EA200700975A1 - Рекомбинантный вирус ньюкаслской болезни - Google Patents
Рекомбинантный вирус ньюкаслской болезниInfo
- Publication number
- EA200700975A1 EA200700975A1 EA200700975A EA200700975A EA200700975A1 EA 200700975 A1 EA200700975 A1 EA 200700975A1 EA 200700975 A EA200700975 A EA 200700975A EA 200700975 A EA200700975 A EA 200700975A EA 200700975 A1 EA200700975 A1 EA 200700975A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ligand
- newcastle disease
- derivatives
- nucleic acid
- therapeutic activity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18141—Use of virus, viral particle or viral elements as a vector
- C12N2760/18143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Abstract
Цель изобретения состоит в том, чтобы увеличить терапевтическую активность онколитического NDV. Эта проблема решается с помощью вируса ньюкаслской болезни, содержащего рекомбинантную нуклеиновую кислоту, в котором нуклеиновая кислота кодирует связывающий белок, обладающий терапевтической активностью при экспрессии инфицированной вирусом опухолевой клеткой. Связывающие белки принадлежат к следующей группе: природный лиганд или генетически модифицированный лиганд, рекомбинантный растворимый домен природного рецептора или его модифицированная версия, пептид-лиганд, молекула антитела и ее производные или подобная антителу молекула, такая как молекулы с анкириновыми повторами или их производные.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04090432 | 2004-11-12 | ||
PCT/EP2005/012186 WO2006050984A2 (en) | 2004-11-12 | 2005-11-10 | Recombinant newcastle disease virus |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200700975A1 true EA200700975A1 (ru) | 2007-12-28 |
EA013615B1 EA013615B1 (ru) | 2010-06-30 |
Family
ID=35892593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200700975A EA013615B1 (ru) | 2004-11-12 | 2005-11-10 | Рекомбинантный онколитический парамиксовирус и его применение |
Country Status (14)
Country | Link |
---|---|
US (2) | US20080206201A1 (ru) |
EP (2) | EP1812026A2 (ru) |
JP (1) | JP2008519590A (ru) |
KR (1) | KR20070085314A (ru) |
CN (2) | CN101875919A (ru) |
AU (1) | AU2005303912B2 (ru) |
BR (1) | BRPI0517834A (ru) |
CA (1) | CA2585435A1 (ru) |
EA (1) | EA013615B1 (ru) |
IL (1) | IL182083A0 (ru) |
NO (1) | NO20072967L (ru) |
NZ (4) | NZ585895A (ru) |
WO (1) | WO2006050984A2 (ru) |
ZA (1) | ZA200705060B (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2550258C2 (ru) * | 2008-11-03 | 2015-05-10 | Молекьюлар Партнерс Аг | Связывающие белки, ингибирующие взаимодействия vegf-a рецептора |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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PL2251034T3 (pl) | 2005-12-02 | 2018-07-31 | Icahn School Of Medicine At Mount Sinai | Chimeryczne wirusy prezentujące nienatywne białka powierzchniowe i zastosowania tych wirusów |
CA2638746C (en) * | 2006-03-15 | 2014-12-02 | Intervet International B.V. | Recombinant mononegaviral virus vectors |
AU2007224430A1 (en) * | 2006-03-15 | 2007-09-20 | Intervet International B.V. | Recombinant Newcastle disease virus expressing H5 hemagglutinin of avian influenza virus |
EP2426142A3 (en) | 2006-10-16 | 2012-06-13 | Genelux Corporation | Modified vaccinia virus strains for use in a diagnostic and therapeutic method |
CN101205544B (zh) * | 2007-08-07 | 2010-12-08 | 中国人民解放军第四军医大学 | 肿瘤靶向性重组新城疫病毒及其构建方法 |
EP2085092A1 (en) | 2008-01-29 | 2009-08-05 | Bayer Schering Pharma Aktiengesellschaft | Attenuated oncolytic paramyxoviruses encoding avian cytokines |
US20090208495A1 (en) * | 2008-02-14 | 2009-08-20 | Bayer Schering Pharma Ag | Anti-tumor effective paramyxovirus |
WO2010032764A1 (ja) * | 2008-09-16 | 2010-03-25 | ジェノミディア株式会社 | 前立腺癌の治療・予防剤 |
WO2010080248A2 (en) * | 2008-12-18 | 2010-07-15 | The Board Of Regents Of The University Of Texas System | Peptides that bind eukaryotic translation initiation factor 4e |
WO2010091262A1 (en) | 2009-02-05 | 2010-08-12 | Mount Sinai School Of Medicine Of New York University | Chimeric newcastle disease viruses and uses thereof |
TW201120210A (en) | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
ATE539148T1 (de) | 2009-11-30 | 2012-01-15 | United Cancer Res Inst | Neuer klon des geflügelpestvirus, herstellung und anwendung bei der medizinischen behandlung von krebs |
AR081361A1 (es) * | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
EP2579884B1 (en) * | 2010-06-10 | 2014-06-04 | Intervet International B.V. | Anti-tumor composition |
WO2013052915A2 (en) * | 2011-10-05 | 2013-04-11 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
AU2013283296A1 (en) * | 2012-06-28 | 2015-02-05 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
BR112015021414B1 (pt) | 2013-03-14 | 2020-11-10 | Icahn School Of Medicine At Mount Sinai | vírus da doença newcastle e seus usos |
CN103451198B (zh) * | 2013-08-20 | 2015-11-25 | 中国农业科学院哈尔滨兽医研究所 | 溶瘤型新城疫病毒D90株的全长感染性cDNA及其构建方法和应用 |
SG11201607130RA (en) | 2014-02-27 | 2016-09-29 | Viralytics Ltd | Combination method for treatment of cancer |
CN104357408A (zh) * | 2014-03-13 | 2015-02-18 | 哈尔滨博翱生物医药技术开发有限公司 | 一种重组新城疫病毒及其应用 |
PL3169341T3 (pl) | 2014-07-16 | 2019-12-31 | Transgene Sa | Wirus onkolityczny do ekspresji modulatorów punktu kontroli immunologicznej |
CN104164410B (zh) * | 2014-08-07 | 2016-07-13 | 哈尔滨博翱生物医药技术开发有限公司 | 一种鸡新城疫病毒毒株及其在制备鸡新城疫病疫苗中的应用 |
AU2015335607B2 (en) | 2014-10-24 | 2020-04-23 | Calidi Biotherapeutics, Inc. | Combination immunotherapy approach for treatment of cancer |
RU2562115C1 (ru) * | 2014-11-13 | 2015-09-10 | Федеральное государственное автономное образовательное учреждение высшего образования "Новосибирский национальный исследовательский государственный университет"(Новосибирский государственный университет, НГУ) | Штамм вируса болезни ньюкасла для изучения онколитических свойств и механизмов онколизиса для создания прототипного противоопухолевого препарата |
EP3270940A4 (en) * | 2015-03-18 | 2018-08-29 | Stemimmune, Incorporated | Virotherapy with an antibody combination |
BR112017020986A2 (pt) | 2015-04-02 | 2018-08-14 | Molecular Partners Ag. | proteínas de ligação recombinantes e seu uso |
GB201505860D0 (en) * | 2015-04-07 | 2015-05-20 | Agalimmune Ltd | Therapeutic compositions and methods of use for treating cancer |
WO2017027757A2 (en) | 2015-08-11 | 2017-02-16 | StemImmune, Incorporated | Smallpox vaccine for cancer treatment |
US10717772B2 (en) | 2016-09-22 | 2020-07-21 | Molecular Partners Ag | Recombinant binding proteins targeting HER2 and serum albumin, and their uses |
US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
CA3106170A1 (en) * | 2018-07-13 | 2020-01-16 | Icahn School Of Medicine At Mount Sinai | Apmv and uses thereof for the treatment of cancer |
EP3795160A1 (en) * | 2019-09-19 | 2021-03-24 | Arno Thaller | Recombinant oncolytic newcastle disease viruses with increased activity |
EP3795161A1 (en) * | 2019-09-19 | 2021-03-24 | Arno Thaller | Recombinant oncolytic newcastle disease viruses with increased activity and improved viral safety |
MX2022007122A (es) | 2019-12-11 | 2022-09-09 | Molecular Partners Ag | Dominios de repetición de anquirina diseñados con residuos de superficie alterados. |
CA3176845A1 (en) | 2020-05-06 | 2021-11-11 | Patrick AMSTUTZ | Novel ankyrin repeat binding proteins and their uses |
WO2022190016A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Novel darpin based multi-specific t-cell engagers |
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ES2210273T5 (es) | 1994-07-18 | 2010-03-29 | Conzelmann, Karl-Klaus, Prof. Dr. | Virus con arn de cadena negativa no segmentado recombinante infeccioso. |
US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
EP0974660A1 (en) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
EP1390046A4 (en) | 1999-04-15 | 2005-04-20 | Wellstat Biologics Corp | TREATMENT OF NEOPLASMS WITH VIRUSES |
DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
CA2312626A1 (en) | 1999-07-27 | 2001-01-27 | Akzo Nobel N.V. | A recombinant newcastle disease virus as an embryo vaccine |
US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
AU7607900A (en) | 1999-09-22 | 2001-04-24 | Mayo Foundation For Medical Education And Research | Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family |
US6896881B1 (en) * | 1999-09-24 | 2005-05-24 | Mayo Foundation For Medical Education And Research | Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family |
WO2003005964A2 (en) | 2001-07-11 | 2003-01-23 | University Of Miami | Recombinant vsv for the treatment of tumor cells |
US20040072276A1 (en) | 2002-05-10 | 2004-04-15 | Direvo BioTech AG. | Process for generating sequence-specific proteases by directed evolution and use thereof |
EP1633866A1 (en) | 2003-06-18 | 2006-03-15 | Direvo Biotech AG | New biological entities and the pharmaceutical or diagnostic use thereof |
WO2005014017A1 (ja) * | 2003-08-08 | 2005-02-17 | Yuji Shino | 癌治療用医薬組成物 |
DE10351744A1 (de) | 2003-10-31 | 2005-06-16 | Schering Ag | Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel |
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2005
- 2005-11-10 NZ NZ585895A patent/NZ585895A/en unknown
- 2005-11-10 EP EP05818947A patent/EP1812026A2/en not_active Ceased
- 2005-11-10 KR KR1020077010755A patent/KR20070085314A/ko not_active Application Discontinuation
- 2005-11-10 NZ NZ581958A patent/NZ581958A/en unknown
- 2005-11-10 NZ NZ591733A patent/NZ591733A/xx not_active IP Right Cessation
- 2005-11-10 AU AU2005303912A patent/AU2005303912B2/en not_active Ceased
- 2005-11-10 BR BRPI0517834-7A patent/BRPI0517834A/pt not_active IP Right Cessation
- 2005-11-10 WO PCT/EP2005/012186 patent/WO2006050984A2/en active Application Filing
- 2005-11-10 EP EP10175701A patent/EP2292246A1/en not_active Withdrawn
- 2005-11-10 CA CA002585435A patent/CA2585435A1/en not_active Abandoned
- 2005-11-10 NZ NZ554429A patent/NZ554429A/en not_active IP Right Cessation
- 2005-11-10 EA EA200700975A patent/EA013615B1/ru not_active IP Right Cessation
- 2005-11-10 US US11/667,563 patent/US20080206201A1/en not_active Abandoned
- 2005-11-10 JP JP2007540601A patent/JP2008519590A/ja active Pending
- 2005-11-10 CN CN2009102220518A patent/CN101875919A/zh active Pending
- 2005-11-10 CN CNA2005800386769A patent/CN101056646A/zh active Pending
-
2007
- 2007-03-21 IL IL182083A patent/IL182083A0/en unknown
- 2007-06-11 NO NO20072967A patent/NO20072967L/no not_active Application Discontinuation
- 2007-06-11 ZA ZA200705060A patent/ZA200705060B/xx unknown
-
2010
- 2010-07-16 US US12/837,793 patent/US20110020282A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2550258C2 (ru) * | 2008-11-03 | 2015-05-10 | Молекьюлар Партнерс Аг | Связывающие белки, ингибирующие взаимодействия vegf-a рецептора |
Also Published As
Publication number | Publication date |
---|---|
CA2585435A1 (en) | 2006-05-18 |
KR20070085314A (ko) | 2007-08-27 |
NO20072967L (no) | 2007-08-10 |
EP2292246A1 (en) | 2011-03-09 |
CN101875919A (zh) | 2010-11-03 |
JP2008519590A (ja) | 2008-06-12 |
BRPI0517834A (pt) | 2008-10-21 |
CN101056646A (zh) | 2007-10-17 |
IL182083A0 (en) | 2007-07-24 |
WO2006050984A2 (en) | 2006-05-18 |
US20080206201A1 (en) | 2008-08-28 |
NZ581958A (en) | 2011-01-28 |
ZA200705060B (en) | 2008-12-31 |
NZ554429A (en) | 2010-08-27 |
AU2005303912B2 (en) | 2011-02-17 |
EP1812026A2 (en) | 2007-08-01 |
EA013615B1 (ru) | 2010-06-30 |
WO2006050984A3 (en) | 2006-09-08 |
US20110020282A1 (en) | 2011-01-27 |
NZ585895A (en) | 2011-05-27 |
AU2005303912A1 (en) | 2006-05-18 |
NZ591733A (en) | 2012-10-26 |
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