MX2016012166A - Metodos para mejorar la potencia de inmunoestimulacion de vacunas adsorbidas con sales de aluminio. - Google Patents

Metodos para mejorar la potencia de inmunoestimulacion de vacunas adsorbidas con sales de aluminio.

Info

Publication number
MX2016012166A
MX2016012166A MX2016012166A MX2016012166A MX2016012166A MX 2016012166 A MX2016012166 A MX 2016012166A MX 2016012166 A MX2016012166 A MX 2016012166A MX 2016012166 A MX2016012166 A MX 2016012166A MX 2016012166 A MX2016012166 A MX 2016012166A
Authority
MX
Mexico
Prior art keywords
aluminum salt
enhancing
methods
adsorbed
mpla
Prior art date
Application number
MX2016012166A
Other languages
English (en)
Inventor
R Alving Carl
H Kim Jerome
Rao Mangala
Original Assignee
The Government Of The Us Secretary Of The Army
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Government Of The Us Secretary Of The Army filed Critical The Government Of The Us Secretary Of The Army
Publication of MX2016012166A publication Critical patent/MX2016012166A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16271—Demonstrated in vivo effect
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

En la presente se proporciona (1) un método para mezclar un inmunógeno adsorbido en sal de aluminio con un liposoma que contiene monofosforil-lípido A (MPLA) (L(MPLA)), y (2) la composición inmunogénica resultante. La composición inmunogénica resultante tiene una potencia mejorada de inmunoestimulación en comparación con ya sea una composición que comprende el inmunológico encapsulado mezclado con el L(MPLA) o el inmunógeno adsorbido en sal de aluminio, solo.
MX2016012166A 2014-03-25 2014-07-09 Metodos para mejorar la potencia de inmunoestimulacion de vacunas adsorbidas con sales de aluminio. MX2016012166A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461969905P 2014-03-25 2014-03-25
PCT/US2014/045940 WO2015147899A1 (en) 2014-03-25 2014-07-09 Methods for enhancing the immunostimulation potency of aluminum salt-adsorbed vaccines

Publications (1)

Publication Number Publication Date
MX2016012166A true MX2016012166A (es) 2017-03-15

Family

ID=51302762

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012166A MX2016012166A (es) 2014-03-25 2014-07-09 Metodos para mejorar la potencia de inmunoestimulacion de vacunas adsorbidas con sales de aluminio.

Country Status (12)

Country Link
US (1) US20170165358A1 (es)
EP (1) EP3122379A1 (es)
JP (1) JP2017509713A (es)
KR (1) KR20170016315A (es)
CN (1) CN106535929A (es)
AU (1) AU2014388299A1 (es)
BR (1) BR112016021692A2 (es)
CA (1) CA2943050A1 (es)
MX (1) MX2016012166A (es)
RU (1) RU2016141621A (es)
SG (2) SG10201808312YA (es)
WO (1) WO2015147899A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3337321A4 (en) 2015-08-19 2019-07-17 President and Fellows of Harvard College LIPIDED PSA COMPOSITIONS AND METHOD
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use
JP7385206B2 (ja) * 2018-12-04 2023-11-22 国立大学法人大阪大学 免疫賦活剤
US20230134067A1 (en) * 2020-07-22 2023-05-04 3H Bio. Co., Ltd. A peptide used for immunotherapeutics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2156525A1 (en) * 1993-02-19 1994-09-01 Susan Dillon Influenza vaccine compositions containing 3-o-deacylated monophosphoryl lipid a
CN1124013A (zh) * 1993-02-19 1996-06-05 史密丝克莱恩比彻姆公司 含3-邻位-脱酰基的单磷酰基脂质a的流感疫苗组合物
ES2162139T5 (es) * 1993-03-23 2008-05-16 Smithkline Beecham Biologicals S.A. Composiciones de vacuna que contienen monofosforil-lipido a 3-o-desacilado.
KR20070110513A (ko) * 2005-02-16 2007-11-19 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 알루미늄 포스페이트 및 3ｄ－ｍｐｌ을 포함하는 보조약조성물
UY31101A1 (es) * 2007-05-24 2009-01-05 Glaxosmithkline Biologicals Sa Composición antigénica liofilizada
CA2794558A1 (en) * 2010-03-26 2011-09-29 Patricia Bourguignon Hiv vaccine

Also Published As

Publication number Publication date
RU2016141621A (ru) 2018-04-25
CN106535929A (zh) 2017-03-22
US20170165358A1 (en) 2017-06-15
BR112016021692A2 (pt) 2017-08-15
RU2016141621A3 (es) 2018-05-11
WO2015147899A1 (en) 2015-10-01
EP3122379A1 (en) 2017-02-01
JP2017509713A (ja) 2017-04-06
SG11201607404PA (en) 2016-10-28
CA2943050A1 (en) 2015-10-01
AU2014388299A1 (en) 2016-10-20
KR20170016315A (ko) 2017-02-13
SG10201808312YA (en) 2018-10-30

Similar Documents

Publication Publication Date Title
EP3416679A4 (en) PATHOGENIC VACCINTS AND METHOD FOR THE PRODUCTION AND USE THEREOF
PH12018500947A1 (en) Crystal form, preparation method and intermediate of dihydropyrido ring compound
EP3484508A4 (en) COMPOSITIONS AND METHODS FOR ALPHAVIRUS VACCINATION
MX2017005855A (es) Particulas de liberacion de prosabor.
SG11202003796XA (en) Zika vaccines and immunogenic compositions, and methods of using the same
EP3413926A4 (en) HIV VACCINATION AND IMMUNOTHERAPY
EP3207142A4 (en) Recombinant listeria vaccine strains and methods of using the same in cancer immunotherapy
SG11201607396WA (en) Non-toxic adjuvant formulation comprising a monophosphoryl lipid a (mpla)-containing liposome composition and a saponin
EP3463450A4 (en) COMPOSITIONS AND METHODS FOR TUMOR VACCINATION WITH PROSTATE CANCER-ASSOCIATED ANTIGENS
MY191539A (en) Streptococcal vaccine
MX2016016746A (es) Composiciones de vacuna con adyuvante dual, preparacion y usos.
EP3717511A4 (en) ZIKA VIRUS VACCINES, IMMUNOGENIC COMPOSITIONS AND THEIR USE PROCEDURES
EP3600396A4 (en) NUCLEIC ACID VACCINE COMPOSITION WITH A LIPID FORMULATION AND METHOD FOR INCREASING THE POTENTIAL OF NUCLEIC ACID VACCINE
HK1255559A1 (zh) Mg53突變體及其製備方法和用途
EP3308800A4 (en) Adjuvant for vaccines, vaccine, and immunity induction method
EP3112351A4 (en) Naphthylamide compound, preparation method and use thereof
MX2022013912A (es) Procedimientos novedosos para inducir una respuesta inmunitaria.
EP3454891A4 (en) EMULSION ADDITIVE FOR INTRAMUSCULAR, INTRADERMAL AND SUBCUTANEOUS ADMINISTRATION
EP3178491A4 (en) Composition for enhancing induction of humoral immunity, and vaccine pharmaceutical composition
MX2016012166A (es) Metodos para mejorar la potencia de inmunoestimulacion de vacunas adsorbidas con sales de aluminio.
EP3357927A4 (en) AEROGEL PROCESSORS, MANUFACTURING METHOD, AEROGEL MANUFACTURED THEREFOR AND AEROGEL PRODUCTION METHOD THEREWITH
EP3543248A4 (en) PHOSPHORESCENT COMPLEX OF PtAg2, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF
EP3241824A4 (en) Trifluoroacethydrazide compound as well as preparation method therefor and application thereof in preparing medicament
EP3730620A4 (en) CROSS-IMMUNIZATION ANTIGENIC VACCINE AND PROCESS FOR PREPARATION
EP3630172A4 (en) COMPOSITIONS AND METHODS FOR TUMOR VACCINATION AND IMMUNOTHERAPY WITH THEIR ANTIGENS