MX2013003764A - Metodos de elaboracion de fenilacetato de l-ornitina. - Google Patents

Metodos de elaboracion de fenilacetato de l-ornitina.

Info

Publication number
MX2013003764A
MX2013003764A MX2013003764A MX2013003764A MX2013003764A MX 2013003764 A MX2013003764 A MX 2013003764A MX 2013003764 A MX2013003764 A MX 2013003764A MX 2013003764 A MX2013003764 A MX 2013003764A MX 2013003764 A MX2013003764 A MX 2013003764A
Authority
MX
Mexico
Prior art keywords
phenyl acetate
making
methods
ornithine phenyl
ornithine
Prior art date
Application number
MX2013003764A
Other languages
English (en)
Other versions
MX360062B (es
Inventor
Jim Behling
Christine Henderson Dougan
Stephen William Watt
Peter Manini
Attilia Figini
Keith H Anderson
Original Assignee
Ocera Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ocera Therapeutics Inc filed Critical Ocera Therapeutics Inc
Publication of MX2013003764A publication Critical patent/MX2013003764A/es
Publication of MX360062B publication Critical patent/MX360062B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41Preparation of salts of carboxylic acids
    • C07C51/412Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32Phenylacetic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describen en la presente los procesos para elaborar el fenilacetato de L-ornitina. El proceso puede incluir por ejemplo, entremezclar una sal de haluro de Lornitina con el fenilacetato de plata. El proceso puede también incluir formar una sal de fenilacetato in situ. La presente solicitud también se refiere a diversas composiciones obtenidas a partir de estos procesos, incluyendo las formas cristalinas.
MX2013003764A 2010-10-06 2011-10-05 Metodos de elaboracion de fenilacetato de l-ornitina. MX360062B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39058510P 2010-10-06 2010-10-06
PCT/US2011/054983 WO2012048043A1 (en) 2010-10-06 2011-10-05 Methods of making l-ornithine phenyl acetate

Publications (2)

Publication Number Publication Date
MX2013003764A true MX2013003764A (es) 2013-05-20
MX360062B MX360062B (es) 2018-10-22

Family

ID=45928120

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013003764A MX360062B (es) 2010-10-06 2011-10-05 Metodos de elaboracion de fenilacetato de l-ornitina.

Country Status (16)

Country Link
US (2) US8946473B2 (es)
EP (1) EP2625162B1 (es)
JP (1) JP6087284B2 (es)
KR (1) KR101888215B1 (es)
CN (1) CN103502203B (es)
AU (1) AU2011312042B2 (es)
BR (1) BR112013008054B1 (es)
CA (1) CA2813563C (es)
EA (1) EA028395B1 (es)
ES (1) ES2720148T3 (es)
IL (1) IL225512A (es)
MX (1) MX360062B (es)
NZ (1) NZ609191A (es)
SG (1) SG189231A1 (es)
TR (1) TR201903978T4 (es)
WO (1) WO2012048043A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
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SI2319581T1 (sl) 2004-11-26 2015-10-30 Ucl Business Plc Pripravki, ki obsegajo ornitin in fenilacetat ali fenilbutirat za zdravljenje hepatične encefalopatije
BRPI1013657A2 (pt) 2009-04-03 2016-04-26 Ocera Therapeutics Inc composições, processos de produção ade sal de acetato de fenil l-ornitina, método de compressão de acetato de fenil l-ornitina e uso de quantidade terapeuticamente efetiva de forma cristalina do sal de acetato de fenil l-ornitina
KR20170026672A (ko) 2009-06-08 2017-03-08 유씨엘 비즈니스 피엘씨 L―오르니틴 페닐아세테이트를 사용한 문맥압 항진증의 치료 및 간 기능 회복
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CN107206021B (zh) 2014-11-24 2021-09-03 Ucl商业有限公司 使用降氨疗法治疗与肝星状细胞激活相关的疾病
US20160338982A1 (en) * 2015-04-20 2016-11-24 Ocera Therapeutics, Inc. Formulations of l-ornithine phenylacetate
US10835506B2 (en) 2015-08-18 2020-11-17 Ocera Therapeutics, Inc. Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
JP7294807B2 (ja) * 2015-11-13 2023-06-20 オセラ セラピューティクス, インコーポレイテッド L-オルニチンフェニルアセテート製剤
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
IL270413B (en) * 2017-05-11 2022-08-01 Ocera Therapeutics Inc Processes for the preparation of l-ornithine phenylacetate
KR20200039748A (ko) 2017-08-14 2020-04-16 악셀라 헬스 인크. 간 질환 치료를 위한 아미노산 조성물
EP3810123A1 (en) 2018-06-20 2021-04-28 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle

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KR20170026672A (ko) 2009-06-08 2017-03-08 유씨엘 비즈니스 피엘씨 L―오르니틴 페닐아세테이트를 사용한 문맥압 항진증의 치료 및 간 기능 회복
KR101888215B1 (ko) 2010-10-06 2018-09-20 오세라 테라퓨틱스, 아이엔씨. L-오르니틴 페닐아세테이트의 제조 방법

Also Published As

Publication number Publication date
MX360062B (es) 2018-10-22
WO2012048043A1 (en) 2012-04-12
BR112013008054A2 (pt) 2016-06-14
CN103502203A (zh) 2014-01-08
AU2011312042A1 (en) 2013-05-02
US8946473B2 (en) 2015-02-03
JP6087284B2 (ja) 2017-03-01
TR201903978T4 (tr) 2019-04-22
NZ609191A (en) 2015-06-26
EP2625162A1 (en) 2013-08-14
CA2813563A1 (en) 2012-04-12
ES2720148T3 (es) 2019-07-18
AU2011312042B2 (en) 2015-08-20
EP2625162A4 (en) 2014-06-25
US20150133684A1 (en) 2015-05-14
IL225512A0 (en) 2013-06-27
KR20140053807A (ko) 2014-05-08
EA028395B1 (ru) 2017-11-30
JP2013542935A (ja) 2013-11-28
IL225512A (en) 2017-12-31
EP2625162B1 (en) 2019-03-13
CN103502203B (zh) 2016-09-07
CA2813563C (en) 2019-02-26
EA201390403A1 (ru) 2013-09-30
SG189231A1 (en) 2013-05-31
US9260379B2 (en) 2016-02-16
US20130211135A1 (en) 2013-08-15
KR101888215B1 (ko) 2018-09-20
BR112013008054B1 (pt) 2019-04-09

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