ZA200708786B - BCRP/ABCG2 inhibitor - Google Patents

BCRP/ABCG2 inhibitor

Info

Publication number
ZA200708786B
ZA200708786B ZA200708786A ZA200708786A ZA200708786B ZA 200708786 B ZA200708786 B ZA 200708786B ZA 200708786 A ZA200708786 A ZA 200708786A ZA 200708786 A ZA200708786 A ZA 200708786A ZA 200708786 B ZA200708786 B ZA 200708786B
Authority
ZA
South Africa
Prior art keywords
bcrp
abcg2 inhibitor
abcg2
inhibitor
Prior art date
Application number
ZA200708786A
Other languages
English (en)
Inventor
Yamazaki Ryuta
Nishiyama Yukiko
Furuta Tomio
Matsuzaki Takeshi
Hatano Hiroshi
Yoshida Oh
Nagaoka Masato
Aiyama Ritsuo
Hashimoto Shusuke
Sugimoto Yoshikazu
Original Assignee
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk
Publication of ZA200708786B publication Critical patent/ZA200708786B/xx

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
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    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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MX352516B (es) 2006-07-05 2017-04-06 Fibrotech Therapeutics Pty Ltd Compuestos terapeuticos.
US9114102B2 (en) 2007-11-07 2015-08-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method of inhibiting ABCG2 and related treatments
TW200927107A (en) * 2007-12-03 2009-07-01 Yakult Honsha Kk ABCG2 inhibitor
US8470888B2 (en) 2008-01-03 2013-06-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Botryllamides and method of inhibiting PGP in a mammal afflicted with cancer
US20110124888A1 (en) * 2008-06-12 2011-05-26 Korea Institute Of Science And Technology Styrylbenzofuran derivatives as inhibitors for beta-amyloid fibril formation and preparation method thereof
JP5904944B2 (ja) * 2009-10-22 2016-04-20 フィブロテック セラピューティクス プロプライエタリー リミテッド 縮合環類似体の抗線維症剤
CN101696183B (zh) * 2009-10-27 2012-11-28 杭州新瑞佳生物医药技术开发有限公司 (z)-2-苯基-3-(吡咯-2-基)-丙烯腈衍生物及其盐、组合物以及制备方法和用途
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WO2012116135A2 (en) * 2011-02-24 2012-08-30 Emory University Noggin blocking compositions for ossification and methods related thereto
WO2013043529A1 (en) 2011-09-19 2013-03-28 Emory University Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto
CA2895392A1 (en) 2012-12-28 2014-07-03 The Board Of Trustees Of The University Of Arkansas Indole compounds for use in treating inflammation and cancer
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US11014873B2 (en) 2017-02-03 2021-05-25 Certa Therapeutics Pty Ltd. Anti-fibrotic compounds
KR102639296B1 (ko) * 2017-08-10 2024-02-21 삼성전자주식회사 화합물, 및 이를 포함하는 유기 광전 소자, 이미지 센서 및 전자 장치
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Family Cites Families (11)

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AU658567B2 (en) * 1990-04-16 1995-04-27 Rhone-Poulenc Rorer International (Holdings) Inc. Styryl-substituted indole and pyridyl compounds
AU669279B2 (en) * 1993-03-10 1996-05-30 Morinaga Milk Industry Company Limited Stilbene derivative and stilbene analog derivative, and use thereof
JP3180127B2 (ja) * 1993-03-10 2001-06-25 森永乳業株式会社 スチルベン誘導体とスチルベン同族体誘導体及びそれらの用途
JP3144662B2 (ja) 1993-08-05 2001-03-12 森永乳業株式会社 スチルベン誘導体とスチルベン同族体誘導体及びそれらの用途
US5424315A (en) * 1993-08-02 1995-06-13 Sri International Benzothiophen analogs as antiviral agents
US5710164A (en) * 1995-06-06 1998-01-20 American Home Products Corporation Diheterocyclic styryl nitriles
DE69918950T2 (de) 1998-02-06 2005-07-28 De Montfort University Durch hydroxylierung aktivierte medikamentvorstufen
US20030125265A1 (en) * 2001-05-09 2003-07-03 Mien-Chie Hung Anti-estrogen receptor agents for chemotherapy
JP4824223B2 (ja) 2001-08-23 2011-11-30 公益財団法人がん研究会 抗癌剤耐性克服剤
KR20050096954A (ko) 2003-02-04 2005-10-06 가부시키가이샤 야쿠루트 혼샤 유방암 내성 단백 저해제
US20060135445A1 (en) 2003-02-04 2006-06-22 Kabushiki Kaisha Yakult Honsha Breast cancer-resistant protein inhibitor

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UA105162C2 (ru) 2014-04-25
HK1120258A1 (en) 2009-03-27
JP5009151B2 (ja) 2012-08-22
US20090253656A1 (en) 2009-10-08
NO20074718L (no) 2007-12-18
IL185996A0 (en) 2008-01-20
KR101424997B1 (ko) 2014-07-31
AU2006232435B8 (en) 2011-09-15
AU2006232435B2 (en) 2011-08-25
JPWO2006106778A1 (ja) 2008-09-11
CA2602467C (en) 2014-09-02
BRPI0609420A2 (pt) 2010-03-30
EA200702110A1 (ru) 2008-02-28
TWI421071B (zh) 2014-01-01
WO2006106778A1 (ja) 2006-10-12
EP1864972A1 (en) 2007-12-12
AU2006232435A1 (en) 2006-10-12
EP1864972A4 (en) 2009-11-11
EP2332905B1 (en) 2017-03-01
MX2007012177A (es) 2007-11-21
NZ562143A (en) 2010-12-24
CN101166719B (zh) 2012-11-07
US8697742B2 (en) 2014-04-15
EA014555B1 (ru) 2010-12-30
NO343883B1 (no) 2019-07-01
KR20080006543A (ko) 2008-01-16
CA2602467A1 (en) 2006-10-12
TW200716089A (en) 2007-05-01
IL185996A (en) 2014-02-27
CN101166719A (zh) 2008-04-23
EP2332905A1 (en) 2011-06-15

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