AR079028A1 - Metodo para evitar la cristalizacion de productos farmaceuticos en una pelicula polimerica - Google Patents
Metodo para evitar la cristalizacion de productos farmaceuticos en una pelicula polimericaInfo
- Publication number
- AR079028A1 AR079028A1 ARP100104207A ARP100104207A AR079028A1 AR 079028 A1 AR079028 A1 AR 079028A1 AR P100104207 A ARP100104207 A AR P100104207A AR P100104207 A ARP100104207 A AR P100104207A AR 079028 A1 AR079028 A1 AR 079028A1
- Authority
- AR
- Argentina
- Prior art keywords
- polymeric film
- pharmaceutical product
- matrix
- group
- forms
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Abstract
Reivindicacion 1: Método para impedir la cristalizacion de un producto farmacéutico en una película polimérica, que se caracteriza porque, la masa de revestimiento extendida, que contiene disolvente para la fabricacion de la película polimérica, que incluye un polímero o mezcla de polímeros que forma una matriz y tiene al menos un producto farmacéutico, se seca a unas temperaturas que se encuentran temporalmente como mínimo 10°C por encima de la temperatura de fusion del producto farmacéutico contenido en la masa de revestimiento. Reivindicacion 6: Método conforme a una de las reivindicaciones anteriores, que se caracteriza porque, el polímero que forma la matriz o al menos uno de los polímeros de la mezcla polimérica que forma la matriz se elige del grupo que se compone de polisiloxanos, poliacrilatos, poliisobutilenos y copolímeros de bloque. Reivindicacion 8: Método conforme a una de las reivindicaciones anteriores, que se caracteriza porque, el disolvente se elige del grupo de disolventes orgánicos compuesto por heptano, hexano, ciclohexano, acetato de etilo, etanol, metanol, isopropanol y tetrahidrofurano. Reivindicacion 10: Método conforme a una de las reivindicaciones anteriores, que se caracteriza porque, el producto farmacéutico se elige del grupo que incluye la Rotigotina y el Fentanilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009052972A DE102009052972A1 (de) | 2009-11-12 | 2009-11-12 | Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079028A1 true AR079028A1 (es) | 2011-12-21 |
Family
ID=43877347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100104207A AR079028A1 (es) | 2009-11-12 | 2010-11-12 | Metodo para evitar la cristalizacion de productos farmaceuticos en una pelicula polimerica |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8932665B2 (es) |
| EP (1) | EP2498762B1 (es) |
| JP (3) | JP5837883B2 (es) |
| KR (1) | KR101685736B1 (es) |
| CN (2) | CN102770128A (es) |
| AR (1) | AR079028A1 (es) |
| AU (1) | AU2010318328B2 (es) |
| BR (1) | BR112012011297B8 (es) |
| CA (1) | CA2780787C (es) |
| DE (1) | DE102009052972A1 (es) |
| EA (1) | EA025301B1 (es) |
| ES (1) | ES2594765T3 (es) |
| IL (1) | IL219674B (es) |
| MX (1) | MX2012005511A (es) |
| PL (1) | PL2498762T3 (es) |
| TW (1) | TWI489998B (es) |
| WO (1) | WO2011057714A2 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3628319T3 (da) | 2008-10-02 | 2024-03-04 | Salix Pharmaceuticals Ltd | Behandling af hepatisk encefalopati ved anvendelse af rifaximin |
| DE102011090178A1 (de) * | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation |
| TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片 |
| CN103919755B (zh) * | 2013-01-15 | 2019-10-18 | 江苏康倍得药业股份有限公司 | 妥洛特罗透皮贴剂及其制备方法 |
| BR112015032929B1 (pt) | 2013-07-03 | 2022-08-23 | Lts Lohmann Therapie-Systeme Ag | Sistema terapêutico transdérmico com componente eletrônico e métodos de produção de um sistema terapêutico transdérmico |
| JP6895755B2 (ja) * | 2014-05-20 | 2021-06-30 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 経皮送達システムにおける活性薬剤の放出を調節するための方法 |
| CN106456566B (zh) * | 2014-05-20 | 2020-06-16 | Lts勒曼治疗系统股份公司 | 含罗替戈汀的经皮递送系统 |
| CN106456568B (zh) | 2014-05-20 | 2020-03-27 | Lts勒曼治疗系统股份公司 | 包含界面调节剂的经皮递送系统 |
| JP6908729B2 (ja) | 2017-12-19 | 2021-07-28 | 久光製薬株式会社 | ロチゴチン含有貼付剤 |
| JP7399633B2 (ja) * | 2019-06-14 | 2023-12-18 | 株式会社大石膏盛堂 | 経皮吸収型製剤の製造方法 |
| DE102019117870B3 (de) * | 2019-07-02 | 2020-11-26 | Lts Lohmann Therapie-Systeme Ag | Oraler Dünnfilm |
| PT3854388T (pt) | 2020-01-24 | 2023-12-11 | Luye Pharma Switzerland Ag | Sistema terapêutico transdérmico com o princípio ativo rotigotina e pelo menos um adesivo de silicone não resistente a aminas |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH066534B2 (ja) | 1986-10-09 | 1994-01-26 | 積水化学工業株式会社 | 経皮吸収貼付剤 |
| US4832953A (en) | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
| US5662928A (en) * | 1995-04-21 | 1997-09-02 | Ciba-Geigy Corporation | Method for the prevention or removal of crystalline scopolamine in a non-aqueous matrix of a transdermal system |
| ES2162124T3 (es) | 1995-12-01 | 2001-12-16 | Alza Corp | Metodo mejorado para evitar la formacion de cristales en una dispersion de un liquido en una matriz. |
| JP2001514213A (ja) * | 1997-09-02 | 2001-09-11 | ノバルティス アクチエンゲゼルシャフト | スコポラミン経皮剤における結晶形成防止の改善法 |
| DE19954936A1 (de) | 1999-11-16 | 2001-05-17 | Bayer Ag | Verfahren zur Herstellung von Benzofuranonoximen |
| CN1185225C (zh) | 1999-11-23 | 2005-01-19 | 阿德里斯制药公司 | 制备氮取代的氨基1,2,3,4－四氢化萘的改进方法 |
| US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
| PT1256340E (pt) | 2001-05-08 | 2003-12-31 | Sanol Arznei Schwarz Gmbh | Sistema terapeutico transdermico aperfeicoado para o tratamento da doenca de parkinson |
| DE10234673B4 (de) | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
| DE10261696A1 (de) * | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| JP4641394B2 (ja) | 2004-08-06 | 2011-03-02 | リンテック株式会社 | 経皮吸収型製剤の製造方法 |
| US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| US20090197824A1 (en) * | 2008-01-31 | 2009-08-06 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
| US20080226698A1 (en) * | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
| EP2170323A2 (en) | 2007-05-30 | 2010-04-07 | Chemagis Ltd. | Crystalline rotigotine base and preparation process therefor |
| WO2009053697A1 (en) | 2007-10-26 | 2009-04-30 | Pliva Hrvatska D.O.O. | Polymorphic forms of ( s ) -rotigotine hydrochloride |
| WO2009063171A1 (en) | 2007-11-16 | 2009-05-22 | Pliva Hrvatska D.O.O. | Novel rotigotine salts |
| SG10201610626PA (en) | 2007-11-28 | 2017-01-27 | Ucb Pharma Gmbh | Polymorphic form of rotigotine |
| WO2009122429A2 (en) * | 2008-02-04 | 2009-10-08 | Matrix Laboratories Limited | Crystalline oxybutynin and process for preparing the same |
| IT1392387B1 (it) | 2008-09-26 | 2012-03-02 | Solmag S P A Ora Fidia Farmaceutici S P A | Processo per la preparazione di rotigotina |
| EP2349230A2 (en) | 2008-10-06 | 2011-08-03 | Mylan Technologies, Inc. | Amorphous rotigotine transdermal system |
| WO2010073124A2 (en) | 2008-12-26 | 2010-07-01 | Actavis Group Ptc Ehf | Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof |
| EP2201941A1 (de) | 2008-12-29 | 2010-06-30 | UCB Pharma GmbH | Pflaster-Herstellungstechnologie |
-
2009
- 2009-11-12 DE DE102009052972A patent/DE102009052972A1/de active Pending
-
2010
- 2010-10-26 AU AU2010318328A patent/AU2010318328B2/en active Active
- 2010-10-26 JP JP2012538214A patent/JP5837883B2/ja active Active
- 2010-10-26 US US13/504,970 patent/US8932665B2/en active Active
- 2010-10-26 MX MX2012005511A patent/MX2012005511A/es unknown
- 2010-10-26 PL PL10773582T patent/PL2498762T3/pl unknown
- 2010-10-26 CA CA2780787A patent/CA2780787C/en active Active
- 2010-10-26 KR KR1020127014898A patent/KR101685736B1/ko active IP Right Grant
- 2010-10-26 EA EA201270618A patent/EA025301B1/ru not_active IP Right Cessation
- 2010-10-26 ES ES10773582.1T patent/ES2594765T3/es active Active
- 2010-10-26 WO PCT/EP2010/006535 patent/WO2011057714A2/de active Application Filing
- 2010-10-26 CN CN2010800514221A patent/CN102770128A/zh active Pending
- 2010-10-26 EP EP10773582.1A patent/EP2498762B1/de not_active Revoked
- 2010-10-26 CN CN201610942520.3A patent/CN106619578B/zh active Active
- 2010-10-26 BR BR112012011297A patent/BR112012011297B8/pt active IP Right Grant
- 2010-11-11 TW TW099138797A patent/TWI489998B/zh active
- 2010-11-12 AR ARP100104207A patent/AR079028A1/es not_active Application Discontinuation
-
2012
- 2012-05-08 IL IL219674A patent/IL219674B/en active IP Right Grant
-
2013
- 2013-10-17 US US14/056,025 patent/US9408809B2/en active Active
-
2015
- 2015-09-11 JP JP2015179315A patent/JP6161668B2/ja active Active
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2017
- 2017-04-20 JP JP2017083469A patent/JP6374566B2/ja active Active
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Legal Events
| Date | Code | Title | Description |
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| FC | Refusal |