EA201270618A1 - Способ предотвращения кристаллизации лекарственных веществ в полимерной пленке - Google Patents

Способ предотвращения кристаллизации лекарственных веществ в полимерной пленке

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Publication number
EA201270618A1
EA201270618A1 EA201270618A EA201270618A EA201270618A1 EA 201270618 A1 EA201270618 A1 EA 201270618A1 EA 201270618 A EA201270618 A EA 201270618A EA 201270618 A EA201270618 A EA 201270618A EA 201270618 A1 EA201270618 A1 EA 201270618A1
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EA
Eurasian Patent Office
Prior art keywords
preventing crystallization
drug substance
polymeric film
medicinal substances
polymer film
Prior art date
Application number
EA201270618A
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English (en)
Other versions
EA025301B1 (ru
Inventor
Йоханнес Ёзеф Леонхард
Вальтер Мюллер
Original Assignee
Лтс Ломанн Тэрапи-Зистеме Аг
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43877347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201270618(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Лтс Ломанн Тэрапи-Зистеме Аг filed Critical Лтс Ломанн Тэрапи-Зистеме Аг
Publication of EA201270618A1 publication Critical patent/EA201270618A1/ru
Publication of EA025301B1 publication Critical patent/EA025301B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)

Abstract

Настоящее изобретение касается способа предотвращения кристаллизации лекарственного вещества в полимерной пленке, в котором распределяемое, содержащее растворитель наносимое покрытие для получения полимерной пленки, содержащее один полимер, образующий матрицу, или смесь полимеров и по меньшей мере одно лекарственное вещество, временно высушивают при температурах, которые по меньшей мере на 10°С выше температуры плавления лекарственного вещества, содержащегося в наносимом покрытии. Таким образом, необходима более высокая, чем для обычного высушивания, максимальная температура и не требуется дополнительный, требующий дополнительного времени и затрат производственный этап.
EA201270618A 2009-11-12 2010-10-26 Способ предотвращения кристаллизации лекарственных веществ в полимерной пленке EA025301B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009052972A DE102009052972A1 (de) 2009-11-12 2009-11-12 Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm
PCT/EP2010/006535 WO2011057714A2 (de) 2009-11-12 2010-10-26 Verfahren zur verhinderung der kristallisation von arzneistoffen in einem polymerfilm

Publications (2)

Publication Number Publication Date
EA201270618A1 true EA201270618A1 (ru) 2013-01-30
EA025301B1 EA025301B1 (ru) 2016-12-30

Family

ID=43877347

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270618A EA025301B1 (ru) 2009-11-12 2010-10-26 Способ предотвращения кристаллизации лекарственных веществ в полимерной пленке

Country Status (17)

Country Link
US (2) US8932665B2 (ru)
EP (1) EP2498762B1 (ru)
JP (3) JP5837883B2 (ru)
KR (1) KR101685736B1 (ru)
CN (2) CN102770128A (ru)
AR (1) AR079028A1 (ru)
AU (1) AU2010318328B2 (ru)
BR (1) BR112012011297B8 (ru)
CA (1) CA2780787C (ru)
DE (1) DE102009052972A1 (ru)
EA (1) EA025301B1 (ru)
ES (1) ES2594765T3 (ru)
IL (1) IL219674B (ru)
MX (1) MX2012005511A (ru)
PL (1) PL2498762T3 (ru)
TW (1) TWI489998B (ru)
WO (1) WO2011057714A2 (ru)

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US20100204173A1 (en) 2008-10-02 2010-08-12 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
DE102011090178A1 (de) * 2011-12-30 2013-07-04 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation
TW201431570A (zh) * 2012-11-22 2014-08-16 Ucb Pharma Gmbh 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片
CN103919755B (zh) * 2013-01-15 2019-10-18 江苏康倍得药业股份有限公司 妥洛特罗透皮贴剂及其制备方法
BR112015032929B1 (pt) 2013-07-03 2022-08-23 Lts Lohmann Therapie-Systeme Ag Sistema terapêutico transdérmico com componente eletrônico e métodos de produção de um sistema terapêutico transdérmico
JP6573913B2 (ja) * 2014-05-20 2019-09-11 エルテーエス ローマン テラピー−ジステーメ アーゲー ロチゴチンを含む経皮送達システム
JP6895755B2 (ja) * 2014-05-20 2021-06-30 エルテーエス ローマン テラピー−ジステーメ アーゲー 経皮送達システムにおける活性薬剤の放出を調節するための方法
CN106456568B (zh) 2014-05-20 2020-03-27 Lts勒曼治疗系统股份公司 包含界面调节剂的经皮递送系统
KR102363218B1 (ko) 2017-12-19 2022-02-14 히사미쓰 세이야꾸 가부시키가이샤 로티고틴 함유 첩부제
JP7399633B2 (ja) * 2019-06-14 2023-12-18 株式会社大石膏盛堂 経皮吸収型製剤の製造方法
DE102019117870B3 (de) * 2019-07-02 2020-11-26 Lts Lohmann Therapie-Systeme Ag Oraler Dünnfilm
FI3854388T3 (fi) 2020-01-24 2023-11-27 Luye Pharma Switzerland Ag Transdermaalinen hoitojärjestelmä, jossa on vaikuttava aine rotigotiini ja ainakin yksi ei-amiiniresistentti silikoniliima

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Also Published As

Publication number Publication date
BR112012011297B8 (pt) 2021-05-25
AU2010318328B2 (en) 2015-01-22
JP6161668B2 (ja) 2017-07-12
CN106619578A (zh) 2017-05-10
EP2498762A2 (de) 2012-09-19
DE102009052972A1 (de) 2011-09-15
US8932665B2 (en) 2015-01-13
IL219674A0 (en) 2012-07-31
AR079028A1 (es) 2011-12-21
JP5837883B2 (ja) 2015-12-24
US20120213912A1 (en) 2012-08-23
CA2780787C (en) 2017-11-07
JP2017149758A (ja) 2017-08-31
ES2594765T3 (es) 2016-12-22
WO2011057714A2 (de) 2011-05-19
JP6374566B2 (ja) 2018-08-15
MX2012005511A (es) 2012-06-14
CN102770128A (zh) 2012-11-07
CA2780787A1 (en) 2011-05-19
US20140046279A1 (en) 2014-02-13
KR20120115258A (ko) 2012-10-17
JP2016028078A (ja) 2016-02-25
JP2013510805A (ja) 2013-03-28
IL219674B (en) 2018-10-31
TWI489998B (zh) 2015-07-01
BR112012011297A2 (pt) 2016-04-12
BR112012011297B1 (pt) 2020-12-15
CN106619578B (zh) 2021-10-01
EP2498762B1 (de) 2016-09-07
WO2011057714A3 (de) 2011-07-07
EA025301B1 (ru) 2016-12-30
US9408809B2 (en) 2016-08-09
PL2498762T3 (pl) 2017-02-28
AU2010318328A1 (en) 2012-05-31
TW201124156A (en) 2011-07-16
KR101685736B1 (ko) 2016-12-12

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