EA200800573A1 - Аминоарильные сульфонамидные производные как функциональные 5-нтлиганды - Google Patents

Аминоарильные сульфонамидные производные как функциональные 5-нтлиганды

Info

Publication number
EA200800573A1
EA200800573A1 EA200800573A EA200800573A EA200800573A1 EA 200800573 A1 EA200800573 A1 EA 200800573A1 EA 200800573 A EA200800573 A EA 200800573A EA 200800573 A EA200800573 A EA 200800573A EA 200800573 A1 EA200800573 A1 EA 200800573A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sulphonamide derivatives
ntligands
aminoarryny
functional
receptor
Prior art date
Application number
EA200800573A
Other languages
English (en)
Other versions
EA013875B1 (ru
Inventor
Венката Сатья Нироги Рамакришна
Викас Шрикришна Ширсатх
Рама Састри Камбхампати
Сантош Вишвакарма
Нагарадж Вишвоттам Кандикере
Сринивасулу Кота
Венкатесварлу Джасти
Original Assignee
Сувен Лайф Сайенсиз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сувен Лайф Сайенсиз Лимитед filed Critical Сувен Лайф Сайенсиз Лимитед
Publication of EA200800573A1 publication Critical patent/EA200800573A1/ru
Publication of EA013875B1 publication Critical patent/EA013875B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Insulated Gate Type Field-Effect Transistor (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)

Abstract

Настоящее изобретение предоставляет аминоарильные сульфонамидные производные, отвечающие формуле (I), которые могут использоваться для лечения нарушений ЦНС, связанных с 5-HTрецептором или находящихся под его влиянием. Фармакологический профиль этих соединений включает высокое сродство к связыванию с 5-HTрецептором, наряду с хорошей селективностью по отношению к указанному рецептору. Настоящее изобретение также включает стереоизомеры, соли, методы получения и медицинские препараты, содержащие указанные аминоарильные сульфонамидные производные.
EA200800573A 2005-08-12 2005-10-26 Аминоарильные сульфонамидные производные как функциональные 5-нтлиганды EA013875B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1127CH2005 2005-08-12
PCT/IN2005/000345 WO2007020652A1 (en) 2005-08-12 2005-10-26 Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands.

Publications (2)

Publication Number Publication Date
EA200800573A1 true EA200800573A1 (ru) 2008-08-29
EA013875B1 EA013875B1 (ru) 2010-08-30

Family

ID=36130030

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800573A EA013875B1 (ru) 2005-08-12 2005-10-26 Аминоарильные сульфонамидные производные как функциональные 5-нтлиганды

Country Status (23)

Country Link
US (1) US7998981B2 (ru)
EP (1) EP1919896B1 (ru)
JP (1) JP5091138B2 (ru)
KR (1) KR101016972B1 (ru)
CN (1) CN101258144B (ru)
AT (1) ATE452885T1 (ru)
AU (1) AU2005335620B2 (ru)
BR (1) BRPI0520579B8 (ru)
CA (1) CA2618636C (ru)
CY (1) CY1110276T1 (ru)
DE (1) DE602005018554D1 (ru)
DK (1) DK1919896T3 (ru)
EA (1) EA013875B1 (ru)
ES (1) ES2337167T3 (ru)
HK (1) HK1116796A1 (ru)
MX (1) MX2008002018A (ru)
NO (1) NO340511B1 (ru)
NZ (1) NZ566495A (ru)
PL (1) PL1919896T3 (ru)
PT (1) PT1919896E (ru)
SI (1) SI1919896T1 (ru)
WO (1) WO2007020652A1 (ru)
ZA (1) ZA200801276B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2114878B1 (en) 2007-01-08 2010-12-15 Suven Life Sciences Limited 5-(heterocyclyl)alkyl-n-(arylsulfonyl)indole compounds and their use as 5-ht6 ligands
CA2683124C (en) 2007-05-03 2012-09-25 Suven Life Sciences Limited Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands
JP5236001B2 (ja) * 2007-10-26 2013-07-17 スヴェン・ライフ・サイエンシズ・リミテッド アミノアリールスルホンアミド化合物および５−ｈｔ６リガンドとしてのその使用
WO2010032257A1 (en) * 2008-09-17 2010-03-25 Suven Life Sciences Limited Aryl indolyl sulfonamide compounds and their use as 5-ht6 ligands
NZ601284A (en) * 2010-01-05 2014-03-28 Suven Life Sciences Ltd Sulfone compounds as 5-ht6 receptor ligands
CN102153884B (zh) * 2011-02-16 2013-06-19 连云港清泰化工有限公司 一种墨水型染料及其制备方法与用途
CN104725295B (zh) 2013-12-20 2019-05-24 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
SG11201610407QA (en) 2014-07-08 2017-01-27 Sunshine Lake Pharma Co Ltd Aromatic heterocyclic derivatives and pharmaceutical applications thereof

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KR0184911B1 (ko) * 1991-11-25 1999-05-01 알렌 제이. 스피겔 인돌유도체
DZ2376A1 (fr) 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
HUP0003073A3 (en) * 1997-07-11 2002-10-28 Smithkline Beecham Plc Benzenesulfonamide derivatives, process for producing them and their use as medicines
GB9801392D0 (en) 1998-01-22 1998-03-18 Smithkline Beecham Plc Novel compounds
GB9803411D0 (en) 1998-02-18 1998-04-15 Smithkline Beecham Plc Novel compounds
GB9926302D0 (en) 1999-11-05 2000-01-12 Smithkline Beecham Plc Novel compounds
BR0116481A (pt) * 2000-12-22 2004-01-06 Wyeth Corp Compostos de heterociclilalquilindol ou azaindol como ligandos de 5-hidroxitriptamina-6
WO2002098878A1 (en) 2001-02-08 2002-12-12 Memory Pharmaceuticals Corporation Trifluoromethylpurines as phosphodiesterase 4 inhibitors
WO2003011284A1 (en) * 2001-08-03 2003-02-13 Pharmacia & Upjohn Company 5-arylsulfonyl indoles having 5-ht6 receptor affinity
JP2005528587A (ja) 2002-02-01 2005-09-22 バイエル・ヘルスケア・アクチェンゲゼルシャフト 新規ヒト５−ｈｔ６受容体に関連する疾患のための診断用および治療用物質
EP1471912A1 (en) 2002-02-05 2004-11-03 Glaxo Group Limited Method of promoting neuronal growth
WO2003072548A1 (en) 2002-02-22 2003-09-04 Pharmacia & Upjohn Company Pyridyl sulfone derivatives as 5-ht receptor antagonists
EP1513809A1 (en) 2002-06-05 2005-03-16 F. Hoffmann-La Roche Ag 1-sulfonyl-4-aminoalkoxy indole derivatives as 5-ht6-receptor modulators for the treatment of cns-disorders
ES2274285T3 (es) 2002-10-18 2007-05-16 F. Hoffmann-La Roche Ag 4-piperanzinilbencenosulfonilindoles con afinidad al receptor 5-ht6.
KR100776118B1 (ko) 2002-11-28 2007-11-15 수벤 라이프 사이언시스 리미티드 엔-아릴술포닐-3-아미노알콕시인돌
ES2310243T3 (es) 2002-11-28 2009-01-01 Suven Life Sciences Limited Indoles n-aril-3-sulfonil sustituidos que tienen afinidad por receptores de serotonina, proceso para su preparacion y composicion farmaceutica que los contiene.
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JP4571507B2 (ja) 2002-12-18 2010-10-27 スベン ライフ サイエンシズ リミティド セロトニン受容体親和性を有する四環系３−置換インドール
EP1663193B1 (en) * 2003-09-12 2012-04-04 Merck Serono SA Sulfonamide derivatives for the treatment of diabetes

Also Published As

Publication number Publication date
ES2337167T3 (es) 2010-04-21
CA2618636C (en) 2011-01-18
US20100168168A1 (en) 2010-07-01
ATE452885T1 (de) 2010-01-15
AU2005335620A1 (en) 2007-02-22
KR101016972B1 (ko) 2011-02-25
EP1919896A1 (en) 2008-05-14
BRPI0520579B8 (pt) 2021-05-25
SI1919896T1 (sl) 2010-04-30
NZ566495A (en) 2010-06-25
MX2008002018A (es) 2008-03-27
AU2005335620B2 (en) 2009-12-10
BRPI0520579A2 (pt) 2009-11-10
CN101258144A (zh) 2008-09-03
HK1116796A1 (en) 2009-01-02
EA013875B1 (ru) 2010-08-30
WO2007020652A1 (en) 2007-02-22
PL1919896T3 (pl) 2010-05-31
US7998981B2 (en) 2011-08-16
CY1110276T1 (el) 2015-01-14
JP5091138B2 (ja) 2012-12-05
ZA200801276B (en) 2009-02-25
EP1919896B1 (en) 2009-12-23
BRPI0520579B1 (pt) 2019-08-06
KR20080039984A (ko) 2008-05-07
JP2009504633A (ja) 2009-02-05
NO340511B1 (no) 2017-05-02
CA2618636A1 (en) 2007-02-22
PT1919896E (pt) 2010-02-26
DE602005018554D1 (de) 2010-02-04
DK1919896T3 (da) 2010-04-19
NO20080705L (no) 2008-05-06
CN101258144B (zh) 2012-05-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU