CY1110276T1 - Αμινοαρυλο σουλφοναμιδικα παραγωγα ως λειτουργικοι συνδετες 5-ητ6 - Google Patents

Αμινοαρυλο σουλφοναμιδικα παραγωγα ως λειτουργικοι συνδετες 5-ητ6

Info

Publication number
CY1110276T1
CY1110276T1 CY20101100110T CY101100110T CY1110276T1 CY 1110276 T1 CY1110276 T1 CY 1110276T1 CY 20101100110 T CY20101100110 T CY 20101100110T CY 101100110 T CY101100110 T CY 101100110T CY 1110276 T1 CY1110276 T1 CY 1110276T1
Authority
CY
Cyprus
Prior art keywords
aminaroul
sulfonamid
products
receptor
functional connectors
Prior art date
Application number
CY20101100110T
Other languages
English (en)
Inventor
Venkata Satya Nirogi Ramakrishna
Vikas Shreekrishna Shirsath
Rama Sastri Kambhampati
Santosh Vishwakarma
Nagaraj Vishwottam Kandikere
Srinivasulu Kota
Venkateswarlu Jasti
Original Assignee
Suven Life Sciences Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Limited filed Critical Suven Life Sciences Limited
Publication of CY1110276T1 publication Critical patent/CY1110276T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Insulated Gate Type Field-Effect Transistor (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει αμινοαρυλο σουλφοναμιδικά παράγωγα του τύπου (I), χρήσιμα για τη θεραπεία μιας διαταραχής του ΚΝΣ που σχετίζεται με ή επηρεάζεται από τον υποδοχέα 5-HTg. Το φαρμακολογικό προφίλ αυτών των ενώσεων περιλαμβάνει σύνδεση υψηλής συγγένειας με τον υποδοχέα 5-HTg μαζί με καλή εκλεκτικότητα έναντι του υποδοχέα αυτού. Η παρούσα εφεύρεση επίσης περιλαμβάνει τα στερεοϊσομερή, τα άλατα, μεθόδους παρασκευής και φάρμακα που περιέχουν αυτά τα αμινοαρυλο σουλφοναμιδικά παράγωγα.
CY20101100110T 2005-08-12 2010-02-04 Αμινοαρυλο σουλφοναμιδικα παραγωγα ως λειτουργικοι συνδετες 5-ητ6 CY1110276T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1127CH2005 2005-08-12
EP05813800A EP1919896B1 (en) 2005-08-12 2005-10-26 Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands.

Publications (1)

Publication Number Publication Date
CY1110276T1 true CY1110276T1 (el) 2015-01-14

Family

ID=36130030

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100110T CY1110276T1 (el) 2005-08-12 2010-02-04 Αμινοαρυλο σουλφοναμιδικα παραγωγα ως λειτουργικοι συνδετες 5-ητ6

Country Status (23)

Country Link
US (1) US7998981B2 (el)
EP (1) EP1919896B1 (el)
JP (1) JP5091138B2 (el)
KR (1) KR101016972B1 (el)
CN (1) CN101258144B (el)
AT (1) ATE452885T1 (el)
AU (1) AU2005335620B2 (el)
BR (1) BRPI0520579B8 (el)
CA (1) CA2618636C (el)
CY (1) CY1110276T1 (el)
DE (1) DE602005018554D1 (el)
DK (1) DK1919896T3 (el)
EA (1) EA013875B1 (el)
ES (1) ES2337167T3 (el)
HK (1) HK1116796A1 (el)
MX (1) MX2008002018A (el)
NO (1) NO340511B1 (el)
NZ (1) NZ566495A (el)
PL (1) PL1919896T3 (el)
PT (1) PT1919896E (el)
SI (1) SI1919896T1 (el)
WO (1) WO2007020652A1 (el)
ZA (1) ZA200801276B (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8470830B2 (en) 2007-01-08 2013-06-25 Suven Life Sciences Limited 5-(heterocyclyl)alkyl-N-(arylsulfonyl)indole compounds and their use as 5-HT6 ligands
ATE513810T1 (de) * 2007-05-03 2011-07-15 Suven Life Sciences Ltd Aminoalkoxy-aryl-sulfonamidverbindungen und ihre verwendung als 5-ht6-liganden
EA017154B1 (ru) * 2007-10-26 2012-10-30 Сувен Лайф Сайенсиз Лимитед Аминоарилсульфонамидные соединения и их применение в качестве 5-нтлигандов
WO2010032257A1 (en) * 2008-09-17 2010-03-25 Suven Life Sciences Limited Aryl indolyl sulfonamide compounds and their use as 5-ht6 ligands
DK2521714T3 (en) * 2010-01-05 2015-10-19 Suven Life Sciences Ltd Aromatic sulfone compositions useful in the treatment of central nervous disorders
CN102153884B (zh) * 2011-02-16 2013-06-19 连云港清泰化工有限公司 一种墨水型染料及其制备方法与用途
JP6454346B2 (ja) 2013-12-20 2019-01-16 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 芳香族複素環式化合物及び医薬におけるその応用
JP6515175B2 (ja) 2014-07-08 2019-05-15 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 芳香族ヘテロ環誘導体及びその医薬的適用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2143992T3 (es) * 1991-11-25 2000-06-01 Pfizer Derivados de 5-(hetero- o carbociclilamino)-indol, su preparacion y uso como 5-ht1 agonistas.
DZ2376A1 (fr) 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
EP0994862B1 (en) * 1997-07-11 2005-06-01 SmithKline Beecham plc Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation
GB9801392D0 (en) 1998-01-22 1998-03-18 Smithkline Beecham Plc Novel compounds
GB9803411D0 (en) 1998-02-18 1998-04-15 Smithkline Beecham Plc Novel compounds
GB9926302D0 (en) 1999-11-05 2000-01-12 Smithkline Beecham Plc Novel compounds
CN1492863A (zh) * 2000-12-22 2004-04-28 作为5-羟色胺-6配基的杂环基烷基-吲哚或氮杂吲哚化合物
BR0207302A (pt) 2001-02-08 2004-02-10 Memory Pharm Corp Trifluorometilpurinas como inibidores da fosfodiesterase 4
MXPA04001089A (es) * 2001-08-03 2004-05-20 Upjohn Co 5-arilsulfonil indoles que tienen afinidad por el receptor de 5-ht.
EP1472544A2 (en) 2002-02-01 2004-11-03 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with a new human 5-ht6 receptor
WO2003066056A1 (en) 2002-02-05 2003-08-14 Glaxo Group Limited Method of promoting neuronal growth
MXPA04008097A (es) 2002-02-22 2004-11-26 Upjohn Co Derivados de piridilsulfona como antagonistas del receptor 5-ht.
CN1293053C (zh) * 2002-06-05 2007-01-03 弗·哈夫曼-拉罗切有限公司 作为5－ht6－受体调节剂用于治疗cns－病症的1－磺酰基－4－氨基烷氧基吲哚衍生物
KR20050073560A (ko) * 2002-10-18 2005-07-14 에프. 호프만-라 로슈 아게 5-ｈｔ6 수용체 친화성을 갖는 4-피페라진일 벤젠설폰일인돌
AU2003285759B2 (en) 2002-11-28 2010-01-28 Suven Life Sciences Limited N-arylsulfonyl-3-aminoalkoxyindoles
WO2004048331A1 (en) 2002-11-28 2004-06-10 Suven Life Sciences Limited N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands
KR100818508B1 (ko) 2002-11-28 2008-03-31 수벤 라이프 사이언시스 리미티드 세로토닌 수용체 친화력을 가지는 엔-아릴술포닐-3-치환인돌, 그 제조방법 및 그를 포함하는 약제학적 조성물
PT1581538E (pt) 2002-12-18 2007-05-31 Suven Life Sciences Ltd Indolos tetracíclicos substituidos na posição 3 que possuem afinidade pelo receptor de serotonina.
ES2385219T3 (es) * 2003-09-12 2012-07-19 Merck Serono Sa Derivados de sulfonamida para el tratamiento de diabetes

Also Published As

Publication number Publication date
US7998981B2 (en) 2011-08-16
CA2618636A1 (en) 2007-02-22
NO20080705L (no) 2008-05-06
AU2005335620A1 (en) 2007-02-22
ATE452885T1 (de) 2010-01-15
PL1919896T3 (pl) 2010-05-31
HK1116796A1 (en) 2009-01-02
US20100168168A1 (en) 2010-07-01
CA2618636C (en) 2011-01-18
BRPI0520579B8 (pt) 2021-05-25
BRPI0520579B1 (pt) 2019-08-06
EA013875B1 (ru) 2010-08-30
SI1919896T1 (sl) 2010-04-30
BRPI0520579A2 (pt) 2009-11-10
CN101258144A (zh) 2008-09-03
EP1919896A1 (en) 2008-05-14
DK1919896T3 (da) 2010-04-19
NO340511B1 (no) 2017-05-02
ZA200801276B (en) 2009-02-25
PT1919896E (pt) 2010-02-26
WO2007020652A1 (en) 2007-02-22
EA200800573A1 (ru) 2008-08-29
EP1919896B1 (en) 2009-12-23
CN101258144B (zh) 2012-05-30
JP2009504633A (ja) 2009-02-05
KR20080039984A (ko) 2008-05-07
DE602005018554D1 (de) 2010-02-04
MX2008002018A (es) 2008-03-27
AU2005335620B2 (en) 2009-12-10
NZ566495A (en) 2010-06-25
KR101016972B1 (ko) 2011-02-25
ES2337167T3 (es) 2010-04-21
JP5091138B2 (ja) 2012-12-05

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