AR066676A1 - Composicion antigenica liofilizada que contiene un agonista del receptor tipo toll - Google Patents
Composicion antigenica liofilizada que contiene un agonista del receptor tipo tollInfo
- Publication number
- AR066676A1 AR066676A1 ARP080102167A ARP080102167A AR066676A1 AR 066676 A1 AR066676 A1 AR 066676A1 AR P080102167 A ARP080102167 A AR P080102167A AR P080102167 A ARP080102167 A AR P080102167A AR 066676 A1 AR066676 A1 AR 066676A1
- Authority
- AR
- Argentina
- Prior art keywords
- liofilized
- antigenic
- composition containing
- type receiver
- compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 239000000556 agonist Substances 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 title 1
- 229940123384 Toll-like receptor (TLR) agonist Drugs 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 239000003970 toll like receptor agonist Substances 0.000 abstract 2
- 239000003981 vehicle Substances 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 102000002689 Toll-like receptor Human genes 0.000 abstract 1
- 108020000411 Toll-like receptor Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001152—Transcription factors, e.g. SOX or c-MYC
- A61K39/001153—Wilms tumor 1 [WT1]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Composiciones liofilizadas que comprenden un antígeno y un agonista del receptor de tipo Toll (TLR) 9 que es un oligonucleotido inmunoestimulado. Tales composiciones se pueden reconstituir en composiciones inmunogénicas para uso en vacunacion con unvehículo seleccionado entre el grupo de vehículos particulados constituidos por liposomas, sales minerales, emulsiones, polímeros e ISCOM. Los procedimientos de preparacion de composiciones inmunogénicas a partir de composiciones liofilizadas y usode la misma en la inmunizacion también se proporcionan en el presente documento
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2007/055037 WO2007137986A2 (en) | 2006-05-26 | 2007-05-24 | Vaccination against cancer |
GB0723044A GB0723044D0 (en) | 2007-11-23 | 2007-11-23 | Lyophillised antigen composition |
GB0723900A GB0723900D0 (en) | 2007-12-06 | 2007-12-06 | Lyophillised antigen composition |
Publications (1)
Publication Number | Publication Date |
---|---|
AR066676A1 true AR066676A1 (es) | 2009-09-02 |
Family
ID=39714209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080102167A AR066676A1 (es) | 2007-05-24 | 2008-05-22 | Composicion antigenica liofilizada que contiene un agonista del receptor tipo toll |
Country Status (23)
Country | Link |
---|---|
US (2) | US20090035360A1 (es) |
EP (3) | EP2148697B1 (es) |
JP (1) | JP5331105B2 (es) |
KR (2) | KR101238795B1 (es) |
CN (1) | CN101678091A (es) |
AR (1) | AR066676A1 (es) |
AU (1) | AU2008252911B2 (es) |
BR (1) | BRPI0811228A2 (es) |
CA (1) | CA2687632C (es) |
CL (1) | CL2008001491A1 (es) |
CY (1) | CY1113446T1 (es) |
DK (1) | DK2148697T3 (es) |
EA (3) | EA201300101A1 (es) |
ES (1) | ES2395333T3 (es) |
HR (1) | HRP20121019T1 (es) |
MX (1) | MX2009012381A (es) |
PE (1) | PE20090281A1 (es) |
PL (1) | PL2148697T3 (es) |
PT (1) | PT2148697E (es) |
SI (1) | SI2148697T1 (es) |
TW (1) | TW200911304A (es) |
UY (1) | UY31101A1 (es) |
WO (1) | WO2008142133A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100028415A1 (en) | 2005-04-12 | 2010-02-04 | Haynes Barton F | Method of Inducing Neutralizing Antibodies to Human Immunodeficiency Virus |
WO2007047764A2 (en) | 2005-10-17 | 2007-04-26 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
US9265816B2 (en) | 2006-04-10 | 2016-02-23 | Sloan Kettering Institute For Cancer Research | Immunogenic WT-1 peptides and methods of use thereof |
CA2683752A1 (en) * | 2007-04-13 | 2008-10-23 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
WO2010114628A2 (en) * | 2009-04-03 | 2010-10-07 | Duke University | Formulation for inducing broadly reactive neutralizing anti-hiv antibodies |
GB0910046D0 (en) * | 2009-06-10 | 2009-07-22 | Glaxosmithkline Biolog Sa | Novel compositions |
GB0910045D0 (en) * | 2009-06-10 | 2009-07-22 | Glaxosmithkline Biolog Sa | Novel compositions |
CN103260642B (zh) | 2010-12-14 | 2018-03-16 | 葛兰素史密丝克莱恩生物有限公司 | 分枝杆菌抗原组合物 |
WO2013014105A1 (en) * | 2011-07-22 | 2013-01-31 | Glaxosmithkline Biologicals S.A. | Prame purification |
JP6282598B2 (ja) | 2012-01-13 | 2018-02-21 | メモリアル スローン ケタリング キャンサー センター | 免疫原性wt1ペプチド及びその使用方法 |
CA2898099A1 (en) | 2013-01-15 | 2014-07-24 | David A. Scheinberg | Immunogenic wt-1 peptides and methods of use thereof |
US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
WO2015048635A1 (en) | 2013-09-27 | 2015-04-02 | Duke University | Mper-liposome conjugates and uses thereof |
EA201691348A1 (ru) * | 2013-12-31 | 2016-11-30 | Инфекшес Дизиз Рисерч Инститьют | Однофлаконные вакцинные составы |
WO2015147899A1 (en) * | 2014-03-25 | 2015-10-01 | The Government Of The United States Of America As Represented By The Secretary Of The Army | Methods for enhancing the immunostimulation potency of aluminum salt-adsorbed vaccines |
CA3003483C (en) | 2015-11-06 | 2022-09-13 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
BR112019011286A2 (pt) | 2016-12-07 | 2019-10-15 | Glaxosmithkline Biologicals Sa | métodos para produzir uma composição de lipossoma, para preparar uma composição de vacina e para preparar um kit de vacina. |
EP3697802A4 (en) * | 2017-10-16 | 2021-11-24 | Adjuvance Technologies, Inc. | TRITERPENIC SAPONIN ANALOGUES |
BR112021000529A2 (pt) | 2018-07-19 | 2021-04-06 | Glaxosmithkline Biologicals S.A. | Processos para preparar polissacarídeos secos |
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US6054438A (en) * | 1987-01-07 | 2000-04-25 | Imperial Cancer Research Technology Limited | Nucleic acid fragments encoding portions of the core protein of the human mammary epithelial mucin |
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US4963484A (en) | 1988-01-29 | 1990-10-16 | Dana-Farber Cancer Institute, Inc. | Genetically engineered polypeptides with determinants of the human DF3 breast carcinoma-associated antigen |
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US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
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US5981215A (en) * | 1995-06-06 | 1999-11-09 | Human Genome Sciences, Inc. | Human criptin growth factor |
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EP1017419A4 (en) * | 1997-09-25 | 2004-12-29 | Sloan Kettering Institutefor C | FUCOSYLE GM1-KLH CONJUGATE VACCINE AGAINST SMALL CELL LUNG CANCER |
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NZ513838A (en) | 1999-03-11 | 2003-02-28 | Smithkline Beecham Biolog S | Novel compounds |
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US20030031684A1 (en) | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
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GB0218821D0 (en) * | 2002-08-13 | 2002-09-18 | Glaxosmithkline Biolog Sa | Novel compositions |
CA2511625A1 (en) * | 2002-12-23 | 2004-07-15 | City Of Hope | Modified vaccinia ankara expressing p53 in cancer immunotherapy |
GB0323968D0 (en) | 2003-10-13 | 2003-11-19 | Glaxosmithkline Biolog Sa | Immunogenic compositions |
EP1547581A1 (en) * | 2003-12-23 | 2005-06-29 | Vectron Therapeutics AG | Liposomal vaccine for the treatment of human hematological malignancies |
GB0409940D0 (en) * | 2004-05-04 | 2004-06-09 | Glaxosmithkline Biolog Sa | Vaccine |
GB0411411D0 (en) | 2004-05-21 | 2004-06-23 | Glaxosmithkline Biolog Sa | Vaccines |
EA200700017A1 (ru) * | 2004-06-12 | 2009-06-30 | Ле Сантр Насьональ Де Ля Решерш Сьентифик ( Снрс ) | Способ усиления иммунного ответа на вакцину |
GB0417494D0 (en) | 2004-08-05 | 2004-09-08 | Glaxosmithkline Biolog Sa | Vaccine |
EP1858526A1 (en) | 2005-03-02 | 2007-11-28 | Solbec Pharmaceuticals Limited | Glycoalkaloid and tlr agonist combinations and various uses thereof |
JP5416968B2 (ja) * | 2005-06-17 | 2014-02-12 | マンカインド コーポレイション | 癌細胞及び腫瘍間質上に発現される優勢及び亜優勢エピトープに対する多価免疫応答を誘発するための方法及び組成物 |
-
2008
- 2008-05-22 EP EP08759906A patent/EP2148697B1/en not_active Not-in-force
- 2008-05-22 AU AU2008252911A patent/AU2008252911B2/en not_active Ceased
- 2008-05-22 UY UY31101A patent/UY31101A1/es unknown
- 2008-05-22 PL PL08759906T patent/PL2148697T3/pl unknown
- 2008-05-22 EP EP12157796A patent/EP2476431A1/en not_active Withdrawn
- 2008-05-22 TW TW097119008A patent/TW200911304A/zh unknown
- 2008-05-22 JP JP2010508850A patent/JP5331105B2/ja not_active Expired - Fee Related
- 2008-05-22 ES ES08759906T patent/ES2395333T3/es active Active
- 2008-05-22 CN CN200880017245A patent/CN101678091A/zh active Pending
- 2008-05-22 US US12/125,182 patent/US20090035360A1/en not_active Abandoned
- 2008-05-22 DK DK08759906.4T patent/DK2148697T3/da active
- 2008-05-22 BR BRPI0811228-2A2A patent/BRPI0811228A2/pt not_active IP Right Cessation
- 2008-05-22 PT PT87599064T patent/PT2148697E/pt unknown
- 2008-05-22 SI SI200830836T patent/SI2148697T1/sl unknown
- 2008-05-22 KR KR1020097025005A patent/KR101238795B1/ko not_active IP Right Cessation
- 2008-05-22 PE PE2008000879A patent/PE20090281A1/es not_active Application Discontinuation
- 2008-05-22 EA EA201300101A patent/EA201300101A1/ru unknown
- 2008-05-22 CL CL2008001491A patent/CL2008001491A1/es unknown
- 2008-05-22 AR ARP080102167A patent/AR066676A1/es not_active Application Discontinuation
- 2008-05-22 CA CA2687632A patent/CA2687632C/en not_active Expired - Fee Related
- 2008-05-22 EP EP20120157797 patent/EP2489367A1/en not_active Withdrawn
- 2008-05-22 EA EA200901434A patent/EA018201B1/ru not_active IP Right Cessation
- 2008-05-22 MX MX2009012381A patent/MX2009012381A/es active IP Right Grant
- 2008-05-22 KR KR1020117016237A patent/KR20110091817A/ko not_active Application Discontinuation
- 2008-05-22 EA EA201300102A patent/EA201300102A1/ru unknown
- 2008-05-22 WO PCT/EP2008/056305 patent/WO2008142133A1/en active Application Filing
-
2010
- 2010-11-15 US US12/946,171 patent/US8557247B2/en not_active Expired - Fee Related
-
2012
- 2012-12-10 CY CY20121101196T patent/CY1113446T1/el unknown
- 2012-12-12 HR HRP20121019AT patent/HRP20121019T1/hr unknown
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