-16 | 北京百奥药业有限责任公司 | 一种苯丁酸钠片剂及其制备方法 |
JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
US11160826B1 (en) | 2017-03-03 | 2021-11-02 | United States Government As Represented By The Department Of Veterans Affairs | Cholesterol lowering drugs for the treatment of hepatic encephalopathy |
CA3063134A1 (en) | 2017-05-11 | 2018-11-15 | Ocera Therapeutics, Inc. | Processes of making l-ornithine phenylacetate |
PE20200747A1 (es) | 2017-08-14 | 2020-07-24 | Axcella Health Inc | Composiciones de aminoacidos para el tratamiento de enfermedad hepatica |
WO2019173148A1 (en) * | 2018-03-05 | 2019-09-12 | The United States Government As Represented By The United States Department Of Veterans Affairs | Cholesterol lowering drugs for the treatment of hepatic encephalopathy |
MA52971A (fr) | 2018-06-20 | 2021-04-28 | Axcella Health Inc | Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle |
KR102237526B1 (ko) * | 2019-11-07 | 2021-04-07 | 한국식품연구원 | 오르니틴 생성능이 우수한 락토바실러스 브레비스 wikim47를 이용한 마늘 발효 조성물 |
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GB965637A (en) | 1962-04-23 | 1964-08-06 | Tanabe Seiyaku Co | L-ornithine l-aspartate |
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