CO6771432A2 - Derivados de fenil-isoxazol y procedimiento para la preparación de los mismos - Google Patents

Derivados de fenil-isoxazol y procedimiento para la preparación de los mismos

Info

Publication number
CO6771432A2
CO6771432A2 CO13196001A CO13196001A CO6771432A2 CO 6771432 A2 CO6771432 A2 CO 6771432A2 CO 13196001 A CO13196001 A CO 13196001A CO 13196001 A CO13196001 A CO 13196001A CO 6771432 A2 CO6771432 A2 CO 6771432A2
Authority
CO
Colombia
Prior art keywords
preparing
isoxazole derivatives
phenyl isoxazole
phenyl
derivatives
Prior art date
Application number
CO13196001A
Other languages
English (en)
Inventor
Dong Yeong Kim
Dae Jin Cho
Dong Yeal Lee
Hong Youb Kim
Seok Hun Woo
Hae Un Leee
Sung Moo Kim
Choong Am Ahn
Seung Bin Yoon
Original Assignee
Il Yang Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46514985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6771432(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Il Yang Pharm Co Ltd filed Critical Il Yang Pharm Co Ltd
Publication of CO6771432A2 publication Critical patent/CO6771432A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CO13196001A 2011-04-19 2013-08-16 Derivados de fenil-isoxazol y procedimiento para la preparación de los mismos CO6771432A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020110036172A KR101369584B1 (ko) 2011-04-19 2011-04-19 페닐-이속사졸 유도체 및 그의 제조방법

Publications (1)

Publication Number Publication Date
CO6771432A2 true CO6771432A2 (es) 2013-10-15

Family

ID=46514985

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13196001A CO6771432A2 (es) 2011-04-19 2013-08-16 Derivados de fenil-isoxazol y procedimiento para la preparación de los mismos

Country Status (21)

Country Link
US (1) US9132126B2 (es)
EP (1) EP2699566B1 (es)
JP (1) JP5833143B2 (es)
KR (1) KR101369584B1 (es)
CN (1) CN103313982B (es)
AR (1) AR086029A1 (es)
AU (1) AU2012246914B2 (es)
CA (1) CA2824757A1 (es)
CL (1) CL2013001910A1 (es)
CO (1) CO6771432A2 (es)
EA (1) EA022336B1 (es)
HK (1) HK1188998A1 (es)
IL (1) IL227711A0 (es)
MX (1) MX340098B (es)
PE (1) PE20140629A1 (es)
SA (1) SA112330457B1 (es)
SG (1) SG192134A1 (es)
TW (1) TWI434836B (es)
UY (1) UY34023A (es)
WO (1) WO2012144752A1 (es)
ZA (1) ZA201305277B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018141854A1 (en) 2017-02-02 2018-08-09 Janssen Vaccines & Prevention B.V. Piperazine derivatives for influenza virus inhibition
JP2020506192A (ja) 2017-02-02 2020-02-27 ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. インフルエンザウイルスを阻害するためのピペラジン誘導体
US10918623B2 (en) * 2017-02-08 2021-02-16 Biotron Limited Methods of treating influenza
TWI765323B (zh) * 2019-08-22 2022-05-21 大陸商四川海思科製藥有限公司 抗流感病毒化合物及其製備方法和用途
CN111704587B (zh) * 2020-06-29 2023-04-07 遵义医科大学 一种三氟甲基化1,3-噁嗪类化合物的合成方法
CN114349746A (zh) * 2020-11-19 2022-04-15 中国医学科学院医药生物技术研究所 一种含有4-氟苯基片段的吡啶类化合物及其制备方法和应用、药物组合物
JP2024506000A (ja) 2021-02-04 2024-02-08 四川海思科制▲薬▼有限公司 Ha阻害剤化合物の塩及び結晶形

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427618D0 (en) * 1984-11-01 1984-12-05 Shell Int Research Anticoccidial compositions
AP249A (en) 1990-04-24 1993-03-17 Biota Scient Management Pty Ltd Anti-viral compounds.
JP3300365B2 (ja) 1995-02-27 2002-07-08 ギリアード サイエンシーズ,インコーポレイテッド ウイルスまたは細菌ノイラミニダーゼの新規な選択的インヒビター
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
ES2180456B1 (es) * 2001-07-20 2004-05-01 Laboratorios S.A.L.V.A.T., S.A. Isoxazoles sustituidos y su utilizacion como antibioticos.
JP2005510479A (ja) 2001-10-12 2005-04-21 オンコノバ・セラピューティックス・インコーポレーテッド 置換イソオキサゾールおよび置換2−イソオキサゾリンを調製する方法
PL375527A1 (en) 2002-06-29 2005-11-28 Zentaris Gmbh Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases
AU2003232650A1 (en) 2003-05-06 2004-11-26 Il Yang Pharm Co., Ltd. N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
KR20050051729A (ko) 2003-11-28 2005-06-02 일양약품주식회사 사이클로 옥시게나제-2 억제제인 페닐 헤테로사이클의제조방법
CN1687075A (zh) * 2005-03-24 2005-10-26 天津药物研究院 3-苯基异噁唑-5-甲酰胺基取代β-内酰胺类衍生物及其用途
WO2007008541A2 (en) 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
KR100674813B1 (ko) 2005-08-05 2007-01-29 일양약품주식회사 N-페닐-2-피리미딘-아민 유도체 및 그의 제조방법
EP2051977A2 (en) * 2006-07-20 2009-04-29 Amgen Inc. SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1
WO2009084024A2 (en) 2007-11-02 2009-07-09 Glenmark Generics Limited A process for the preparation of r-sit agliptin and its pharmaceutically acceptable salts thereof
US20090192326A1 (en) 2007-11-13 2009-07-30 Nurit Perlman Preparation of sitagliptin intermediate
WO2009086303A2 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
KR101044880B1 (ko) 2008-06-12 2011-06-28 일양약품주식회사 항궤양제 화합물의 합성에 유용한 중간체의 제조방법
KR20100021321A (ko) 2008-08-14 2010-02-24 일양약품주식회사 Ν-페닐-2-피리미딘-아민 유도체의 제조방법
US20100297079A1 (en) * 2009-05-20 2010-11-25 Chimerix, Inc. Compounds, compositions and methods for treating viral infection
AU2010281265A1 (en) * 2009-08-05 2012-03-22 Versitech Limited Antiviral compounds and methods of making and using thereof
GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
SI2614052T1 (sl) 2010-09-08 2015-04-30 Bristol-Myers Squibb Company Novi analogi piperazina kot širokospektralna protivirusna sredstva proti gripi
MX2013003227A (es) 2010-09-28 2013-05-31 Bristol Myers Squibb Co Nuevos analogos de piperazina con grupos heteroarilo sustituidos como antivirales de la influenza de espectro amplio.
KR101956586B1 (ko) 2012-03-27 2019-03-11 일양약품주식회사 약제학적 조성물 및 이의 제조방법

Also Published As

Publication number Publication date
CA2824757A1 (en) 2012-10-26
US20140031364A1 (en) 2014-01-30
NZ613314A (en) 2015-09-25
EA022336B1 (ru) 2015-12-30
WO2012144752A1 (en) 2012-10-26
EA201300805A1 (ru) 2013-11-29
US9132126B2 (en) 2015-09-15
JP5833143B2 (ja) 2015-12-16
AR086029A1 (es) 2013-11-13
KR20120118665A (ko) 2012-10-29
TW201309658A (zh) 2013-03-01
MX340098B (es) 2016-06-27
SG192134A1 (en) 2013-08-30
CN103313982B (zh) 2016-02-03
AU2012246914B2 (en) 2015-09-24
MX2013007661A (es) 2013-08-12
HK1188998A1 (zh) 2014-05-23
JP2014503601A (ja) 2014-02-13
CL2013001910A1 (es) 2014-04-21
AU2012246914A1 (en) 2013-08-15
IL227711A0 (en) 2013-09-30
KR101369584B1 (ko) 2014-03-06
UY34023A (es) 2012-06-29
ZA201305277B (en) 2014-09-25
TWI434836B (zh) 2014-04-21
EP2699566B1 (en) 2017-02-22
SA112330457B1 (ar) 2015-08-19
PE20140629A1 (es) 2014-05-22
CN103313982A (zh) 2013-09-18
EP2699566A4 (en) 2014-09-03
EP2699566A1 (en) 2014-02-26

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