EA200901434A1 - Лиофилизированная антигенная композиция - Google Patents

Лиофилизированная антигенная композиция

Info

Publication number
EA200901434A1
EA200901434A1 EA200901434A EA200901434A EA200901434A1 EA 200901434 A1 EA200901434 A1 EA 200901434A1 EA 200901434 A EA200901434 A EA 200901434A EA 200901434 A EA200901434 A EA 200901434A EA 200901434 A1 EA200901434 A1 EA 200901434A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
lyophilising
antigen composition
antigen
lyophilized
Prior art date
Application number
EA200901434A
Other languages
English (en)
Other versions
EA018201B1 (ru
Inventor
Доминик Ингрид Лемуан
Original Assignee
Глаксосмитклайн Байолоджикалс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2007/055037 external-priority patent/WO2007137986A2/en
Priority claimed from GB0723044A external-priority patent/GB0723044D0/en
Priority claimed from GB0723900A external-priority patent/GB0723900D0/en
Application filed by Глаксосмитклайн Байолоджикалс С.А. filed Critical Глаксосмитклайн Байолоджикалс С.А.
Publication of EA200901434A1 publication Critical patent/EA200901434A1/ru
Publication of EA018201B1 publication Critical patent/EA018201B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001152—Transcription factors, e.g. SOX or c-MYC
    • A61K39/001153—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

В изобретении предложены лиофилизированные композиции, содержащие антиген и агонист Толл-подобного рецептора (TLR) 9. Такие композиции можно разводить носителем, выбранным из группы носителей в форме частиц, состоящей из липосом, минеральных солей, эмульсий, полимеров и иммуностимулирующих комплексов (ISCOM), с получением иммуногенных композиций для применения в вакцинации. Здесь также предложены способы изготовления иммуногенных композиций из лиофилизированных композиций по изобретению и их применение в иммунизации.
EA200901434A 2007-05-24 2008-05-22 Лиофилизированная антигенная композиция EA018201B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/EP2007/055037 WO2007137986A2 (en) 2006-05-26 2007-05-24 Vaccination against cancer
GB0723044A GB0723044D0 (en) 2007-11-23 2007-11-23 Lyophillised antigen composition
GB0723900A GB0723900D0 (en) 2007-12-06 2007-12-06 Lyophillised antigen composition
PCT/EP2008/056305 WO2008142133A1 (en) 2007-05-24 2008-05-22 Lyophilised antigen composition

Publications (2)

Publication Number Publication Date
EA200901434A1 true EA200901434A1 (ru) 2010-06-30
EA018201B1 EA018201B1 (ru) 2013-06-28

Family

ID=39714209

Family Applications (3)

Application Number Title Priority Date Filing Date
EA200901434A EA018201B1 (ru) 2007-05-24 2008-05-22 Лиофилизированная антигенная композиция
EA201300101A EA201300101A1 (ru) 2007-05-24 2008-05-22 Лиофилизированная антигенная композиция
EA201300102A EA201300102A1 (ru) 2007-05-24 2008-05-22 Лиофилизированная антигенная композиция

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA201300101A EA201300101A1 (ru) 2007-05-24 2008-05-22 Лиофилизированная антигенная композиция
EA201300102A EA201300102A1 (ru) 2007-05-24 2008-05-22 Лиофилизированная антигенная композиция

Country Status (23)

Country Link
US (2) US20090035360A1 (ru)
EP (3) EP2489367A1 (ru)
JP (1) JP5331105B2 (ru)
KR (2) KR101238795B1 (ru)
CN (1) CN101678091A (ru)
AR (1) AR066676A1 (ru)
AU (1) AU2008252911B2 (ru)
BR (1) BRPI0811228A2 (ru)
CA (1) CA2687632C (ru)
CL (1) CL2008001491A1 (ru)
CY (1) CY1113446T1 (ru)
DK (1) DK2148697T3 (ru)
EA (3) EA018201B1 (ru)
ES (1) ES2395333T3 (ru)
HR (1) HRP20121019T1 (ru)
MX (1) MX2009012381A (ru)
PE (1) PE20090281A1 (ru)
PL (1) PL2148697T3 (ru)
PT (1) PT2148697E (ru)
SI (1) SI2148697T1 (ru)
TW (1) TW200911304A (ru)
UY (1) UY31101A1 (ru)
WO (1) WO2008142133A1 (ru)

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WO2007120673A2 (en) 2006-04-10 2007-10-25 Sloan Kettering Institute For Cancer Research Immunogenic wt-1 peptides and methods of use thereof
US8956627B2 (en) * 2007-04-13 2015-02-17 Duke University Method of inducing antibodies to human immunodeficiency virus involving the administration of MPER peptide-liposome conjugates
WO2010114628A2 (en) * 2009-04-03 2010-10-07 Duke University Formulation for inducing broadly reactive neutralizing anti-hiv antibodies
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Also Published As

Publication number Publication date
BRPI0811228A2 (pt) 2014-10-21
PT2148697E (pt) 2012-12-24
ES2395333T3 (es) 2013-02-12
KR20100017519A (ko) 2010-02-16
MX2009012381A (es) 2009-12-01
JP2010527964A (ja) 2010-08-19
DK2148697T3 (da) 2012-12-17
US8557247B2 (en) 2013-10-15
PE20090281A1 (es) 2009-03-28
EA018201B1 (ru) 2013-06-28
CA2687632A1 (en) 2008-11-27
EP2148697A1 (en) 2010-02-03
HRP20121019T1 (hr) 2013-01-31
AR066676A1 (es) 2009-09-02
EP2476431A1 (en) 2012-07-18
KR20110091817A (ko) 2011-08-12
CN101678091A (zh) 2010-03-24
KR101238795B1 (ko) 2013-03-07
CL2008001491A1 (es) 2008-11-28
AU2008252911B2 (en) 2013-09-05
WO2008142133A1 (en) 2008-11-27
PL2148697T3 (pl) 2013-02-28
SI2148697T1 (sl) 2013-01-31
JP5331105B2 (ja) 2013-10-30
CY1113446T1 (el) 2016-06-22
TW200911304A (en) 2009-03-16
AU2008252911A1 (en) 2008-11-27
UY31101A1 (es) 2009-01-05
US20110059163A1 (en) 2011-03-10
EP2148697B1 (en) 2012-10-03
EA201300101A1 (ru) 2014-02-28
CA2687632C (en) 2013-01-15
EA201300102A1 (ru) 2014-02-28
US20090035360A1 (en) 2009-02-05
EP2489367A1 (en) 2012-08-22

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