EA201100970A1 - МЕЗИЛАТ 5-( 2-{[6-(2.2-ДИФТОР-2-ФЕНИЛЭТОКСИ)ГЕКСИЛ]АМИНО}-1-ГИДРОКСИЭТИЛ)-8-ГИДРОКСИХИНОЛИН-2(1H)-ОНА В КАЧЕСТВЕ АГОНИСТА β2 АДРЕНЕРГИЧЕСКОГО РЕЦЕПТОРА - Google Patents

МЕЗИЛАТ 5-( 2-{[6-(2.2-ДИФТОР-2-ФЕНИЛЭТОКСИ)ГЕКСИЛ]АМИНО}-1-ГИДРОКСИЭТИЛ)-8-ГИДРОКСИХИНОЛИН-2(1H)-ОНА В КАЧЕСТВЕ АГОНИСТА β2 АДРЕНЕРГИЧЕСКОГО РЕЦЕПТОРА

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Publication number
EA201100970A1
EA201100970A1 EA201100970A EA201100970A EA201100970A1 EA 201100970 A1 EA201100970 A1 EA 201100970A1 EA 201100970 A EA201100970 A EA 201100970A EA 201100970 A EA201100970 A EA 201100970A EA 201100970 A1 EA201100970 A1 EA 201100970A1
Authority
EA
Eurasian Patent Office
Prior art keywords
chief
hydroxyethyl
amino
phenyletoxi
mezilat
Prior art date
Application number
EA201100970A
Other languages
English (en)
Other versions
EA019440B1 (ru
Inventor
Франсеск Каррера-Каррера
Карлос Пуиг-Дуран
Иоланда Марчуета-Эреу
Энрике Мойес-Валльс
Original Assignee
Альмираль, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Альмираль, С.А. filed Critical Альмираль, С.А.
Publication of EA201100970A1 publication Critical patent/EA201100970A1/ru
Publication of EA019440B1 publication Critical patent/EA019440B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/32—Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Описаны мезилат 5-(2-{[6-(2,2-дифтор-2-фенилэтокси)гексил]амино}-1-гидроксиэтил)-8-гидроксихинолин-2(1H)-она и его фармацевтически приемлемые сольваты
EA201100970A 2008-12-22 2009-12-15 МЕЗИЛАТ 5-(2-{[6-(2,2-ДИФТОР-2-ФЕНИЛЭТОКСИ)ГЕКСИЛ]АМИНО}-1-ГИДРОКСИЭТИЛ)-8-ГИДРОКСИХИНОЛИН-2(1H)-ОНА В КАЧЕСТВЕ АГОНИСТА β2 АДРЕНЕРГИЧЕСКОГО РЕЦЕПТОРА EA019440B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08382082 2008-12-22
PCT/EP2009/008970 WO2010072354A1 (en) 2008-12-22 2009-12-15 MESYLATE SALT OF 5-(2-{[6-(2,2-DIFLUORO-2-PHENYLETHOXY)HEXYL]AMINO }-1-HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE AS AGONIST OF THE β2 ADRENERGIC RECEPTOR

Publications (2)

Publication Number Publication Date
EA201100970A1 true EA201100970A1 (ru) 2011-12-30
EA019440B1 EA019440B1 (ru) 2014-03-31

Family

ID=40383583

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100970A EA019440B1 (ru) 2008-12-22 2009-12-15 МЕЗИЛАТ 5-(2-{[6-(2,2-ДИФТОР-2-ФЕНИЛЭТОКСИ)ГЕКСИЛ]АМИНО}-1-ГИДРОКСИЭТИЛ)-8-ГИДРОКСИХИНОЛИН-2(1H)-ОНА В КАЧЕСТВЕ АГОНИСТА β2 АДРЕНЕРГИЧЕСКОГО РЕЦЕПТОРА

Country Status (33)

Country Link
US (1) US8563731B2 (ru)
EP (1) EP2367796B1 (ru)
JP (1) JP5645844B2 (ru)
KR (1) KR101738700B1 (ru)
CN (1) CN102264703B (ru)
AR (1) AR074792A1 (ru)
AU (1) AU2009331961B2 (ru)
BR (1) BRPI0918370B8 (ru)
CA (1) CA2748105C (ru)
CL (1) CL2011001544A1 (ru)
CO (1) CO6390056A2 (ru)
CY (1) CY1114706T1 (ru)
DK (1) DK2367796T3 (ru)
EA (1) EA019440B1 (ru)
ES (1) ES2397209T3 (ru)
HK (1) HK1156318A1 (ru)
HR (1) HRP20120941T1 (ru)
IL (1) IL213161A (ru)
ME (1) ME01497B (ru)
MX (1) MX2011006491A (ru)
MY (1) MY155609A (ru)
NZ (1) NZ592797A (ru)
PE (1) PE20110929A1 (ru)
PL (1) PL2367796T3 (ru)
PT (1) PT2367796E (ru)
SG (1) SG171992A1 (ru)
SI (1) SI2367796T1 (ru)
SM (1) SMT201300001B (ru)
TW (1) TWI412520B (ru)
UA (1) UA105913C2 (ru)
UY (1) UY32297A (ru)
WO (1) WO2010072354A1 (ru)
ZA (1) ZA201103312B (ru)

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JP6267685B2 (ja) 2012-04-13 2018-01-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 集合粒子
EP2668941A1 (en) 2012-05-31 2013-12-04 Almirall, S.A. Novel dosage form and formulation of abediterol
WO2014060431A1 (en) 2012-10-16 2014-04-24 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
EP2738172A1 (en) 2012-11-28 2014-06-04 Almirall, S.A. New bicyclic compounds as crac channel modulators
GB201222679D0 (en) 2012-12-17 2013-01-30 Glaxo Group Ltd Pharmaceutical combination products
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CN103864670B (zh) * 2014-03-17 2015-08-26 苏州明锐医药科技有限公司 阿普司特的制备方法
CN105168136B (zh) * 2015-11-08 2018-03-20 长沙佰顺生物科技有限公司 一种阿普斯特传递体及其制备方法
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