UA105162C2 - Производное акрилонитрила и его применение как ингибитора bcrp/abcg2 - Google Patents

Производное акрилонитрила и его применение как ингибитора bcrp/abcg2 Download PDF

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UA105162C2
UA105162C2 UAA200711923A UAA200711923A UA105162C2 UA 105162 C2 UA105162 C2 UA 105162C2 UA A200711923 A UAA200711923 A UA A200711923A UA A200711923 A UAA200711923 A UA A200711923A UA 105162 C2 UA105162 C2 UA 105162C2
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Ukraine
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group
dimethoxyphenyl
acrylonitrile
compound
alkyl
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UAA200711923A
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English (en)
Ukrainian (uk)
Inventor
Йукико Нисияма
Риута Ямазаки
Томио Фурута
Такеси Мацузаки
Хироси Хатано
Ох Йосида
Масато Нагаока
Рицуо Аийама
Сусуке Хасимото
Йосиказу Сугимото
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Кабусики Кайся Якулт Хонса
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Publication of UA105162C2 publication Critical patent/UA105162C2/ru

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    • C07C255/32Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
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Abstract

Описан ингибитор белка, который определяет резистентность при раке молочной железы (BCRP/ABCG2).Ингибитор BCRP включает как активный ингредиент производное акрилонитрила, представленное общей формулой (1), или его соль: (1) (Е или Z), где один из Rи Rозначает цианогруппу, и другой означает атом водорода; Arозначает группу, выбранную из групп, представленных формулами (2)-(4), приведенными ниже; и Arозначает ароматическую углеводную группу, которая содержит конденсированное кольцо, необязательно замещенное атомом галогена или группой, выбранной из групп, представленных формулами (5)-(15), приведенными ниже.(Е или Z),
UAA200711923A 2005-03-30 2006-03-29 Производное акрилонитрила и его применение как ингибитора bcrp/abcg2 UA105162C2 (ru)

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US20090253656A1 (en) 2009-10-08
NO20074718L (no) 2007-12-18
IL185996A0 (en) 2008-01-20
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AU2006232435B8 (en) 2011-09-15
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JPWO2006106778A1 (ja) 2008-09-11
CA2602467C (en) 2014-09-02
BRPI0609420A2 (pt) 2010-03-30
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AU2006232435A1 (en) 2006-10-12
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US8697742B2 (en) 2014-04-15
EA014555B1 (ru) 2010-12-30
NO343883B1 (no) 2019-07-01
KR20080006543A (ko) 2008-01-16
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