EA200501881A1 - ЗАМЕЩЁННЫЕ ПРОИЗВОДНЫЕ ПИРРОЛА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ HMG-CoA - Google Patents

ЗАМЕЩЁННЫЕ ПРОИЗВОДНЫЕ ПИРРОЛА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ HMG-CoA

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EA200501881A1
EA200501881A1 EA200501881A EA200501881A EA200501881A1 EA 200501881 A1 EA200501881 A1 EA 200501881A1 EA 200501881 A EA200501881 A EA 200501881A EA 200501881 A EA200501881 A EA 200501881A EA 200501881 A1 EA200501881 A1 EA 200501881A1
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Prior art keywords
hmg
cholesterol
pyrrola
application
substituted derivatives
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EA200501881A
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English (en)
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EA009646B1 (ru
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Мохаммад Салман
Джитендра Саттигери
Ятендра Кумар
Рам Чандер Ариян
Викрам Кришна Раманатан
Анита Чугх
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Рэнбакси Лабораториз Лимитед
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Application filed by Рэнбакси Лабораториз Лимитед filed Critical Рэнбакси Лабораториз Лимитед
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Publication of EA009646B1 publication Critical patent/EA009646B1/ru

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Abstract

Настоящее изобретение относится к замещенным производным пиррола формулы I, которые могут использоваться в качестве ингибиторов 3-гидрокси-3-метилглутарил-кофермент A (HMG-CoA) редуктазы. Описываемые здесь соединения могут действовать как снижающие холестерин агенты и использоваться для лечения связанных с холестерином заболеваний и симптомов. Предложен способ получения описываемых соединений, а также фармацевтические композиции, содержащие описываемые соединения, и способы лечения связанных с холестерином заболеваний и симптомов. Предложены также их фармацевтически приемлемые соли, фармацевтически приемлемые сольваты, пролекарства, метаболиты, полиморфы, таутомеры, рацематы, чистые энантиомеры, диастереоизомеры или N-оксиды.
EA200501881A 2003-05-30 2004-05-28 Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa EA009646B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44941803A 2003-05-30 2003-05-30
PCT/IB2004/001761 WO2004106299A2 (en) 2003-05-30 2004-05-28 Substituted pyrrole derivatives and their use as hmg-co inhibitors

Publications (2)

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EA200501881A1 true EA200501881A1 (ru) 2006-06-30
EA009646B1 EA009646B1 (ru) 2008-02-28

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EA200501881A EA009646B1 (ru) 2003-05-30 2004-05-28 Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa

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US (3) US7923467B2 (ru)
EP (2) EP1658283A2 (ru)
JP (2) JP4901474B2 (ru)
KR (2) KR20060021870A (ru)
CN (2) CN1812983A (ru)
AP (2) AP2501A (ru)
AR (1) AR044470A1 (ru)
AU (1) AU2004242777B2 (ru)
BR (1) BRPI0410840A (ru)
CA (2) CA2753318A1 (ru)
CO (1) CO5720994A2 (ru)
CR (1) CR8111A (ru)
EA (1) EA009646B1 (ru)
EC (1) ECSP056193A (ru)
GE (1) GEP20084406B (ru)
IL (1) IL172257A0 (ru)
IS (1) IS8195A (ru)
MA (1) MA27844A1 (ru)
MX (1) MXPA05012900A (ru)
MY (1) MY148499A (ru)
NO (1) NO20056218L (ru)
NZ (2) NZ577031A (ru)
OA (1) OA13174A (ru)
RS (1) RS20050890A (ru)
SG (1) SG141430A1 (ru)
TN (1) TNSN05306A1 (ru)
UA (1) UA82698C2 (ru)
WO (1) WO2004106299A2 (ru)
ZA (1) ZA200510277B (ru)

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KR102013157B1 (ko) * 2015-03-31 2019-08-23 대원제약주식회사 결정형 및 이의 제조방법
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KR102218320B1 (ko) * 2019-07-12 2021-02-23 대원제약주식회사 (3r,5r)-7-(2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-((4-히드록시메틸페닐아미노)카보닐)-피롤-1-일)-3,5-디히드록시 헵탄산 헤미칼슘염의 제조방법, 및 이에 사용되는 중간체의 제조방법

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