MX2013003764A - Metodos de elaboracion de fenilacetato de l-ornitina. - Google Patents
Metodos de elaboracion de fenilacetato de l-ornitina.Info
- Publication number
- MX2013003764A MX2013003764A MX2013003764A MX2013003764A MX2013003764A MX 2013003764 A MX2013003764 A MX 2013003764A MX 2013003764 A MX2013003764 A MX 2013003764A MX 2013003764 A MX2013003764 A MX 2013003764A MX 2013003764 A MX2013003764 A MX 2013003764A
- Authority
- MX
- Mexico
- Prior art keywords
- phenyl acetate
- making
- methods
- ornithine phenyl
- ornithine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- LRSYFEZBIMVWRY-VWMHFEHESA-N (2s)-2,5-diaminopentanoic acid;2-phenylacetic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)CC1=CC=CC=C1 LRSYFEZBIMVWRY-VWMHFEHESA-N 0.000 title abstract 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 2
- UIQPERPLCCTBGX-UHFFFAOYSA-N 2-phenylacetic acid;silver Chemical compound [Ag].OC(=O)CC1=CC=CC=C1 UIQPERPLCCTBGX-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- -1 halide salt Chemical class 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- IPBVNPXQWQGGJP-UHFFFAOYSA-N phenyl acetate Chemical class CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/32—Phenylacetic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se describen en la presente los procesos para elaborar el fenilacetato de L-ornitina. El proceso puede incluir por ejemplo, entremezclar una sal de haluro de Lornitina con el fenilacetato de plata. El proceso puede también incluir formar una sal de fenilacetato in situ. La presente solicitud también se refiere a diversas composiciones obtenidas a partir de estos procesos, incluyendo las formas cristalinas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39058510P | 2010-10-06 | 2010-10-06 | |
PCT/US2011/054983 WO2012048043A1 (en) | 2010-10-06 | 2011-10-05 | Methods of making l-ornithine phenyl acetate |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013003764A true MX2013003764A (es) | 2013-05-20 |
MX360062B MX360062B (es) | 2018-10-22 |
Family
ID=45928120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013003764A MX360062B (es) | 2010-10-06 | 2011-10-05 | Metodos de elaboracion de fenilacetato de l-ornitina. |
Country Status (16)
Country | Link |
---|---|
US (2) | US8946473B2 (es) |
EP (1) | EP2625162B1 (es) |
JP (1) | JP6087284B2 (es) |
KR (1) | KR101888215B1 (es) |
CN (1) | CN103502203B (es) |
AU (1) | AU2011312042B2 (es) |
BR (1) | BR112013008054B1 (es) |
CA (1) | CA2813563C (es) |
EA (1) | EA028395B1 (es) |
ES (1) | ES2720148T3 (es) |
IL (1) | IL225512A (es) |
MX (1) | MX360062B (es) |
NZ (1) | NZ609191A (es) |
SG (1) | SG189231A1 (es) |
TR (1) | TR201903978T4 (es) |
WO (1) | WO2012048043A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2319581T1 (sl) | 2004-11-26 | 2015-10-30 | Ucl Business Plc | Pripravki, ki obsegajo ornitin in fenilacetat ali fenilbutirat za zdravljenje hepatične encefalopatije |
BRPI1013657A2 (pt) | 2009-04-03 | 2016-04-26 | Ocera Therapeutics Inc | composições, processos de produção ade sal de acetato de fenil l-ornitina, método de compressão de acetato de fenil l-ornitina e uso de quantidade terapeuticamente efetiva de forma cristalina do sal de acetato de fenil l-ornitina |
KR20170026672A (ko) | 2009-06-08 | 2017-03-08 | 유씨엘 비즈니스 피엘씨 | L―오르니틴 페닐아세테이트를 사용한 문맥압 항진증의 치료 및 간 기능 회복 |
KR101888215B1 (ko) * | 2010-10-06 | 2018-09-20 | 오세라 테라퓨틱스, 아이엔씨. | L-오르니틴 페닐아세테이트의 제조 방법 |
CN107206021B (zh) | 2014-11-24 | 2021-09-03 | Ucl商业有限公司 | 使用降氨疗法治疗与肝星状细胞激活相关的疾病 |
US20160338982A1 (en) * | 2015-04-20 | 2016-11-24 | Ocera Therapeutics, Inc. | Formulations of l-ornithine phenylacetate |
US10835506B2 (en) | 2015-08-18 | 2020-11-17 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
JP7294807B2 (ja) * | 2015-11-13 | 2023-06-20 | オセラ セラピューティクス, インコーポレイテッド | L-オルニチンフェニルアセテート製剤 |
JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
IL270413B (en) * | 2017-05-11 | 2022-08-01 | Ocera Therapeutics Inc | Processes for the preparation of l-ornithine phenylacetate |
KR20200039748A (ko) | 2017-08-14 | 2020-04-16 | 악셀라 헬스 인크. | 간 질환 치료를 위한 아미노산 조성물 |
EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB965637A (en) | 1962-04-23 | 1964-08-06 | Tanabe Seiyaku Co | L-ornithine l-aspartate |
NL302572A (es) | 1962-12-27 | |||
GB1067742A (en) | 1963-09-16 | 1967-05-03 | Kyowa Hakko Kogyo Kk | Process for the preparation of l-ornithine l-aspartate |
ZA716628B (en) | 1970-10-15 | 1972-06-28 | Richardson Merrell Spa | Composition and method for treatment of hepatic disease and mental fatigue |
US4100293A (en) | 1974-04-15 | 1978-07-11 | The Johns Hopkins University | Treatment of hepatic disorders with therapeutic compositions comprising keto analogs of essential amino acids |
US3950529A (en) | 1975-02-03 | 1976-04-13 | Massachusetts General Hospital | Amino acid formulations for patients with liver disease and method of using same |
US4320146A (en) | 1978-03-17 | 1982-03-16 | The Johns Hopkins University | Treatment of hepatic and renal disorders with ornithine and arginine salts of branched chain keto acids |
US4228099A (en) | 1978-03-17 | 1980-10-14 | The Johns Hopkins University | Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorders |
US4352814A (en) | 1979-04-18 | 1982-10-05 | The Johns Hopkins University | Treatment of hepatic and renal disorders with mixed salts of essential or semi-essential amino acids and nitrogen-free analogs |
US4284647A (en) | 1980-03-31 | 1981-08-18 | The Johns Hopkins University | Process for waste nitrogen removal |
US4457942A (en) | 1982-08-20 | 1984-07-03 | Brusilow Saul W | Process for waste nitrogen removal |
US5591613A (en) | 1990-07-02 | 1997-01-07 | Degussa Aktiengesellschaft | Method for the preparation of D-arginine and L-ornithine |
DE4020980C1 (es) | 1990-07-02 | 1991-09-26 | Degussa Ag, 6000 Frankfurt, De | |
JP3127484B2 (ja) | 1991-02-28 | 2001-01-22 | 味の素株式会社 | 肝炎治療薬 |
US5767086A (en) | 1992-04-03 | 1998-06-16 | Terrapin Technologies, Inc. | Bone marrow stimulation by certain glutathione analogs |
US5560490A (en) | 1992-09-09 | 1996-10-01 | Fisons Plc | Pharmaceutical packaging with capsule sealing means |
US5571783A (en) | 1993-03-09 | 1996-11-05 | Clintec Nutrition Company | Composition and method for treating patients with hepatic disease |
JP3273578B2 (ja) * | 1993-09-21 | 2002-04-08 | 第一化学薬品株式会社 | オルニチンと酸性アミノ酸類又はケト酸類との塩の製造法 |
US5856481A (en) | 1994-07-28 | 1999-01-05 | Syntex (U.S.A.) Inc. | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
AU2251897A (en) | 1996-02-13 | 1997-09-02 | Trustees Of The University Of Pennsylvania, The | Method of treating liver disorders |
ZA986614B (en) | 1997-07-25 | 1999-01-27 | Gilead Sciences | Nucleotide analog composition |
GB9815567D0 (en) | 1998-07-18 | 1998-09-16 | Glaxo Group Ltd | Antiviral compound |
US6258849B1 (en) | 1998-07-23 | 2001-07-10 | Stanislaw R. Burzynski | Treatment regimen for administration of phenylacetylglutamine, phenylacetylisoglutamine, and/or phenylacetate |
AU4778700A (en) | 1999-05-21 | 2000-12-12 | Takeda Chemical Industries Ltd. | Liver function controlling agents |
US6768024B1 (en) | 2000-08-04 | 2004-07-27 | Lion Bioscience Ag | Triamine derivative melanocortin receptor ligands and methods of using same |
JP3211824B1 (ja) | 2000-10-26 | 2001-09-25 | 味の素株式会社 | 分岐鎖アミノ酸含有医薬用顆粒製剤とその製造方法 |
JPWO2002074302A1 (ja) | 2001-03-15 | 2005-07-14 | 独立行政法人理化学研究所 | 肝機能障害改善用アミノ酸組成物 |
US6503530B1 (en) | 2001-11-01 | 2003-01-07 | Chunghee Kimberly Kang | Method of preventing development of severe metabolic derangement in inborn errors of metabolism |
US20030105104A1 (en) | 2001-11-27 | 2003-06-05 | Burzynski Stanislaw R. | Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy |
US20030195255A1 (en) | 2002-04-12 | 2003-10-16 | Summar Marshall L. | Method for treating hepatic encephalopathies |
US20040229948A1 (en) | 2002-04-12 | 2004-11-18 | Summar Marshall L. | Method for preventing hepatic encephalopathic episodes |
CN1383815A (zh) | 2002-05-08 | 2002-12-11 | 刘万忠 | 防治肝病、肝性脑病的鸟氨酸和门冬氨酸的复方制剂及其制备方法 |
US20040152784A1 (en) | 2002-07-23 | 2004-08-05 | Special Products Limited | Pharmaceutical composition and method for treatment of a urea cycle deficiency or sickle-cell anaemia |
WO2004019928A1 (ja) | 2002-08-30 | 2004-03-11 | Ajinomoto Co., Inc. | 肝疾患治療剤 |
US20050059150A1 (en) | 2003-09-17 | 2005-03-17 | Becton, Dickinson And Company | Environments that maintain function of primary liver cells |
MXPA03009902A (es) * | 2003-10-29 | 2005-05-03 | Manuel Francisco Lara Och Jose | Compuestos para reducir la hiperamonemia en pacientes con cirrosis u otras incapacidad para la eliminacion de amonio. |
WO2005082023A2 (en) | 2004-02-23 | 2005-09-09 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
AU2005240257B2 (en) | 2004-05-06 | 2011-11-24 | Osteologix A/S | High yield and rapid syntheses methods for producing metallo-organic salts |
JP2008511611A (ja) | 2004-08-30 | 2008-04-17 | ルナメツド・インコーポレーテツド | 治療用4−フェニル酪酸制御放出製剤 |
SI2319581T1 (sl) | 2004-11-26 | 2015-10-30 | Ucl Business Plc | Pripravki, ki obsegajo ornitin in fenilacetat ali fenilbutirat za zdravljenje hepatične encefalopatije |
RS53324B (en) | 2005-11-17 | 2014-10-31 | Silverstone Pharma Est. | STABLE FORMULATION OF AMORPHIC SALES OF PERINDOPRIL, PROCEDURE FOR THEIR PREPARATION, IN PARTICULAR INDUSTRIAL PREPARATION, AND THEIR USE IN HYPERTENSION THERAPY |
CN201421432Y (zh) * | 2009-02-20 | 2010-03-10 | 山东师范大学 | 一种相干衍射成像处理装置 |
BRPI1013657A2 (pt) | 2009-04-03 | 2016-04-26 | Ocera Therapeutics Inc | composições, processos de produção ade sal de acetato de fenil l-ornitina, método de compressão de acetato de fenil l-ornitina e uso de quantidade terapeuticamente efetiva de forma cristalina do sal de acetato de fenil l-ornitina |
KR20170026672A (ko) | 2009-06-08 | 2017-03-08 | 유씨엘 비즈니스 피엘씨 | L―오르니틴 페닐아세테이트를 사용한 문맥압 항진증의 치료 및 간 기능 회복 |
KR101888215B1 (ko) | 2010-10-06 | 2018-09-20 | 오세라 테라퓨틱스, 아이엔씨. | L-오르니틴 페닐아세테이트의 제조 방법 |
-
2011
- 2011-10-05 KR KR1020137011664A patent/KR101888215B1/ko active IP Right Grant
- 2011-10-05 EP EP11831546.4A patent/EP2625162B1/en active Active
- 2011-10-05 AU AU2011312042A patent/AU2011312042B2/en not_active Ceased
- 2011-10-05 BR BR112013008054-0A patent/BR112013008054B1/pt active IP Right Grant
- 2011-10-05 CA CA2813563A patent/CA2813563C/en active Active
- 2011-10-05 NZ NZ609191A patent/NZ609191A/en unknown
- 2011-10-05 ES ES11831546T patent/ES2720148T3/es active Active
- 2011-10-05 SG SG2013024559A patent/SG189231A1/en unknown
- 2011-10-05 CN CN201180058441.1A patent/CN103502203B/zh active Active
- 2011-10-05 EA EA201390403A patent/EA028395B1/ru not_active IP Right Cessation
- 2011-10-05 US US13/878,146 patent/US8946473B2/en active Active
- 2011-10-05 JP JP2013532925A patent/JP6087284B2/ja active Active
- 2011-10-05 TR TR2019/03978T patent/TR201903978T4/tr unknown
- 2011-10-05 MX MX2013003764A patent/MX360062B/es active IP Right Grant
- 2011-10-05 WO PCT/US2011/054983 patent/WO2012048043A1/en active Application Filing
-
2013
- 2013-04-02 IL IL225512A patent/IL225512A/en active IP Right Grant
-
2015
- 2015-01-21 US US14/601,591 patent/US9260379B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
MX360062B (es) | 2018-10-22 |
WO2012048043A1 (en) | 2012-04-12 |
BR112013008054A2 (pt) | 2016-06-14 |
CN103502203A (zh) | 2014-01-08 |
AU2011312042A1 (en) | 2013-05-02 |
US8946473B2 (en) | 2015-02-03 |
JP6087284B2 (ja) | 2017-03-01 |
TR201903978T4 (tr) | 2019-04-22 |
NZ609191A (en) | 2015-06-26 |
EP2625162A1 (en) | 2013-08-14 |
CA2813563A1 (en) | 2012-04-12 |
ES2720148T3 (es) | 2019-07-18 |
AU2011312042B2 (en) | 2015-08-20 |
EP2625162A4 (en) | 2014-06-25 |
US20150133684A1 (en) | 2015-05-14 |
IL225512A0 (en) | 2013-06-27 |
KR20140053807A (ko) | 2014-05-08 |
EA028395B1 (ru) | 2017-11-30 |
JP2013542935A (ja) | 2013-11-28 |
IL225512A (en) | 2017-12-31 |
EP2625162B1 (en) | 2019-03-13 |
CN103502203B (zh) | 2016-09-07 |
CA2813563C (en) | 2019-02-26 |
EA201390403A1 (ru) | 2013-09-30 |
SG189231A1 (en) | 2013-05-31 |
US9260379B2 (en) | 2016-02-16 |
US20130211135A1 (en) | 2013-08-15 |
KR101888215B1 (ko) | 2018-09-20 |
BR112013008054B1 (pt) | 2019-04-09 |
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