EA200801716A1 - Тиазольные соединения и их применение - Google Patents
Тиазольные соединения и их применениеInfo
- Publication number
- EA200801716A1 EA200801716A1 EA200801716A EA200801716A EA200801716A1 EA 200801716 A1 EA200801716 A1 EA 200801716A1 EA 200801716 A EA200801716 A EA 200801716A EA 200801716 A EA200801716 A EA 200801716A EA 200801716 A1 EA200801716 A1 EA 200801716A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- thiazole compounds
- application
- formula
- treatment
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75954606P | 2006-01-18 | 2006-01-18 | |
PCT/US2007/000871 WO2007084391A2 (en) | 2006-01-18 | 2007-01-11 | Thiazole compounds as protein kinase b ( pkb) inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200801716A1 true EA200801716A1 (ru) | 2009-04-28 |
Family
ID=38180602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200801716A EA200801716A1 (ru) | 2006-01-18 | 2007-01-11 | Тиазольные соединения и их применение |
Country Status (21)
Families Citing this family (56)
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LT2445502T (lt) | 2009-06-25 | 2017-09-25 | Alkermes Pharma Ireland Limited | Heterocikliniai junginiai, skirti neurologinių ir fiziologinių susirgimų gydymui |
EA023018B1 (ru) * | 2009-10-08 | 2016-04-29 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Комбинация для лечения рака или предраковых синдромов |
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MY173795A (en) | 2009-11-05 | 2020-02-24 | Incozen Therapeutics Pvt Ltd | Novel benzopyran kinase modulators |
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JP5578705B2 (ja) * | 2010-03-29 | 2014-08-27 | 公益財団法人相模中央化学研究所 | (アリール)ジフルオロ酢酸エステル誘導体及びその製造方法 |
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CA2850166C (en) | 2011-09-27 | 2019-12-03 | Amgen Inc. | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer |
CN103304468A (zh) * | 2012-03-13 | 2013-09-18 | 华东师范大学 | 一种氧化吲哚的一锅法串联合成方法 |
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SI3260455T1 (sl) | 2012-07-04 | 2019-07-31 | Rhizen Pharmaceuticals S.A. | Selektivni inhibitorji PI3K-delta |
MX362896B (es) | 2013-02-19 | 2019-02-22 | Amgen Inc | Cis-morfolinona y otros compuestos como inhibidores de mdm2 para el tratamiento del cáncer. |
KR20150127249A (ko) * | 2013-03-13 | 2015-11-16 | 보스톤 바이오메디칼, 인크. | 암 치료를 위한 암 줄기세포 경로 키나아제의 저해제로서 3-(아릴 또는 헤테로아릴)메틸렌인돌린-2-온 유도체 |
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JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
DK3068393T5 (da) | 2013-11-11 | 2022-08-22 | Amgen Inc | Kombinationsterapi som inkluderer en mdm2-inhibitor og et eller flere yderligere farmaceutisk aktive midler til behandlingen af kræftformer |
ES2789331T3 (es) * | 2015-03-02 | 2020-10-26 | Rigel Pharmaceuticals Inc | Inhibidores de TGF-beta |
US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
EP3426652B1 (en) * | 2016-03-10 | 2021-12-01 | Astrazeneca AB | Novel inhibitors of phosphatidylinositol 3-kinase gamma |
PE20200008A1 (es) | 2017-03-30 | 2020-01-06 | Hoffmann La Roche | Isoquinolinas como inhibidores de hpk1 |
JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
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EP3761983A1 (en) | 2018-03-05 | 2021-01-13 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
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US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法 |
EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
SG11202112855WA (en) | 2019-05-21 | 2021-12-30 | Amgen Inc | Solid state forms |
US20220372018A1 (en) * | 2019-08-02 | 2022-11-24 | Amgen Inc. | Kif18a inhibitors |
WO2021076655A1 (en) | 2019-10-15 | 2021-04-22 | Amgen Inc. | Combination therapy of kras inhibitor and shp2 inhibitor for treatment of cancers |
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CN111603466B (zh) * | 2020-06-29 | 2022-07-22 | 江南大学 | 一种乙酮类化合物在制备治疗肿瘤药物中的应用 |
CN114014787B (zh) * | 2022-01-10 | 2022-03-22 | 苏州开元民生科技股份有限公司 | 一种制备(2s,3r)-对甲砜基苯丝氨酸乙酯的不对称合成方法 |
CN116813608B (zh) * | 2023-06-08 | 2024-03-22 | 英矽智能科技(上海)有限公司 | 噻唑类化合物及其应用 |
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- 2007-01-11 BR BRPI0706621-0A patent/BRPI0706621A2/pt not_active IP Right Cessation
- 2007-01-11 CN CNA2007800097081A patent/CN101421265A/zh active Pending
- 2007-01-11 ES ES07718125T patent/ES2389062T3/es active Active
- 2007-01-11 US US11/652,728 patent/US7514566B2/en active Active
- 2007-01-11 EA EA200801716A patent/EA200801716A1/ru unknown
- 2007-01-11 WO PCT/US2007/000871 patent/WO2007084391A2/en active Application Filing
- 2007-01-11 EP EP07718125A patent/EP1981884B1/en active Active
- 2007-01-11 KR KR1020087019941A patent/KR20080091369A/ko not_active Application Discontinuation
- 2007-01-11 JP JP2008551297A patent/JP5199885B2/ja not_active Expired - Fee Related
- 2007-01-11 MY MYPI20082598A patent/MY149143A/en unknown
- 2007-01-11 AU AU2007207743A patent/AU2007207743B2/en not_active Ceased
- 2007-01-17 TW TW096101796A patent/TW200738657A/zh unknown
- 2007-01-18 UY UY30098A patent/UY30098A1/es not_active Application Discontinuation
- 2007-01-18 AR ARP070100212A patent/AR059064A1/es unknown
- 2007-01-18 PE PE2007000057A patent/PE20071114A1/es not_active Application Discontinuation
- 2007-11-01 UA UAA200810455A patent/UA91895C2/ru unknown
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2008
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- 2008-07-23 ZA ZA200806386A patent/ZA200806386B/xx unknown
- 2008-08-18 CR CR10211A patent/CR10211A/es not_active Application Discontinuation
- 2008-08-18 NO NO20083572A patent/NO20083572L/no not_active Application Discontinuation
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2009
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Also Published As
Publication number | Publication date |
---|---|
PE20071114A1 (es) | 2008-01-10 |
CN101421265A (zh) | 2009-04-29 |
US20070173506A1 (en) | 2007-07-26 |
IL192751A0 (en) | 2009-02-11 |
EP1981884B1 (en) | 2012-06-13 |
AU2007207743B2 (en) | 2010-07-08 |
ZA200806386B (en) | 2009-11-25 |
ES2389062T3 (es) | 2012-10-22 |
US8084479B2 (en) | 2011-12-27 |
JP5199885B2 (ja) | 2013-05-15 |
AU2007207743A1 (en) | 2007-07-26 |
UA91895C2 (en) | 2010-09-10 |
WO2007084391A3 (en) | 2008-03-20 |
AR059064A1 (es) | 2008-03-12 |
EP1981884A2 (en) | 2008-10-22 |
US7514566B2 (en) | 2009-04-07 |
BRPI0706621A2 (pt) | 2011-04-05 |
MY149143A (en) | 2013-07-15 |
CA2636077C (en) | 2012-01-03 |
WO2007084391A2 (en) | 2007-07-26 |
TW200738657A (en) | 2007-10-16 |
UY30098A1 (es) | 2007-10-31 |
NO20083572L (no) | 2008-10-17 |
KR20080091369A (ko) | 2008-10-10 |
CA2636077A1 (en) | 2007-07-26 |
JP2009525960A (ja) | 2009-07-16 |
CR10211A (es) | 2008-10-03 |
US20090270445A1 (en) | 2009-10-29 |
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