DE602005016712D1 - Rter dna - Google Patents

Rter dna

Info

Publication number
DE602005016712D1
DE602005016712D1 DE602005016712T DE602005016712T DE602005016712D1 DE 602005016712 D1 DE602005016712 D1 DE 602005016712D1 DE 602005016712 T DE602005016712 T DE 602005016712T DE 602005016712 T DE602005016712 T DE 602005016712T DE 602005016712 D1 DE602005016712 D1 DE 602005016712D1
Authority
DE
Germany
Prior art keywords
nucleic acid
polypeptide
acid molecule
present application
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005016712T
Other languages
English (en)
Inventor
Michael Rehli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sequenom Inc
Original Assignee
Klinikum der Universitaet Regensburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinikum der Universitaet Regensburg filed Critical Klinikum der Universitaet Regensburg
Publication of DE602005016712D1 publication Critical patent/DE602005016712D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N21/00—Selective content distribution, e.g. interactive television or video on demand [VOD]
    • H04N21/20—Servers specifically adapted for the distribution of content, e.g. VOD servers; Operations thereof
    • H04N21/23—Processing of content or additional data; Elementary server operations; Server middleware
    • H04N21/24—Monitoring of processes or resources, e.g. monitoring of server load, available bandwidth, upstream requests
    • H04N21/2402—Monitoring of the downstream path of the transmission network, e.g. bandwidth available
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N21/00—Selective content distribution, e.g. interactive television or video on demand [VOD]
    • H04N21/20—Servers specifically adapted for the distribution of content, e.g. VOD servers; Operations thereof
    • H04N21/23—Processing of content or additional data; Elementary server operations; Server middleware
    • H04N21/24—Monitoring of processes or resources, e.g. monitoring of server load, available bandwidth, upstream requests
    • H04N21/2401—Monitoring of the client buffer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/164—Methylation detection other then bisulfite or methylation sensitive restriction endonucleases

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Multimedia (AREA)
  • Signal Processing (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE602005016712T 2004-11-29 2005-11-28 Rter dna Active DE602005016712D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04028267 2004-11-29
PCT/EP2005/012707 WO2006056480A2 (en) 2004-11-29 2005-11-28 Means and methods for detecting methylated dna

Publications (1)

Publication Number Publication Date
DE602005016712D1 true DE602005016712D1 (de) 2009-10-29

Family

ID=34927572

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005016712T Active DE602005016712D1 (de) 2004-11-29 2005-11-28 Rter dna

Country Status (9)

Country Link
US (4) US9074013B2 (de)
EP (1) EP1817430B1 (de)
JP (2) JP5149013B2 (de)
CN (1) CN101243191B (de)
AT (1) ATE443161T1 (de)
AU (1) AU2005308918B2 (de)
CA (1) CA2589487C (de)
DE (1) DE602005016712D1 (de)
WO (1) WO2006056480A2 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101124338B (zh) 2004-11-29 2011-05-04 雷根斯堡大学临床中心 用于检测甲基化dna的试剂盒和方法
EP1817430B1 (de) 2004-11-29 2009-09-16 Klinikum der Universität Regensburg Mittel und verfahren für den nachweis von methylierter dna
EP2602321B1 (de) 2006-05-31 2017-08-23 Sequenom, Inc. Verfahren und Zusammensetzungen zur Nukleinsäureextraktion und -verstärkung aus einer Probe
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
AU2008230813B2 (en) 2007-03-26 2014-01-30 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
JP5211790B2 (ja) * 2007-03-26 2013-06-12 住友化学株式会社 Ｄｎａメチル化測定方法
US9404150B2 (en) 2007-08-29 2016-08-02 Sequenom, Inc. Methods and compositions for universal size-specific PCR
US7888127B2 (en) 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
US8206926B2 (en) 2008-03-26 2012-06-26 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
BRPI0913578A2 (pt) 2008-05-14 2017-06-06 Dermtech Int diagnose de melanoma e lentigo solar por análise de ácido nucléico
AU2009293232B2 (en) * 2008-09-16 2015-05-14 Sequenom Center For Molecular Medicine Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) * 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
EP2414545B1 (de) 2009-04-03 2017-01-11 Sequenom, Inc. Zusammensetzungen und verfahren für die herstellung von nukleinsäuren
CN101906414B (zh) * 2009-06-03 2012-12-26 博尔诚（北京）科技有限公司 甲基化dna的浓缩方法和检测方法以及试剂盒
EP2484698A4 (de) * 2009-09-28 2014-07-02 Sysmex Corp Hybridome zur produktion von antikörpern gegen methylierte dna und verwendung davon
WO2011046214A1 (ja) * 2009-10-16 2011-04-21 独立行政法人理化学研究所 メチル化dna結合ペプチド
WO2011087760A2 (en) 2009-12-22 2011-07-21 Sequenom, Inc. Processes and kits for identifying aneuploidy
KR20120107512A (ko) * 2010-01-26 2012-10-02 엔아이피디 제네틱스 리미티드 태아 이수성의 비침해성 출생전 진단을 위한 방법과 조성물
JP5492696B2 (ja) * 2010-07-26 2014-05-14 大屋敷 一馬 一分子蛍光分析法によるｄｎａのメチル化度の決定方法
JP5832760B2 (ja) * 2011-02-28 2015-12-16 シスメックス株式会社 試料中のメチル化ｄｎａを検出する方法
US9145580B2 (en) * 2011-04-02 2015-09-29 New England Biolabs, Inc. Methods and compositions for enriching either target polynucleotides or non-target polynucleotides from a mixture of target and non-target polynucleotides
US8980553B2 (en) 2011-04-02 2015-03-17 New England Biolabs, Inc. Methods and compositions for enriching either target polynucleotides or non-target polynucleotides from a mixture of target and non-target polynucleotides
KR101274765B1 (ko) * 2011-04-27 2013-06-14 피씨엘 (주) 바이오칩 제조용 졸-겔 키트 및 이를 이용한 바이오 칩의 제조방법
US8951736B2 (en) 2011-04-29 2015-02-10 Sequenom, Inc. Multimer glycosylated nucleic acid binding protein conjugates and uses thereof
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2764459B1 (de) 2011-10-06 2021-06-30 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013052907A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2766496B1 (de) 2011-10-11 2017-03-08 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
ES2929923T3 (es) 2012-01-20 2022-12-02 Sequenom Inc Procesos de diagnóstico que condicionan las condiciones experimentales
EP2820157B1 (de) 2012-03-02 2019-05-01 Winthrop-University Hospital Verfahren zur verwendung von sondenbasierter pcr-detektion zum messen der konzentration von dna aus zirkulierenden entmethylierten beta-zellen als massstab für beta-zell-verlust bei diabetes
EP4155401A1 (de) 2012-03-02 2023-03-29 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
EP4276194A3 (de) 2012-05-21 2024-03-06 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
MX2014014356A (es) 2012-05-24 2015-07-06 Fundació Inst D Investigació Biomédica De Bellvitge Idibell Metodo para la identificacion del origen de un cancer de origen primario desconocido.
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2878979C (en) 2012-07-13 2021-09-14 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2904534B1 (de) 2012-10-04 2021-12-15 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2746403A1 (de) * 2012-12-21 2014-06-25 Life Science Inkubator GmbH & Co. KG Verfahren zur Bestimmung des DNA-Methylierungsgrades
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140235484A1 (en) * 2013-02-19 2014-08-21 The Johns Hopkins University Methods for detection and differentiation of origin of viral dna
US20130189684A1 (en) 2013-03-12 2013-07-25 Sequenom, Inc. Quantification of cell-specific nucleic acid markers
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
WO2014168711A1 (en) 2013-03-13 2014-10-16 Sequenom, Inc. Primers for dna methylation analysis
ES2939547T3 (es) 2013-04-03 2023-04-24 Sequenom Inc Métodos y procedimientos para la evaluación no invasiva de variaciones genéticas
WO2014190286A2 (en) 2013-05-24 2014-11-27 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2721051T3 (es) 2013-06-21 2019-07-26 Sequenom Inc Método para la evaluación no invasiva de variaciones genéticas
CN105992634B (zh) 2013-08-30 2019-06-14 华盛顿大学商业中心 选择性修饰聚合物亚单位以改进基于纳米孔的分析
BR112016007401B1 (pt) 2013-10-04 2023-04-11 Sequenom, Inc. Método para determinar a presença ou ausência de uma aneuploidia cromossômica em uma amostra
US10438691B2 (en) 2013-10-07 2019-10-08 Sequenom, Inc. Non-invasive assessment of chromosome alterations using change in subsequence mappability
EP3117011B1 (de) 2014-03-13 2020-05-06 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
EP3598452B1 (de) 2014-05-30 2023-07-26 Sequenom, Inc. Chromosomendarstellungsbestimmungen
US11783911B2 (en) 2014-07-30 2023-10-10 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
WO2016057901A1 (en) 2014-10-10 2016-04-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984201B2 (en) 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
WO2016189388A1 (en) 2015-05-22 2016-12-01 Nipd Genetics Ltd Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
EP4043581A1 (de) 2016-05-27 2022-08-17 Sequenom, Inc. Verfahren zur erzeugung eines paralog assay systems
US10202650B2 (en) 2016-05-31 2019-02-12 Youhealth Biotech, Limited Methods for monitoring ELOVL2, KLF14 and PENK gene expression following treatment with vitamin C
CN107847515B (zh) 2016-07-06 2021-01-29 优美佳生物技术有限公司 实体瘤甲基化标志物及其用途
US10093986B2 (en) 2016-07-06 2018-10-09 Youhealth Biotech, Limited Leukemia methylation markers and uses thereof
WO2018009703A1 (en) 2016-07-06 2018-01-11 Youhealth Biotech, Limited Breast and ovarian cancer methylation markers and uses thereof
AU2017295717B2 (en) 2016-07-15 2021-06-24 The Regents Of The University Of California Methods of producing nucleic acid libraries
WO2018022890A1 (en) 2016-07-27 2018-02-01 Sequenom, Inc. Genetic copy number alteration classifications
EP3491561A1 (de) 2016-07-27 2019-06-05 Sequenom, Inc. Verfahren zur nicht-invasiven beurteilung von genomischer instabilität
CA3049457C (en) 2017-01-20 2023-05-16 Sequenom, Inc. Methods for non-invasive assessment of copy number alterations
CA3049682C (en) 2017-01-20 2023-06-27 Sequenom, Inc. Methods for non-invasive assessment of genetic alterations
WO2018136881A1 (en) 2017-01-20 2018-07-26 Sequenom, Inc. Sequencing adapter manufacture and use
CA3207879A1 (en) 2017-01-24 2018-08-02 Sequenom, Inc. Methods and processes for assessment of genetic variations
WO2018145068A1 (en) * 2017-02-06 2018-08-09 Trustees Of Boston University An integrated system for programmable dna methylation
US10513739B2 (en) 2017-03-02 2019-12-24 Youhealth Oncotech, Limited Methylation markers for diagnosing hepatocellular carcinoma and lung cancer
CA3056118A1 (en) 2017-03-17 2018-09-20 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
CN106951729A (zh) * 2017-03-19 2017-07-14 中国海洋大学 一种利用细胞器基因组的同源模块进行系统发生分析的方法
EP3655418A4 (de) 2017-06-22 2021-05-19 Triact Therapeutics, Inc. Verfahren zur behandlung von glioblastom
WO2019067991A1 (en) 2017-09-29 2019-04-04 Triact Therapeutics, Inc. INIPARIB FORMULATIONS AND USES THEREOF
JP7296969B2 (ja) 2018-01-12 2023-06-23 クラレット バイオサイエンス， エルエルシー 核酸を解析するための方法および組成物
AU2019280712A1 (en) 2018-06-06 2021-01-07 The Regents Of The University Of California Methods of producing nucleic acid libraries and compositions and kits for practicing same
CA3134936A1 (en) 2019-03-26 2020-10-01 Dermtech, Inc. Novel gene classifiers and uses thereof in skin cancers
CA3134831A1 (en) 2019-04-05 2020-10-08 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
CN114616343A (zh) 2019-09-30 2022-06-10 夸登特健康公司 用于在甲基化分区测定中分析无细胞dna的组合物和方法
US20230014607A1 (en) 2019-10-09 2023-01-19 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
WO2021087491A1 (en) 2019-10-31 2021-05-06 Sequenom, Inc. Application of mosaicism ratio in multifetal gestations and personalized risk assessment
EP4065725A1 (de) * 2019-11-26 2022-10-05 Guardant Health, Inc. Verfahren, zusammensetzungen und systeme zum verbessern der bindung von methylierten polynukleotiden
CA3186974A1 (en) 2020-06-24 2021-12-30 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
WO2022076574A1 (en) 2020-10-08 2022-04-14 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
IL293201B2 (en) * 2022-05-22 2023-04-01 Nucleix Ltd Preparations contain a reaction buffer for DNA amplification and sequencing
CN117003850B (zh) * 2023-09-19 2024-04-12 汲迈生命科技(苏州)有限公司 一种甲基化富集蛋白及其编码基因、制备方法和应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116638A (en) * 1977-03-03 1978-09-26 Warner-Lambert Company Immunoassay device
US5175086A (en) * 1983-01-24 1992-12-29 Olympus Optical Co., Ltd. Method for effecting heterogeneous immunological analysis
JPH0614048B2 (ja) 1983-02-14 1994-02-23 オリンパス光学工業株式会社 酵素免疫学的自動分析装置
US4608231A (en) * 1984-12-12 1986-08-26 Becton, Dickinson And Company Self-contained reagent package device for an assay
JPS61292556A (ja) 1985-06-20 1986-12-23 Green Cross Corp:The 酵素免疫測定方法およびキツト
EP0322102A3 (de) 1987-11-30 1990-06-13 McCue, John P. Verfahren und Fangtests für Antigene und dafür geeignete Verbindungen
JPH04136762A (ja) 1990-09-28 1992-05-11 Hitachi Ltd イムノアッセイ用反応容器
DE4037837A1 (de) * 1990-11-28 1992-06-04 Behringwerke Ag Zellfreie rezeptorbindungsteste, ihre herstellung und verwendung
US5399500A (en) * 1992-06-26 1995-03-21 Becton Dickinson And Company Two step process for coating of antibodies to a solid phase
US5441895A (en) * 1993-12-07 1995-08-15 Jakubowicz; Raymond F. Reagent cup shape allowing stacking without dislodging reagent
FR2733165B1 (fr) * 1995-04-20 1997-06-13 Inst Francais Du Petrole Carbonates alcalins ou alcalino-terreux colloidaux contenant un compose de calcium,de phospore et de soufre sous forme miscellisee
IL136621A0 (en) 1997-12-17 2001-06-14 Immunex Corp Cell surface glycoproteins associated with human b cell lymphomas
PT1490386E (pt) 1998-03-10 2008-11-24 Genentech Inc Novos polipéptidos e ácidos nucleicos que os codificam
US6927024B2 (en) * 1998-11-30 2005-08-09 Genentech, Inc. PCR assay
DE19941756B4 (de) 1999-09-02 2013-05-16 Christof Niemeyer Verfahren zur Verwendung von oligomeren Nucleinsäure-Protein-Konjugaten als Reagenzien für immunologische Nachweisverfahren insbesondere die Immuno-PCR
WO2002022809A2 (en) 2000-09-15 2002-03-21 Coley Pharmaceutical Gmbh PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST
EP1392861A1 (de) 2001-02-27 2004-03-03 EOS Biotechnology, Inc. Neue verfahren zur diagnose von metastatischem kolorektalkarzinom, zusammensetzungen und verfahren zum screening auf modulatoren von metastatischem kolorektalkarzinom
DE10112515B4 (de) 2001-03-09 2004-02-12 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität
WO2002101353A2 (en) 2001-06-08 2002-12-19 U.S. Genomics, Inc. Methods and products for analyzing nucleic acids based on methylation status
JP2003125766A (ja) 2001-10-24 2003-05-07 Toray Res Center:Kk 抗５−メチル−２’−デオキシシチジン抗体および５−メチル−２’−デオキシシチジンの測定法
US6783759B2 (en) * 2002-03-27 2004-08-31 Trustees Of The University Of Pennsylvania Compositions and methods for modulating variola virus
EP1541668A4 (de) 2002-06-17 2008-08-06 Prec System Science Co Ltd REAKTIONSGEFûSS UND REAKTIONSPRODUKT-EXTRAKTIONSVORRICHTUNG
GB0230203D0 (en) * 2002-12-27 2003-02-05 Domantis Ltd Fc fusion
AU2003900368A0 (en) 2003-01-24 2003-02-13 Human Genetic Signatures Pty Ltd Assay for nucleic acid molecules
GB0423991D0 (en) 2004-10-29 2004-12-01 Univ Edinburgh Applications of nucleic acid fragments
CN101124338B (zh) 2004-11-29 2011-05-04 雷根斯堡大学临床中心 用于检测甲基化dna的试剂盒和方法
EP1817430B1 (de) * 2004-11-29 2009-09-16 Klinikum der Universität Regensburg Mittel und verfahren für den nachweis von methylierter dna
DE102005034628B4 (de) 2005-07-19 2007-08-23 Epigenomics Ag Verfahren zur Untersuchung von Cytosin-Methylierungen in DNA
US7906288B2 (en) 2006-01-04 2011-03-15 The Johns Hopkins University Compare-MS: method rapid, sensitive and accurate detection of DNA methylation

Also Published As

Publication number Publication date
CA2589487A1 (en) 2006-06-01
AU2005308918A1 (en) 2006-06-01
US20180220176A1 (en) 2018-08-02
WO2006056480A3 (en) 2008-03-27
US20080260743A1 (en) 2008-10-23
US9074013B2 (en) 2015-07-07
CN101243191A (zh) 2008-08-13
CA2589487C (en) 2014-07-29
EP1817430B1 (de) 2009-09-16
CN101243191B (zh) 2014-04-16
JP2008521389A (ja) 2008-06-26
US20210337252A1 (en) 2021-10-28
US20150267263A1 (en) 2015-09-24
US9873919B2 (en) 2018-01-23
ATE443161T1 (de) 2009-10-15
JP5149013B2 (ja) 2013-02-20
EP1817430A2 (de) 2007-08-15
JP2013027399A (ja) 2013-02-07
AU2005308918B2 (en) 2012-09-27
WO2006056480A2 (en) 2006-06-01

Similar Documents

Publication Publication Date Title
DE602005016712D1 (de) Rter dna
CY1118979T1 (el) Αντισωματα που κατευθυνονται εναντι her-3 και χρησεις αυτων
ES2379283T3 (es) Proteínas de unión a albúmina sérica
EA201071323A1 (ru) Axmi-115, axmi-113, axmi-005, axmi-163, axmi-184 инсектицидные белки и способы их применения
MX348154B (es) Anticuerpos de enlace a il-1-beta y fragmentos de los mismos.
WO2006089230A3 (en) Human monoclonal antibodies to prostate specific membrane antigen (psma)
MXPA04008077A (es) Anticuerpos ant-a° y su uso.
WO2008077945A3 (en) Anti-chemokine (ccl2, ccl3, ccl5, cxcl11, cxcl12) single-domain antibodies
ATE470673T1 (de) Impfstoffe mit lawsoniaintrazellularis- untereinheit
WO2002026822A3 (en) Pumpcn compositions and uses thereof
DK1641818T3 (da) Polypeptider der har bindingsaffinitet for HER2
NZ583282A (en) Human c-fms antigen binding proteins
WO2003065003A3 (en) Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof
WO2008109533A3 (en) Human antibodies that bind multiple irta family proteins, and uses thereof
ATE450545T1 (de) Impfstoff mit lawsonia intracellularis- untereinheit
SE0301987D0 (sv) New polypeptide
WO2001064913A3 (en) Cell cycle proteins associated with rad9, compositions and methods of use
WO2003104426A3 (en) ISOLATED NUCLEIC ACID MOLECULE ENCODING A MOTOR-LIKE PROTEIN ASSOCIATED WITH A CENTROMER, AND USES THEREOF
WO2006020824A3 (en) Diagnosis and treatment of kawasaki disease and coronavirus infection
WO2011015379A8 (en) Human hcv-interacting proteins and methods of use
DK1664097T3 (da) Piroplasmidvaccine
WO2001036476A3 (en) Ing2, an iaps associated cell cycle protein, compositions and methods of use
WO2004029276A3 (en) Nucleic acids encoding a mammalian raptor polypeptide and uses therefor
WO1999042586A3 (en) Exo1 and exo2, exocytotic proteins
WO2004011496A3 (en) Novel t-cell proteins, peptides and antibodies derived therefrom and uses thereof

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SEQUENOM, INC., SAN DIEGO, CALIF., US

8364 No opposition during term of opposition