EA201300805A1 - Производные фенилизоксазола и способ его получения - Google Patents

Производные фенилизоксазола и способ его получения

Info

Publication number
EA201300805A1
EA201300805A1 EA201300805A EA201300805A EA201300805A1 EA 201300805 A1 EA201300805 A1 EA 201300805A1 EA 201300805 A EA201300805 A EA 201300805A EA 201300805 A EA201300805 A EA 201300805A EA 201300805 A1 EA201300805 A1 EA 201300805A1
Authority
EA
Eurasian Patent Office
Prior art keywords
preparation
derivatives
phenyl isoxazole
compound
derivative
Prior art date
Application number
EA201300805A
Other languages
English (en)
Other versions
EA022336B1 (ru
Inventor
Донг Йеон Ким
Дае Джин Чо
Гонг Йеал Лее
Хонг Йоуб Ким
Сеок Хун Воо
Хае Ун Лее
Сунг Моо Ким
Чоонг Ам Ахн
Сеунг Бин Йоон
Original Assignee
Ил-Янг Фарм. Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46514985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201300805(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ил-Янг Фарм. Ко., Лтд. filed Critical Ил-Янг Фарм. Ко., Лтд.
Publication of EA201300805A1 publication Critical patent/EA201300805A1/ru
Publication of EA022336B1 publication Critical patent/EA022336B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Раскрыты соединение производное фенилизоксазола или его фармацевтически приемлемое производное, которое пригодно для применения в качестве препарата для лечения вирусных инфекций, в частности инфекции вируса гриппа, способ его получения, а также фармацевтическая композиция для лечения заболеваний, содержащая указанное соединение в качестве активного ингредиента.
EA201300805A 2011-04-19 2012-03-30 Производные фенилизоксазола и способ его получения EA022336B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110036172A KR101369584B1 (ko) 2011-04-19 2011-04-19 페닐-이속사졸 유도체 및 그의 제조방법
PCT/KR2012/002362 WO2012144752A1 (en) 2011-04-19 2012-03-30 Phenyl-isoxazol derivatives and preparation process thereof

Publications (2)

Publication Number Publication Date
EA201300805A1 true EA201300805A1 (ru) 2013-11-29
EA022336B1 EA022336B1 (ru) 2015-12-30

Family

ID=46514985

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300805A EA022336B1 (ru) 2011-04-19 2012-03-30 Производные фенилизоксазола и способ его получения

Country Status (21)

Country Link
US (1) US9132126B2 (ru)
EP (1) EP2699566B1 (ru)
JP (1) JP5833143B2 (ru)
KR (1) KR101369584B1 (ru)
CN (1) CN103313982B (ru)
AR (1) AR086029A1 (ru)
AU (1) AU2012246914B2 (ru)
CA (1) CA2824757A1 (ru)
CL (1) CL2013001910A1 (ru)
CO (1) CO6771432A2 (ru)
EA (1) EA022336B1 (ru)
HK (1) HK1188998A1 (ru)
IL (1) IL227711A0 (ru)
MX (1) MX340098B (ru)
PE (1) PE20140629A1 (ru)
SA (1) SA112330457B1 (ru)
SG (1) SG192134A1 (ru)
TW (1) TWI434836B (ru)
UY (1) UY34023A (ru)
WO (1) WO2012144752A1 (ru)
ZA (1) ZA201305277B (ru)

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US11040963B2 (en) 2017-02-02 2021-06-22 Janssen Vaccines & Prevention B.V. Piperazine derivatives for influenza virus inhibitions
WO2018141854A1 (en) 2017-02-02 2018-08-09 Janssen Vaccines & Prevention B.V. Piperazine derivatives for influenza virus inhibition
KR102607599B1 (ko) * 2017-02-08 2023-11-28 바이오트론 리미티드 인플루엔자의 치료 방법
TWI765323B (zh) * 2019-08-22 2022-05-21 大陸商四川海思科製藥有限公司 抗流感病毒化合物及其製備方法和用途
CN111704587B (zh) * 2020-06-29 2023-04-07 遵义医科大学 一种三氟甲基化1,3-噁嗪类化合物的合成方法
CN114349746A (zh) * 2020-11-19 2022-04-15 中国医学科学院医药生物技术研究所 一种含有4-氟苯基片段的吡啶类化合物及其制备方法和应用、药物组合物
WO2022166767A1 (zh) 2021-02-04 2022-08-11 四川海思科制药有限公司 Ha抑制剂化合物的盐及晶型

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Also Published As

Publication number Publication date
TW201309658A (zh) 2013-03-01
SG192134A1 (en) 2013-08-30
PE20140629A1 (es) 2014-05-22
NZ613314A (en) 2015-09-25
CN103313982A (zh) 2013-09-18
SA112330457B1 (ar) 2015-08-19
AU2012246914A1 (en) 2013-08-15
IL227711A0 (en) 2013-09-30
US20140031364A1 (en) 2014-01-30
KR101369584B1 (ko) 2014-03-06
MX340098B (es) 2016-06-27
CL2013001910A1 (es) 2014-04-21
CN103313982B (zh) 2016-02-03
JP5833143B2 (ja) 2015-12-16
AU2012246914B2 (en) 2015-09-24
CA2824757A1 (en) 2012-10-26
TWI434836B (zh) 2014-04-21
AR086029A1 (es) 2013-11-13
UY34023A (es) 2012-06-29
WO2012144752A1 (en) 2012-10-26
HK1188998A1 (zh) 2014-05-23
KR20120118665A (ko) 2012-10-29
CO6771432A2 (es) 2013-10-15
ZA201305277B (en) 2014-09-25
US9132126B2 (en) 2015-09-15
MX2013007661A (es) 2013-08-12
EA022336B1 (ru) 2015-12-30
EP2699566A4 (en) 2014-09-03
EP2699566A1 (en) 2014-02-26
JP2014503601A (ja) 2014-02-13
EP2699566B1 (en) 2017-02-22

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU