EA201290073A1 - Соединения мочевины, содержащие 5,6-бициклический гетероарил, как ингибиторы киназ - Google Patents
Соединения мочевины, содержащие 5,6-бициклический гетероарил, как ингибиторы киназInfo
- Publication number
- EA201290073A1 EA201290073A1 EA201290073A EA201290073A EA201290073A1 EA 201290073 A1 EA201290073 A1 EA 201290073A1 EA 201290073 A EA201290073 A EA 201290073A EA 201290073 A EA201290073 A EA 201290073A EA 201290073 A1 EA201290073 A1 EA 201290073A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- bicyclic heteroaryl
- urea compounds
- compounds containing
- kinaz
- inhibitors
- Prior art date
Links
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 108010055196 EphA2 Receptor Proteins 0.000 abstract 1
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 abstract 1
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 abstract 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 abstract 1
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 abstract 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 abstract 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003672 ureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23627409P | 2009-08-24 | 2009-08-24 | |
| PCT/CN2010/076199 WO2011023081A1 (en) | 2009-08-24 | 2010-08-20 | 5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201290073A1 true EA201290073A1 (ru) | 2013-01-30 |
Family
ID=43627250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201290073A EA201290073A1 (ru) | 2009-08-24 | 2010-08-20 | Соединения мочевины, содержащие 5,6-бициклический гетероарил, как ингибиторы киназ |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8648086B2 (OSRAM) |
| EP (1) | EP2470533A4 (OSRAM) |
| JP (1) | JP2013502444A (OSRAM) |
| KR (1) | KR20120089459A (OSRAM) |
| CN (1) | CN102066372B (OSRAM) |
| AU (1) | AU2010289143A1 (OSRAM) |
| BR (1) | BR112012003462A2 (OSRAM) |
| CA (1) | CA2769151A1 (OSRAM) |
| CO (1) | CO6491087A2 (OSRAM) |
| EA (1) | EA201290073A1 (OSRAM) |
| EC (1) | ECSP12011691A (OSRAM) |
| IL (1) | IL218114A0 (OSRAM) |
| IN (1) | IN2012DN01983A (OSRAM) |
| MA (1) | MA33559B1 (OSRAM) |
| MX (1) | MX2012002317A (OSRAM) |
| PH (1) | PH12012500366A1 (OSRAM) |
| SG (1) | SG178092A1 (OSRAM) |
| TN (1) | TN2012000042A1 (OSRAM) |
| WO (1) | WO2011023081A1 (OSRAM) |
| ZA (1) | ZA201200890B (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010045095A1 (en) | 2008-10-14 | 2010-04-22 | Ning Xi | Compounds and methods of use |
| WO2010111063A1 (en) | 2009-03-21 | 2010-09-30 | Ning Xi | Amino ester derivatives, salts thereof and methods of use |
| US20130165475A1 (en) * | 2010-09-01 | 2013-06-27 | Ascepion Pharmaceuticals, Inc. | Deuterium-enriched heterocyclic compounds as kinase inhibitors |
| BR112013013659B8 (pt) * | 2010-12-03 | 2024-02-27 | Epizyme Inc | Compostos moduladores de enzimas epigenéticas, composição farmacêutica compreendendo ditos compostos e usos da dita composição farmacêutica para tratar câncer, câncer hematológico ou leucemia |
| CN102408426B (zh) * | 2011-09-14 | 2013-07-10 | 湖南有色凯铂生物药业有限公司 | 取代的芳香脲类化合物及其作为抗癌药物的应用 |
| FR2985257B1 (fr) * | 2011-12-28 | 2014-02-14 | Sanofi Sa | Composes dimeres agonistes des recepteurs des fgfs (fgfrs), leur procede de preparation et leur application en therapeutique |
| CN103420895A (zh) * | 2012-05-18 | 2013-12-04 | 苏州爱斯鹏药物研发有限责任公司 | 一种4-氨基吲哚的制备方法 |
| US20150284422A1 (en) | 2012-08-10 | 2015-10-08 | Epizyme, Inc. | Inhibitors of protein methyltransferase dot1l and methods of use thereof |
| WO2014039839A1 (en) | 2012-09-06 | 2014-03-13 | Epizyme, Inc. | Method of treating leukemia |
| CA2903303A1 (en) | 2013-03-15 | 2014-09-25 | Epizyme, Inc. | Methods of synthesizing substituted purine compounds |
| CN103613580B (zh) * | 2013-09-03 | 2016-02-10 | 遵义医学院 | 用于抗肿瘤药物的3-羟基吲哚-2-酮类化合物或其药学上能够接受的盐 |
| CN106279154A (zh) * | 2016-08-02 | 2017-01-04 | 叶芳 | 一种7‑氮杂吲哚‑3‑甲醛的制备方法 |
| CN108191874B (zh) * | 2018-01-16 | 2019-11-29 | 成都施贝康生物医药科技有限公司 | 一种C-Kit抑制剂及其应用 |
| CN111518016B (zh) * | 2018-06-01 | 2022-02-25 | 厦门宝太生物科技股份有限公司 | 一种csf1r抑制剂中间体及其制备方法 |
| EP3833762A4 (en) | 2018-08-09 | 2022-09-28 | Verseau Therapeutics, Inc. | Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof |
| US20220204449A1 (en) * | 2020-12-11 | 2022-06-30 | Ildong Pharmaceutical Co., Ltd. | Biased agonists of opioid receptors |
| PE20250155A1 (es) | 2021-06-14 | 2025-01-22 | Scorpion Therapeutics Inc | Derivados de la urea que pueden ser utilizados para tratar el cancer |
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| GB9412719D0 (en) | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
| GB9604361D0 (en) | 1996-02-29 | 1996-05-01 | Pharmacia Spa | 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors |
| US6300325B1 (en) | 1997-01-23 | 2001-10-09 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| WO2000053591A1 (de) * | 1999-03-08 | 2000-09-14 | Bayer Aktiengesellschaft | Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel |
| CO5190696A1 (es) | 1999-06-16 | 2002-08-29 | Smithkline Beecham Corp | Antagonistas de los receptores il-8 |
| US6525067B1 (en) * | 1999-11-23 | 2003-02-25 | Pfizer Inc | Substituted heterocyclic derivatives |
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| AR054416A1 (es) | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
| NZ556433A (en) | 2005-01-14 | 2010-10-29 | Cgi Pharmaceuticals Inc | 1, 3-diaryl substituted ureas as modulators of kinase activity |
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| UA95244C2 (ru) | 2005-06-22 | 2011-07-25 | Плексикон, Инк. | Соединения и способ модулирования активности киназ, и показания для их применения |
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| PT1940844E (pt) * | 2005-10-28 | 2010-01-06 | Scripps Research Inst | Compostos e composições como inibidores de proteína-quinase |
| US8232309B2 (en) | 2005-10-28 | 2012-07-31 | Abbott Laboratories | Prodrugs of compounds that inhibit TRPV1 receptor |
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| WO2007090141A2 (en) | 2006-02-01 | 2007-08-09 | Smithkline Beecham Corporation | Pyrrolo [2, 3, b] pyridine derivatives useful as raf kinase inhibitors |
| CN101058561B (zh) * | 2006-04-19 | 2011-01-26 | 苏州爱斯鹏药物研发有限责任公司 | 用于抑制蛋白激酶的二苯脲衍生物及其组合物和用途 |
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| WO2008079909A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| PE20081581A1 (es) | 2006-12-21 | 2008-11-12 | Plexxikon Inc | COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA |
| WO2008125014A1 (fr) * | 2007-04-13 | 2008-10-23 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. | Composés d'urée, leurs procédés de préparation et leurs utilisations pharmaceutiques |
-
2010
- 2010-08-20 EP EP10811241A patent/EP2470533A4/en not_active Withdrawn
- 2010-08-20 JP JP2012525875A patent/JP2013502444A/ja active Pending
- 2010-08-20 WO PCT/CN2010/076199 patent/WO2011023081A1/en not_active Ceased
- 2010-08-20 CN CN201080001560.9A patent/CN102066372B/zh not_active Expired - Fee Related
- 2010-08-20 SG SG2012004917A patent/SG178092A1/en unknown
- 2010-08-20 EA EA201290073A patent/EA201290073A1/ru unknown
- 2010-08-20 BR BR112012003462A patent/BR112012003462A2/pt not_active Application Discontinuation
- 2010-08-20 US US12/922,527 patent/US8648086B2/en not_active Expired - Fee Related
- 2010-08-20 MX MX2012002317A patent/MX2012002317A/es not_active Application Discontinuation
- 2010-08-20 PH PH1/2012/500366A patent/PH12012500366A1/en unknown
- 2010-08-20 KR KR1020127006772A patent/KR20120089459A/ko not_active Withdrawn
- 2010-08-20 AU AU2010289143A patent/AU2010289143A1/en not_active Abandoned
- 2010-08-20 IN IN1983DEN2012 patent/IN2012DN01983A/en unknown
- 2010-08-20 CA CA2769151A patent/CA2769151A1/en not_active Abandoned
-
2012
- 2012-01-26 CO CO12012075A patent/CO6491087A2/es not_active Application Discontinuation
- 2012-01-26 TN TNP2012000042A patent/TN2012000042A1/en unknown
- 2012-02-06 ZA ZA2012/00890A patent/ZA201200890B/en unknown
- 2012-02-14 IL IL218114A patent/IL218114A0/en unknown
- 2012-02-22 MA MA34647A patent/MA33559B1/fr unknown
- 2012-02-23 EC ECSP12011691 patent/ECSP12011691A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8648086B2 (en) | 2014-02-11 |
| US20120122895A1 (en) | 2012-05-17 |
| CA2769151A1 (en) | 2011-03-03 |
| EP2470533A1 (en) | 2012-07-04 |
| KR20120089459A (ko) | 2012-08-10 |
| PH12012500366A1 (en) | 2012-10-22 |
| JP2013502444A (ja) | 2013-01-24 |
| ZA201200890B (en) | 2012-10-31 |
| MA33559B1 (fr) | 2012-09-01 |
| SG178092A1 (en) | 2012-03-29 |
| ECSP12011691A (es) | 2012-04-30 |
| BR112012003462A2 (pt) | 2016-02-23 |
| CN102066372B (zh) | 2014-09-17 |
| WO2011023081A1 (en) | 2011-03-03 |
| CO6491087A2 (es) | 2012-07-31 |
| IL218114A0 (en) | 2012-04-30 |
| EP2470533A4 (en) | 2013-01-23 |
| TN2012000042A1 (en) | 2013-09-19 |
| IN2012DN01983A (OSRAM) | 2015-07-24 |
| MX2012002317A (es) | 2012-06-25 |
| AU2010289143A1 (en) | 2012-02-16 |
| CN102066372A (zh) | 2011-05-18 |
Similar Documents
| Publication | Publication Date | Title |
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