EA200800573A1 - Аминоарильные сульфонамидные производные как функциональные 5-нтлиганды - Google Patents

Аминоарильные сульфонамидные производные как функциональные 5-нтлиганды

Info

Publication number
EA200800573A1
EA200800573A1 EA200800573A EA200800573A EA200800573A1 EA 200800573 A1 EA200800573 A1 EA 200800573A1 EA 200800573 A EA200800573 A EA 200800573A EA 200800573 A EA200800573 A EA 200800573A EA 200800573 A1 EA200800573 A1 EA 200800573A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sulphonamide derivatives
ntligands
aminoarryny
functional
receptor
Prior art date
Application number
EA200800573A
Other languages
English (en)
Other versions
EA013875B1 (ru
Inventor
Венката Сатья Нироги Рамакришна
Викас Шрикришна Ширсатх
Рама Састри Камбхампати
Сантош Вишвакарма
Нагарадж Вишвоттам Кандикере
Сринивасулу Кота
Венкатесварлу Джасти
Original Assignee
Сувен Лайф Сайенсиз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сувен Лайф Сайенсиз Лимитед filed Critical Сувен Лайф Сайенсиз Лимитед
Publication of EA200800573A1 publication Critical patent/EA200800573A1/ru
Publication of EA013875B1 publication Critical patent/EA013875B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Insulated Gate Type Field-Effect Transistor (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)

Abstract

Настоящее изобретение предоставляет аминоарильные сульфонамидные производные, отвечающие формуле (I), которые могут использоваться для лечения нарушений ЦНС, связанных с 5-HTрецептором или находящихся под его влиянием. Фармакологический профиль этих соединений включает высокое сродство к связыванию с 5-HTрецептором, наряду с хорошей селективностью по отношению к указанному рецептору. Настоящее изобретение также включает стереоизомеры, соли, методы получения и медицинские препараты, содержащие указанные аминоарильные сульфонамидные производные.
EA200800573A 2005-08-12 2005-10-26 Аминоарильные сульфонамидные производные как функциональные 5-нтлиганды EA013875B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1127CH2005 2005-08-12
PCT/IN2005/000345 WO2007020652A1 (en) 2005-08-12 2005-10-26 Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands.

Publications (2)

Publication Number Publication Date
EA200800573A1 true EA200800573A1 (ru) 2008-08-29
EA013875B1 EA013875B1 (ru) 2010-08-30

Family

ID=36130030

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800573A EA013875B1 (ru) 2005-08-12 2005-10-26 Аминоарильные сульфонамидные производные как функциональные 5-нтлиганды

Country Status (23)

Country Link
US (1) US7998981B2 (ru)
EP (1) EP1919896B1 (ru)
JP (1) JP5091138B2 (ru)
KR (1) KR101016972B1 (ru)
CN (1) CN101258144B (ru)
AT (1) ATE452885T1 (ru)
AU (1) AU2005335620B2 (ru)
BR (1) BRPI0520579B8 (ru)
CA (1) CA2618636C (ru)
CY (1) CY1110276T1 (ru)
DE (1) DE602005018554D1 (ru)
DK (1) DK1919896T3 (ru)
EA (1) EA013875B1 (ru)
ES (1) ES2337167T3 (ru)
HK (1) HK1116796A1 (ru)
MX (1) MX2008002018A (ru)
NO (1) NO340511B1 (ru)
NZ (1) NZ566495A (ru)
PL (1) PL1919896T3 (ru)
PT (1) PT1919896E (ru)
SI (1) SI1919896T1 (ru)
WO (1) WO2007020652A1 (ru)
ZA (1) ZA200801276B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE491685T1 (de) 2007-01-08 2011-01-15 Suven Life Sciences Ltd 5-(heterocyclyl)alkyl-n- (arylsulfonyl)indolverbindungen und ihre verwendung als 5-ht6-liganden
DK2155674T3 (da) * 2007-05-03 2011-09-26 Suven Life Sciences Ltd Aminoalkoxy-aryl-sulfonamidforbindelser og anvendelse heraf som 5-HT6-ligander
BRPI0816571A2 (pt) * 2007-10-26 2015-12-22 Suven Life Sciences Ltd "composto, processo para preparação do composto, composição farmacêutica, agente e método para o tratamento de uma doença ou uma desordem do sistema nervoso central relacionada à ou afetada pelo recptor 5-ht6"
US8318725B2 (en) 2008-09-17 2012-11-27 Suven Life Sciences Limited Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands
JP5628937B2 (ja) * 2010-01-05 2014-11-19 スベン ライフ サイエンシズ リミティド ５−ｈｔ６受容体リガンドとしてのスルホン化合物
CN102153884B (zh) * 2011-02-16 2013-06-19 连云港清泰化工有限公司 一种墨水型染料及其制备方法与用途
WO2015090233A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
AU2015286049B2 (en) 2014-07-08 2018-03-01 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA41297C2 (ru) * 1991-11-25 2001-09-17 Пфайзер, Інк. Производные индола, фармацевтическая композиция и способ лечения
DZ2376A1 (fr) 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
US6316450B1 (en) * 1997-07-11 2001-11-13 Smithkline Beecham P.L.C. Compounds
GB9801392D0 (en) 1998-01-22 1998-03-18 Smithkline Beecham Plc Novel compounds
GB9803411D0 (en) 1998-02-18 1998-04-15 Smithkline Beecham Plc Novel compounds
GB9926302D0 (en) 1999-11-05 2000-01-12 Smithkline Beecham Plc Novel compounds
DE60119982T2 (de) * 2000-12-22 2006-12-21 Wyeth Heterozyklylalkylindole oder -azaindole als 5-hydroxytryptamine-6 liganden
US7342021B2 (en) 2001-02-08 2008-03-11 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
JP2005500345A (ja) * 2001-08-03 2005-01-06 ファルマシア・アンド・アップジョン・カンパニー ５−ｈｔ６受容体親和性を有する５−アリールスルホニルインドール
WO2003065046A2 (en) 2002-02-01 2003-08-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with a new human 5-ht6 receptor
JP2005522432A (ja) 2002-02-05 2005-07-28 グラクソ　グループ　リミテッド ニューロン成長の促進方法
JP4467307B2 (ja) * 2002-02-22 2010-05-26 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ５−ｈｔ受容体アンタゴニストとしてのピリジルスルホン誘導体
WO2003104193A1 (en) 2002-06-05 2003-12-18 F. Hoffmann-La Roche Ag 1-sulfonyl-4-aminoalkoxy indole derivatives as 5-ht6-receptor modulators for the treatment of cns-disorders
PL376479A1 (en) * 2002-10-18 2005-12-27 F.Hoffmann-La Roche Ag 4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity
CA2509982C (en) 2002-11-28 2011-11-08 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
AU2003292508A1 (en) 2002-11-28 2004-06-18 Suven Life Sciences Limited N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands
AU2003285759B2 (en) 2002-11-28 2010-01-28 Suven Life Sciences Limited N-arylsulfonyl-3-aminoalkoxyindoles
NZ540841A (en) 2002-12-18 2008-08-29 Suven Life Sciences Ltd Tetracyclic 3-substituted indoles having serotonin receptor affinity
JP4870562B2 (ja) * 2003-09-12 2012-02-08 メルク セローノ ソシエテ アノニム 糖尿病の治療のためのスルホンアミド誘導体

Also Published As

Publication number Publication date
JP2009504633A (ja) 2009-02-05
ZA200801276B (en) 2009-02-25
ATE452885T1 (de) 2010-01-15
CA2618636C (en) 2011-01-18
CN101258144B (zh) 2012-05-30
NO340511B1 (no) 2017-05-02
BRPI0520579B1 (pt) 2019-08-06
CY1110276T1 (el) 2015-01-14
JP5091138B2 (ja) 2012-12-05
AU2005335620A1 (en) 2007-02-22
BRPI0520579A2 (pt) 2009-11-10
EP1919896A1 (en) 2008-05-14
CN101258144A (zh) 2008-09-03
NO20080705L (no) 2008-05-06
DE602005018554D1 (de) 2010-02-04
PT1919896E (pt) 2010-02-26
KR20080039984A (ko) 2008-05-07
EA013875B1 (ru) 2010-08-30
NZ566495A (en) 2010-06-25
US7998981B2 (en) 2011-08-16
ES2337167T3 (es) 2010-04-21
AU2005335620B2 (en) 2009-12-10
MX2008002018A (es) 2008-03-27
US20100168168A1 (en) 2010-07-01
KR101016972B1 (ko) 2011-02-25
PL1919896T3 (pl) 2010-05-31
DK1919896T3 (da) 2010-04-19
BRPI0520579B8 (pt) 2021-05-25
CA2618636A1 (en) 2007-02-22
EP1919896B1 (en) 2009-12-23
SI1919896T1 (sl) 2010-04-30
HK1116796A1 (en) 2009-01-02
WO2007020652A1 (en) 2007-02-22

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU