EA200701355A1 - ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ - Google Patents

ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ

Info

Publication number
EA200701355A1
EA200701355A1 EA200701355A EA200701355A EA200701355A1 EA 200701355 A1 EA200701355 A1 EA 200701355A1 EA 200701355 A EA200701355 A EA 200701355A EA 200701355 A EA200701355 A EA 200701355A EA 200701355 A1 EA200701355 A1 EA 200701355A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tricyclic
modulators
opioid
opioid modulators
pharmaceutical
Prior art date
Application number
EA200701355A
Other languages
English (en)
Other versions
EA011674B1 (ru
Inventor
Стивен Дж. Коутс
Скотт Л. Дакс
Барт Декорт
Ли Лю
Марк Макдоннелл
Джеймс Дж. Макналли
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200701355A1 publication Critical patent/EA200701355A1/ru
Publication of EA011674B1 publication Critical patent/EA011674B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Electroluminescent Light Sources (AREA)
  • Lock And Its Accessories (AREA)
  • Credit Cards Or The Like (AREA)
  • Semiconductor Lasers (AREA)
  • Oscillators With Electromechanical Resonators (AREA)

Abstract

Изобретение относится к модуляторам дельта-опиоидных рецепторов. Более конкретно, изобретение относится к трициклическим δ-опиоидным модуляторам. Также описаны фармацевтические и ветеринарные композиции и способы лечения боли, от слабой до сильной, и различных заболеваний с помощью соединений по изобретению.
EA200701355A 2004-12-22 2005-12-21 ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ EA011674B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63831504P 2004-12-22 2004-12-22
PCT/US2005/046691 WO2006069276A2 (en) 2004-12-22 2005-12-21 TRICYCLIC ō-OPIOID MODULATORS

Publications (2)

Publication Number Publication Date
EA200701355A1 true EA200701355A1 (ru) 2008-02-28
EA011674B1 EA011674B1 (ru) 2009-04-28

Family

ID=36481352

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701355A EA011674B1 (ru) 2004-12-22 2005-12-21 ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ

Country Status (17)

Country Link
US (3) US7439239B2 (ru)
EP (1) EP1833826B1 (ru)
JP (1) JP2008525482A (ru)
KR (1) KR20070092293A (ru)
CN (1) CN101115751A (ru)
AT (1) ATE432279T1 (ru)
AU (1) AU2005319060A1 (ru)
BR (1) BRPI0518563A2 (ru)
CA (1) CA2591963A1 (ru)
DE (1) DE602005014671D1 (ru)
EA (1) EA011674B1 (ru)
IL (1) IL184064A0 (ru)
MX (1) MX2007007626A (ru)
NI (1) NI200700163A (ru)
NO (1) NO20073776L (ru)
WO (1) WO2006069276A2 (ru)
ZA (1) ZA200706029B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4810423B2 (ja) 2003-06-27 2011-11-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式デルタオピオイド調節剤
WO2007030089A1 (en) * 2004-08-05 2007-03-15 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
EP1836196A1 (en) * 2004-12-22 2007-09-26 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
BRPI0519201A2 (pt) * 2004-12-22 2008-12-30 Janssen Pharmaceutica Nv moduladores de delta-opiàide tricÍclico
WO2006069276A2 (en) 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. TRICYCLIC ō-OPIOID MODULATORS
JP2008526878A (ja) * 2005-01-06 2008-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
DE602006018604D1 (de) * 2005-06-16 2011-01-13 Janssen Pharmaceutica Nv Tricyclische opioidmodulatoren
WO2007014137A2 (en) 2005-07-21 2007-02-01 Rensselaer Polytechnic Institute 8-carboxamido-substituted-2 , 6-methano-3-benzazocines and 3 - carboxamido- substituted morphanes as opioid receptor binding agents
MX2010011636A (es) * 2008-04-24 2010-11-25 Allergan Inc Gamma lactamas sustituidas como agentes terapeuticos.
US8846655B2 (en) 2009-10-30 2014-09-30 Janssen Pharmaceutica, Nv 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators
IT1396951B1 (it) 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
EP2654751B1 (en) * 2010-12-22 2016-11-23 Purdue Pharma L.P. Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof
AU2012275181B2 (en) 2011-06-29 2016-04-07 Alkermes, Inc. Peripherally acting opioid compounds
CN104884064A (zh) * 2012-12-24 2015-09-02 纽洛佳斯特拉斯公司 用于治疗胃肠道病症的方法
WO2015200369A1 (en) 2014-06-24 2015-12-30 Neurogastrx, Inc. Prodrugs of metopimazine
US10836757B1 (en) 2020-04-02 2020-11-17 Neurogastrx, Inc. Polymorphic forms of metopimazine
CN114236024B (zh) * 2021-12-07 2023-12-29 江苏宝众宝达药业股份有限公司 一种同时测定4-氟-3-硝基苯腈及其异构体含量的方法
CN114334022B (zh) * 2021-12-31 2022-11-18 杭州剂泰医药科技有限责任公司 一种化合物分子的溶解度预测模型及应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2368006A (en) * 1943-10-07 1945-01-23 Searle & Co Heterocyclic tertiary amines
US2784185A (en) * 1953-03-27 1957-03-05 Promonta Chem Fab Phenothiazine compounds
US2901478A (en) * 1957-02-11 1959-08-25 Promonta Chem Fab Phenothiazine compounds
US3179665A (en) * 1959-12-16 1965-04-20 Wander Ag Dr A 9-(n-ethyl and n-propyl piperidyl-3'-methyl)-thioxanthenes
DE1159954B (de) * 1961-11-25 1963-12-27 Boehringer & Soehne Gmbh Verfahren zur Herstellung neuer 10-(Alkoxypiperidinopropyl)-phenthiazine und ihrer Salze
DE1670118A1 (de) 1966-07-22 1970-11-05 Boehringer Mannheim Gmbh Verfahren zur Herstellung neuer Derivate des 6,11-Dihydro-dibenz[b,e]oxepins und ihrer Salze
US3470188A (en) * 1967-01-05 1969-09-30 Smithkline Corp 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes
NL6818027A (ru) * 1968-01-09 1969-07-11
US3987042A (en) * 1969-03-03 1976-10-19 Claude Gueremy Phenothiazine derivative
GB1250534A (ru) 1969-03-03 1971-10-20
US3931232A (en) * 1974-06-24 1976-01-06 Smithkline Corporation 3-Alkyl xanthene compounds
ZA756550B (en) 1974-11-06 1976-09-29 Smithkline Corp Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms
US4086350A (en) * 1974-11-06 1978-04-25 Smithkline Corporation Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms
US4285956A (en) * 1978-05-12 1981-08-25 Kefalas A/S Xanthene and thioxanthene derivatives, compositions thereof and treatment therewith
US4356184A (en) * 1980-06-04 1982-10-26 G. D. Searle & Co. Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines
US4666907A (en) * 1983-10-05 1987-05-19 Merck Frosst Canada, Inc. Phenothiazine and derivatives and analogs and use as leukotriene biosynthesis inhibitors
US4777177A (en) * 1984-10-19 1988-10-11 Ciba-Geigy Corporation Pesticidal thioxanthen-9-ylidenepiperidines
FR2689013B1 (fr) * 1992-03-30 1995-05-05 Rhone Poulenc Rorer Sa Nouvelle application thérapeutique des dérivés de la phénothiazine.
ZA978792B (en) * 1996-10-04 1998-04-06 Novo Nordisk As N-substituted azaheterocyclic compounds.
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
US6040318A (en) * 1997-06-25 2000-03-21 Novo Nordisk A/S Tricycle substituted with azaheterocyclic carboxylic acids
AU7907298A (en) 1997-06-25 1999-01-19 Novo Nordisk A/S Novel heterocyclic compounds
EP1049676B1 (en) 1997-12-24 2005-10-12 Ortho-Mcneil Pharmaceutical, Inc. 4- aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
JP2003518119A (ja) * 1999-12-22 2003-06-03 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ４−［アリール（８−アザビシクロ［３．２．１］オクタン−３−イル）］アミノ安息香酸誘導体
EP1263758A2 (en) 2000-03-03 2002-12-11 Ortho-McNeil Pharmaceutical, Inc. 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
AU2001249250A1 (en) 2000-03-29 2001-10-08 Research Triangle Institute Selective ligands for the delta opioid receptor
AU2002227135B2 (en) 2000-10-31 2008-01-03 Rensselaer Polytechnic Institute 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents
AU2002234010A1 (en) 2000-12-14 2002-06-24 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
JP4566459B2 (ja) * 2001-06-07 2010-10-20 株式会社日立製作所 表示装置
US6601009B2 (en) * 2001-07-12 2003-07-29 Yahoo Inc Method and system of automatic bandwidth detection
EP1306376A1 (en) 2001-10-25 2003-05-02 Biofrontera Pharmaceuticals AG Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
US7060711B2 (en) * 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
EP1321169A1 (en) 2001-12-18 2003-06-25 Biofrontera Pharmaceuticals AG Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament
BR0314108A (pt) 2002-09-18 2006-04-25 Fmc Corp derivados tricìclios inseticidas
US20040082612A1 (en) 2002-10-15 2004-04-29 Baxter Ellen W Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives
CA2522199A1 (en) 2003-04-15 2004-10-28 Pfizer Products Inc. 3-benzhydrylidene-8-aza-bicyclo¬3.2.1|octane derivatives with opioid receptor activity
JP4810423B2 (ja) 2003-06-27 2011-11-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式デルタオピオイド調節剤
US7372923B2 (en) * 2003-12-19 2008-05-13 Infineon Technologies Ag Method for equalization of a payload signal, taking into account an interference source
WO2007030089A1 (en) * 2004-08-05 2007-03-15 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
DE102004055057A1 (de) * 2004-11-15 2006-05-24 Infineon Technologies Ag Ausgangsschaltung
BRPI0519201A2 (pt) 2004-12-22 2008-12-30 Janssen Pharmaceutica Nv moduladores de delta-opiàide tricÍclico
EP1836196A1 (en) 2004-12-22 2007-09-26 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
WO2006069276A2 (en) 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. TRICYCLIC ō-OPIOID MODULATORS
JP2008526878A (ja) * 2005-01-06 2008-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
DE602006018604D1 (de) * 2005-06-16 2011-01-13 Janssen Pharmaceutica Nv Tricyclische opioidmodulatoren

Also Published As

Publication number Publication date
WO2006069276A2 (en) 2006-06-29
US7652005B2 (en) 2010-01-26
MX2007007626A (es) 2008-01-28
CN101115751A (zh) 2008-01-30
EP1833826A2 (en) 2007-09-19
DE602005014671D1 (de) 2009-07-09
BRPI0518563A2 (pt) 2008-11-25
WO2006069276A3 (en) 2006-08-10
US20060135763A1 (en) 2006-06-22
US7439239B2 (en) 2008-10-21
IL184064A0 (en) 2007-10-31
EA011674B1 (ru) 2009-04-28
ZA200706029B (en) 2008-12-31
CA2591963A1 (en) 2006-06-29
KR20070092293A (ko) 2007-09-12
ATE432279T1 (de) 2009-06-15
NO20073776L (no) 2007-09-21
EP1833826B1 (en) 2009-05-27
US20100093709A1 (en) 2010-04-15
JP2008525482A (ja) 2008-07-17
NI200700163A (es) 2008-02-04
US20090042871A1 (en) 2009-02-12
AU2005319060A1 (en) 2006-06-29

Similar Documents

Publication Publication Date Title
ATE432279T1 (de) Tricyclische delta-opioid-modulatoren
TW200716134A (en) Tricyclic opioid modulators
TW200621767A (en) Tricyclic δ-opioid modulators
UA86024C2 (ru) Трициклические дельта-опиоидные модуляторы
TW200716546A (en) Oxindole compounds and their uses as therapeutic agents
EA200700118A1 (ru) Амидосоединения и их применение в качестве лекарственных средств
BRPI0510177B8 (pt) composto, composição farmacêutica e uso do mesmo
TW200608960A (en) 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
MY142589A (en) Benzimidazole derivatives : preparation and pharmaceutical applications
EA200900828A1 (ru) Соединения и композиции в качестве ингибиторов активности каннабиноидного рецептора 1
EA200602242A1 (ru) 3-аминоциклопентанкарбоксамиды в качестве модуляторов хемокиновых рецепторов
TW200724543A (en) Heterocyclic compounds and their uses as therapeutic agents
EA200601212A1 (ru) Ингибиторы фосфодиэстеразы, получение и их терапевтическое применение
WO2006074388A3 (en) TRICYCLIC δ-OPIOID MODULATORS
TW200621244A (en) Modulators of muscarinic receptors
ATE457027T1 (de) Substituierte 1,4,8-triazaspiroä4.5 decan-2-on- verbindungen zur behandlung von fettsucht
EA200602115A1 (ru) Опиоидные соединения, замещенные карбоксамидогруппой
MXPA06003363A (es) Derivados de fenil-piperazina como moduladores de receptores muscarinicos.
MX2007007627A (es) Moduladores delta-opioides triciclicos.
MX2007006382A (es) Moduladores de receptores muscarinicos.
MA31630B1 (fr) Dérivés de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamides et de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]-diazépine-7-carboxamides, leur préparation et leur application en thérapeutique
EA200702136A1 (ru) Композиции станнсопорфина и их применение
TW200603791A (en) Compounds and compositions as cathepsin S inhibitors
UA83142C2 (en) 3-aminocyclopentane carboxyamidine as modulators of chemokine receptors
EA200701227A1 (ru) Замещённые индолы, содержащие их композиции, способ получения и применение

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU