EA200702110A1 - Ингибитор bcrp/abcg2 - Google Patents

Ингибитор bcrp/abcg2

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Publication number
EA200702110A1
EA200702110A1 EA200702110A EA200702110A EA200702110A1 EA 200702110 A1 EA200702110 A1 EA 200702110A1 EA 200702110 A EA200702110 A EA 200702110A EA 200702110 A EA200702110 A EA 200702110A EA 200702110 A1 EA200702110 A1 EA 200702110A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bcrp
inhibitor
formulas
group selected
groups represented
Prior art date
Application number
EA200702110A
Other languages
English (en)
Other versions
EA014555B1 (ru
Inventor
Йукико Нисияма
Риута Ямазаки
Томио Фурута
Такеси Мацузаки
Хироси Хатано
Ох Йосида
Масато Нагаока
Рицуо Аийама
Сусуке Хасимото
Йосиказу Сугимото
Original Assignee
Кабусики Кайся Якулт Хонса
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кабусики Кайся Якулт Хонса filed Critical Кабусики Кайся Якулт Хонса
Publication of EA200702110A1 publication Critical patent/EA200702110A1/ru
Publication of EA014555B1 publication Critical patent/EA014555B1/ru

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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
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    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
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    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4409Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

Настоящее изобретение относится к ингибитору белка, определяющего резистентность при лечении рака молочной железы (BCRP/ABCG2). Ингибитор BCRP содержит в качестве активного ингредиента производное акрилонитрила, представленное формулой (I)где один из Rи Rозначает цианогруппу и другой означает атом водорода;Arозначает группу, выбранную из групп, представленных формулами (2)-(4):и Arозначает ароматическую углеводородную группу, содержащую конденсированное кольцо, которое может быть замещено атомом галогена или группой, выбранной из групп, представленных формулами (5)-(15):или его соль.
EA200702110A 2005-03-30 2006-03-29 Ингибитор bcrp/abcg2 EA014555B1 (ru)

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CN101166719B (zh) 2012-11-07
CA2602467A1 (en) 2006-10-12
EP2332905B1 (en) 2017-03-01
NO20074718L (no) 2007-12-18
AU2006232435B8 (en) 2011-09-15
IL185996A (en) 2014-02-27
TWI421071B (zh) 2014-01-01
HK1120258A1 (en) 2009-03-27
NO343883B1 (no) 2019-07-01
US8697742B2 (en) 2014-04-15
AU2006232435A1 (en) 2006-10-12
KR20080006543A (ko) 2008-01-16
MX2007012177A (es) 2007-11-21
CA2602467C (en) 2014-09-02
JP5009151B2 (ja) 2012-08-22
KR101424997B1 (ko) 2014-07-31
UA105162C2 (ru) 2014-04-25
US20090253656A1 (en) 2009-10-08
WO2006106778A1 (ja) 2006-10-12
EP2332905A1 (en) 2011-06-15
CN101166719A (zh) 2008-04-23
JPWO2006106778A1 (ja) 2008-09-11
AU2006232435B2 (en) 2011-08-25

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