UA105162C2 - Производное акрилонитрила и его применение как ингибитора bcrp/abcg2 - Google Patents

Производное акрилонитрила и его применение как ингибитора bcrp/abcg2 Download PDF

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Publication number
UA105162C2
UA105162C2 UAA200711923A UAA200711923A UA105162C2 UA 105162 C2 UA105162 C2 UA 105162C2 UA A200711923 A UAA200711923 A UA A200711923A UA A200711923 A UAA200711923 A UA A200711923A UA 105162 C2 UA105162 C2 UA 105162C2
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Ukraine
Prior art keywords
group
dimethoxyphenyl
acrylonitrile
compound
alkyl
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UAA200711923A
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English (en)
Ukrainian (uk)
Inventor
Йукико Нисияма
Риута Ямазаки
Томио Фурута
Такеси Мацузаки
Хироси Хатано
Ох Йосида
Масато Нагаока
Рицуо Аийама
Сусуке Хасимото
Йосиказу Сугимото
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Кабусики Кайся Якулт Хонса
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Publication of UA105162C2 publication Critical patent/UA105162C2/ru

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

Описан ингибитор белка, который определяет резистентность при раке молочной железы (BCRP/ABCG2).Ингибитор BCRP включает как активный ингредиент производное акрилонитрила, представленное общей формулой (1), или его соль: (1) (Е или Z), где один из Rи Rозначает цианогруппу, и другой означает атом водорода; Arозначает группу, выбранную из групп, представленных формулами (2)-(4), приведенными ниже; и Arозначает ароматическую углеводную группу, которая содержит конденсированное кольцо, необязательно замещенное атомом галогена или группой, выбранной из групп, представленных формулами (5)-(15), приведенными ниже.(Е или Z),
UAA200711923A 2005-03-30 2006-03-29 Производное акрилонитрила и его применение как ингибитора bcrp/abcg2 UA105162C2 (ru)

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TWI510241B (zh) 2010-02-18 2015-12-01 Vtv Therapeutice Llc 苯基－雜芳基衍生物及其使用方法
WO2012116135A2 (en) * 2011-02-24 2012-08-30 Emory University Noggin blocking compositions for ossification and methods related thereto
WO2013043529A1 (en) 2011-09-19 2013-03-28 Emory University Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto
CA2895392A1 (en) 2012-12-28 2014-07-03 The Board Of Trustees Of The University Of Arkansas Indole compounds for use in treating inflammation and cancer
AU2014254078A1 (en) 2013-04-19 2015-10-15 Bioventures, Llc Combretastatin analogs
CA2940694A1 (en) 2014-03-31 2015-10-08 Board Of Trustees Of The University Of Arkansas Disubstituted triazole analogs
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KR102639296B1 (ko) * 2017-08-10 2024-02-21 삼성전자주식회사 화합물, 및 이를 포함하는 유기 광전 소자, 이미지 센서 및 전자 장치
FR3099156B1 (fr) * 2019-07-25 2022-01-28 Univ Grenoble Alpes Inhibiteurs selectifs du transporteur bcrp/abcg2 utilises comme agents pour abolir la resistance aux anticancereux
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CA2602467C (en) 2014-09-02
BRPI0609420A2 (pt) 2010-03-30
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