EA201000775A1 - Ингибиторы бета-лактамазы - Google Patents

Ингибиторы бета-лактамазы

Info

Publication number
EA201000775A1
EA201000775A1 EA201000775A EA201000775A EA201000775A1 EA 201000775 A1 EA201000775 A1 EA 201000775A1 EA 201000775 A EA201000775 A EA 201000775A EA 201000775 A EA201000775 A EA 201000775A EA 201000775 A1 EA201000775 A1 EA 201000775A1
Authority
EA
Eurasian Patent Office
Prior art keywords
lactamase inhibitors
beta lactamase
beta
application
describes
Prior art date
Application number
EA201000775A
Other languages
English (en)
Inventor
Кристофер Дж. Бёрнс
Ранди У. Джексон
Раджеш Госуами
Хунгюй Сю
Original Assignee
Новартис Интернэшнл Фармасьютикл Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Интернэшнл Фармасьютикл Лтд. filed Critical Новартис Интернэшнл Фармасьютикл Лтд.
Publication of EA201000775A1 publication Critical patent/EA201000775A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

В заявке описаны α-аминобороновые кислоты и их производные, которые действуют в качестве ингибиторов бета-лактамаз. В заявке также описаны фармацевтические композиции, включающие α-аминобороновые кислоты, и способы их применения.
EA201000775A 2007-11-13 2008-11-13 Ингибиторы бета-лактамазы EA201000775A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US279707P 2007-11-13 2007-11-13
PCT/US2008/012706 WO2009064414A1 (en) 2007-11-13 2008-11-13 Beta-lactamase inhibitors

Publications (1)

Publication Number Publication Date
EA201000775A1 true EA201000775A1 (ru) 2010-12-30

Family

ID=40344560

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201000775A EA201000775A1 (ru) 2007-11-13 2008-11-13 Ингибиторы бета-лактамазы
EA201000774A EA201000774A1 (ru) 2007-11-13 2008-11-13 Ингибиторы бета-лактамазы

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201000774A EA201000774A1 (ru) 2007-11-13 2008-11-13 Ингибиторы бета-лактамазы

Country Status (21)

Country Link
US (2) US20100286092A1 (ru)
EP (2) EP2220096A1 (ru)
JP (2) JP2011503181A (ru)
KR (2) KR20100109901A (ru)
CN (2) CN101861324A (ru)
AR (2) AR069310A1 (ru)
AU (2) AU2008321444A1 (ru)
BR (2) BRPI0820532A2 (ru)
CA (2) CA2705389A1 (ru)
CO (1) CO6331427A2 (ru)
CR (1) CR11372A (ru)
EA (2) EA201000775A1 (ru)
EC (1) ECSP10010246A (ru)
GT (1) GT201000143A (ru)
IL (1) IL205205A0 (ru)
MA (1) MA31874B1 (ru)
MX (2) MX2010005252A (ru)
TN (1) TN2010000203A1 (ru)
TW (2) TW200930707A (ru)
WO (2) WO2009064414A1 (ru)
ZA (1) ZA201002467B (ru)

Families Citing this family (44)

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US20100120715A1 (en) * 2007-11-13 2010-05-13 Burns Christopher J Beta-lactamase inhibitors
AR076667A1 (es) * 2009-05-12 2011-06-29 Novartis Int Pharm Ltd Inhibidores de beta-lactamasa
ES2691468T3 (es) 2010-08-10 2018-11-27 Rempex Pharmaceuticals, Inc. Derivados de éster del ácido borónico cíclicos y usos terapéuticos de los mismos
US9012491B2 (en) 2011-08-31 2015-04-21 Rempex Pharmaceuticals, Inc. Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
SG10201605152SA (en) * 2011-12-22 2016-08-30 Ares Trading Sa Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
MX2014008278A (es) * 2012-01-06 2014-11-10 Univ South Florida Composiciones, metodos de uso y metodos de tratamiento.
TW201343645A (zh) * 2012-03-30 2013-11-01 Cubist Pharm Inc １，３，４－□二唑及１，３，４－噻二唑β－內醯胺酶抑制劑
US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
RU2654692C2 (ru) * 2012-12-07 2018-05-22 Венаторкс Фармасьютикалс, Инк. Ингибиторы бета-лактамаз
JP2016509594A (ja) * 2013-01-04 2016-03-31 レンペックス・ファーマシューティカルズ・インコーポレイテッド ボロン酸誘導体及びその治療的使用
JP6324409B2 (ja) 2013-01-04 2018-05-16 レンペックス・ファーマシューティカルズ・インコーポレイテッド ボロン酸誘導体及びその治療的使用
US9101638B2 (en) 2013-01-04 2015-08-11 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2014110442A1 (en) 2013-01-10 2014-07-17 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
EP2970340B1 (en) * 2013-03-14 2020-02-12 Venatorx Pharmaceuticals, Inc. Beta-lactamase inhibitors
DK3140310T3 (da) 2014-05-05 2019-10-21 Rempex Pharmaceuticals Inc Syntese af boronatsalte og brug deraf
EP3139930A4 (en) * 2014-05-05 2018-01-17 Rempex Pharmaceuticals, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
EP3145936B1 (en) * 2014-05-19 2020-09-30 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
RU2686740C2 (ru) * 2014-06-11 2019-04-30 Венаторкс Фармасьютикалс, Инк. Ингибиторы бета-лактамазы
US9511142B2 (en) 2014-06-11 2016-12-06 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
EP3164406A4 (en) * 2014-07-01 2018-04-04 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
ES2811273T3 (es) * 2014-10-01 2021-03-11 Merck Patent Gmbh Derivados del ácido borónico
EP3201207B1 (en) * 2014-10-01 2021-02-24 Merck Patent GmbH Boronic acid derivatives
US10253049B2 (en) * 2014-10-01 2019-04-09 Merck Patent Gmbh Boronic acid derivatives
WO2016081297A1 (en) 2014-11-18 2016-05-26 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
CN107207537B (zh) 2014-12-19 2019-05-31 莱姆派克斯制药公司 用于生产硼酸衍生物的设备和连续流方法
WO2016149393A1 (en) 2015-03-17 2016-09-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
CN108472284A (zh) 2015-09-11 2018-08-31 维纳拓尔斯制药公司 β-内酰胺酶抑制剂
WO2017100537A1 (en) 2015-12-10 2017-06-15 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
CN109563033B (zh) 2016-06-21 2023-04-04 奥瑞恩眼科有限责任公司 脂族脯氨酰胺衍生物
ES2894251T3 (es) 2016-06-30 2022-02-14 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos
WO2018027062A1 (en) 2016-08-04 2018-02-08 VenatoRx Pharmaceuticals, Inc. Boron-containing compounds
EP3592362A4 (en) 2017-03-06 2020-09-02 Venatorx Pharmaceuticals, Inc. SOLID FORMS AND COMBINATION COMPOSITIONS WITH A BETA LACTAMASE INHIBITOR AND USES THEREOF
US11267826B2 (en) 2017-05-26 2022-03-08 VenatoRx Pharmaceuticals, Inc. Penicillin-binding protein inhibitors
CN110959008A (zh) * 2017-05-26 2020-04-03 维纳拓尔斯制药公司 青霉素结合蛋白抑制剂
WO2019009369A1 (ja) * 2017-07-06 2019-01-10 大日本住友製薬株式会社 イミン誘導体
TW201906616A (zh) * 2017-07-06 2019-02-16 日商大日本住友製藥股份有限公司 醯胺衍生物
JP7377545B2 (ja) 2017-10-11 2023-11-10 キューペックス バイオファーマ， インコーポレイテッド ボロン酸誘導体およびその合成
CN112424209A (zh) 2018-04-20 2021-02-26 Qpex生物制药有限公司 硼酸衍生物及其治疗用途
WO2020112542A1 (en) * 2018-11-29 2020-06-04 VenatoRx Pharmaceuticals, Inc. Combination compositions comprising a beta-lactamase inhibitor and uses thereof
CN110156820B (zh) * 2019-04-25 2021-06-25 四川大学 一类巯基酰胺硼酸类衍生物及其作为mbl和/或sbl抑制剂的用途
WO2020257306A1 (en) 2019-06-19 2020-12-24 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
CN113135944A (zh) * 2020-01-19 2021-07-20 首药控股(北京)有限公司 硼酸衍生物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112572B2 (en) * 2002-09-09 2006-09-26 Trigen Limited Multivalent metal salts of boronic acids
US20060084592A1 (en) * 2002-09-09 2006-04-20 Trigen Limited Peptide boronic acid inhibitors
US7271186B1 (en) * 2002-12-09 2007-09-18 Northwestern University Nanomolar β-lactamase inhibitors
US7183267B2 (en) * 2003-06-10 2007-02-27 The Johns Hopkins University β-lactamase inhibitors and methods of use thereof
US20100120715A1 (en) * 2007-11-13 2010-05-13 Burns Christopher J Beta-lactamase inhibitors
AR076667A1 (es) * 2009-05-12 2011-06-29 Novartis Int Pharm Ltd Inhibidores de beta-lactamasa

Also Published As

Publication number Publication date
MX2010005252A (es) 2011-04-11
AU2008321444A1 (en) 2009-05-22
AU2008321443A1 (en) 2009-05-22
WO2009064414A1 (en) 2009-05-22
ZA201002467B (en) 2011-02-23
GT201000143A (es) 2012-04-30
BRPI0820532A2 (pt) 2012-07-10
AR069310A1 (es) 2010-01-13
CO6331427A2 (es) 2011-10-20
JP2011503181A (ja) 2011-01-27
AR069463A1 (es) 2010-01-27
BRPI0820531A2 (pt) 2012-07-10
EP2220097A1 (en) 2010-08-25
US20100317621A1 (en) 2010-12-16
CN101983203A (zh) 2011-03-02
ECSP10010246A (es) 2010-07-30
CR11372A (es) 2010-09-14
KR20100109901A (ko) 2010-10-11
TN2010000203A1 (en) 2011-11-11
CN101861324A (zh) 2010-10-13
CA2705393A1 (en) 2009-05-22
US20100286092A1 (en) 2010-11-11
JP2011504468A (ja) 2011-02-10
KR20100113485A (ko) 2010-10-21
CA2705389A1 (en) 2009-05-22
TW200930707A (en) 2009-07-16
WO2009064413A1 (en) 2009-05-22
MA31874B1 (fr) 2010-11-01
IL205205A0 (en) 2010-12-30
EA201000774A1 (ru) 2010-12-30
EP2220096A1 (en) 2010-08-25
MX2010005250A (es) 2010-11-05
TW200936143A (en) 2009-09-01

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