HK1255559A1 - Mg53突變體及其製備方法和用途 - Google Patents

Mg53突變體及其製備方法和用途

Info

Publication number
HK1255559A1
HK1255559A1 HK18114549.7A HK18114549A HK1255559A1 HK 1255559 A1 HK1255559 A1 HK 1255559A1 HK 18114549 A HK18114549 A HK 18114549A HK 1255559 A1 HK1255559 A1 HK 1255559A1
Authority
HK
Hong Kong
Prior art keywords
mutant
preparation
method therefor
therefor
Prior art date
Application number
HK18114549.7A
Other languages
English (en)
Inventor
肖瑞平
呂鳳祥
張岩
郭寺樂
Original Assignee
北京大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201610847346.4A external-priority patent/CN107868125A/zh
Application filed by 北京大學 filed Critical 北京大學
Publication of HK1255559A1 publication Critical patent/HK1255559A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/02—Aminoacyltransferases (2.3.2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK18114549.7A 2016-08-01 2018-11-14 Mg53突變體及其製備方法和用途 HK1255559A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201610621989 2016-08-01
CN201610847346.4A CN107868125A (zh) 2016-09-23 2016-09-23 Mg53突变体及其制备方法和用途
CN201710560975 2017-07-11
PCT/CN2017/093640 WO2018024110A1 (zh) 2016-08-01 2017-07-20 Mg53突变体及其制备方法和用途

Publications (1)

Publication Number Publication Date
HK1255559A1 true HK1255559A1 (zh) 2019-08-23

Family

ID=61073266

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18114549.7A HK1255559A1 (zh) 2016-08-01 2018-11-14 Mg53突變體及其製備方法和用途

Country Status (11)

Country Link
US (1) US11306296B2 (zh)
EP (1) EP3492491A4 (zh)
JP (1) JP7144402B2 (zh)
KR (1) KR102483242B1 (zh)
CN (1) CN108473546B (zh)
CA (1) CA3031856A1 (zh)
HK (1) HK1255559A1 (zh)
MA (1) MA45797A (zh)
SG (1) SG11201900459RA (zh)
TW (1) TWI781948B (zh)
WO (1) WO2018024110A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108478800A (zh) * 2018-04-02 2018-09-04 慎东 含mg53/其突变体的组合物在制备炎症性肠病药物的应用
US20200179482A1 (en) * 2018-12-07 2020-06-11 Ohio State Innovation Foundation Composition for and method of facilitating corneal tissue repair
EP3982999A4 (en) * 2019-06-17 2023-07-19 Trim-Edicine, Inc. COMPOSITION AND METHODS OF TREATMENT OF LIVER TISSUE DAMAGE
CN115379823A (zh) * 2020-01-23 2022-11-22 俄亥俄州立创新基金会 药妆组合物
WO2024002062A1 (en) * 2022-06-28 2024-01-04 Sineugene Therapeutics Co., Ltd. A truncated protein and use thereof
WO2024002059A1 (en) * 2022-06-28 2024-01-04 Sineugene Therapeutics Co., Ltd. Method for treating a parkinson's disease
WO2024002056A1 (en) * 2022-06-28 2024-01-04 Sineugene Therapeutics Co., Ltd. Aav gene therapy for treating a nervous system disease

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703219B1 (en) 1993-02-26 2004-03-09 Immtech International Inc. Mutant protein and methods and materials for making and using it
JP4734251B2 (ja) 2003-10-07 2011-07-27 ユニバーシティ・オブ・オックスフォード チロシナーゼ突然変異体及びその使用方法
US9139630B2 (en) 2006-07-11 2015-09-22 Rutgers, The State University Of New Jersey Compositions and methods for preparing recombinant MG53 and methods for optimizing same
EP2471809B1 (en) 2006-07-11 2015-09-02 University Of Medicine And Dentistry Of New Jersey Proteins, nucleic acids encoding the same and associated methods of use
EP2215126A4 (en) * 2007-12-04 2011-03-23 Univ New Jersey Med COMPOSITIONS AND METHOD FOR MODULATING THE CELL MEMBRANE RE-SEALING
JOP20190083A1 (ar) 2008-06-04 2017-06-16 Amgen Inc بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
CN101797375B (zh) * 2009-12-02 2013-01-23 北京大学 Mg53蛋白预防和/或治疗心脏缺血/再灌损伤的用途
CN101912617B (zh) * 2010-07-29 2012-09-26 北京大学 Mg53基因在治疗胰岛素抵抗和ⅱ型糖尿病及其相关病症中的应用
US8420338B2 (en) 2010-11-05 2013-04-16 University Of Medicine And Dentistry Of New Jersey Serum MG53 as a diagnostic marker for tissue injury
WO2012134478A1 (en) 2011-03-31 2012-10-04 University Of Medicine And Dentistry Of New Jersey Compositions and methods for the treatment and prevention of cardiac ischemic injury
US20140024594A1 (en) 2011-03-31 2014-01-23 Noah Weisleder Compositions and methods for the treatment and prevention of cardiac ischemic injury
CN104066452A (zh) * 2011-09-07 2014-09-24 新泽西医科和牙科大学 治疗和预防气道损伤的含mg53组合物及方法
CN103965342B (zh) * 2013-01-25 2015-06-10 北京博雅和瑞科技有限公司 一种mg53突变体及其突变方法和应用
CN103966227B (zh) 2014-03-06 2015-05-27 北京博雅和瑞科技有限公司 密码子优化的mg53蛋白的编码核苷酸序列、其重组体及其应用
CN107266551B (zh) * 2016-04-06 2021-03-05 牡丹江友搏药业有限责任公司 一种mg53突变体及其制备方法和应用
CN107987147A (zh) * 2016-10-26 2018-05-04 王惠琴 一种mg53多聚体制备方法及其用途
CN108721601A (zh) 2018-07-26 2018-11-02 海南博芝康医疗科技有限公司 一种预防和/或治疗肾损伤和肾衰竭的组合物
CN109528684A (zh) 2018-12-26 2019-03-29 牡丹江友搏药业有限责任公司 一种mg53蛋白/mg53突变体蛋白肠溶胶囊及其制备方法
CN109432404A (zh) 2018-12-26 2019-03-08 牡丹江友搏药业有限责任公司 一种含mg53蛋白/mg53突变体蛋白凝胶及其制备方法和应用

Also Published As

Publication number Publication date
KR102483242B1 (ko) 2022-12-29
US11306296B2 (en) 2022-04-19
CN108473546B (zh) 2022-08-16
JP2019530433A (ja) 2019-10-24
WO2018024110A8 (zh) 2018-11-01
US20190153406A1 (en) 2019-05-23
MA45797A (fr) 2021-04-21
TW201805299A (zh) 2018-02-16
EP3492491A1 (en) 2019-06-05
CN108473546A (zh) 2018-08-31
SG11201900459RA (en) 2019-02-27
CA3031856A1 (en) 2018-02-08
JP7144402B2 (ja) 2022-09-29
EP3492491A4 (en) 2020-02-19
KR20190034278A (ko) 2019-04-01
WO2018024110A1 (zh) 2018-02-08
TWI781948B (zh) 2022-11-01

Similar Documents

Publication Publication Date Title
ZA201804362B (en) Mutant virus, preparation method therefor and application thereof
HK1251551A1 (zh) 氮雜環丁烷衍生物、其製備方法及用途
EP3104865A4 (en) Micro-organoids, and methods of making and using the same
HK1255559A1 (zh) Mg53突變體及其製備方法和用途
EP3246327A4 (en) 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof
EP3412665A4 (en) INTERMEDIATE FOR SUVOREXANT AND PREPARATION METHOD THEREOF
IL252430A0 (en) Antibodies, uses and methods
GB2561629B (en) Methods, Compositions and uses relating thereto
SG11202007554TA (en) Dioxazoline compound, preparation method therefor, and uses thereof
GB2560212B (en) Methods, compositions and uses relating thereto
GB2554485B (en) Methods, compositions and uses relating thereto
EP3424899A4 (en) SACUBITRIL INTERMEDIATE PRODUCT AND MANUFACTURING METHOD THEREFOR
EP3210634A4 (en) Microcarrier adjustment method, microcarrier, and application thereof
GB201603311D0 (en) New uses and methods
EP3112351A4 (en) Naphthylamide compound, preparation method and use thereof
GB201605217D0 (en) New uses and methods
GB2560213C (en) Methods, compositions and uses relating thereto
GB2559644B (en) Methods, compositions and uses relating thereto
GB2559645B (en) Methods, compositions and uses relating thereto
GB201715799D0 (en) Methods, compositions and uses relating thereto
PL3234494T3 (pl) Maszyna do wyrzucania rzutków i sposób jej regulowania
EP3239168A4 (en) Conotoxin peptide -cptx-btl02, preparation method therefor, and uses thereof
EP3239169A4 (en) Conotoxin peptide -cptx-btl05, preparation method therefor, and uses thereof
PT3515899T (pt) Éteres de solketal, método de produção e suas utilizações
GB201616676D0 (en) Methods, compositions and uses relating thereto